Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1/Th2 Responses.

abstract：:The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects ...

journal_title：Frontiers in pharmacology

authors： Majdan M,Kiss AK,Hałasa R,Granica S,Osińska E,Czerwińska ME

更新日期：2020-08-13 00:00:00

abstract：:β2-adrenoceptor agonists are commonly used as bronchodilators to treat obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), however, they induce severe side effects. Therefore, developing new bronchodilators is essential. Herbal plants were extracted and the extracts' effect on ai...

journal_title：Frontiers in pharmacology

authors： She YS,Ma LQ,Liu BB,Zhang WJ,Qiu JY,Chen YY,Li MY,Xue L,Luo X,Wang Q,Xu H,Zang DA,Zhao XX,Cao L,Shen J,Peng YB,Zhao P,Yu MF,Chen W,Nie X,Shen C,Chen S,Chen S,Qin G,Dai J,Chen J,Liu QH

更新日期：2018-12-04 00:00:00

abstract：:Introduction: There are increasing concerns world-wide with growing rates of antibiotic resistance necessitating urgent action. There have been a number of initiatives in the Republic of Srpska in recent years to address this and improve rational antibiotic prescribing and dispensing despite limited resources to fund ...

journal_title：Frontiers in pharmacology

authors： Bojanić L,Marković-Peković V,Škrbić R,Stojaković N,Ðermanović M,Bojanić J,Fürst J,Kurdi AB,Godman B

更新日期：2018-05-29 00:00:00

abstract：:Most breast and prostate tumors are hormone-dependent, making it possible to use hormone therapy in patients with these tumors. The design of effective endocrine drugs that block the growth of tumors and have no severe side effects is a challenge. Thereupon, synthetic steroids are promising therapeutic drugs for the t...

journal_title：Frontiers in pharmacology

authors： Scherbakov AM,Komkov AV,Komendantova AS,Yastrebova MA,Andreeva OE,Shirinian VZ,Hajra A,Zavarzin IV,Volkova YA

更新日期：2018-01-10 00:00:00

abstract：:Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxicity risk. In the pre...

journal_title：Frontiers in pharmacology

authors： de Freitas RCC,Bortolin RH,Lopes MB,Tamborlin L,Meneguello L,Silbiger VN,Hirata RDC,Hirata MH,Luchessi AD,Luchessi AD

更新日期：2017-12-12 00:00:00

abstract：:The aim of this experimental study was to assess whether 5 weeks of preoperative supplementation with vitamin D affects the intensity of pain and the level of inflammatory markers in patients undergoing posterior lumbar interbody fusion (PLIF) followed by rehabilitation. 42 patients were divided, by double-blind rando...

journal_title：Frontiers in pharmacology

authors： Krasowska K,Skrobot W,Liedtke E,Sawicki P,Flis DJ,Dzik KP,Libionka W,Kloc W,Kaczor JJ

更新日期：2019-05-22 00:00:00

abstract：:Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain (CaM-BD) of ...

journal_title：Frontiers in pharmacology

authors： Shim H,Brown BM,Singh L,Singh V,Fettinger JC,Yarov-Yarovoy V,Wulff H

更新日期：2019-09-20 00:00:00

abstract：:Background: Several initiatives have assessed if mining electronic health records (EHRs) may accelerate the process of drug safety signal detection. In Europe, Exploring and Understanding Adverse Drug Reactions (EU-ADR) Project Focused on utilizing clinical data from EHRs of over 30 million patients from several Europ...

journal_title：Frontiers in pharmacology

authors： Patadia VK,Schuemie MJ,Coloma PM,Herings R,van der Lei J,Sturkenboom M,Trifirò G

更新日期：2018-06-06 00:00:00

abstract：:Neuronal activity, astrocytic responses to this activity, and energy homeostasis are linked together during baseline, conscious conditions, and short-term rapid activation (as occurs with sensory or motor function). Nervous system energy homeostasis also varies during long-term physiological conditions (i.e., developm...

journal_title：Frontiers in pharmacology

authors： Shetty PK,Galeffi F,Turner DA

更新日期：2012-03-20 00:00:00

abstract：:Endothelium dysfunction induced by reactive oxygen species (ROS) is an important initial event at the onset of myocardial ischemia/reperfusion in which the Egr-1 transcription factor often serves as a master switch for various damage pathways following reperfusion injury. We hypothesized that an intracellular ROS/MAPK...

journal_title：Frontiers in pharmacology

authors： Lu S,Zhang Y,Zhong S,Gao F,Chen Y,Li W,Zheng F,Shi G

更新日期：2017-01-05 00:00:00

abstract：:There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and validating the morphology of nanoparticles is of key importance for th...

journal_title：Frontiers in pharmacology

authors： Robson AL,Dastoor PC,Flynn J,Palmer W,Martin A,Smith DW,Woldu A,Hua S

更新日期：2018-02-06 00:00:00

abstract：:Scoring functions play an important role in structure-based virtual screening. It has been widely accepted that target-specific scoring functions (TSSFs) may achieve better performance compared with universal scoring functions in actual drug research and development processes. A method that can effectively construct T...

journal_title：Frontiers in pharmacology

authors： Wang D,Cui C,Ding X,Xiong Z,Zheng M,Luo X,Jiang H,Chen K

更新日期：2019-08-22 00:00:00

abstract：:There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host defense with specific cytotoxic and immune-modulatory properties. ...

journal_title：Frontiers in pharmacology

authors： Prats-Ejarque G,Lu L,Salazar VA,Moussaoui M,Boix E

更新日期：2019-10-09 00:00:00

abstract：:The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I interferon (IFN) receptors, composed of IFNAR1 and IFNAR2, have differe...

journal_title：Frontiers in pharmacology

authors： Lee S,Son WS,Yang HB,Rajasekaran N,Kim SS,Hong S,Choi JS,Choi JY,Song K,Shin YK

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:Human 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) formally known as aldo-keto reductase 1C3 (AKR1C3) play a major role in the formation and metabolism of androgens. The enzyme is highly expressed in the prostate gland and previous studies indicate that genetic variation in the AKR1C3 gene may influenc...

journal_title：Frontiers in pharmacology

authors： Schulze JJ,Karypidis H,Ekström L

更新日期：2012-08-06 00:00:00

abstract：INTRODUCTION:European countries need to learn from each other to address unsustainable increases in pharmaceutical expenditures. OBJECTIVE:To assess the influence of the many supply and demand-side initiatives introduced across Europe to enhance prescribing efficiency in ambulatory care. As a result provide future gui...

journal_title：Frontiers in pharmacology

authors： Godman B,Shrank W,Andersen M,Berg C,Bishop I,Burkhardt T,Garuoliene K,Herholz H,Joppi R,Kalaba M,Laius O,Lonsdale J,Malmström RE,Martikainen JE,Samaluk V,Sermet C,Schwabe U,Teixeira I,Tilson L,Tulunay FC,Vlahović-

更新日期：2011-01-07 00:00:00

abstract：:In-depth research on processing can promote the globalization of processed herbs. The purpose of this study is to propose an improved strategy for processing effect investigation. Frankincense and processed frankincense were used as research subjects. First, high-speed countercurrent chromatography (HSCCC) and prepara...

journal_title：Frontiers in pharmacology

authors： Ning Z,Wang C,Liu Y,Song Z,Ma X,Liang D,Liu Z,Lu A

更新日期：2018-12-18 00:00:00

abstract：Objective:Drawing a growth curve of multidrug-resistant Pseudomonas aeruginosa (MDR-PA) provides a foundation for susceptibility testing. By observing in vitro antibacterial activity and ultrastructure cthanges on MDR-PA of the effective components in the drug-containing serum of rats after the administration of Fuzhen...

journal_title：Frontiers in pharmacology

authors： Xu H,Liu C,Li M,Wang C,Liu G,Wang H,Ma J,Li L,Chen M,Cheng M,Yao X,Lin Y,Zhao S,Wang Y,Wang M

更新日期：2020-02-12 00:00:00

abstract：:Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI) and INSTIs are the latest class of potent anti-HIV drugs. Compared to the first generation INSTIs, raltegravir, and elvitegravir, DTG shows a limited cross-resistance profile. More interestingly, clinical resistance mutations to DTG ...

journal_title：Frontiers in pharmacology

authors： Wainberg MA,Han YS

更新日期：2015-04-29 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. It takes some time from chronic gastritis to develop in GC. Early detection of GC will help patients obtain timely treatment. Understanding disease evolution is crucial for the prevention and treatment of GC. Here, we present a convolu...

journal_title：Frontiers in pharmacology

authors： Ma B,Guo Y,Hu W,Yuan F,Zhu Z,Yu Y,Zou H

更新日期：2020-10-02 00:00:00

abstract：:Uncontrolled bacteremia is a common and life threatening condition that can lead to sepsis and septic shock with significant morbidity and mortality. Neutrophil granulocytes, the most abundant phagocytic leukocyte of the innate immune system, play an essential role in capturing and killing invading pathogens. Their an...

journal_title：Frontiers in pharmacology

authors： Meier A,Chien J,Hobohm L,Patras KA,Nizet V,Corriden R

更新日期：2019-04-05 00:00:00

abstract：:Hypertension is a prevalent, complex, and polygenic cardiovascular disease, which is associated with increased mortality and morbidity. Across the world, traditional Chinese medicine (TCM) constituted by herbal medicine and non-pharmacological therapies is used to assist blood pressure management. Though widely accept...

journal_title：Frontiers in pharmacology

authors： Yang M,Lao L

更新日期：2019-03-08 00:00:00

abstract：:Oral cancers refer to malignant tumors associated with high morbidity and mortality, and oral squamous cell carcinoma accounts for the majority of cases. It is an important part of head and neck, and oral cancer is one of the six most common cancers in the world. At present, the traditional treatment methods for oral ...

journal_title：Frontiers in pharmacology

authors： Zhao Z,Li D,Wu Z,Wang Q,Ma Z,Zhang C

更新日期：2020-12-17 00:00:00

abstract：Objective:Huangqin decoction (HQD), a classical traditional Chinese medicinal formula, has been commonly used to treat gastrointestinal diseases for thousands of years. We investigated the anti-inflammatory effects and underlying mechanisms of HQD on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). Method...

journal_title：Frontiers in pharmacology

authors： Li MY,Luo HJ,Wu X,Liu YH,Gan YX,Xu N,Zhang YM,Zhang SH,Zhou CL,Su ZR,Huang XQ,Zheng XB

更新日期：2020-01-20 00:00:00

abstract：:Hippocampal theta activity is related to spatial information processing, and high-frequency theta activity, in particular, has been linked to efficient spatial memory performance. Theta activity is regulated by the synchronizing ascending system (SAS), which includes mesencephalic and diencephalic relays. The supramam...

journal_title：Frontiers in pharmacology

authors： Hernández-Pérez JJ,Gutiérrez-Guzmán BE,López-Vázquez MÁ,Olvera-Cortés ME

更新日期：2015-10-29 00:00:00

abstract：Background:Erectile dysfunction (ED) occurs more frequently and causes a worse response to the first-line therapies in diabetics compared with nondiabetic men. Corpus cavernosum vascular dysfunction plays a pivotal role in the occurrence of diabetes mellitus ED (DMED). The aim of this study was to investigate the prote...

journal_title：Frontiers in pharmacology

authors： Yuan P,Ma D,Gao X,Wang J,Li R,Liu Z,Wang T,Wang S,Liu J,Liu X

更新日期：2020-08-12 00:00:00

abstract：:Exhaustive exercise has emerged as an important health issue nowadays. This study was designed to assess the metabolite abnormalities of rats after exhaustive exercise and the holistic efficacy of Chinese medicine Sanqi oral solution (SQ). Through exhaustive swimming, the exhaustive exercise model in rats was establis...

journal_title：Frontiers in pharmacology

authors： Xu P,Li S,Tian R,Han L,Mao W,Li L,Li C,Wang Y,Luo G,Yang N

更新日期：2019-07-04 00:00:00

abstract：:With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set o...

journal_title：Frontiers in pharmacology

authors： Belizário JE,Sangiuliano BA,Perez-Sosa M,Neyra JM,Moreira DF

更新日期：2016-09-29 00:00:00

abstract：:Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin and is released with 0.1 M trimethylammonium bromide (TMA) with full...

journal_title：Frontiers in pharmacology

authors： Onder S,David E,Tacal O,Schopfer LM,Lockridge O

更新日期：2017-10-10 00:00:00

abstract：:Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-supporting microenvironme...

journal_title：Frontiers in pharmacology

authors： Colapietro A,Yang P,Rossetti A,Mancini A,Vitale F,Martellucci S,Conway TL,Chakraborty S,Marampon F,Mattei V,Gravina GL,Biordi AL,Wei D,Newman RA,Festuccia C

更新日期：2020-09-11 00:00:00