Abstract:
:The aim of this study is to evaluate the expression of cytokines in response to mineral trioxide aggregate (MTA) plus selenium in germ-free mice with experimental furcal perforation. The first left maxillary molar was opened, and the furcal area was perforated and treated with post-MTA-Se (experimental group). The same surgical intervention was performed for the maxillary right first molar, which was treated with MTA (control group). Fifteen mice were sacrificed 7, 14, and 21 days after furcal perforation, and periapical tissue samples were collected. The mRNA expression levels of the cytokines TGF-β, TNF-α, IFN-γ, HPRT, IL-10, IL-4, RANK, RANKL, IL-1, and IL-17 were assessed by using real-time polymerase chain reaction. In the experimental group, at 21-days post-MTA-Se sealing, the mRNA levels of TNF-α and IL-10 were upregulated compared with those in the control group (p < 0.05). Futher assessment revealed basal mRNA expression levels of IL-1α, IFN-γ, RANK, RANKL, IL-17A, IL-4, and TGF-β, over long experimental times, in both the experimental and control groups (p > 0.05). In conclusion, MTA+Se sealing favoured increased expression of IL-10 and TNF-α at later time points (day 21).
journal_name
Braz Oral Resjournal_title
Brazilian oral researchauthors
Espaladori MC,Maciel KF,Brito LCN,Kawai T,Vieira LQ,Ribeiro Sobrinho APdoi
10.1590/1807-3107bor-2018.vol32.0103subject
Has Abstractpub_date
2018-10-11 00:00:00pages
e103eissn
1806-8324issn
1807-3107pii
S1806-83242018000100280journal_volume
32pub_type
杂志文章abstract::This study aimed to evaluate the role of photobiomodulation (PBM) in apexification and apexogenesis of necrotic rat molars with an open apex. Rat molars were exposed to the oral environment for 3 weeks. Canals were rinsed with 2.5% NaOCl and 17% EDTA, filled with antibiotic paste and sealed. After 7 days, canals were ...
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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