Abstract：
:The disabling pathophysiologic effects of lipid and neuroprotective effects of statins have recently been demonstrated for acute spinal cord injuries in animal models. This large scale population-based study aimed to investigate the effect hyperlipidemia and the use of statins in patients with lumbar spine injury. The National Health Insurance Research Database of Taiwan was used to identify patients with lumbar spine injury. A total of 2844 patients were grouped into three: no hyperlipidemia, hyperlipidemia using low-dose of statins (≤90 of the defined daily dosage (DDD)), and severe hyperlipidemia using high-dose of statins (>90 DDD). A Cox multiple regression model was used to compare the incidence rates of disability among the three groups. The results showed that patients with hyperlipidemia appeared a higher risk of permanent disability (adjusted HR = 1.38, p = 0.28). In subgroup analysis, patients with severe hyperlipidemia had a higher risk of disability (adjusted HR = 3.1, p < 0.004), whereas hyperlipidemia using low-dose statins had a similar risk of permanently disability (adjusted HR = 0.83, p = 0.661). Hyperlipidemia adversely affected the neurological outcomes of lumbar spinal injury. Statins may have the potential to reverse this higher risk of disability. However, this beneficiary effect of statins only existed in patients using a lower dose (≤90 DDD).
journal_name
Int J Environ Res Public Healthauthors
Chung WF,Liu SW,Chang PY,Lin FS,Chen LF,Wu JC,Chen YC,Liu L,Huang WC,Cheng H,Lo SSdoi
10.3390/ijerph120100402subject
Has Abstractpub_date
2015-01-05 00:00:00pages
402-13issue
1eissn
1661-7827issn
1660-4601pii
ijerph120100402journal_volume
12pub_type
杂志文章abstract：:On 22 March 2019 the Thai Department of Disease Control (DDC) was notified that 16 workers, including Thai and Myanmar migrant workers, from two factories located in Nakhon Phathom Province, had presented with a fever with rash during the previous 2 weeks. Active case finding was conducted among workers in both factor...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17134627
更新日期：2020-06-27 00:00:00
abstract：:Chronic cigarette smoking is associated with numerous abnormalities in brain neurobiology, but few studies specifically investigated the chronic effects of smoking (compared to the acute effects of smoking, nicotine administration, or nicotine withdrawal) on cerebral perfusion (i.e., blood flow). Predominately middle-...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph120708198
更新日期：2015-07-16 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2020-02-04 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16193752
更新日期：2019-10-04 00:00:00
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journal_title：International journal of environmental research and public health
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doi：10.3390/ijerph17031118
更新日期：2020-02-10 00:00:00
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journal_title：International journal of environmental research and public health
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更新日期：2020-11-13 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2011-05-01 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15102088
更新日期：2018-09-22 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
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更新日期：2020-02-26 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
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更新日期：2017-11-14 00:00:00
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journal_title：International journal of environmental research and public health
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更新日期：2020-01-25 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,meta分析
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更新日期：2019-04-25 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17239113
更新日期：2020-12-06 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17020479
更新日期：2020-01-11 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2019-03-20 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2019-06-04 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph14111315
更新日期：2017-10-28 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph111213097
更新日期：2014-12-16 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15102192
更新日期：2018-10-08 00:00:00
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journal_title：International journal of environmental research and public health
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更新日期：2020-06-22 00:00:00
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更新日期：2021-01-17 00:00:00
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更新日期：2018-02-21 00:00:00
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journal_title：International journal of environmental research and public health
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更新日期：2021-01-13 00:00:00
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journal_title：International journal of environmental research and public health
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更新日期：2011-06-01 00:00:00
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更新日期：2018-06-17 00:00:00
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journal_title：International journal of environmental research and public health
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journal_title：International journal of environmental research and public health
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph110504560
更新日期：2014-04-25 00:00:00
