Abstract：
INTRODUCTION:Multiacinar regenerative nodules are benign hepatocellular nodules related to vascular disturbances of the liver. They strongly resemble conventional focal nodular hyperplasia but are connected to different clinical settings, typically chronic liver disease. The purpose of the present study was to describe the key imaging features of these lesions and compare them with a control arm of focal nodular hyperplasia. MATERIAL AND METHODS:A blinded consensus review of liver magnetic resonance consisting of 26 cases of multiacinar regenerative nodules and 25 cases of focal nodular hyperplasia was performed. Lesion size, shape, margins, structure, T1 and T2 signal intensity, diffusion and contrast-enhanced features (including hepatobiliary phase), presence of a central scar and of a peripheral hypointense rim were compared between the two groups. RESULTS:Significant differences between multiacinar regenerative nodules and focal nodular hyperplasia included size (median 2.35 cm, IQR: 2.13, vs 6.00 cm, IQR: 5.20, respectively, p < 0.001), presence of a peripheral hypointense rim after contrast (n = 9 vs n = 2 cases, p = 0.038) and of a central scar (n = 9 vs n = 20, p = 0.002). There were no other significant differences. DISCUSSION:Overall multiacinar regenerative nodules and focal nodular hyperplasia have very similar imaging features but lack of a central scar and presence of a hypointense rim should suggest a diagnosis of multiacinar regenerative nodules. CONCLUSIONS:Recognition of the imaging findings of multiacinar regenerative nodules can explain some atypical cases of focal nodular hyperplasia, avoiding unnecessary biopsies. They may also be the trigger to investigate an unsuspected underlying liver vascular abnormality. :Introdução: Nódulos regenerativos multiacinares são nódulos hepatocelulares benignos relacionados com alterações vasculares hepáticas. São muito semelhantes à hiperplasia nodular focal mas ocorrem num contexto diferente de doença hepática crónica. O objectivo deste trabalho foi descrever os achados imagiológicos principais destes nódulos e compará-los com um grupo controlo de hiperplasia nodular focal. Material e Métodos: Foi efectuada uma revisão cega de estudos por ressonância magnética de 26 casos de nódulos regenerativos multiacinares e 25 de hiperplasia nodular focal, sendo os dois grupos comparados quanto à dimensão das lesões, morfologia, margens, estrutura, aspecto em T1, T2, difusão e após contraste (incluindo na fase hepatobiliar), presença de cicatriz central e halo hipointenso. Resultados: Foram encontradas diferenças significativas entre nódulos regenerativos multiacinares e hiperplasia nodular focal quanto às dimensões das lesões (mediana 2,35 cm AIQ: 2,13 vs 6,00 cm AIQ: 5,20 respectivamente, p < 0,001), presença de halo hipointenso após contraste (n = 9 vs n = 2, p = 0,038) e de cicatriz central (n = 9 vs n = 20, p = 0,002). Não se observaram outras diferenças significativas. Discussão: Nódulos regenerativos multiacinares e hiperplasia nodular focal são globalmente muito semelhantes mas a ausência de cicatriz central e a presença de halo hipointenso deve sugerir o diagnóstico de nódulos regenerativos multiacinares. Conclusão: O reconhecimento dos achados imagiológicos de nódulos regenerativos multiacinares pode explicar alguns dos casos atípicos de hiperplasia nodular focal e prevenir biopsias desnecessárias. Pode também desencadear uma investigação mais aprofundada de anomalias vasculares hepáticas subjacentes eventualmente desconhecidas.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Donato H,Andrade L,Bastati N,Cipriano A,Ba-Ssalamah A,Caseiro-Alves Fdoi
10.20344/amp.10259subject
Has Abstractpub_date
2018-09-28 00:00:00pages
470-477issue
9eissn
0870-399Xissn
1646-0758journal_volume
31pub_type
杂志文章abstract：:Central diabetes insipidus, is a syndrome characterized by the excretion of abnormally elevated volumes of diluted urine, due to the diminution of reabsorption of water in the collecting ducts, induced by the diminution of production of antidiuretic hormone. The involvement of the central nervous system in the leukaem...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：:Osteoporosis in men, despite being a less important public health problem than osteoporosis in women, should not be neglected as it has many deleterious effects as well as social and economic costs. Finding the cause of osteoporosis is more complex in men than in women, and prevention should be based on an early evalu...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-05-01 00:00:00
abstract：:In Portugal, piroxicam is one of the most prescribed non-steroidal anti-inflammatory agents (NSAIDs) and is frequently associated to photosensitivity skin reactions, well known by all dermatologists. The authors review the physiopathology and clinical patterns of this adverse drug reaction. Importance is given to the ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：INTRODUCTION:To analyze the cesarean section rate evolution in a tertiary hospital and the main indications for cesarean section. MATERIAL AND METHODS:A retrospective study was conducted at a major academic hospital and included 5 751 women who had a cesarean section from 2005 to 2011. The rates of overall, primary an...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：INTRODUCTION AND AIM:In Portugal, there is very few experience in pediatric retroperitoneoscopy. The authors present the first Portuguese series of retroperitoneal laparoscopic nephrectomies (RLN) in children younger than nine years-old, as well as a literature review about the theme. MATERIAL AND METHODS:Retrospectiv...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2011-12-01 00:00:00
abstract：:Over the past 20 years allogeneic bone marrow transplantation has been increasingly utilized in the treatment of acute and chronic leukemias, aplastic anemia, severe forms of thalassemia, immunodeficiency syndromes and metabolic disorders due to a lack of specific enzymes in the monocyte-macrophage system. Despite the...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:In the medical press there are several data confirming the value of E.R.C.P. and E.E.S., in the therapeutical approach of acute lithiasic pancreatitis (A.L.P.). Nowadays it is a first line endoscopic technic on the therapeutical approach in A.L.P. permitting to clean out the biliary tree of stones, eliminating the eti...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：OBJECTIVE:To assess epidemiological profile of spinal cord injury outpatients which have been participating of rehabilitation programme using neuromuscular electrical stimulation, in order to implement campaigns for preventing spinal cord trauma. METHODS:From January to April 2009, 30 patients at the spinal cord injur...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：:Referring to examples from the poetry of Fernando Pessoa and Mário de Sá Carneiro, we draw attention to the narcissistic relationship between mother and baby, to the role of the mirror-image of the mother's face, and to the organization of a false self caused by a deficiency both of that function, and of the narcissis...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:In a housing estate population with a high prevalence of tuberculosis, the authors conducted tuberculosis screening with the tuberculin test, and an investigation with three purposes: evaluation of tuberculosis infection (defined as > 10 mm on tuberculin test), evaluation of BCG effect on tuberculin test, and evaluati...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:After the discovery of insulin and during almost an half of a century, physicians and researchers apply their efforts in a better knowledge to reduce the perinatal mortality of the offspring of the diabetic mother. The optimisation of glucose control--the main key of the management of diabetic pregnancy--and the new m...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2002-05-01 00:00:00
abstract：:Sepsis is a common pathology during the neonatal period. Low-birth weight is the most important isolated risk factor. With the purpose of determining the prevalence of nosocomial infection in newborns of very low birth weight (VLBW), finding the microbial flora and the mortality of these patients, the authors retrospe...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:The effects of immunodepression on several disease states have constituted an important area of research, leading to the identification of relevant associations between immunodepression and a vast set of comorbidities, including infectious diseases, cardiovascular diseases and cancer. Research on the effects of immuno...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：10.20344/amp.7997
更新日期：2017-01-31 00:00:00
abstract：:Considering the geographical asymmetric distribution of viral hepatitis A, B and E, having a much higher prevalence in the less developed world, travellers from developed countries are exposed to a considerable and often underestimated risk of hepatitis infection. In fact a significant percentage of viral hepatitis oc...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:Female Urinary Incontinence (UI) is a major public health issue given its high prevalence and its physical, psychological and social impact on women's lives. The aim of this study was to determine the prevalence and impact of Stress Urinary Incontinence (SUI) before and during pregnancy in parturients from...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Neurocysticercosis (NCC) is the most frequent parasitic disease of the central nervous system. Other Portuguese works showed it to be endemic in the north of our country. The purpose of this paper is to aid the characterization of NCC in the geographic area of our Institution. We retrospectively reviewed the findings ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Because the metabolic syndrome (MS) poses a growing public health problem, it is crucial to identify related modifiable risk factors. The MS is a multifaceted syndrome, however, physical activity (PA) is thought to be one of the protective factors in MS occurrence. The purpose of this study is to analyse recent litera...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：:A case of a 44 years old patient with inoperable gastric adenocarcinoma and exuberant lesions of Acanthosis Nigricans is described. He died nine months after the diagnosis, having experienced disappearance of the cutaneous manifestations after the cytostatic treatment done. The literature about Acanthosis Nigricans is...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1989-01-01 00:00:00
abstract：:In order to clarify the early systolic partial closure (notching) of aortic valve in patients (pts) with dilated cardiomyopathy (DC), authors (AA) evaluated the M-mode echocardiograms corresponding to 41 pts with DC. Pts were separated in two groups, according to the presence of systolic notching: group A (18 pts) pre...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:Fever of unknown origin is a diagnostic challenge. When the diagnosis remains elusive despite extensive non-invasive diagnostic studies, it can be necessary to conduct more invasive procedures, such as liver biopsy. We report a male with fever of unknown origin who had tender enlarged liver and raised liver enzymes wh...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:In recent years, the time for motherhood has been postponed, which is related to social aspects and can lead to health problems for the pregnant women and the child. An appropriate follow-up of the pregnancy is essential for identification and early treatment of possible complications. The purpose of this study was to...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：:The correct practice of specialized Clinical Pathology is dependent on the acquired aptitude and capacity gained by residents during their specialization. So, the adopted program for residents must be practical and detailed, obviously exceeding the simple and routine execution of laboratory methods and techniques. In ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:Whipple's Disease is a rare multisystemic disease caused by Gram-positive bacillus, Tropheryma whippelii, family of Actinobacterias and group of Actinomycetes. Because the disease is rare and has different forms of presentation the diagnosis comes frequently late. The authors present the case of a white man, 50 years ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：:The circumstances preceding the future revision of the medical curriculum are analysed, main internal and external stimuli are described, and sources of resistance to changes in medical training require new educational philosophy, privileging oriented training during undergraduation, as a preliminary phase of medical ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：INTRODUCTION:Metals are a common cause of allergic contact dermatitis. After the introduction of the EU Nickel Directive (1994/27/CE; 2004/96/EC) and, more recently, the Cement Directive (2003/53/EC) there has been a significant decrease in sensitization to metals mainly in the Nordic countries. The applicability of th...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:This study was undertaken to assess the value of Cockroft-Gault Formula (FCG) in the patients of an Internal Medicine ward. METHODS:FCG was compared with creatinine clearance (DC) adjusted for corporal area. Serum creatinine was measured after 24 h urine collection and 8 h fast. By the subtraction of FCG fr...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：:The authors review and discuss the medical treatment in the prehospital phase of acute myocardial infarction while working at the Referral Centre for Emergency Patients of the National Institute for Medical Emergencies (CODU-INEM). The diagnosis of myocardial infarction should be suspected immediately by the doctor on...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1998-05-01 00:00:00
abstract：:Temporal arteritis is a systemic vasculitis mainly affecting large and medium sized vessels, temporal artery in particular. The authors report the case of a male who presented with large painful scalp ulcers over the temporo-parietal area, ipsilateral headache, amaurosis fugax and jaw claudication. Temporal arteries w...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:On page 761, in the first sentence of the Introduction, where it reads: "Cardiovascular Botulinum toxin A (BoNT-A) has beenapproved for spasticity management."It should read: "Botulinum toxin A (BoNT-A) has been approved for spasticity management."Article published with errors: https://www.actamedicaportuguesa.com/rev...
journal_title：Acta medica portuguesa
pub_type： 已发布勘误
doi：10.20344/amp.15226
更新日期：2020-12-02 00:00:00
abstract：:Epidemiologic data on prevalence of bronchial asthma among childhood in the Azores have been unknown so far. In October of 1993 a study was carried out to determine the prevalence of bronchial asthma in children aged 6-12 years on the island of Faial. Nine hundred and twenty seven schoolchildren, representing more tha...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
