Abstract:
INTRODUCTION:Severity in systemic lupus erythematosus may vary from mild to even fatal consequences. There are no biomarkers to predict the disease's prognosis. The Systemic Lupus International Collaborating Clinics/ Systemic Damage Index defines systemic lupus erythematosus disease severity and is found to predict prognosis. OBJECTIVE:To test damage determinants in a single-centre systemic lupus erythematosus cohort. MATERIAL AND METHODS:Retrospectively followed systemic lupus erythematosus female patients (defined by the identification of at least four systemic lupus erythematosus American College of Rheumatology criteria - fulfillment 100%, n = 76) over the past five years. Age of onset, ethnicity, disease duration, number of American College of Rheumatology criteria at the end of follow-up, cumulative: renal, neuropsychiatric and articular phenotypes, hypertension, dyslipidaemia, smoking and Systemic Lupus Erythematosus Disease Activity Index 2K were correlated to the presence and degree of irreversible damage (Systemic Lupus International Collaborating Clinics Damage Index). Accumulation of American College of Rheumatology criteria was measured in a sub-group of patients followed from disease onset (within a year of the first symptom ascribed to systemic lupus erythematosus) (n = 39 - 51%); Systemic Lupus Erythematosus Disease Activity Index and Systemic Lupus International Collaborating Clinics Damage Index were performed. Statistical analysis was performed using Chi-square, Wilcoxon Mann-Whitney tests and Spearman correlation rho (Sig. 2-tailed p < 0.05). RESULTS:Systemic Lupus International Collaborating Clinics/Systemic Damage Index > 0 was present in 56.6% and significantly associated to a longer duration, a higher number of American College of Rheumatology criteria and a neuropsychiatric phenotype when compared with those with no damage. The final number of American College of Rheumatology criteria accrued was positively correlated to a higher disease activity over the past five years of follow-up (Spearman´s rho 0.02 and p < 0.05). There was no effect from other features. DISCUSSION AND CONCLUSION:Disease duration and number of American College of Rheumatology criteria predict Systemic Lupus International Collaborating Clinics/ Systemic Damage Index. neuropsychiatric disease has an impact on damage accrual. :Introdução: O lúpus eritematoso sistémico pode apresentar uma gravidade variável. Contudo, não existem biomarcadores que preveem o curso da doença. O dano é medido pelo índice Systemic Lupus International Collaborating Clinics/Systemic Damage Index que define a gravidade e prevê o seu prognóstico. Obetivo: Avaliação dos fatores que determinam dano nos doentes com lúpus eritematoso sistémico. Material e Métodos: Estudo retrospetivo, monocêntrico, em doentes com lúpus eritematoso sistémico (≥ 4 critérios do American College of Rheumatology – 100% dos doentes, n = 76), do sexo feminino, seguidos por um período ≥ 5 anos. Início da doença, etnia, duração, número de critérios American College of Rheumatology no final do seguimento, fenótipo renal, neuropsiquiátrico (e articular, co-morbilidades e Systemic Lupus Erythematosus Disease Activity Index -2K foram correlacionados com a presença e grau de dano medido pelo índice Systemic Lupus International Collaborating Clinics/Systemic Damage Index. A acumulação de critérios American College of Rheumatology foi objetivada num sub-grupo de doentes seguidos desde o início. A análise estatística utilizou o qui-quadrado, Wilcoxon Mann-Whitney e a correlação de Spearman (p < 0,05). Resultados: O Systemic Lupus International Collaborating Clinics Index era superior a 0 em 56,5% dos doentes. Estes doentes tinham um maior tempo de doença, um maior número de critérios American College of Rheumatology e um fenótipo neuropsiquiátrico, quando comparados com doentes sem dano (p < 0,05). Verificou-se uma correlação positiva entre o valor numérico de critérios American College of Rheumatology acumulados no final do seguimento e a atividade da doença nos últimos cinco anos (Spearman rho 0,02 e p < 0,05). Não se verificaram diferenças em relação às outras variáveis. Discussão e Conclusão: A duração da doença e o número de critérios do American College of Rheumatology acumulados conseguem prever a presença de dano. A doença neuropsiquiátrica teve impacto na morbilidade dos doentes com lúpus eritematoso sistémico, identificando um subgrupo em risco.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Jacinto M,Silva E,Riso N,Moraes-Fontes MFdoi
10.20344/amp.8082subject
Has Abstractpub_date
2017-05-31 00:00:00pages
368-372issue
5eissn
0870-399Xissn
1646-0758journal_volume
30pub_type
杂志文章abstract::Labour is very important in breech presentation and it is associated to significant morbidity and mortality enhancement in recent years. The authors made a retrospective study of breech presentation and labour with this kind of fetal presentation, in Santa Maria Hospital in 1993 and analysed the following data: matern...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Two types of platelet alloantigens are considered: type I, which refers to platelet alloantigens shared by platelets and other cells; and type II, which comprises the platelet-specific alloantigens. The Human Platelet Alloantigens (HPA) System consists of five diallelic alloantigens and eleven low frequency antigens. ...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::Twelve cases of extreme umbilical blood flow impairement (8 cases with loss of end-diastolic blood flow and 4 cases with reversed flow) found among 658 pregnancies studied by continuous Doppler between April 1st 1989 and March 31st 1990, are reported. The findings were associated to intra-uterine growth retardation (9...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::On page 761, in the first sentence of the Introduction, where it reads: "Cardiovascular Botulinum toxin A (BoNT-A) has beenapproved for spasticity management."It should read: "Botulinum toxin A (BoNT-A) has been approved for spasticity management."Article published with errors: https://www.actamedicaportuguesa.com/rev...
journal_title:Acta medica portuguesa
pub_type: 已发布勘误
doi:10.20344/amp.15226
更新日期:2020-12-02 00:00:00
abstract::This paper describes the process followed to create and validate the Portuguese versión of a quality of life measurement instrument for patients in palliative care. After a literature review about the measurement of the quality of life in this particular and very specific kind of patients, we opt by the Irene Higginso...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::This is a case report of a 29-year-old white female patient with Kikuchi's disease, presenting fever, polyarthritis, lymph gland enlargement, anemia, leucopenia with a relative lymphocytosis, altered liver function tests and circulating immune complexes. A literature review is made with emphasis on the etiology, clini...
journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::This paper summons to contest some of the bonds that will be severed, probably, by the new eugenics, and may be repaired by narrative-based medicine, two of the most extreme and contradictory challenges to today's--and tomorrow's--medical practice. Accordingly, I intend to frame its development into the unbounded math...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract:INTRODUCTION:Cervix cancer is the fourth most common female cancer and the second most frequent in women aged 15 to 44 years. The infection by the human papillomavirus is a necessary condition in almost all of cervix cancer cases; it is a sexually transmitted disease and all women sexually active are at risk of being i...
journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:10.20344/amp.7095
更新日期:2016-06-01 00:00:00
abstract::The diagnosis of cerebral cardioembolism requires, apart from evidence of an embolic cardiopathy, a cause-effect relation to be established between the potential cardioembolic source and the occurrence of ischemic stroke. There are several arguments in favour of this reaction, namely the neurologic aspects put forward...
journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
更新日期:1997-08-01 00:00:00
abstract:INTRODUCTION:Telemedicine is the provision of health services, where distance is a critical factor, using information and communication technologies. Cape Verde has bet on using this tool to increase access of the population of its islands to specialized care. MATERIAL AND METHODS:Qualitative study, covering the perio...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:10.20344/amp.7578
更新日期:2017-04-28 00:00:00
abstract::Correct food intake and physical exercise, together with insulin or oral antidiabetics constitute the basic triad of diabetes treatment. The authors discuss the general rules of dietetic measures in diabetes and review the importance of physical exercise, its indications and limitations in the metabolic control of the...
journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract::A new case of nephrotoxic effect of Maneb is related. The patient used this product as fungicide and developed a progressive illness with acute renal failure. The study by light and electron microscopy revealed severe tubular lesions that disappeared some months later with tubular cell regeneration. However, in spite ...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::The circumstances preceding the future revision of the medical curriculum are analysed, main internal and external stimuli are described, and sources of resistance to changes in medical training require new educational philosophy, privileging oriented training during undergraduation, as a preliminary phase of medical ...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic neuroinflammatory autoimmune disease believed to arise from complex interactions of both environmental and genetic factors. As in other complex diseases with autoimmune features, a genetic association with the human leukocyte antigen (HLA) complex is well documented. Association...
journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
更新日期:2012-07-01 00:00:00
abstract:INTRODUCTION:The consumption of potentially inappropriate medicines is high among institutionalized elderly, predisposing to potential drug interactions, adverse drug events, risk of iatrogenic cascade, increased morbidity and mortality and health costs. Medication review is a promising strategy for therapeutic optimiz...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:10.20344/amp.13030
更新日期:2020-07-30 00:00:00
abstract:INTRODUCTION:Crohn's disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC), commonly known as Inflammatory Bowel Disease (IBD) represent a heterogeneous group of chronic diseases of unknown origin and varying course, diagnosed in pediatric age at 25 to 30% of cases. Epidemiological international studies ...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract:UNLABELLED:Tobacco smoking is the cause of more than half million deaths/year in the European Union (EU). Monitoring smoking prevalence is an important tool to evaluate the epidemic and its evolution and to assess the effectiveness of preventive measures. The comparison between countries may help us identify good contr...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::The authors present a case of a 60-year-old male patient, previously diagnosed with B-cell chronic lymphocytic leukemia, who was admitted to the Emergency Room with dyspnea. The initial evaluation revealed severe anemia (Hgb = 5.0 g/dL) with hyperleukocytosis (800.000/µL), nearly all of the cells being mature lymphocy...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2016-05-01 00:00:00
abstract:INTRODUCTION:The objective of the study was to evaluate the experience of our service in the treatment of esophageal perforations. MATERIALS AND METHODS:Retrospective chart review of the nine cases occurred between January 1, 1996 and December 31, 2011. Seven occurred after accidental ingestion of foreign bodies and i...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2013-03-01 00:00:00
abstract:INTRODUCTION:Adolescents are a target group for reproductive health intervention. Family physicians, gynecologists and pediatricians are the main providers of contraceptive counseling. MATERIAL AND METHODS:Correlational, cross-sectional study, approved by the ethics committee of Leiria Hospital, Portugal. Data was col...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:10.20344/amp.11088
更新日期:2019-08-01 00:00:00
abstract::As far as we know, there is no experience of quality management in mental health care in Portugal. This study fills a gap in the area of consultation-liaison psychiatry. Due to its multidisciplinarity and to the complexity of the problems it deals with, consultation-liaison psychiatry seems a privileged field for the ...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::In order to clarify the early systolic partial closure (notching) of aortic valve in patients (pts) with dilated cardiomyopathy (DC), authors (AA) evaluated the M-mode echocardiograms corresponding to 41 pts with DC. Pts were separated in two groups, according to the presence of systolic notching: group A (18 pts) pre...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Our study included 42 patients with obstructive sleep apnea (OSAS) confirmed by polysomnography. In these patients we investigated the clinical manifestations, the results of the laboratory examinations, including polysomnography, ORL observations and tests of pulmonary function, as well as the therapeutic results. Ou...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::During pregnancy immunological, metabolic, hormonal and vascular changes occur, and can cause specific skin diseases. The specific dermatoses of pregnancy have undergone numerous changes in nomenclature and classification, partly due to advances in the knowledge of the pathogenesis of these skin diseases. Currently th...
journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
更新日期:2013-09-01 00:00:00
abstract::Several intra-arterial embolization techniques with polimerization substances, particles, thrombogenic coils and silicone and latex balloons have been used in the endovascular therapy of arteriovenous fistulas in different vascular territories. Using the Seldinger technique by femural route and with a coaxial system i...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::In a housing estate population with a high prevalence of tuberculosis, the authors conducted tuberculosis screening with the tuberculin test, and an investigation with three purposes: evaluation of tuberculosis infection (defined as > 10 mm on tuberculin test), evaluation of BCG effect on tuberculin test, and evaluati...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:The large wounds of the body wall, due to traumas, removal of tumors or prolonged laparostomies are a difficult surgical challenge with complex treatment. This paper presents the efficacy of the closure of large surgical wounds using rubber elastic bands. METHODS:One or two circular rubber elastic bands wer...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2011-05-01 00:00:00
abstract::The case of a 31 man with acute disautonomia envolving the parasympathetic and sympathetic systems but sparing sympathetic cholinergic division is presented. A Hodgkin lymphoma was diagnosed allowing the diagnosis of a paraneoplastic syndrome. ...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::The objective of this manuscript is to discuss the existing barriers for the dissemination of medical guidelines, and to present strategies that facilitate the adaptation of the recommendations into clinical practice. The literature shows that it usually takes several years until new scientific evidence is adopted in ...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Inherited errors of purine and pyrimidine metabolism are a group of disorders with a broad spectrum of clinical manifestations. They may involve nervous, renal, haematological and immunological systems, presenting at any age. The incidence and prevalence of these disorders are unknown. Most clinicians are not aware of...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00