Abstract：
:Nonalcoholic steatohepatitis (NASH) has similar clinical pathological changes to alcoholic hepatitis. It shows increased incidence and young trend year by year. Polyene phosphatidyl choline (PPC) is widely used in clinic for liver disease treatment. The effect and mechanism of PPC on NASH have not been fully elucidated. Thirty healthy male Wistar rats were randomly equally divided into control, NASH group, and PPC group. NASH model was established by high fat diet. PPC was intraperitoneal injected to NASH rat from the second week at 80 mg/kg·d for three weeks. Body weight, liver weight index, ALT, AST, TG, and TC were tested. TNF-α and IL-1β levels were detected by ELISA. NF-κB mRNA and protein expression in liver tissue were determined by real time PCR and Western blot. SOD activity and ROS content were measured by colorimetry. NASH rat presented significantly elevated body weight and liver weight index, increased ROS content, declined SOD activity, enhanced liver function and inflammatory factors expression, and upregulated NF-κB mRNA and protein levels compared with control (P < 0.05). PPC intervention obviously reduced body weight and liver weight index, declined ROS content, amplified SOD activity, decreased liver function, weakened inflammatory factor TNF-α and IL-1β expression, and downregulated NF-κB mRNA and protein levels compared with NASH group (P < 0.05). PPC can play a treatment effect on NASH through regulating oxidative balance, inhibiting inflammatory factors and NF-κB signaling pathway.
journal_name
Am J Transl Resjournal_title
American journal of translational researchauthors
Cao M,Li X,Zhang B,Han S,Yang Y,Zhou B,Zhang Ysubject
Has Abstractpub_date
2016-05-15 00:00:00pages
2325-30issue
5issn
1943-8141journal_volume
8pub_type
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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更新日期：2018-05-15 00:00:00
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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更新日期：2016-03-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2019-04-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2019-09-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2016-05-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-07-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2017-05-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2019-10-15 00:00:00
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journal_title：American journal of translational research
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doi：
更新日期：2019-08-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2020-08-15 00:00:00
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journal_title：American journal of translational research
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doi：
更新日期：2019-10-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2017-11-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2020-09-15 00:00:00
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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更新日期：2018-12-15 00:00:00
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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更新日期：2019-06-15 00:00:00
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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更新日期：2016-02-15 00:00:00
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journal_title：American journal of translational research
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doi：
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
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