Abstract：
:Multiple sclerosis (MS) is a chronic neuroinflammatory autoimmune disease believed to arise from complex interactions of both environmental and genetic factors. As in other complex diseases with autoimmune features, a genetic association with the human leukocyte antigen (HLA) complex is well documented. Association and genome-wide studies were performed in Portuguese patients with MS over several years. Genes such as HLA-DRB1, HLA-A, HFE, TNFA, CTLA-4, PTPN22 and ApoE were investigated. ApoE, PTPN22 1858T, CTLA-4 -318C, TNFA-308A, HFE C282Y and TLR9 T-1237C polymorphisms were not shown to be associated with the development of MS. The HLA-DRB1*15 allele was confirmed as the major genetic marker for susceptibility to MS. The presence of HLA-A*02 and TNFA -238A alleles decreased the risk of developing MS. Patients carrying the HFE C282Y variant seem to have a worse prognosis. The HLA-DRB1*15 and PTPN22 1858T variants were associated with a better outcome in this population.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Bettencourt A,Martins da Silva A,Pinho E Costa P,Martins Silva Bsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
224-30issue
4eissn
0870-399Xissn
1646-0758journal_volume
25pub_type
杂志文章,评审abstract：:The use of the transoesophageal echocardiography (TEE) in the critically ill patient admitted to the general intensive care unit begins to turn out to be very important but it is still little spread. The full implementation of the echocardiography in the general intensive cares is compromised by the acoustic window. H...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2011-12-01 00:00:00
abstract：:Biomedical simulation is an effective educational complement for healthcare training, both at undergraduate and postgraduate level. It enables knowledge, skills and attitudes to be acquired in a safe, educationally orientated and efficient manner. In this context, simulation provides skills and experience that facilit...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.8403
更新日期：2016-12-30 00:00:00
abstract：:Suicidal behaviour still represents a serious public health problem. Although the existence of some consultations on this subject, their efficacy remains very far from what we wish. In that sense, the research on the biological markers of suicidal behaviour might be of considerable importance. The aim of this paper is...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：:Despite the recent advances in the development of complementary diagnostic exams and modern targeted therapies, colorectal cancer remains a major cause of morbidity and mortality worldwide. In this context, a lot of research has been conducted in the last years to find new markers of poor prognosis. The existence of a...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：10.20344/amp.5398
更新日期：2015-05-01 00:00:00
abstract：:The exercise tolerance test (ETT) is the ancillary test of choice for the evaluation of the patient with ischaemic heart disease. When faced with complaints suggestive of angina pectoris, ETT is useful in confirming or excluding such a diagnosis, frequently reproducing the complaints while recording the tell-tale elec...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1997-04-01 00:00:00
abstract：:Ankle injuries are the most frequently encountered injuries in clinical practice. They are often managed by general practicians, and not only by orthopaedic or physiatric physicians. This injury is usually non-complicated, but some care should be taken to assure an adequate management and to exclude severe lesions. Th...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2008-05-01 00:00:00
abstract：INTRODUCTION:The Power of Food Scale measures appetite for, rather than consumption of, palatable foods - a construct frequently designated as hedonic hunger. The purpose of this study was to examine the psychometric properties of a Portuguese version of the Power of Food Scale, namely reliability and construct validit...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.6517
更新日期：2015-09-01 00:00:00
abstract：:Atrial septum aneurysms are an uncommon condition, underestimated before the routine use of echocardiography. Their clinical importance has increased after being associated with thromboembolic events. The authors made a review of clinical, diagnostic and therapeutic features of this entity after reporting six clinical...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：INTRODUCTION:The percentage of citizens who were not registered with a family physician in Portugal reached 16.6% in 2011. In 2012 the Ministry of Health implemented several measures aiming at improving access to family physicians. One clear objective was that all individuals would be registered with a family physician...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.9873
更新日期：2018-12-28 00:00:00
abstract：:The aim of this study was to evaluate the accuracy of ultrasound biometric and hemodynamic fetal parameters for the prenatal diagnosis of intrauterine retardation in a sample of 438 pregnant women who had their first visit before the 16th week of gestation at the outpatient clinic of the Department of Obstetrics and G...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：INTRODUCTION:MEN2A is an autossomal dominant cancer syndrome characterised by the presence of medullary thyroid cancer, pheochromocytoma and primary hyperparathyroidism. Germline mutations of the RET protooncogene constitute the molecular defect and can be identified in affected individuals. Genetic screening of family...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：:The accurate treatment of a dyslipidaemia is based on correct diagnosis. Together with the laboratory values. A good clinical interview, focusing on the family history, is the bases for a good diagnosis strategy. The author schematze the rules of etiological diagnosis of inherited defects of lipid metabolism. ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:Lithopedions are extremely rare conditions. Less than 300 cases were described worldwide. We report a case occurring in a woman of 77 years of age, admitted with dehydration, urinary tract infection and infected limb pressure ulcers. She had been recently admitted in a Surgery ward for incarcerated umbilical hernia. A...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：:Significative enhancement of free radical formation (FRO) in vivo is an important feature of hypertensive disorders of pregnancy (HDP), namely preeclampsia (PIH). The latest investigations about the pathology of HDP, showed the contribution of placental circulation to the development and evolution of such disease. The...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:Rhabdomyolysis is a common entity that often has a multifactorial etiology. It usually affects healthy individuals, following trauma, excessive physical activity, convulsive crisis, alcohol and other drugs consumption or infections. Accumulation of intracellular calcium, activation of proteases and lipases, production...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2005-07-01 00:00:00
abstract：:Endoscopic interventional techniques have created a wide new perspective for non-surgical treatment of chronic pancreatitis (CP). Surgery and endoscopy differ in their techniques, but are comparable with regard to tactics. The aim of methods in CP is to relieve pain and/or local complications. The preliminary results ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:The oncocytic tumors of the adrenal gland are rare. To date there's only 147 cases published. The authors present a case of a 34 year-old man admitted to the hospital with lumbar pain and fever. At medical examination a mass was found in the left upper quadrant of the abdomen. The hormonal measurements of the adrenal ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:In this work, 139 intra-cranial aneurysms diagnosed at the Egas Moniz Hospital were studied, from 1980 to the first quarter of 1992. The nature of this type of lesions was discussed, and aneurysms were defined as an abnormal and segmental dilatation of an intracranial artery wall. A statistical study was performed, in...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Referring to examples from the poetry of Fernando Pessoa and Mário de Sá Carneiro, we draw attention to the narcissistic relationship between mother and baby, to the role of the mirror-image of the mother's face, and to the organization of a false self caused by a deficiency both of that function, and of the narcissis...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：INTRODUCTION:In Portugal child abuse is a reality, although its true incidence is still unknown. POPULATION AND METHODS:Retrospective study by consulting child abuse processes of children hospitalized in Paediatric Nursery and Neonatal Special Care Unit of Centro Hospitalar de Setúbal, E.P.E between January 1, 2006 an...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：:In Portugal, piroxicam is one of the most prescribed non-steroidal anti-inflammatory agents (NSAIDs) and is frequently associated to photosensitivity skin reactions, well known by all dermatologists. The authors review the physiopathology and clinical patterns of this adverse drug reaction. Importance is given to the ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：:Selected medical students for undergraduate medical courses in Portugal exhibit each year substantial deficiencies in chemistry. The group of students admitted to the Faculty of Medicine of Lisbon in 1989/1990 were selected by admission criteria apparently more restrictive than before. The aim of this study was to eva...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Histology records from 63 nephrectomies were reviewed; 22 patients had unilateral totally dysplastic kidneys and 5 had polar or segmental dysplasia. A clinicopathological study of these cases was undertaken. In the first group, there was a slight male preponderance and 75% of the patients presented were under two year...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:In order to assess the weight of Rheumatic Diseases, the Authors retrospectively studied 117 patients admitted to the Internal Medicine Service of the Faro District Hospital over a 3 year period (1989-1991). The selection criterion comprised the final rheumatological diagnosis. The diseases were arranged in nosologica...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:In the literature, there are few reports of posterior cerebral artery aneurysms resulting from isolated dissections. In these cases the treatment is still a matter of discussion and includes anticoagulation, surgical intervention, endovascular techniques and conservative management. We present five cases of Posterior ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
abstract：:The authors present a case of a 60-year-old male patient, previously diagnosed with B-cell chronic lymphocytic leukemia, who was admitted to the Emergency Room with dyspnea. The initial evaluation revealed severe anemia (Hgb = 5.0 g/dL) with hyperleukocytosis (800.000/µL), nearly all of the cells being mature lymphocy...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：:The authors describe the ambulatory treatment of a young man, the son of a divorced mother, where they used a methodology called Combined Treatment of Heroin Addicts, which was done in stages. They used family sessions, with a concomitant hearing of the patient alone, combined with the use of an opioid antagonist, cal...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:Helicobacter pylori infection is a risk factor for gastric adenocarcinoma. Identification of individuals with this infection and its eradication may be considered as a primary prevention strategy to reduce the incidence of gastric adenocarcinoma; however, the magnitude of benefit and the effectiveness of this strategy...
journal_title：Acta medica portuguesa
pub_type： 评论,杂志文章
doi：
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:The consumption of potentially inappropriate medicines is high among institutionalized elderly, predisposing to potential drug interactions, adverse drug events, risk of iatrogenic cascade, increased morbidity and mortality and health costs. Medication review is a promising strategy for therapeutic optimiz...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.13030
更新日期：2020-07-30 00:00:00
abstract：:Whipple's Disease is a rare multisystemic disease caused by Gram-positive bacillus, Tropheryma whippelii, family of Actinobacterias and group of Actinomycetes. Because the disease is rare and has different forms of presentation the diagnosis comes frequently late. The authors present the case of a white man, 50 years ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
