Abstract：
:The incidence rate of inflammatory bowel disease (IBD) is becoming a global health problem that could be caused by changes in environmental and lifestyle habits. The study aimed to identify the association between the quality of drinking water, i.e., physiochemical and biological aspects of the phenotype and activity of IBD in Eastern Croatia. The study included 312 patients (63.4% ulcerative colitis, UC, and 36.6% Crohn's disease, CD) from the area of Eastern Croatia. The data were collected by questionnaires and the analysis of the water safety, based on 65 samples of drinking water by the patient's water supply method (public supply, rural water supply, and private well). IBD was active in 38.0% patients (34.0% CD and 40.0% UC). Significant differences (p = 0.001) were observed in the distribution of patients, according to counties in which they lived in. The largest deviation was noted in coliform bacteria, Escherichia coli, and enterococci bacteria, Fe, Al, and nitrate in rural water supply and private wells, although, without significant impact on IBD phenotype and activity. The hazard quotient (HQ) simulations showed that children are a sensitive group, regarding exposure to nitrates in drinking water over a long period of time, so there is a need for further monitoring and analysis of this issue.
journal_name
Int J Environ Res Public Healthauthors
Holik D,Bezdan A,Marković M,Orkić Ž,Milostić-Srb A,Mikšić Š,Včev Adoi
10.3390/ijerph17228495subject
Has Abstractpub_date
2020-11-16 00:00:00issue
22eissn
1661-7827issn
1660-4601pii
ijerph17228495journal_volume
17pub_type
杂志文章abstract：:Arsenic is a toxic metalloid with known adverse effects on human health. Glutathione-S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play a major role in detoxification and metabolism of xenobiotics. We investigated the association between GST genotypes and whole blood arsenic concentrations (BASC) in Ja...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph110807874
更新日期：2014-08-06 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2020-04-27 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-30 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-22 00:00:00
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pub_type： 杂志文章
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更新日期：2011-08-01 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2019-10-02 00:00:00
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更新日期：2020-02-25 00:00:00
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pub_type： 杂志文章
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更新日期：2018-02-13 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-05 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-19 00:00:00
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journal_title：International journal of environmental research and public health
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更新日期：2020-09-25 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15102209
更新日期：2018-10-10 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16204043
更新日期：2019-10-22 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-21 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-10 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17010375
更新日期：2020-01-06 00:00:00
