Abstract:
INTRODUCTION:There is a known connection between periodontitis and atherosclerosis and the presence of periopathogens in blood vessels. However, changes of the oral microflora related to the aging process and its possible effects on atherosclerosis, have yet to be analyzed. The aim of this study was to assess temporal changes in the frequency of periodontal bacteria in the subgingival plaque and in atherosclerotic blood vessels of patients with atherosclerosis. METHODOLOGY:The study included 100 patients with atherosclerosis and periodontitis, divided into two groups, below and over 60 years of age. Clinical examinations were performedand subgingival plaque specimens were collected as well as biopsy specimens from the following arteries: coronary (34), carotid (29), abdominal (10), femoral (10), mammary (13) and iliac (4). Subgingival and artery specimens were subjected to PCR detection of 5 major periodontal pathogens: Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythensis (Tf) and Treponema denticola (Td). RESULTS:Tf was the most and Td the least frequent bacteria in both age groups and in both types of samples. The frequencies of bacteria in subgingival versus atherosclerotic samples were: Tf (76%:53%), Pi (71%:31%), Pg (60%:38%), Aa (39%:14%) and Td (21%:6%). Only Aa and Pi showed a significant difference of prevalence between younger and older patients. The most colonized artery was a. coronaria, followed by a. carotis, a. abdominalis, a. mammaria, and a. femoralis. CONCLUSIONS:Patient's age and the distance of a given blood vessel from the oral cavity influenced microbiological findings in the atherotic plaque.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Kannosh I,Staletovic D,Toljic B,Radunovic M,Pucar A,Matic Petrovic S,Grubisa I,Lazarevic M,Brkic Z,Knezevic Vukcevic J,Milasin Jdoi
10.3855/jidc.10980subject
Has Abstractpub_date
2018-12-31 00:00:00pages
1088-1095issue
12eissn
2036-6590issn
1972-2680journal_volume
12pub_type
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