Acinetobacter baumannii Ventilator-Associated Pneumonia: Clinical Efficacy of Combined Antimicrobial Therapy and in vitro Drug Sensitivity Test Results.


:Objective: To evaluate therapeutic efficacy of different combined antimicrobial treatments against Acinetobacter baumannii ventilator-associated pneumonia (VAP). Methods: Clinical outcomes were retrospectively analyzed to elucidate the efficacy of four combined antimicrobial regimens. The chessboard and micro broth dilution methods determined the minimum inhibitory concentrations (MICs) of four antiseptic drugs singly used and combined two drugs against 36 isolates of multidrug-resistant (MDR) A. baumannii. Results: The incidence of VAP was approximately 6.9% (237/3424) between January 1, 2015 and December 31, and 35.9% (85/237) of the cases were caused by A. baumannii. Among these cases, 60 belonged to AB-VAP, for whom antimicrobial treatment plan was centralized and clinical data was complete. Moreover, all 60 strains of A. baumannii were MDR bacteria from reports microbiological laboratory. Resistance rate was lowest for amikacin (68.3%) and ampicillin sulbactam (71.7%). Resistance rate for imipenem increased from 63.2 to 90.9% during the 3 years. However, in these 60 cases of AB-VAP, the combination between 4 antibiotics was effective in most cases: the effective rate was 75% (18/24) for sulbactam combined with etilmicin, 71.4% (10/14) for sulbactam combined with levofloxacin, 72.7% (8/11) for meropenem combined with etilmicin, and 63.6% (7/11) for meropenem combined with levofloxacin. There was no statistical difference between four regimens (P > 0.05). Sulbactam combined with etilmicin decreased 1/2 of MIC50 and MIC90 of sulbactam while the decreases in etilmicin were more obviously than single drug. When adopting meropenem combined with levofloxacin or etilmicin, the MIC of meropenem reduced to 1/2 of that in applying single drug. As for sulbactam or meropenem combined with levofloxacin, it also lessened the MIC50 of levofloxacin to 1/2 of that for single drug. FIC results suggested that the effects of four combined antimicrobial regimens were additive or unrelated. When sulbactam was combined with etimicin, the additive effect was 63.89%. Conclusion: Drug combination sensitivity test in vitro may be helpful for choosing antimicrobial treatment plans. Sulbactam or meropenem as the basis of treatment regimens can function as the alternatives against AB-VAP. Sulbactam combined with etimicin has been regarded as a recommended regimen in Suizhou, Hubei, China.


Front Pharmacol


Huang Y,Zhou Q,Wang W,Huang Q,Liao J,Li J,Long L,Ju T,Zhang Q,Wang H,Xu H,Tu M




Has Abstract


2019-02-13 00:00:00








  • Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model.

    abstract::Advances in molecular pathology have changed the landscape of oncology. The ability to interrogate tissue samples for oncogene amplification, driver mutations, and other molecular alterations provides clinicians with an enormous level of detail about their patient's cancer. In some cases, this information informs trea...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Kersh AE,Sasaki M,Cooper LA,Kissick HT,Pollack BP

    更新日期:2016-09-26 00:00:00

  • Traditional Chinese Medicine Combined With Chemotherapy and Cetuximab or Bevacizumab for Metastatic Colorectal Cancer: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

    abstract:Background:Huangci Granule is a traditional Chinese medicine for treating metastatic colorectal cancer (mCRC). Objective:To evaluate the efficacy and safety of Huangci Granule combination with chemotherapy and cetuximab (CET) or bevacizumab (BV) for treating mCRC. Methods:We performed a randomized, controlled, and do...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Liu N,Wu C,Jia R,Cai G,Wang Y,Zhou L,Ji Q,Sui H,Zeng P,Xiao H,Liu H,Huo J,Feng Y,Deng W,Li Q

    更新日期:2020-04-21 00:00:00

  • miR-133: A Suppressor of Cardiac Remodeling?

    abstract::Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a significant pathophysiological process involved in almost all forms of heart diseases. MicroRNAs (miRNAs) are a group of non-coding RNAs of 20-25 nucleotides in length that primarily regulate gene expression by promoting mRNA degr...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Li N,Zhou H,Tang Q

    更新日期:2018-08-17 00:00:00

  • Sodium Tanshinone II-A Sulfonate (DS-201) Induces Vasorelaxation of Rat Mesenteric Arteries via Inhibition of L-Type Ca2+ Channel.

    abstract::Background: We previously have proved that sodium tanshinone II-A sulfonate (DS-201), a derivative of traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), is an opener and vasodilator of BKCa channel in the vascular smooth muscle cells (VSMCs). Vascular tension is closely associated with Ca2+ dynamics and...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zhang XD,He CX,Cheng J,Wen J,Li PY,Wang N,Li G,Zeng XR,Cao JM,Yang Y

    更新日期:2018-02-02 00:00:00

  • Effect of Cognitive Style on Learning and Retrieval of Navigational Environments.

    abstract::Field independence (FI) has been found to correlate with a wide range of cognitive processes requiring cognitive restructuring. Cognitive restructuring, that is going beyond the information given by the setting, is pivotal in creating stable mental representations of the environment, the so-called "cognitive maps," an...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Boccia M,Vecchione F,Piccardi L,Guariglia C

    更新日期:2017-07-25 00:00:00

  • Beta2-Adrenergic Receptor Polymorphisms and Haplotypes Associate With Chronic Pain in Sickle Cell Disease.

    abstract::Pain in sickle cell disease (SCD) is severe, variable, and inadequately comprehended. The β2-adrenergic receptor (ADRB2) is critical in mediating neurotransmitter response in the sympathetic nervous system. In this association study, we examined 16 single nucleotide polymorphisms (SNPs) covering 5'-UTR and coding regi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Jhun EH,Sadhu N,Hu X,Yao Y,He Y,Wilkie DJ,Molokie RE,Wang ZJ

    更新日期:2019-02-07 00:00:00

  • The Extent and Reasons for Dissatisfaction From Outpatients Provided With Pharmacy Services at Two Public Hospitals in Eastern Ethiopia.

    abstract::Background: Satisfaction of patients for pharmaceutical services reflects their preferences and expectations, and the realities of care. It is critical to understand the extent of dissatisfaction for pharmaceutical services and its associated factors in order to optimize the required quality of the services provided. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Nigussie S,Edessa D

    更新日期:2018-10-12 00:00:00

  • H2 Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction via Blocking TLR4-Mediated Cytokines Expression.

    abstract::Background and Purpose: Septic cardiomyopathy, which is one of the features of multi-organ dysfunction in sepsis, is characterized by ventricular dilatation, reduced ventricular contractility, and reduction in ejection fraction and, if severe, can lead to death. To date, there is no specific therapy that exists, and i...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Tan S,Long Z,Hou X,Lin Y,Xu J,You X,Wang T,Zhang Y

    更新日期:2019-08-05 00:00:00

  • Resins and Gums in Historical Iatrosophia Texts from Cyprus - A Botanical and Medico-pharmacological Approach.

    abstract::This study explores historical iatrosophia texts from Cyprus from a botanical and medico-pharmacological point of view focusing on remedies containing resins and gums. The iatrosophia are a genre of Greek medical literature of Byzantine origin and can be described as medicine handbooks which serve as therapeutic repos...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lardos A,Prieto-Garcia J,Heinrich M

    更新日期:2011-07-01 00:00:00

  • The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties.

    abstract::Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-supporting microenvironme...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Colapietro A,Yang P,Rossetti A,Mancini A,Vitale F,Martellucci S,Conway TL,Chakraborty S,Marampon F,Mattei V,Gravina GL,Biordi AL,Wei D,Newman RA,Festuccia C

    更新日期:2020-09-11 00:00:00

  • The Droplet Digital PCR: A New Valid Molecular Approach for the Assessment of B-RAF V600E Mutation in Hairy Cell Leukemia.

    abstract::Hairy cell leukemia (HCL) is a chronic lymphoproliferative B-cell disorder where the B-RAF V600E mutation has been recently detected, as reported for solid neoplasias but not for other B-cell lymphomas. The digital droplet PCR (dd-PCR) is a molecular technique that, without standard references, is able to accurately q...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Guerrini F,Paolicchi M,Ghio F,Ciabatti E,Grassi S,Salehzadeh S,Ercolano G,Metelli MR,Del Re M,Iovino L,Petrini I,Carulli G,Cecconi N,Rousseau M,Cervetti G,Galimberti S

    更新日期:2016-10-13 00:00:00

  • Optimal Regimens and Cutoff Evaluation of Tildipirosin Against Pasteurella multocida.

    abstract::Pasteurella multocida (PM) can invade the upper respiratory tract of the body and cause death and high morbidity. Tildipirosin, a new 16-membered-ring macrolide antimicrobial, has been recommended for the treatment of respiratory diseases. The objective of this research was to improve the dose regimes of tildipirosin ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lei Z,Liu Q,Qi Y,Yang B,Khaliq H,Xiong J,Moku GK,Ahmed S,Li K,Zhang H,Zhang W,Cao J,He Q

    更新日期:2018-07-26 00:00:00

  • DT-13 Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells Through Blocking PI3K/Akt Pathway.

    abstract::DT-13, a saponin monomer 13 from the dwarf lilyturf tuber, was reported to exhibit anti-inflammatory, hepatoprotective, cardioprotective as well as antitumor activities in a number of tumor cells. Prostate cancer is the second leading cause of cancer death in males, discovery of novel antitumor drug for therapy of pro...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wang Z,Wang Y,Zhu S,Liu Y,Peng X,Zhang S,Zhang Z,Qiu Y,Jin M,Wang R,Zhong Y,Kong D

    更新日期:2018-12-07 00:00:00

  • Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer.

    abstract::The efficacy of lamotrigine in the treatment of focal epilepsies have already been reported in several case reports and open studies, which is thought to act by inhibiting glutamate release through voltage-sensitive sodium channels blockade and neuronal membrane stabilization. However, recent findings have also illust...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Prabhavalkar KS,Poovanpallil NB,Bhatt LK

    更新日期:2015-10-23 00:00:00

  • Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.

    abstract::Many current chemotherapies function by damaging genomic DNA in rapidly dividing cells ultimately leading to cell death. This therapeutic approach differentially targets cancer cells that generally display rapid cell division compared to normal tissue cells. However, although these treatments are initially effective i...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Davidson D,Amrein L,Panasci L,Aloyz R

    更新日期:2013-01-31 00:00:00

  • Key Clinical Interest Outcomes of Pharmaceutical Administration for Veterans With Post-Traumatic Stress Disorder Based on Pooled Evidences of 36 Randomised Controlled Trials With 2,331 Adults.

    abstract::Background: The effects of drug treatment on veterans, who have a high risk of post-traumatic stress disorder (PTSD), are not clear, and the guidelines are different from the recommendations of the recent meta-analysis. Our goal was to find the efficacy and frequencies of complications of drugs that can treat PTSD in ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Zhao YF,Huang ZD,Gu HY,Guo GL,Yuan RX,Zhang C

    更新日期:2020-12-17 00:00:00

  • Artificial Intelligence-Based Multiclass Classification of Benign or Malignant Mucosal Lesions of the Stomach.

    abstract::Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. It takes some time from chronic gastritis to develop in GC. Early detection of GC will help patients obtain timely treatment. Understanding disease evolution is crucial for the prevention and treatment of GC. Here, we present a convolu...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Ma B,Guo Y,Hu W,Yuan F,Zhu Z,Yu Y,Zou H

    更新日期:2020-10-02 00:00:00

  • Short-Term Efficacy and Tolerability of Paroxetine Versus Placebo for Panic Disorder: A Meta-Analysis of Randomized Controlled Trials.

    abstract:Objective:To explore the short-term efficacy and tolerability of paroxetine in the treatment of panic disorder in adults. Methods:Multiple electronic databases were searched to find randomized controlled trials (RCTs) on paroxetine and panic disorder. The primary efficacy outcomes were: the mean change compared to the...

    journal_title:Frontiers in pharmacology



    authors: Zhang B,Wang C,Cui L,Gao J,Wang C,Tan X,Fang S

    更新日期:2020-03-31 00:00:00

  • Chymase Inhibitor as a Novel Therapeutic Agent for Non-alcoholic Steatohepatitis.

    abstract::Non-alcoholic steatohepatitis (NASH) is characterized by inflammation and fibrosis, in addition to steatosis, of the liver, but no therapeutic agents have yet been established. The mast cell protease chymase can generate angiotensin II, matrix metalloproteinase-9 and transforming growth factor-β, all of which are asso...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Takai S,Jin D

    更新日期:2018-02-21 00:00:00

  • Skeletal Dysplasias: Growing Therapy for Growing Bones.

    abstract::Skeletal dysplasias represent a large and diverse group of rare conditions affecting collagen and bone. They can be clinically classified based on radiographic and physical features, and many can be further defined at a molecular level (Bonafe et al., 2015). Early diagnosis is critical to proper medical management inc...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Jelin AC,O'Hare E,Blakemore K,Jelin EB,Valle D,Hoover-Fong J

    更新日期:2017-03-06 00:00:00

  • Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption.

    abstract::Osteoporosis is a common health problem worldwide caused by an imbalance of bone formation vs. bone resorption. However, current therapeutic approaches aimed at enhancing bone formation or suppressing bone resorption still have some limitations. In this study, we demonstrated for the first time that cepharanthine (CEP...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zhou CH,Meng JH,Yang YT,Hu B,Hong JQ,Lv ZT,Chen K,Heng BC,Jiang GY,Zhu J,Cheng ZH,Zhang W,Cao L,Wang W,Shen WL,Yan SG,Wu HB

    更新日期:2018-03-27 00:00:00

  • Anti-Inflammatory Activity and Mechanism of Hydrostatin-SN1 From Hydrophis cyanocinctus in Interleukin-10 Knockout Mice.

    abstract::Biopeptides derived from marine species have garnered significant research interest owing to their anti-inflammatory, antibacterial, and anticancer activities. In our previous study, Hydrostatin-SN1, a bioactive peptide extracted from the Hydrophis cyanocinctus venom gland T7 phage display library, demonstrated anti-i...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zhang C,Guo S,Wang J,Li A,Sun K,Qiu L,Li J,Wang S,Ma X,Lu Y

    更新日期:2020-06-19 00:00:00

  • EGCG Reduces Obesity and White Adipose Tissue Gain Partly Through AMPK Activation in Mice.

    abstract::(-)-Epigallocatechin-3-gallate (EGCG), which is the most abundant catechin in green tea, has many potential health benefits, including decreased weight gain and/or adipose tissue weight. Suggested mechanisms for body weight reduction by EGCG include: (1) a decrease in calorie intake and (2) activation of AMPK in liver...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Li F,Gao C,Yan P,Zhang M,Wang Y,Hu Y,Wu X,Wang X,Sheng J

    更新日期:2018-11-22 00:00:00

  • The Use of Ozenoxacin in Pediatric Patients: Clinical Evidence, Efficacy and Safety.

    abstract::Impetigo is the most common childhood skin infection in the world. There are two patterns of impetigo: nonbullous (or impetigo contagiosa) and bullous. The nonbullous type is due to Staphylococcus aureus and group A beta-haemolytic Streptococcus and occurs in 70% of impetigo cases. Impetigo is often a self-limited dis...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Davino G,D'Alvano T,Esposito S

    更新日期:2020-11-18 00:00:00

  • A New Pharmacophore Model for the Design of Sigma-1 Ligands Validated on a Large Experimental Dataset.

    abstract::The recent publication of the σ1R crystal structure is an important cornerstone for the derivation of more accurate activity prediction models. We report here a comparative study involving a set of more than 25,000 structures from our internal database that had been screened for σ1R affinity. Using the recently publis...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Pascual R,Almansa C,Plata-Salamán C,Vela JM

    更新日期:2019-05-31 00:00:00

  • The Active Components of Fuzheng Huayu Formula and Their Potential Mechanism of Action in Inhibiting the Hepatic Stellate Cells Viability - A Network Pharmacology and Transcriptomics Approach.

    abstract::Purpose: This study aimed to identify the active components of Fuzheng Huayu (FZHY) formula and the mechanism by which they inhibit the viability of hepatic stellate cells (HSCs) by a combination of network pharmacology and transcriptomics. Methods: The active components of FZHY formula were screened out by text minin...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xing X,Chen S,Li L,Cao Y,Chen L,Wang X,Zhu Z

    更新日期:2018-05-24 00:00:00

  • Ophiopogonin D', a Natural Product From Radix Ophiopogonis, Induces in Vitro and in Vivo RIPK1-Dependent and Caspase-Independent Apoptotic Death in Androgen-Independent Human Prostate Cancer Cells.

    abstract::Objective: The purpose of this study was to evaluate the anticancer effects of Ophiopogonin D' (OPD', a natural product extracted from a traditional Chinese medicine (Radix Ophiopogonis) against androgen-independent prostate cancer cells and to explore the underlying molecular mechanism(s) of action. Methods: The CCK-...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lu Z,Wang H,Zhu M,Song W,Wang J,Wu C,Kong Y,Guo J,Li N,Liu J,Li Y,Xu H

    更新日期:2018-04-30 00:00:00

  • Pre-clinical Pharmacokinetic and Metabolomic Analyses of Isorhapontigenin, a Dietary Resveratrol Derivative.

    abstract::Background: Isorhapontigenin (trans-3,5,4'-trihydroxy-3'-methoxystilbene, ISO), a dietary resveratrol (trans-3,5,4'-trihydroxystilbene) derivative, possesses various health-promoting activities. To further evaluate its medicinal potentials, the pharmacokinetic and metabolomic profiles of ISO were examined in Sprague-D...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Dai Y,Yeo SCM,Barnes PJ,Donnelly LE,Loo LC,Lin HS

    更新日期:2018-07-11 00:00:00

  • The Top-100 Highly Cited Original Articles on Drug Therapy for Ventilator-Associated Pneumonia.

    abstract::Background: In recent decades, research on drug therapy for ventilator-associated pneumonia (VAP) remains one of the major hot-spots in the field of critical care medicine, but relevant data are not satisfactory. Our aim was to assess the status and trends of the most cited articles on drug therapy for VAP through bib...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wang CY,Li BH,Ma LL,Zhao MJ,Deng T,Jin YH,Ren XQ

    更新日期:2019-02-12 00:00:00

  • Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways.

    abstract::Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one of the strategies to treat osteoclast-related bone diseases. Fumitremorgin C (Fum) is a mycotoxin...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yuan Y,Chen K,Chen X,Wang C,Qiu H,Cao Z,Song D,Sun Y,Guo J,Tickner J,Xu J,Zou J

    更新日期:2020-03-10 00:00:00