Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses.

abstract：:Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of marine natural products or to deduce their ecological significan...

journal_title：Frontiers in pharmacology

authors： Agrawal S,Adholeya A,Deshmukh SK

更新日期：2016-10-25 00:00:00

abstract：:Photodamages caused by UVA radiation induced oxidative injuries are closely related to photoaging and skin cancer. Paeoniflorin (PF), extracted from the root of Paeonia lactiflora, has been reported to be an effective antioxidant. PLIN2, known as adipose differentiation-related protein, has been previously involved in...

journal_title：Frontiers in pharmacology

authors： Lu YS,Jiang Y,Yuan JP,Jiang SB,Yang Y,Zhu PY,Sun YZ,Qi RQ,Liu T,Wang HX,Wu Y,Gao XH,Chen HD

更新日期：2020-05-15 00:00:00

abstract：:Bangpungtongsung-san (BTS) is a traditional Korean medicine consisting of 18 herbs, some which have antidepressant effects. Here, we used an animal model of reserpine-induced depression and lipopolysaccharide (LPS)-stimulated BV2 microglia to assess the antidepressant and anti-neuroinflammatory effects of BTS. Aside f...

journal_title：Frontiers in pharmacology

authors： Park BK,Kim NS,Kim YR,Yang C,Jung IC,Jang IS,Seo CS,Choi JJ,Lee MY

更新日期：2020-07-10 00:00:00

abstract：:Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

journal_title：Frontiers in pharmacology

authors： Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

更新日期：2018-01-24 00:00:00

abstract：:Natural products (NPs) are an important source for new drug discovery over the past decades, which have been demonstrated to be effectively used in cancer prevention, treatment, and adjuvant therapy. Many methods, such as the genomic and metabolomic approaches, immunochemistry, mass spectrometry, and chromatography, h...

journal_title：Frontiers in pharmacology

authors： Yan T,Zeng Q,Wang L,Wang N,Cao H,Xu X,Chen X

更新日期：2019-11-28 00:00:00

abstract：:Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury is driven by degeneration, neuroinflammation, and neuronal plasticity which results in neuropathic pain (NP) symptoms such as allody...

journal_title：Frontiers in pharmacology

authors： Silva RV,Oliveira JT,Santos BLR,Dias FC,Martinez AMB,Lima CKF,Miranda ALP

更新日期：2017-10-17 00:00:00

abstract：:PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depen...

journal_title：Frontiers in pharmacology

authors： El Boustani M,De Stefano L,Caligiuri I,Mouawad N,Granchi C,Canzonieri V,Tuccinardi T,Giordano A,Rizzolio F

更新日期：2019-01-22 00:00:00

abstract：:Biopeptides derived from marine species have garnered significant research interest owing to their anti-inflammatory, antibacterial, and anticancer activities. In our previous study, Hydrostatin-SN1, a bioactive peptide extracted from the Hydrophis cyanocinctus venom gland T7 phage display library, demonstrated anti-i...

journal_title：Frontiers in pharmacology

authors： Zhang C,Guo S,Wang J,Li A,Sun K,Qiu L,Li J,Wang S,Ma X,Lu Y

更新日期：2020-06-19 00:00:00

abstract：:Phytoestrogen has been proposed as an alternative to hormone replacement therapy, which has been demonstrated to promote a high risk of breast cancer. However, the effect of phytoestrogen on breast cancer development has not been fully understood. Bakuchiol is an active ingredient of a traditional Chinese herbal medic...

journal_title：Frontiers in pharmacology

authors： Li L,Chen X,Liu CC,Lee LS,Man C,Cheng SH

更新日期：2016-05-24 00:00:00

abstract：:The objective of this study was to investigate the regulation of X-ray irradiation and its effect on the activity and protein and mRNA expression levels of CYP1A2 and CYP2E1 in rats. Rats were randomly divided into 0 Gy (control), 1 Gy (low-dose irradiation), and 5 Gy (high-dose irradiation) groups. CYP1A2 and CYP2E1 ...

journal_title：Frontiers in pharmacology

authors： Li XY,Qu N,Wang XJ,Yang JX,Xin YY,Zhu JB,Bai X,Duan YB

更新日期：2020-01-28 00:00:00

abstract：:Background: Isorhapontigenin (trans-3,5,4'-trihydroxy-3'-methoxystilbene, ISO), a dietary resveratrol (trans-3,5,4'-trihydroxystilbene) derivative, possesses various health-promoting activities. To further evaluate its medicinal potentials, the pharmacokinetic and metabolomic profiles of ISO were examined in Sprague-D...

journal_title：Frontiers in pharmacology

authors： Dai Y,Yeo SCM,Barnes PJ,Donnelly LE,Loo LC,Lin HS

更新日期：2018-07-11 00:00:00

abstract：:As a typical traditional Chinese medicine, Bu-Yin-Qian-Zheng Formula (BYQZF) has been shown to have neuroprotective effects in patients with Parkinson's disease (PD), particularly by ameliorating mitochondrial dysfunction and regulating expression of the parkin protein. However, the underlying mechanisms by which BYQZ...

journal_title：Frontiers in pharmacology

authors： Ma HJ,Gai C,Chai Y,Feng WD,Cheng CC,Zhang JK,Zhang YX,Yang LP,Guo ZY,Gao YS,Sun HM

更新日期：2020-12-18 00:00:00

abstract：:Field independence (FI) has been found to correlate with a wide range of cognitive processes requiring cognitive restructuring. Cognitive restructuring, that is going beyond the information given by the setting, is pivotal in creating stable mental representations of the environment, the so-called "cognitive maps," an...

journal_title：Frontiers in pharmacology

authors： Boccia M,Vecchione F,Piccardi L,Guariglia C

更新日期：2017-07-25 00:00:00

abstract：:This paper reported a feasibility study strategy of identifying pharmacokinetic (PK) markers for a cardiovascular herbal medicine, Guanxin Danshen drop pill (GDDP). First, quantification analysis revealed the constituent composition in the preparation by high-performance liquid chromatography (HPLC). Subsequently, phy...

journal_title：Frontiers in pharmacology

authors： Yao H,Huang X,Xie Y,Huang X,Ruan Y,Lin X,Huang L,Shi P

更新日期：2018-12-21 00:00:00

abstract：:Over recent years, utilization of green synthesized nanomaterials has been widely growing on human body because of its special properties. With the increasing acceptance of nanoparticle approach for various clinical treatments, the biosafety and toxicological effects on the vital organs such as central nervous system,...

journal_title：Frontiers in pharmacology

authors： Yadav E,Singh D,Yadav P,Verma A

更新日期：2018-05-23 00:00:00

abstract：:Interest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g., the European Union's Cosmetic Directive and REACH, demands the use of altern...

journal_title：Frontiers in pharmacology

authors： Batke M,Gütlein M,Partosch F,Gundert-Remy U,Helma C,Kramer S,Maunz A,Seeland M,Bitsch A

更新日期：2016-09-21 00:00:00

abstract：:Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N-Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotectio...

journal_title：Frontiers in pharmacology

authors： Inserra A

更新日期：2018-04-05 00:00:00

abstract：:Aims and Hypothesis: This study aims to investigate the mechanism involved in intracellular regulation of EGFR degradation induced by EGF. Methods: Phosphorylation of proteins related to EGFR signaling was examined by western blot analysis. Activation, connection between Rab35 and folliculin (FLCN) were assessed by pu...

journal_title：Frontiers in pharmacology

authors： Zheng J,Duan B,Sun S,Cui J,Du J,Zhang Y

更新日期：2017-09-26 00:00:00

abstract：:MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still large...

journal_title：Frontiers in pharmacology

authors： Huang T,Ning Z,Hu D,Zhang M,Zhao L,Lin C,Zhong LLD,Yang Z,Xu H,Bian Z

更新日期：2018-03-26 00:00:00

abstract：:Objective: Advanced age is associated with impaired angiogenesis in part because of mitochondrial dysfunction. We have recently reported that leonurine exerts protective effects in neuron via regulation of mitochondrial function. The aim of this study was to explore whether leonurine is able to attenuate mitochondrial...

journal_title：Frontiers in pharmacology

authors： Qi J,Wang JJ,Duan JL,Lu ZY,Yuan YG

更新日期：2017-06-06 00:00:00

abstract：:The pathophysiology of inflammation and oxidative stress generated during different types of cancers and anticancer treatments is well documented. Traditionally, grape pomace is used for animal feed, organic fertilizers, ethanol production or is disposed as waste. Because grape pomace is a rich source of antioxidant c...

journal_title：Frontiers in pharmacology

authors： Balea ŞS,Pârvu AE,Pârvu M,Vlase L,Dehelean CA,Pop TI

更新日期：2020-07-03 00:00:00

abstract：:The casein kinase 2 (CK2) protein kinase is a pro-survival kinase and therapeutic target in treatment of various human cancers. CK2 overexpression has been demonstrated in hematological malignancies, including chronic lymphocytic leukemia, chronic myeloid leukemia, acute lymphoblastic leukemia, acute myeloid leukemia,...

journal_title：Frontiers in pharmacology

authors： Chon HJ,Bae KJ,Lee Y,Kim J

更新日期：2015-03-31 00:00:00

abstract：:The use of nanomaterials to modulate the tumor microenvironment has great potential to advance outcomes in patients with lung cancer. Nanomaterials can be used to prolong the delivery time of therapeutics enabling their specific targeting to tumors while minimizing and potentially eliminating cytotoxic effects. Using ...

journal_title：Frontiers in pharmacology

authors： Seshadri DR,Ramamurthi A

更新日期：2018-07-16 00:00:00

abstract：:Metabolic syndrome is a disorder of energy use and storage, which is characterized by central obesity, dyslipidemia, and raised blood pressure and blood sugar levels. Maternal 25-hydroxyvitamin D deficiency is known to cause metabolic changes, chronic disease, and increased adiposity in adulthood. However, the underlyi...

journal_title：Frontiers in pharmacology

authors： Zheng J,Liu X,Zheng B,Zheng Z,Zhang H,Zheng J,Sun C,Chen H,Yang J,Wang Z,Lin M,Chen J,Zhou Q,Zheng Z,Xu X,Ying H

更新日期：2020-02-28 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00512.]. ...

journal_title：Frontiers in pharmacology

authors： Jiang YH,Jiang LY,Wang YC,Ma DF,Li X

更新日期：2020-05-29 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. It takes some time from chronic gastritis to develop in GC. Early detection of GC will help patients obtain timely treatment. Understanding disease evolution is crucial for the prevention and treatment of GC. Here, we present a convolu...

journal_title：Frontiers in pharmacology

authors： Ma B,Guo Y,Hu W,Yuan F,Zhu Z,Yu Y,Zou H

更新日期：2020-10-02 00:00:00

abstract：:Limited data are available on the adherence to opioid therapy and the influence of different patient groups on adherence. This study examined the patterns of adherence in opioid naïve and opioid existing patients with varying age and gender. This retrospective cohort study was conducted using the prescription database...

journal_title：Frontiers in pharmacology

authors： Zin CS,Taufek NH,Ahmad MM

更新日期：2019-10-29 00:00:00

abstract：:Although endothelin (ET)-1 is a highly potent vasoconstrictor with considerable efficacy in numerous vascular beds, the role of endogenous ET-1 in the regulation of vascular tone remains unclear. The perspective that ET-1 plays little role in the on-going regulation of vascular tone at least under physiologic conditio...

journal_title：Frontiers in pharmacology

authors： Rapoport RM,Merkus D

更新日期：2017-10-24 00:00:00

abstract：:Parkinson's disease (PD), characterized with bradykinesia, static tremor, rigidity and disturbances in balance, is the second most common neurodegenerative disorder. Along with the largely aging population in the world, the incidence is increasing year by year, which imposes the negative impacts on patients, their fam...

journal_title：Frontiers in pharmacology

authors： Li X,Zhang Y,Wang Y,Xu J,Xin P,Meng Y,Wang Q,Kuang H

更新日期：2017-09-19 00:00:00

abstract：:[This retracts the article DOI: 10.3389/fphar.2018.00987.]. ...

journal_title：Frontiers in pharmacology

authors： Frontiers Editorial Office.

更新日期：2019-02-07 00:00:00