Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy.

abstract：:Following the discovery that the amyloid precursor protein (APP) is the source of β-amyloid peptides (Aβ) that accumulate in Alzheimer's disease (AD), structural analyses suggested that the holoprotein resembles a transmembrane receptor. Initial studies using reconstituted membranes demonstrated that APP can directly ...

journal_title：Frontiers in molecular neuroscience

authors： Copenhaver PF,Kögel D

更新日期：2017-01-31 00:00:00

abstract：:Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Her...

journal_title：Frontiers in molecular neuroscience

authors： Huang C,Lu F,Li P,Cao C,Liu Z

更新日期：2017-06-28 00:00:00

abstract：:The importance of catecholamines in post-traumatic stress disorder (PTSD) still needs to be explored. We aimed to evaluate epinephrine's (EPI) causal role and molecular mechanism for the persistence of PTSD traumatic memories. Wild-type (WT) and EPI-deficient mice (phenylethanolamine-N-methyltransferase-knockout mice,...

journal_title：Frontiers in molecular neuroscience

authors： Martinho R,Oliveira A,Correia G,Marques M,Seixas R,Serrão P,Moreira-Rodrigues M

更新日期：2020-10-26 00:00:00

abstract：:Microglia are the innate sentinels of the central nervous system (CNS) and are responsible for the homeostasis and immune defense of the CNS. Under the influence of the local environment and cell-cell interaction, microglia exhibit a multidimensional and context-dependent phenotypes that can be cytotoxic and neuroprot...

journal_title：Frontiers in molecular neuroscience

authors： Siew JJ,Chern Y

更新日期：2018-05-14 00:00:00

abstract：:Transcription factors regulate multiple processes during brain development and in the adult brain, from brain patterning to differentiation and maturation of highly specialized neurons as well as establishing and maintaining the functional neuronal connectivity. The members of the zinc-finger transcription factor fami...

journal_title：Frontiers in molecular neuroscience

authors： Simon R,Wiegreffe C,Britsch S

更新日期：2020-04-08 00:00:00

abstract：:Aim: Traumatic brain injury (TBI) is a leading cause of mortality/morbidity and is associated with chronic neuroinflammation. Melanocortin receptor agonists including adrenocorticotropic hormone (ACTH) ameliorate inflammation and provide a novel therapeutic approach. We examined the effect of long-acting cosyntropin (...

journal_title：Frontiers in molecular neuroscience

authors： Siebold L,Krueger AC,Abdala JA,Figueroa JD,Bartnik-Olson B,Holshouser B,Wilson CG,Ashwal S

更新日期：2020-06-26 00:00:00

abstract：:Ischemic stroke is one of the most common causes of death and disability worldwide. Neuroinflammation is a major pathological event involved in the process of ischemic injury and repair. In particular, microglia play a dual role in neuroinflammation. During the acute phase of stroke onset, M2 microglia are the dominan...

journal_title：Frontiers in molecular neuroscience

authors： Lian L,Zhang Y,Liu L,Yang L,Cai Y,Zhang J,Xu S

更新日期：2021-01-07 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in biological systems. Though the field of lncRNA has been progressing rapidly, a complete understanding of the role of lncRNAs in neuroblastoma pathogenesis is still lacking. To identify the abrogated lncRNAs in primary neuroblastoma and i...

journal_title：Frontiers in molecular neuroscience

authors： Prajapati B,Fatma M,Fatima M,Khan MT,Sinha S,Seth PK

更新日期：2019-12-12 00:00:00

abstract：:Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in ...

journal_title：Frontiers in molecular neuroscience

authors： Schlichting M,Rieger D,Cusumano P,Grebler R,Costa R,Mazzotta GM,Helfrich-Förster C

更新日期：2018-07-18 00:00:00

abstract：:Recoverin (Rcv) is a low molecular-weight, neuronal calcium sensor (NCS) primarily located in photoreceptor outer segments of the vertebrate retina. Calcium ions (Ca2+)-bound Rcv has been proposed to inhibit G-protein-coupled receptor kinase (GRKs) in darkness. During the light response, the Ca2+-free Rcv releases GRK...

journal_title：Frontiers in molecular neuroscience

authors： Zang J,Neuhauss SCF

更新日期：2018-12-20 00:00:00

abstract：:Although second harmonic generation (SHG) microscopy provides unique imaging advantages for voltage imaging and other biological applications, genetically-encoded SHG chromophores remain relatively unexplored. SHG only arises from non-centrosymmetric media, so an anisotropic arrangement of chromophores is essential to...

journal_title：Frontiers in molecular neuroscience

authors： Jinno Y,Shoda K,Rial-Verde E,Yuste R,Miyawaki A,Tsutsui H

更新日期：2014-11-27 00:00:00

abstract：:Cytoplasmic FMR1-interacting protein 2 (CYFIP2) is a key component of the WAVE regulatory complex (WRC) which regulates actin polymerization and branching in diverse cellular compartments. Recent whole exome sequencing studies identified de novo hotspot variants in CYFIP2 from patients with early-onset epileptic encep...

journal_title：Frontiers in molecular neuroscience

authors： Zhang Y,Kang H,Lee Y,Kim Y,Lee B,Kim JY,Jin C,Kim S,Kim H,Han K

更新日期：2019-01-04 00:00:00

abstract：:The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) are major excitatory receptors that mediate fast neurotransmission in the mammalian brain. The surface expression of functional AMPARs is crucial for synaptic transmission and plasticity. AMPAR auxiliary subunits control ...

journal_title：Frontiers in molecular neuroscience

authors： Wei M,Jia M,Zhang J,Yu L,Zhao Y,Chen Y,Ma Y,Zhang W,Shi YS,Zhang C

更新日期：2017-03-02 00:00:00

abstract：:In the last decade, bioinformatic analyses of high-throughput proteomics and transcriptomics data have enabled researchers to gain insight into the molecular networks that may underlie lasting changes in synaptic efficacy. Development and utilization of these techniques have advanced the field of learning and memory s...

journal_title：Frontiers in molecular neuroscience

authors： Namjoshi SV,Raab-Graham KF

更新日期：2017-02-24 00:00:00

abstract：:The application of super-resolution optical microscopy to investigating synaptic structures has revealed a highly heterogeneous and variable intra-synaptic organization. Dense subsynaptic protein assemblies named subsynaptic domains or SSDs have been proposed as structural units that regulate the efficacy of neuronal ...

journal_title：Frontiers in molecular neuroscience

authors： Yang X,Specht CG

更新日期：2019-07-02 00:00:00

abstract：:Neuronal calcium sensor-1 (NCS-1) protein is abundantly expressed in the central nervous system and retinal neurons, where it regulates many vital processes such as synaptic transmission. It coordinates three calcium ions by EF-hands 2-4, thereby transducing Ca2+ signals to a wide range of protein targets, including G...

journal_title：Frontiers in molecular neuroscience

authors： Tsvetkov PO,Roman AY,Baksheeva VE,Nazipova AA,Shevelyova MP,Vladimirov VI,Buyanova MF,Zinchenko DV,Zamyatnin AA Jr,Devred F,Golovin AV,Permyakov SE,Zernii EY

更新日期：2018-12-14 00:00:00

abstract：:Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer's Disease (AD), but APP may also regulate multiple aspects of neuronal development, albeit via mechanisms that are not well understood. APP is a member of a family of transmembrane gl...

journal_title：Frontiers in molecular neuroscience

authors： Ramaker JM,Cargill RS,Swanson TL,Quirindongo H,Cassar M,Kretzschmar D,Copenhaver PF

更新日期：2016-11-25 00:00:00

abstract：:Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) is a gatekeeper of mitochondrial quality control. The present study was aimed to examine whether PINK1 possesses a protective function against gentamicin (GM)-induced sensory hair cell (HC) damage in vitro. The formation of parkin particles (a mar...

journal_title：Frontiers in molecular neuroscience

authors： Yang Q,Zhou Y,Yin H,Li H,Zhou M,Sun G,Cao Z,Man R,Wang H,Li J

更新日期：2018-11-12 00:00:00

abstract：:The role of ion channels in neurons and muscles has been well characterized. However, recent work has demonstrated both the presence and necessity of ion channels in diverse cell types for morphological development. For example, mutations that disrupt ion channels give rise to abnormal structural development in specie...

journal_title：Frontiers in molecular neuroscience

authors： Ozekin YH,Isner T,Bates EA

更新日期：2020-06-09 00:00:00

abstract：:GABAergic interneuron diversity is a key feature in the brain that helps to create different brain activity patterns and behavioral states. Cell type classification schemes-based on anatomical, physiological and molecular features-have provided us with a detailed understanding of the distinct types that constitute thi...

journal_title：Frontiers in molecular neuroscience

authors： Que L,Winterer J,Földy C

更新日期：2019-05-07 00:00:00

abstract：:Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. It is caused by the overexpansion of cytosine-guanine-guanine (CGG) trinucleotide in Fmr1 gene, resulting in complete loss of the fragile X mental retardation protein (FMRP). Previous studies using Fmr1 knockout (Fmr1 KO) mice have ...

journal_title：Frontiers in molecular neuroscience

authors： Yau SY,Bettio L,Chiu J,Chiu C,Christie BR

更新日期：2019-01-17 00:00:00

abstract：:Human achaete-scute homolog-1 (hASH1), encoded by the human ASCL1 gene, belongs to the family of basic helix-loop-helix transcription factors. hASH1 and its mammalian homolog Mash1 are expressed in the central and peripheral nervous system during development, and promote early neuronal differentiation. Furthermore, hA...

journal_title：Frontiers in molecular neuroscience

authors： Benko E,Winkelmann A,Meier JC,Persson PB,Scholz H,Fähling M

更新日期：2011-02-07 00:00:00

abstract：:The constitutively active protein glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, acts paradoxically as a tumor suppressor in some cancers while potentiates growth in others. Deciphering what governs its actions is vital for understanding many pathological conditions, including brain cancer. What are see...

journal_title：Frontiers in molecular neuroscience

authors： Mills CN,Nowsheen S,Bonner JA,Yang ES

更新日期：2011-11-25 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and is characterized by the buildup of β-amyloid plaques and neurofibrillary Tau tangles. This leads to decreased synaptic efficacy, cell death, and, consequently, brain atrophy in patients. Behaviorally, this manifests as memory loss and confusion. Using a...

journal_title：Frontiers in molecular neuroscience

authors： Greene AN,Parks LG,Solomon MB,Privette Vinnedge LM

更新日期：2020-11-16 00:00:00

abstract：:Many genes controlling neuronal development also regulate adult neurogenesis. We investigated in vivo the effect of Sonic hedgehog (Shh) signaling activation on patterning and neurogenesis of the hippocampus and behavior of Patched1 (Ptch1) heterozygous mice (Ptch1+/- ). We demonstrated for the first time, that Ptch1+...

journal_title：Frontiers in molecular neuroscience

authors： Antonelli F,Casciati A,Tanori M,Tanno B,Linares-Vidal MV,Serra N,Bellés M,Pannicelli A,Saran A,Pazzaglia S

更新日期：2018-05-23 00:00:00

abstract：:Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within and amongst cells. Not surprisingly therefore, cysteines are associated...

journal_title：Frontiers in molecular neuroscience

authors： Fra A,Yoboue ED,Sitia R

更新日期：2017-06-06 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00177.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Belin S,Herron J,VerPlank JJS,Park Y,Feltri LM,Poitelon Y

更新日期：2019-10-18 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00099.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Yadav SC,Tetenborg S,Dedek K

更新日期：2019-06-12 00:00:00

abstract：:An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration (FTLD). Both gain-of-function (gf) and loss-of-function (lf) mechanisms have been involved in C9ORF72 related ALS/FTLD. The gf mechanism of C9ORF72 ...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Hao L,Saur T,Joyal K,Zhao Y,Zhai D,Li J,Pribadi M,Coppola G,Cohen BM,Buttner EA

更新日期：2016-11-08 00:00:00

abstract：:In the brain, metabolic supply and demand is directly coupled to neuronal activation. Methods for culturing primary rodent brain cells have come of age and are geared toward sophisticated modeling of human brain physiology and pathology. However, the impact of the culture microenvironment on neuronal function is rarel...

journal_title：Frontiers in molecular neuroscience

authors： Sünwoldt J,Bosche B,Meisel A,Mergenthaler P

更新日期：2017-09-29 00:00:00