Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones.

Abstract:

:To study the hormonal perturbations in FMS patients we injected sixteen FMS patients and seventeen controls a cocktail of the hypothalamic releasing hormones: Corticotropin-releasing hormone (CRH), Thyrotropin-releasing hormone (TRH), Growth hormone-releasing hormone (GHRH), and Luteinizing hormone-releasing hormone (LHRH) and observed the hormonal secretion pattern of the pituitary together with the hormones of the peripheral endocrine glands. We found in FMS patients elevated basal values of ACTH and cortisol, lowered basal values of insulin-like growth factor I (IGF-I) and of triiodothyronine (T3), elevated basal values of follicle-stimulating hormone (FSH) and lowered basal values of estrogen. Following injection of the four releasing-hormones, we found in FMS patients an augmented response of ACTH, a blunted response of TSH, while the prolactin response was exaggerated. The effects of LHRH stimulation were investigated in six FMS patients and six controls and disclosed a significantly blunted response of LH in FMS. We explain the deviations of hormonal secretion in FMS patients as being caused by chronic stress, which, after being perceived and processed by the central nervous system (CNS), activates hypothalamic CRH neurons. CRH, on the one hand, activates the pituitary-adrenal axis, but also stimulates at the hypothalamic level somatostatin secretion which, in turn, causes inhibition of GH and TSH at the pituitary level. The suppression of gonadal function may also be attributed to elevated CRH by its ability to inhibit hypothalamic LHRH release, although it could act also directly on the ovary by inhibiting FSH-stimulated estrogen production. We conclude that the observed pattern of hormonal deviations in FMS patients is a CNS adjustment to chronic pain and stress, constitutes a specific entity of FMS, and is primarily evoked by activated CRH neurons.

journal_name

Z Rheumatol

authors

Riedel W,Layka H,Neeck G

doi

10.1007/s003930050242

keywords:

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

81-7

eissn

0340-1855

issn

1435-1250

journal_volume

57 Suppl 2

pub_type

杂志文章
  • [Visceral diseases as cause of lumbar syndromes].

    abstract::30 patients with hepatitis, 50 patients with gynecological diseases, and 100 with urological diseases were investigated with regards to lumbago to find out whether there is a correlation between the internal disease and the signs of low back pain. The patients were compared with a control group of 33 healthy people. T...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Tilscher H,Bogner G,Landsiedl F

    更新日期:1977-05-01 00:00:00

  • [Immunoablation followed by autologous stem cell transplantation in lupus: a clinical update].

    abstract::Systemic lupus erythematosus (SLE) is a classic systemic autoimmune disease. Standard treatment consists of chronic therapy with antimalarials, glucocorticoids and immunosuppressive/cytotoxic drugs, which is associated with considerable side effects. In contrast, immunoablation of autoreactive immunologic memory follo...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-008-0391-5

    authors: Alexander T,Arnold R,Hiepe F

    更新日期:2009-05-01 00:00:00

  • Orthopädische Rheumatologie.

    abstract:: ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 新闻

    doi:10.1007/s00393-018-0509-3

    authors:

    更新日期:2018-11-01 00:00:00

  • Toxic epidermal necrolysis due to therapy with cyclophosphamide and mesna. A case report of a patient with seronegative rheumatoid arthritis and rheumatoid vasculitis.

    abstract::Rheumatoid vasculitis usually occurs on the background of seropositive rheumatoid arthritis, although in rare cases the patients can be seronegative. We report a woman with seronegative rheumatoid arthritis with rheumatoid vasculitis who developed toxic epidermal necrolysis involving most of her body surface area, whi...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-015-1632-z

    authors: Chowdhury AC,Misra DP,Patro PS,Agarwal V

    更新日期:2016-03-01 00:00:00

  • [§ 116b SGB V (social insurance code, book five) for rheumatology patients. An empirical assessment on the basis of administrative data].

    abstract:BACKGROUND:The choice between outpatient and inpatient care is currently undergoing major changes within the German health care system with the amendment of § 116b SGB V. This study investigates what proportion of hitherto inpatient rheumatologic care could potentially be given on an outpatient basis. METHODS:The anal...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-010-0703-4

    authors: Rath T,Bokern E,Sefo-Bukow E,Büscher G,Lüngen M,Rubbert-Roth A

    更新日期:2011-01-01 00:00:00

  • [Epidemiology and patient management in the area of spondyloarthritis].

    abstract::Within the group of inflammatory rheumatic diseases, spondyloarthropathy is the most common diagnosis after rheumatoid arthritis. Its prevalence was long underestimated. Ankylosing spondylitis (AS) and undifferentiated spondyloathropathy (uSpA) are the most common subgroups in western countries. There are still diffic...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s003930200004

    authors: Haibel H,Rudwaleit M,Braun J,Sieper J

    更新日期:2002-02-01 00:00:00

  • [Essential cryoglobulinemic vasculitis with severe peripheral neuropathy and neurogenic muscular atrophy -- inducing remission by cascade filtration].

    abstract::We report on a 60 year old patient with peripheral neuropathy, neurogenic muscular atrophy, skin ulcers, arthritis and weakness. Detection of cryoglobulins in association with typical clinical symptoms, exclusion of hepatitis C and any other disease led to a rare diagnosis: essential cryoglobulinemic vasculitis. The c...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-002-0389-3

    authors: Strunk J,Taborski U,Neeck G

    更新日期:2002-12-01 00:00:00

  • [Blood pressure in arm and finger arteries in rheumatoid arthritis].

    abstract::The pressure load is critical for vascular wall alteration. Systolic blood pressure was measured by Doppler sonography in the finger and arm arteries of 24 patients with rheumatoid arthritis and compared to a control group (n = 22) of nearly the same age. The transmitter frequency of the ultrasound probe was 9.6 MHz. ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Beste KW

    更新日期:1985-05-01 00:00:00

  • The treatment of rheumatoid arthritis with OM-8930, a bacterial immunostimulating agent.

    abstract::OM 8930, a bacterial product with immunostimulatory capacities, was studied for its efficacy in the long-term treatment of rheumatoid arthritis (RA). Ten (10) patients with active seropositive rheumatoid arthritis were treated intermittently for six months with the agent and were evaluated according to clinical, labor...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Rosenthal M,Plattner S

    更新日期:1981-09-01 00:00:00

  • [Healthcare research in rheumatology. Current state].

    abstract::Health services research in rheumatology investigates the healthcare needs, the quality of care and trends in healthcare for patients with musculoskeletal disorders. Using rheumatoid arthritis (RA) as an example, key results of health services research during the last 25 years are summarized. There are currently appro...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-013-1258-y

    authors: Zink A

    更新日期:2014-03-01 00:00:00

  • [Significance of interleukin 1 and related monokines in the pathogenesis of chronic polyarthritis].

    abstract::Activated monocytes/macrophages secrete monokines, regulatory proteins which are capable of initiating and maintaining immune processes as well as having an effect on other non immunocompetent cells. In rheumatoid arthritis the monokine Interleukin-1 (IL-1) was detected in the synovial fluid. IL-1 activates immunocomp...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Hermann E,Müller W

    更新日期:1985-09-01 00:00:00

  • Successful combination therapy using adalimumab and 5-aminosalicylic acid for a resistant case of intestinal Behçet's disease.

    abstract::Behçet's disease (BD) is a recurrent, multisystemic, inflammatory blood vessel disorder that can result in mouth, genital, and skin ulcers; arthritis; and eye and intestinal inflammation. We describe a 21-year-old Korean female patient with intestinal BD refractory to conventional medical treatment and biologic drugs....

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-020-00816-0

    authors: Kim HJ,Kim KT,Lee SG,Kim Y

    更新日期:2020-09-01 00:00:00

  • [The temporomandibular joint from the rheumatologic viewpoint].

    abstract::Temporomandibular joint affections in rheumatic disease are described. They were seen in inflamed joint diseases, mostly in rheumatoid arthritis, and less so in juvenile rheumatoid arthritis, psoriatic arthritis, Reiter's syndrome, ankylosing spondylitis, and collagen vascular disease. In osteoarthrosis, the temporoma...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:

    authors: Wörth WD,Keller B,Graber G,Müller W

    更新日期:1988-03-01 00:00:00

  • [Early recognition and screening consultation: a necessary way to improve early detection and treatment in rheumatology? : Overview of the early recognition and screening consultation models for rheumatic and musculoskeletal diseases in Germany].

    abstract::In order to reduce the prognostically relevant time interval between the initial manifestation of a rheumatic and musculoskeletal disease and diagnosis as well as the consecutive initiation of an appropriate treatment, several rheumatological centers in Germany have improved the access to initial rheumatologic evaluat...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-019-0683-y

    authors: Benesova K,Lorenz HM,Lion V,Voigt A,Krause A,Sander O,Schneider M,Feuchtenberger M,Nigg A,Leipe J,Briem S,Tiessen E,Haas F,Rihl M,Meyer-Olson D,Baraliakos X,Braun J,Schwarting A,Dreher M,Witte T,Assmann G,Hoeper

    更新日期:2019-10-01 00:00:00

  • [Inflammatory muscle diseases].

    abstract::Inflammatory myopathies are as a rule rare diseases of skeletal muscle. In the majority of cases noninfective autoimmunological reactions are assumed. Only few diseases have an infectious origin. From a myopathological point of view, polymyositis must be selected from interstitial nodular myositis. The most important ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Pongratz D

    更新日期:1986-07-01 00:00:00

  • [Pneumocystis jiroveci pneumonia (PcP) in patients with rheumatic diseases: case report and review].

    abstract::A 74-year-old female patient with rheumatoid arthritis was diagnosed with Pneumocystis jiroveci pneumonia (PcP) following therapy with methotrexate and prednisone. Although bactrim treatment was initiated and PcP was not detected by a control bronchoalveolar lavage, the patient died. The precise cause of death remains...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-005-0019-y

    authors: Bertisch B,Ruef C

    更新日期:2006-02-01 00:00:00

  • [Pathogenesis of spontaneous chronic polyarthritis in MRL mice].

    abstract::In a sequential study the pathogenesis of chronic polyarthritis occurring spontaneously in MRL mice was analysed by light microscopy. A total of 128 MRL mice of both substrains (MRL/Mp-lpr/lpr and +/+) and different age groups was studied. In 50 lpr/lpr mice, tinctorial and histochemical methods were applied for the i...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Hewicker M,Garcés LH,Kromschröder E,Trautwein G

    更新日期:1988-07-01 00:00:00

  • [Expanded anamnesis and psychodiagnostic classification of psychosomatic rheumatic patients. I: Anamnestic indications of psychosomatic correlations with manifestations of the locomotor system].

    abstract::The author describes the information gained from anamnesis which points to a psychogenetic cause of rheumatic complaints. These symptoms are part of the diagnostically important criteria which must be supplemented still further by means of a personal discussion with the patient. A great deal depends on the skill of th...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Mathies H

    更新日期:1993-07-01 00:00:00

  • [Histopathogenesis of synovialitis in experimental allergic rabbit arthritis. Comparative studies on rheumatoid synovialitis].

    abstract::The development of synovitis was studied in 64 rabbits with experimentally produced allergic arthritis and in 30 rabbits with experimentally produced non-allergic arthritis. The results are compared with the morphological changes of the synovial membrane in rheumatoid arthritis, especially in early stages, known from ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Püschel W

    更新日期:1982-01-01 00:00:00

  • Cartilage destruction in septic arthritis--electron microscopy and historical considerations.

    abstract::Light and electron microscopic investigations of joint cartilage in 13 cases of septic arthritis revealed sites of cartilaginous matrix infiltrated with polymorphonuclear granulocytes. This finding confirms rather unknown morphological works done by investigators on this diseases in the late 19th and beginning of the ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Gauger M,Mohr W

    更新日期:1995-07-01 00:00:00

  • [Acetylcholine receptor antibody in D-penicillamine therapy].

    abstract::Since 1978 a 63-year-old woman with rheumatoid arthritis received D-penicillamine (D-PA) in a daily dose of 250-500 mg (mean 300 mg/d). In 1982 the patient complained of diplopia for several days, the ophthalmological and neurological examinations three days later were normal. In July 1983 she developed a myasthenic s...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Kolarz G,Maida EM

    更新日期:1986-05-01 00:00:00

  • Alopecia universalis in a patient with rheumatoid arthritis developed during treatment with adalimumab.

    abstract::Alopecia universalis is an advanced form of alopecia areata, characterized by complete loss of hair on all hair-bearing areas. It is currently believed to be an autoimmune disorder. The development of alopecia during treatment with tumor necrosis factor alpha (TNF-α) inhibitors is a rarely observed adverse event. This...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-018-0464-z

    authors: Ostojic P,Pavlov-Dolijanovic S

    更新日期:2018-06-01 00:00:00

  • Behçet's syndrome coexisting with clinically occult ankylosing spondylitis.

    abstract::The case of a 36-year old man with Behçet's disease (BS) for 16 years had low back pain and stiffness in the cervical and lumbar spine. He was diagnosed as having ankylosing spondylitis (AS). In this report we wish to emphasize the clinically occult co-existence of AS in BS and revelation of AS after a long time of BS...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-002-0319-4

    authors: Cimen OB,Sahin G,Biçer A,Erdoğan C

    更新日期:2002-08-01 00:00:00

  • [Activity leakage and radiation exposure in radiation synovectomy of the knee: influence of different therapeutic modalities].

    abstract::In rheumatic diseases, radiation synovectomy is a reliable method. Meanwhile, radiation synovectomy is an outpatient therapy. In addition, combination with arthroscopic synovectomy is an increasing therapeutic modality. In comparison to the hitherto inpatient modality, a greater lymphatic emigration of the radionuclid...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s003930050172

    authors: Klett R,Puille M,Matter HP,Steiner D,Stürz H,Bauer R

    更新日期:1999-08-01 00:00:00

  • [DRESS syndrome following sulfasalazine treatment].

    abstract::A female patient developed systemic rash, lung edema, electrocardiogram (ECG) abnormalities and fulminant hepatitis with partial liver failure 4 weeks after the start of sulfasalazine treatment. Peripheral T-cell activation, a positive PCR test for human herpesvirus (HHV) 6 as well as eosinophilia in bronchial lavage ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-013-1308-5

    authors: Pirklbauer M,Gruber J

    更新日期:2014-03-01 00:00:00

  • [Medical treatment of rheumatoid arthritis in 2014 : Current data from the German Collaborative Arthritis Centers].

    abstract:BACKGROUND:Since the introduction of biologic treatment in rheumatoid arthritis (RA), disease activity and treatment modalities have changed substantially. The current provision and developments in recent years are analyzed with annual data from the National Database of the Collaborative Arthritis Centers in Germany. ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00393-016-0156-5

    authors: Albrecht K,Huscher D,Eidner T,Kleinert S,Späthling-Mestekemper S,Bischoff S,Zink A

    更新日期:2017-02-01 00:00:00

  • The cytokine-HPA axis feed-back circuit.

    abstract::Due to their anti-inflammatory effects and their capacity to affect the synthesis of most cytokines and the Th1/Th2 balance, endogenous glucocorticoids contribute to control the basal operation of immune cells. Immune processes result in the production of cytokines, such as IL-1, IL-2, IL-6, IL-11, IL-12, TNF-alpha, a...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s003930070014

    authors: Besedovsky HO,del Rey A

    更新日期:2000-01-01 00:00:00

  • [Enzyme therapy in comparison with immune complex determinations in chronic polyarthritis].

    abstract::42 patients with definite or classic rheumatoid arthritis were treated with an enzyme mixture (Wobenzym) for 6 weeks. Circulating immune complexes were investigated with a Clq-solid phase RIA in weekly intervals and also rheumatoid factors were determined together with other routine laboratory tests. The condition of ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Steffen C,Smolen J,Miehlke K,Hörger I,Menzel J

    更新日期:1985-03-01 00:00:00

  • [Rheumatic tendon pathologies].

    abstract:BACKGROUND:Rheumatoid arthritis is found in approximately 2 % of the total population in Europe and the peak incidence of the disease is during the fourth and fifth decades of life. In approximately 15 % the first symptoms of the disease occur at the level of the foot and ankle. If the early stage-dependent therapy wit...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-014-1407-y

    authors: Thomas M,Jordan M

    更新日期:2014-11-01 00:00:00

  • [Systemic sclerosis-clinical picture, diagnosis, and treatment].

    abstract::Systemic sclerosis is a rare rheumatologic disease that is characterised by skin and organ fibrosis as well as vascular changes and the occurrence of specific autoantibodies. It has a high morbidity and mortality while its manifestations show significant heterogeneity in patients. Thus, diagnosis and follow-up of pati...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-019-0639-2

    authors: Becker MO,Distler O,Maurer B

    更新日期:2019-06-01 00:00:00