Abstract:
:Alongside biological, psychological, and social risk factors, psychotic syndromes may be related to disturbances of neuronal migration. This highly complex process characterizes the developing brain of the fetus, the early postnatal brain, and the adult brain, as reflected by changes within the subventricular zone and the dentate gyrus of the hippocampus, where neurogenesis persists throughout life. Psychosis also appears to be linked to human cytomegalovirus (HCMV) infection. However, little is known about the connection between psychosis, HCMV infection, and disruption of neuronal migration. The present study addresses the hypothesis that HCMV infection may lead to mental disorders through mechanisms of autoimmune cross-reactivity. Searching for common peptides that underlie immune cross-reactions, the analyses focus on HCMV and human proteins involved in neuronal migration. Results demonstrate a large overlap of viral peptides with human proteins associated with neuronal migration, such as ventral anterior homeobox 1 and cell adhesion molecule 1 implicated in GABAergic and glutamatergic neurotransmission. The present findings support the possibility of immune cross-reactivity between HCMV and human proteins that-when altered, mutated, or improperly functioning-may disrupt normal neuronal migration. In addition, these findings are consistent with a molecular and mechanistic framework for pathological sequences of events, beginning with HCMV infection, followed by immune activation, cross-reactivity, and neuronal protein variations that may ultimately contribute to the emergence of mental disorders, including psychosis.
journal_name
Front Psychiatryjournal_title
Frontiers in psychiatryauthors
Lucchese G,Flöel A,Stahl Bdoi
10.3389/fpsyt.2020.00349subject
Has Abstractpub_date
2020-05-08 00:00:00pages
349issn
1664-0640journal_volume
11pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2019.00355
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doi:10.3389/fpsyt.2019.00552
更新日期:2019-07-30 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2013.00112
更新日期:2013-09-20 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2020-06-30 00:00:00
abstract::[This corrects the article DOI: 10.3389/fpsyt.2019.00786.]. ...
journal_title:Frontiers in psychiatry
pub_type: 已发布勘误
doi:10.3389/fpsyt.2019.00900
更新日期:2019-12-17 00:00:00
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doi:10.3389/fpsyt.2019.00518
更新日期:2019-07-19 00:00:00
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pub_type: 杂志文章,评审
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