Abstract:
:Lipid metabolism plays a key role in many cellular processes. We show here that regulatory T cells have enhanced lipid storage within subcellular lipid droplets (LD). They also express elevated amounts of both isoforms of diacylglycerol acyl transferase (DGAT1 & 2), enzymes required for the terminal step of triacylglycerol synthesis. In regulatory T-cells (Tregs), the conversion of diacylglycerols to triacylglycerols serves two additional purposes other than lipid storage. First, we demonstrate that it protects T cells from the toxic effects of saturated long chain fatty acids. Second, we show that Triglyceride formation is essential for limiting activation of protein kinase C via free diacyl glycerol moieties. Inhibition of DGAT1 resulted in elevated active PKC and nuclear NFKB, as well as impaired Foxp3 induction in response to TGFβ. Thus, Tregs utilize a positive feedback mechanism to promote sustained expression of Foxp3 associated with control of LD formation.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Howie D,Ten Bokum A,Cobbold SP,Yu Z,Kessler BM,Waldmann Hdoi
10.3389/fimmu.2019.01860subject
Has Abstractpub_date
2019-08-13 00:00:00pages
1860issn
1664-3224journal_volume
10pub_type
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