Abstract：
:Two types of platelet alloantigens are considered: type I, which refers to platelet alloantigens shared by platelets and other cells; and type II, which comprises the platelet-specific alloantigens. The Human Platelet Alloantigens (HPA) System consists of five diallelic alloantigens and eleven low frequency antigens. According to serological antigen capture assays, immunochemical methods and studies of Molecular Genetics, the glycoproteins (GP) of platelet membrane that are most frequently associated with antibodies are GPIIb-IIIa, GPIb-IX and GPIa-IIa. It is possible to detect platelet antibodies using different laboratory methods. Our experience was restricted to a solid phase system. In this method we used the indirect technique for the screening of alloantibodies and the direct technique for the detection of autoantibodies. The procedure with chloroquine solution was performed in order to differentiate between the presence of HLA and non-HLA platelet specific antibodies. Our comments are based on results obtained in a hundred samples tested throughout a period of eleven months and we briefly review the clinical features related to the diagnosis of autoimmune and alloimmune thrombocytopenia, drug-induced thrombocytopenia and other different factors of platelet destruction. The concepts of transfusional practice applied to emergency situations, platelet refractoriness strategy and the comprehensive management of patients are approached in this work.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Campos MM,Fernández E,Marques MJ,Cordeiro Asubject
Has Abstractpub_date
2000-09-01 00:00:00pages
265-71issue
5-6eissn
0870-399Xissn
1646-0758journal_volume
13pub_type
杂志文章abstract：:Endoscopic interventional techniques have created a wide new perspective for non-surgical treatment of chronic pancreatitis (CP). Surgery and endoscopy differ in their techniques, but are comparable with regard to tactics. The aim of methods in CP is to relieve pain and/or local complications. The preliminary results ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：INTRODUCTION:Metals are a common cause of allergic contact dermatitis. After the introduction of the EU Nickel Directive (1994/27/CE; 2004/96/EC) and, more recently, the Cement Directive (2003/53/EC) there has been a significant decrease in sensitization to metals mainly in the Nordic countries. The applicability of th...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：INTRODUCTION:The growing concern surrounding health safety issues makes it essential that everyone, in particular the elderly due to their commonly prescribed multiple drugs, has a complete and up to date list of prescriptions. We planned to assess the quality of the electronic records of prolonged medication. MATERIA...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,多中心研究
doi：
更新日期：2014-09-01 00:00:00
abstract：:The authors, using the Cancer Registry data of S. Antonio General Hospital in Oporto, selected the cancer cases from 1981 to 1993. Distribution according to age, sex, topography and morphology is presented. Seven point nine percent of the 12,124 cases mentioned in the Registry were skin cancers (n = 883). They were mo...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Many workers in the textile industry have respiratory symptoms that are related to their work environment. In this study we observed the dust level conditions of eleven textile industries of the North of Portugal. The dust levels determined were between 0.1 mg/m3 and 1.25 mg/m3, in many cases above the Portuguese stan...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：:Correct food intake and physical exercise, together with insulin or oral antidiabetics constitute the basic triad of diabetes treatment. The authors discuss the general rules of dietetic measures in diabetes and review the importance of physical exercise, its indications and limitations in the metabolic control of the...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
abstract：:The Panels of São Vicente de Fora, a polyptych dated from 1470 to 1480, are a work composed of 6 panels, authored by Nuno Gonçalves, a painter of King Afonso V. This work reveals one of the most remarkable collective portraits of European painting, making this polyptych an inexhaustible source of readings and interpre...
journal_title：Acta medica portuguesa
pub_type： 历史文章,杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：:Central diabetes insipidus, is a syndrome characterized by the excretion of abnormally elevated volumes of diluted urine, due to the diminution of reabsorption of water in the collecting ducts, induced by the diminution of production of antidiuretic hormone. The involvement of the central nervous system in the leukaem...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：INTRODUCTION:Creatine deficiency syndromes are a recently described group of diseases characterized by inborn errors of creatine metabolism. Clinical features include a spectrum of neurodevelopment disorders of diverse severity. They are characterized by low levels of cerebral creatine caused by different pathogenic mu...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：:The availability of scientific information is growing exponentially. Healthcare professionals who wish to keep up-to-date with scientific literature and find the best information should spend their time finding resources that summarize the best available evidence. This manuscript aims to provide bibliographic research...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：:The accurate treatment of a dyslipidaemia is based on correct diagnosis. Together with the laboratory values. A good clinical interview, focusing on the family history, is the bases for a good diagnosis strategy. The author schematze the rules of etiological diagnosis of inherited defects of lipid metabolism. ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：INTRODUCTION:Telemedicine is the provision of health services, where distance is a critical factor, using information and communication technologies. Cape Verde has bet on using this tool to increase access of the population of its islands to specialized care. MATERIAL AND METHODS:Qualitative study, covering the perio...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.7578
更新日期：2017-04-28 00:00:00
abstract：:The authors report a case of seronegative polyarthritis resistant to the anti-inflammatory therapy in a 16-year-old male with intermittent diarrhea. A stool examination showed the presence of cysts of Giardia lamblia and an immunological study detected a partial serum IgA deficiency, including its secretory fraction. ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1993-12-01 00:00:00
abstract：:Despite the recent advances in the development of complementary diagnostic exams and modern targeted therapies, colorectal cancer remains a major cause of morbidity and mortality worldwide. In this context, a lot of research has been conducted in the last years to find new markers of poor prognosis. The existence of a...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：10.20344/amp.5398
更新日期：2015-05-01 00:00:00
abstract：:The authors present a case of a 60-year-old male patient, previously diagnosed with B-cell chronic lymphocytic leukemia, who was admitted to the Emergency Room with dyspnea. The initial evaluation revealed severe anemia (Hgb = 5.0 g/dL) with hyperleukocytosis (800.000/µL), nearly all of the cells being mature lymphocy...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：:Spinal arachnoiditis, an inflammatory process involving all three meningeal layers as well as the nerve roots, is a cause of persistent symptoms in 6% to 16% of postoperative patients. Although spinal surgery is the most common antecedent associated with arachnoiditis, multiple causes have been reported, including inf...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：INTRODUCTION:The determination of hand grip strength is an objective method of evaluation of upper members' integrity. It is also used as a general health indicator. Data about grip strength values in healthy children is useful in the research and diagnosis of diseases that interfere with grip force. The aim of this st...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：INTRODUCTION:Crohn's disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC), commonly known as Inflammatory Bowel Disease (IBD) represent a heterogeneous group of chronic diseases of unknown origin and varying course, diagnosed in pediatric age at 25 to 30% of cases. Epidemiological international studies ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:Amyotrophic lateral sclerosis is a rare neurodegenerative disease affecting motor neurons. Patients present with progressive physical impairment, respiratory failure being the main cause of death. A significant portion of patients presents neurobehavioral problems as well. As severe impairment occurs, pati...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：10.20344/amp.6590
更新日期：2016-01-01 00:00:00
abstract：INTRODUCTION:Our neonatal service is part of a differentiated perinatal hospital and has contributed to the Vermont Oxford Network for more than 15 years. This data base includes data on the morbidity and mortality of newborns born in the member hospitals with birth weight between 401 and 1500 g and/ or from 22 to 29 w...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.9130
更新日期：2019-11-04 00:00:00
abstract：OBJECTIVES:To determine the prevalence of infertility in Porto and to assess the association between infertility and women's year of birth and socioeconomic status. MATERIAL AND METHODS:In a cross-sectional study were evaluated in Porto, in 1999-2003, 1540 women aged 18-90 years. Structured face-to-face interviews com...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：INTRODUCTION:Visceral leishmaniasis is an endemic disseminated infection, considered to be the third most frequent opportunistic parasitic infection in Europe. It is especially prevalent in patients co-infected with human immunodeficiency virus, in whom it poses a great therapeutic challenge due to increased risk of re...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.8291
更新日期：2017-06-30 00:00:00
abstract：:Diaphragmatic Pacing was used to treat ventilatory failure in a young boy with bilateral diaphragmatic palsy secondary to cervical cord injury, on chronic mechanical ventilation for 6 months. The indications for diaphragmatic pacing in ventilatory failure were discussed, as well as the assessment of phrenic nerve inte...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：:The exercise tolerance test (ETT) is the ancillary test of choice for the evaluation of the patient with ischaemic heart disease. When faced with complaints suggestive of angina pectoris, ETT is useful in confirming or excluding such a diagnosis, frequently reproducing the complaints while recording the tell-tale elec...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1997-04-01 00:00:00
abstract：:Fabry disease (FD) is a rare disorder resulting from mutations of the alpha-Galactosidase A lysosomal enzyme gene. Accumulation of enzyme substrates leads to multisystemic clinical manifestations and multiorgan progressive damage with high morbidity and mortality. Recombinant enzyme replacement therapy (RERT) now avai...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：:Alpha-1 antitrypsin deficiency is an autosomal co-dominant inherited disorder that results in decreased circulating levels of alpha-1 antitrypsin (also known as alpha-1 proteinase inhibitor) and predisposes affected individuals to early onset lung and liver disease. There is currently no cure for alpha-1 antitrypsin d...
journal_title：Acta medica portuguesa
pub_type： 实务指引
doi：10.20344/amp.12950
更新日期：2020-06-01 00:00:00
abstract：INTRODUCTION:In the context of a pronounced population ageing and rising mortality due to chronic illnesses, this national epidemiological study compares the places where people die with population preferences. MATERIAL AND METHODS:Data on numbers of deaths in 2010 by gender, age group, region of residence NUTS II and...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the safety and efficacy in the first sixteen patients operated by endoscopic third ventriculostomy for triventricular obstructive hydrocephalus in the Hospital of S. João-Porto. METHODS:Operated from December 1998 to December 1999, there were one adult, one teenager...
journal_title：Acta medica portuguesa
pub_type： 临床试验,杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:To evaluate importance of homocysteinemia as risk factor of thrombotic cerebrovascular disease, in terms of age and homocysteinemia levels. METHODS:A group of patients under 55 years old (n = 35, 21 males) that had suffered a stroke 3 months to 1 year before the study, defined by clinical criteria and the pres...
journal_title：Acta medica portuguesa
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:The authors present their clinical experience of leg and foot reconstruction with 227 clinical cases. Based on these cases the authors analyse the use of 18 musculocutaneous, 53 axial, 72 septocutaneous and 84 free flaps, totalling 29 different kinds of flaps performed. Although no definitive conclusions can be drawn ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
