Abstract:
:There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin pharmacokinetics in groups of patients with normal renal function and in those with chronic kidney failure. The study used a population pharmacokinetic modeling approach, based on plasma vancomycin concentrations and other data from 78 patients with chronic kidney failure and 32 patients with normal renal function. The model was developed using NONMEM software and validated by bootstrapping. The final model for patients with impaired kidney function was described by the following equation: CL (L/h) = 0.284 + 0.000596 x DD + 0.00194 x AST, and that for the patients with normal kidney function by: CL (L/h) = 0.0727 + 0.205 x FIB. If our results are confirmed by new studies on two similar populations, these factors could be considered when dosing vancomycin in patients with chronically damaged kidneys, as well as in patients with normal kidneys who frequently require high doses of vancomycin.
journal_name
Open Med (Wars)journal_title
Open medicine (Warsaw, Poland)authors
Zaric RZ,Milovanovic J,Rosic N,Milovanovic D,Zecevic DR,Folic M,Jankovic Sdoi
10.1515/med-2018-0068subject
Has Abstractpub_date
2018-10-22 00:00:00pages
512-519issn
2391-5463pii
med-2018-0068journal_volume
13pub_type
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