Metabolomics Reveals the Efficacy of Caspase Inhibition for Saikosaponin D-Induced Hepatotoxicity.

abstract：:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nu...

journal_title：Frontiers in pharmacology

authors： Mangieri RA,Maier EY,Buske TR,Lasek AW,Morrisett RA

更新日期：2017-08-15 00:00:00

abstract：:Tumor cells acquire invasive and metastatic behavior by sensing changes in the localization and activation of signaling pathways, which in turn determine changes in actin cytoskeleton. The core-scaffold machinery associated to β-arrestin (β-arr) is a key mechanism of G-protein coupled receptors (GPCR) to achieve spati...

journal_title：Frontiers in pharmacology

authors： Bagnato A,Rosanò L

更新日期：2019-02-19 00:00:00

abstract：:The objective of this study was to investigate the effect of human adipose tissue-derived mesenchymal stem cells (AdMSCs) on atopic dermatitis (AD) in the BALB/c mouse model. The AdMSCs attenuated clinical symptoms associated with AD, decreased numbers of degranulated mast cells (MCs), IgE level, amount of histamine r...

journal_title：Frontiers in pharmacology

authors： Kim M,Lee SH,Kim Y,Kwon Y,Park Y,Lee HK,Jung HS,Jeoung D

更新日期：2018-11-06 00:00:00

abstract：:The activation of microglia is decisively involved with the neurodegeneration observed in many neuroinflammatory pathologies, such as multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants, such as Pueraria thunbergiana Benth, Belamc...

journal_title：Frontiers in pharmacology

authors： Lim HS,Kim YJ,Kim BY,Park G,Jeong SJ

更新日期：2018-05-09 00:00:00

abstract：:Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo. Luciferase reporter assay showed that JC-5411 increased the activity ...

journal_title：Frontiers in pharmacology

authors： Jiang X,Li Y,Wang W,Han X,Han J,Chen M,Zhang J,Wang C,Li S,Luo J,Wang X,Xu Y,Xu Y,Cheng J,Si S

更新日期：2020-11-16 00:00:00

abstract：:Background: Rheumatoid arthritis is a type of systemic and complex autoimmune other disease characterized by chronic joint inflammation. Spleen tyrosine kinase (Syk) inhibitors are regarded as an effective alternative to existing drugs for the treatment of this disease. However, studies evaluating fostamatinib, a new ...

journal_title：Frontiers in pharmacology

authors： Kang Y,Jiang X,Qin D,Wang L,Yang J,Wu A,Huang F,Ye Y,Wu J

更新日期：2019-08-14 00:00:00

abstract：:Cellular senescence is an irreversible cell growth arrest and is associated with aging and age-related diseases. High plasma phosphate (Pi) and deficiency of Klotho contribute to aging and kidney fibrosis, a pathological feature in the aging kidney and chronic kidney disease. This study examined the interactive role o...

journal_title：Frontiers in pharmacology

authors： Maique J,Flores B,Shi M,Shepard S,Zhou Z,Yan S,Moe OW,Hu MC

更新日期：2020-08-20 00:00:00

abstract：:Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Luteolin (Lut), a compound extracted from Rhizoma Drynariae, is reported to possess ...

journal_title：Frontiers in pharmacology

authors： Yan Z,Zhan J,Qi W,Lin J,Huang Y,Xue X,Pan X

更新日期：2020-08-12 00:00:00

abstract：:Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-supporting microenvironme...

journal_title：Frontiers in pharmacology

authors： Colapietro A,Yang P,Rossetti A,Mancini A,Vitale F,Martellucci S,Conway TL,Chakraborty S,Marampon F,Mattei V,Gravina GL,Biordi AL,Wei D,Newman RA,Festuccia C

更新日期：2020-09-11 00:00:00

abstract：:Liver fibrosis, a chronic damage process related to further progression of hepatic cirrhosis, has yet no truly effective treatment. Isochlorogenic acid A (ICQA), isolated from a traditional Chinese herbal medicine named Laggera alata (DC.) Sch.Bip. ex Oliv. (Asteraceae), is proved to exhibit anti-inflammatory, hepatop...

journal_title：Frontiers in pharmacology

authors： Liu X,Huang K,Zhang RJ,Mei D,Zhang B

更新日期：2020-05-01 00:00:00

abstract：:Background: Up to date, the efficacy and safety of warfarin treatment in atrial fibrillation patients receiving hemodialysis remain controversial. So we performed this meta-analysis to try to offer recommendations regarding warfarin management in this population. Methods: We searched Pubmed, Embase, and Cochrane libra...

journal_title：Frontiers in pharmacology

authors： Lei H,Yu LT,Wang WN,Zhang SG

更新日期：2018-11-06 00:00:00

abstract：:Orientin is a flavonoid extracted from Chinese traditional herb, Polygonum orientale L. Previous study has reported that orientin protected myocardial from ischemia reperfusion injury. However, whether orientin could protect against cardiac remodeling after myocardial injury remains unclear. The aim of our study is to...

journal_title：Frontiers in pharmacology

authors： Li F,Zong J,Zhang H,Zhang P,Xu L,Liang K,Yang L,Yong H,Qian W

更新日期：2017-12-21 00:00:00

abstract：:Over the last decade, several studies demonstrated that prenylation of flavonoids enhances various biological activities as compared to the respective nonprenylated compounds. In line with this, the natural prenylated isoflavonoid alpinumisoflavone (AIF) has been explored for a number of biological and pharmacological...

journal_title：Frontiers in pharmacology

authors： Ateba SB,Mvondo MA,Djiogue S,Zingué S,Krenn L,Njamen D

更新日期：2019-09-10 00:00:00

abstract：:Blockchain systems are a fast emerging and a currently widely discussed novel strategy for a decentralized cryptographically enhanced digital ledger recording transactions among stakeholders. This perspective paper looks at its potential uses in the context of high value and mostly low volume botanical material traded...

journal_title：Frontiers in pharmacology

authors： Heinrich M,Scotti F,Booker A,Fitzgerald M,Kum KY,Löbel K

更新日期：2019-04-24 00:00:00

abstract：:The unfolded protein response (UPR) is an evolutionarily conserved defensive mechanism that is used by cells to correct misfolded proteins that accumulate in the endoplasmic reticulum. These proteins are misfolded as a result of physical stress on a cell and initiate a host of downstream effects that govern processes ...

journal_title：Frontiers in pharmacology

authors： Timberlake MA 2nd,Dwivedi Y

更新日期：2016-01-12 00:00:00

abstract：:Tolvaptan (TLV), an oral non-peptide antagonist of vasopressin V2 receptor, has been increasingly used for managements in patients with hyponatremia and/or syndrome of inappropriate antidiuretic hormone secretion. However, none of the studies have thus far been investigated with regard to its possible perturbations on...

journal_title：Frontiers in pharmacology

authors： Lu TL,Chang WT,Chan CH,Wu SN

更新日期：2019-02-18 00:00:00

abstract：:Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)-orientated, single target, and conventional antidepressants are insufficient and far from ideal. Traditional Chinese Medicine (TCM) has historically been used to treat depression up till today, particularly in Asia. Its holistic, ...

journal_title：Frontiers in pharmacology

authors： Li C,Huang J,Cheng YC,Zhang YW

更新日期：2020-05-07 00:00:00

abstract：:Uric acid (UA) is the end product of purine nucleotide metabolism in the human body. Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and gout. The prevalence of hyperuricemia has been increasing globally. Epidemiological studies have shown that UA levels are positively correlat...

journal_title：Frontiers in pharmacology

authors： Yu W,Cheng JD

更新日期：2020-11-16 00:00:00

abstract：:The mTOR signaling pathway is abnormally activated in pancreatic cancer and is related to tumor glucose metabolism. However, its specific regulation mechanism is still unclear. Therefore, this study aims to investigate whether Sestrin2 affects the glucose metabolism of pancreatic cancer by modulating mTOR signal and t...

journal_title：Frontiers in pharmacology

authors： Guo Y,Zhu H,Weng M,Zhang H,Wang C,Sun L

更新日期：2020-11-11 00:00:00

abstract：:Low solubility, tissue accumulation, and toxicity are chief obstacles to developing triptolide derivatives, so a better understanding of the pharmacokinetics and toxicity of triptolide derivatives will help with these limitations. To address this, we studied pharmacokinetics and toxicity of (5R)-5-hydroxytriptolide (L...

journal_title：Frontiers in pharmacology

authors： Yu C,Li Y,Liu M,Gao M,Li C,Yan H,Li C,Sun L,Mo L,Wu C,Qi X,Ren J

更新日期：2017-11-21 00:00:00

abstract：:Background: Biomarkers that predict clinical outcomes in depression are essential for increasing the precision of treatments and clinical outcomes. The electroencephalogram (EEG) is a non-invasive neurophysiological test that has promise as a biomarker sensitive to treatment effects. The aim of our study was to invest...

journal_title：Frontiers in pharmacology

authors： Shalbaf R,Brenner C,Pang C,Blumberger DM,Downar J,Daskalakis ZJ,Tham J,Lam RW,Farzan F,Vila-Rodriguez F

更新日期：2018-10-30 00:00:00

abstract：:Purpose: The present study compared the risk of ischemic stroke in atrial fibrillation (AF) patients receiving digoxin and amiodarone. Methods: A retrospective cohort study was conducted using the longitudinal population-based database of Taiwan's National Health Insurance program. Patients with AF who received amioda...

journal_title：Frontiers in pharmacology

authors： Lai KC,Chen SJ,Lin CS,Yang FC,Lin CL,Hsu CW,Huang WC,Kao CH

更新日期：2018-05-07 00:00:00

abstract：:Objectives: The study is performed to analyze the relationship between immune-related long non-coding RNAs (lncRNAs) and the prognosis of cervical cancer patients. We constructed a prognostic model and explored the immune characteristics of different risk groups. Methods: We downloaded the gene expression profiles and...

journal_title：Frontiers in pharmacology

authors： Chen P,Gao Y,Ouyang S,Wei L,Zhou M,You H,Wang Y

更新日期：2020-11-30 00:00:00

abstract：Background:Takotsubo syndrome (TTS) and acute coronary syndrome (ACS) patients have a similar mortality rate. In this study, we sought to determine the short- and long-term outcome of TTS patients as compared to ACS patients both treated with beta-blockers. Objectives:In the present study we described the data of 5 ye...

journal_title：Frontiers in pharmacology

authors： Kummer M,El-Battrawy I,Gietzen T,Ansari U,Behnes M,Lang S,Zhou X,Borggrefe M,Akin I

更新日期：2020-05-14 00:00:00

abstract：:We explored the therapeutic effects of Dendrobium officinale polysaccharide (DOP) on CCl4-induced liver fibrosis with respect to the intestinal hepatic axis using a rat model. Histopathological staining results showed that DOP alleviated extensive fibrous tissue proliferation in interstitium and lessened intestinal mu...

journal_title：Frontiers in pharmacology

authors： Wang K,Yang X,Wu Z,Wang H,Li Q,Mei H,You R,Zhang Y

更新日期：2020-03-12 00:00:00

abstract：:Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue. Methods: We conducted a population-based case-control study to identify ...

journal_title：Frontiers in pharmacology

authors： Cheng KC,Liao KF,Lin CL,Lai SW

更新日期：2017-07-19 00:00:00

abstract：:Trichloroethylene (TCE) is a common volatile organic solvent which is considered as an ubiquitous environmental pollutant. It is claimed to be a developmental neurotoxicant. Our group evaluated previously its impact on three-dimensional neurospheres in vitro. The current work aims to investigate the neurotoxic effects...

journal_title：Frontiers in pharmacology

authors： Salama MM,El-Naggar DA,Abdel-Rahman RH,Elhak SAG

更新日期：2018-07-10 00:00:00

abstract：:Objective: To evaluate therapeutic efficacy of different combined antimicrobial treatments against Acinetobacter baumannii ventilator-associated pneumonia (VAP). Methods: Clinical outcomes were retrospectively analyzed to elucidate the efficacy of four combined antimicrobial regimens. The chessboard and micro broth di...

journal_title：Frontiers in pharmacology

authors： Huang Y,Zhou Q,Wang W,Huang Q,Liao J,Li J,Long L,Ju T,Zhang Q,Wang H,Xu H,Tu M

更新日期：2019-02-13 00:00:00

abstract：:There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and validating the morphology of nanoparticles is of key importance for th...

journal_title：Frontiers in pharmacology

authors： Robson AL,Dastoor PC,Flynn J,Palmer W,Martin A,Smith DW,Woldu A,Hua S

更新日期：2018-02-06 00:00:00

abstract：:Mainstay chemotherapy for malaria is often faced with the problem of instability and poor bio-distribution thus resulting in impaired pharmacokinetics. Nanomedicine has been acclaimed for its success in drug delivery and improved efficacy. The aim of the study was to assess the antiplasmodial efficacy and safety of cu...

journal_title：Frontiers in pharmacology

authors： Oyeyemi O,Morenkeji O,Afolayan F,Dauda K,Busari Z,Meena J,Panda A

更新日期：2018-05-30 00:00:00