Abstract:
:Melanin-concentrating hormone (MCH) is a cyclic 19 amino acid orexigenic hypothalamic peptide. MCH is located in the lateral and dorsal hypothalamus, as well as in the zona incerta. In mammals MCH increases food intake, contributes to regulation of energy balance, temperature, reproductive function, endocrine homeostasis and biological rhythms. Several studies have proved the significance of MCH in obesity, diabetes and depression. Although the peptide is well-characterized in mouse models, much less is known about its functions in avians. In birds the MCH system especially in the lateral and basal hypothalamus has important connections to the limbic system and it coordinates the vegetative and endocrine functions, as well as the emotional behaviour. Pharmacological modulation of MCH system could contribute to the therapy of eating disorders and improve agricultural efficiency regarding avians. Reviewing the current knowledge on MCH system in human, rodents and avians may stimulate a new wave of studies in the field.
journal_name
Open Med (Wars)journal_title
Open medicine (Warsaw, Poland)authors
Bencze J,Pocsai K,Murnyák B,Gergely PA,Juhász B,Szilvássy Z,Hortobágyi Tdoi
10.1515/med-2018-0040subject
Has Abstractpub_date
2018-07-06 00:00:00pages
264-269issn
2391-5463pii
med-2018-0040journal_volume
13pub_type
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