Abstract:
:Arsenic is a toxic metalloid with known adverse effects on human health. Glutathione-S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play a major role in detoxification and metabolism of xenobiotics. We investigated the association between GST genotypes and whole blood arsenic concentrations (BASC) in Jamaican children with and without autism spectrum disorder (ASD). We used data from 100 ASD cases and their 1:1 age- and sex-matched typically developing (TD) controls (age 2-8 years) from Jamaica. Using log-transformed BASC as the dependent variable in a General Linear Model, we observed a significant interaction between GSTP1 and ASD case status while controlling for several confounding variables. However, for GSTT1 and GSTM1 we did not observe any significant associations with BASC. Our findings indicate that TD children who had the Ile/Ile or Ile/Val genotype for GSTP1 had a significantly higher geometric mean BASC than those with genotype Val/Val (3.67 µg/L vs. 2.69 µg/L, p < 0.01). Although, among the ASD cases, this difference was not statistically significant, the direction of the observed difference was consistent with that of the TD control children. These findings suggest a possible role of GSTP1 in the detoxification of arsenic.
journal_name
Int J Environ Res Public Healthauthors
Rahbar MH,Samms-Vaughan M,Ma J,Bressler J,Loveland KA,Ardjomand-Hessabi M,Dickerson AS,Grove ML,Shakespeare-Pellington S,Beecher C,McLaughlin W,Boerwinkle Edoi
10.3390/ijerph110807874subject
Has Abstractpub_date
2014-08-06 00:00:00pages
7874-95issue
8eissn
1661-7827issn
1660-4601pii
ijerph110807874journal_volume
11pub_type
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