Abstract:
:The microRNA-29 family, which contains mir-29a, mir-29b, and mir-29c, can promote or resist the development of several types of tumors. However, its role in rhabdomyosarcoma (RMS) has not been determined. In this work, we detected the expression of mir-29a/b/c in RMS. Results showed that the tissues and cell lines in RMS were significantly lower than those in muscle and human skeletal muscle cells, and that these cell lines could also inhibit the proliferation, migration, and invasion and induce apoptosis of RMS cells. Dual-luciferase reporter assay and RNA immunoprecipitation verified the direct binding site between mir-29a/b/c and GEFT. Under the combined actions of mir-29a/b/c and GEFT, the former weakened the promoting effect of GEFT on RMS cells. Finally, mir-29a inhibited the tumorigenesis of subcutaneous xenografts in nude mice and inhibited the mRNA and protein expression levels of GEFT in transplanted tumors. These findings proved that mir-29 inhibits the occurrence of RMS and may be a potential molecular target.
journal_name
Am J Transl Resjournal_title
American journal of translational researchauthors
Wang Y,Zhang L,Pang Y,Song L,Shang H,Li Z,Liu Q,Zhang Y,Wang X,Li Q,Zhang Q,Liu C,Li Fsubject
Has Abstractpub_date
2020-03-15 00:00:00pages
1136-1154issue
3issn
1943-8141journal_volume
12pub_type
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journal_title:American journal of translational research
pub_type: 杂志文章
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journal_title:American journal of translational research
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journal_title:American journal of translational research
pub_type: 杂志文章
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journal_title:American journal of translational research
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journal_title:American journal of translational research
pub_type: 杂志文章
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journal_title:American journal of translational research
pub_type: 杂志文章
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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doi:
更新日期:2016-05-15 00:00:00
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journal_title:American journal of translational research
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doi:
更新日期:2017-07-15 00:00:00
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journal_title:American journal of translational research
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更新日期:2016-02-15 00:00:00
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journal_title:American journal of translational research
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更新日期:2016-01-15 00:00:00
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journal_title:American journal of translational research
pub_type: 杂志文章
doi:
更新日期:2019-04-15 00:00:00
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journal_title:American journal of translational research
pub_type: 杂志文章
doi:
更新日期:2020-06-15 00:00:00
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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doi:
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journal_title:American journal of translational research
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journal_title:American journal of translational research
pub_type: 杂志文章
doi:
更新日期:2016-10-15 00:00:00
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journal_title:American journal of translational research
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doi:
更新日期:2017-04-15 00:00:00
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journal_title:American journal of translational research
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doi:
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journal_title:American journal of translational research
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journal_title:American journal of translational research
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