Abstract：
:B-cell lymphoma/leukaemia 11A (BCL11A) is a modulator of foetal-to-adult globin switching and is involved in brain development and normal lymphopoiesis. The three-dimensional structure of BCL11A and its structural domains had not yet been completely determined; hence, this study aimed to elucidate the structural domains of BCL11A. Molecular modelling and dynamics simulation studies were conducted using in silico tools with the templates selected based on Basic Local Alignment Search Tool (BLAST) searches of the Protein Data Bank (PDB). Ten protein models were generated using the MODELLER software, and the best model was selected according to the Discrete Optimised Protein Energy (DOPE) score and validated using the RAMPAGE server by evaluation of the Ramachandran plot. More than 93% of the amino acid residues of the best model of BCL11A were found to be in the favoured and allowed regions. The best model was validated using a 100-ns time span molecular dynamics simulation. The root-mean-square deviation, root-mean-square fluctuation, and radius of gyration values were found to explain the stability of the best BCL11A protein molecular model generated in the study. The validated best model of the BCL11A protein may be useful for effective modulator studies on foetal-to-adult globin switching and related research.
journal_name
Am J Transl Resjournal_title
American journal of translational researchauthors
Abdulazeez Ssubject
Has Abstractpub_date
2019-06-15 00:00:00pages
3689-3697issue
6issn
1943-8141journal_volume
11pub_type
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2019-05-15 00:00:00
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journal_title：American journal of translational research
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abstract：:Extracorporeal pulsed electromagnetic field (PEMF) has been shown the ability to improve regeneration in various ischemic episodes. Here, we examined whether PEMF therapy facilitate cardiac recovery in rat myocardial infarction (MI), and the cellular/molecular mechanisms underlying PEMF-related therapy was further inv...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2014-05-15 00:00:00
abstract：BACKGROUND:Glioma is the most common malignant tumor in the adult human brain and has one of the lowest patient survival rates. MicroRNAs (miRNAs) play important roles in the development of cancers, including glioma, and potentially have valuable therapeutic applications in glioma; however, their specific functions and...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2018-09-15 00:00:00
abstract：:Nonalcoholic steatohepatitis represents a significant and rapidly growing unmet medical need. The development of novel therapies has been hindered in part, by the limitations of existing preclinical models. There is a strong need for physiologically relevant in vivo and in vitro liver fibrosis models that are characte...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2019-03-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2019-04-15 00:00:00
abstract：:Global microRNA (miRNA) profile may predict prostate cancer (PCa) behaviors. In this study, we examined global miRNA expression by miRNA profiling as well as specific miRNA expression levels in PCa epithelium and stroma by in situ hybridization (ISH) and correlated with various clinicopathological features. We first p...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2014-07-18 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2019-05-15 00:00:00
abstract：:Radiation-induced heart disease (RIHD) is a common sequelae of thoracic irradiation. Currently, there is no effective prevention and treatment strategy. Oxidative stress is associated with the development of RIHD. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) has been defined as the multipotent prope...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2019-10-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2018-12-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2018-07-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2015-03-15 00:00:00
abstract：:MicroRNAs (miRNAs) have been involved in some human malignancies and correlated with tumor progression. The dysregulation of miR-130 is found in various cancers and correlated with tumor proliferation and apoptosis. However, its expression and function in non-small cell lung cancer (NSCLC) have not been investigated y...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-04-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-07-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2016-12-15 00:00:00
abstract：:As two major non-operative methods, physiotherapy and acupuncture have been proved to be safe and effective in osteoarthritis (OA) treatment. However, only a little study focused on functions of both methods on cartilage repairing. The main goal of this research is to prove and compare effectiveness of acupuncture and...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2016-09-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2018-02-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-02-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-06-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章,评审
doi：
更新日期：2017-05-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2009-05-08 00:00:00
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journal_title：American journal of translational research
pub_type：
doi：
更新日期：2019-04-15 00:00:00
abstract：:EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target genes via local chromatin reorganization. Numerous evidences show that EZH2 plays a critical role in cancer initiation, progression and metastasis,...
journal_title：American journal of translational research
pub_type： 杂志文章,评审
doi：
更新日期：2015-02-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2018-08-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-11-15 00:00:00
abstract：:Computed tomography imaging of the temporomandibular joint was carried out in 22 previously-diagnosed arthritis patients (3 men, 19 women). This descriptive, cross-sectional observational, qualitative study allowed to characterize the type of condylar morphology condition, the space between temporomandibular joint, th...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2019-01-15 00:00:00
abstract：:Lupus nephritis (LN) is a kidney disorder resulting from systemic lupus erythematosus (SLE), an autoimmune inflammatory disease. MicroRNAs (miRNAs) have emerged as a new class of therapeutic targets in LN treatment, but how they specifically contribute to the disease development remains unknown. In this study, the exp...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-08-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2020-02-15 00:00:00
abstract：:Both POEMS syndrome and IgG4 related diseases are uncommon and clinical manifestations have been multifarious and nonspecific. There is still no literature describing the relationships between these two diseases. This study describes a case of a 33-year-old woman with POEMS syndrome, who had high serum IgG4 concentrat...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2016-02-15 00:00:00
abstract：:As an autoimmune disease, myasthenia gravis is caused by the dysfunction of neural transmission. Acetylcholine is known to exert its function after entering into synaptic cleft through binding onto postsynaptic membrane. The role of acetylcholine in binding MuSK in myasthenia gravis, however, remains unknown. A total ...
journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2016-04-15 00:00:00
