Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy.

abstract：:Due to their lower systemic toxicity, faster kidney clearance and higher tumor accumulation, ultrasmall gold nanoparticles (less than 10 nm in diameter) have been proved to be promising in biomedical applications. However, their potential applications in cancer imaging and treatment have not been reviewed yet. This re...

journal_title：Theranostics

authors： Fan M,Han Y,Gao S,Yan H,Cao L,Li Z,Liang XJ,Zhang J

更新日期：2020-03-31 00:00:00

abstract：:In the field of ischemic cerebral injury, precise characterization of neurovascular hemodynamic is required to select candidates for reperfusion treatments. It is thus admitted that advanced imaging-based approaches would be able to better diagnose and prognose those patients and would contribute to better clinical ca...

journal_title：Theranostics

authors： Hingot V,Brodin C,Lebrun F,Heiles B,Chagnot A,Yetim M,Gauberti M,Orset C,Tanter M,Couture O,Deffieux T,Vivien D

更新日期：2020-06-12 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) and their gene-engineered cells display great application prospects in tumor immunotherapy. The timing of CTL-induced molecular events in tumor cells is unclear, and we also unknow whether the killing efficiency of CTLs is restrained in the liver, an immunotolerant organ with a high tumo...

journal_title：Theranostics

authors： Liu L,Dai B,Li R,Liu Z,Zhang Z

更新日期：2021-01-01 00:00:00

abstract：:Detection of biomarkers is extremely important for the early diagnosis of diseases. Here, we developed an easy and highly sensitive fluorescence detection system for the determination of biomarkers by combining the rapid separation of magnetic beads and silver nanoparticles labeled antibodies. An ultrasensitive silver...

journal_title：Theranostics

authors： Zhao LJ,Yu RJ,Ma W,Han HX,Tian H,Qian RC,Long YT

更新日期：2017-02-08 00:00:00

abstract：:New ways to target and treat metastatic disease are urgently needed. Tumor "self-homing" describes the recruitment of circulating tumor cells (CTCs) back to a previously excised primary tumor location, contributing to tumor recurrence, as well as their migration to established metastatic lesions. Recently, self-homing...

journal_title：Theranostics

authors： Parkins KM,Dubois VP,Kelly JJ,Chen Y,Knier NN,Foster PJ,Ronald JA

更新日期：2020-06-29 00:00:00

abstract：:Rationale: Tumor vascular normalization (TVN) is emerging to enhance the efficacy of anticancer treatment in many cancers including glioblastoma (GBM). However, a common and severe challenge being currently faced is the transient TVN effect, hampering the sustained administration of anticancer therapy during TVN windo...

journal_title：Theranostics

authors： Zhang J,Xue W,Xu K,Yi L,Guo Y,Xie T,Tong H,Zhou B,Wang S,Li Q,Liu H,Chen X,Fang J,Zhang W

更新日期：2020-06-05 00:00:00

abstract：:A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positi...

journal_title：Theranostics

authors： Hou FQ,Song LW,Yuan Q,Fang LL,Ge SX,Zhang J,Sheng JF,Xie DY,Shang J,Wu SH,Sun YT,Wei SF,Wang MR,Wan MB,Jia JD,Luo GH,Tang H,Li SC,Niu JQ,Zhou WD,Sun L,Xia NS,Wang GQ

更新日期：2015-01-01 00:00:00

abstract：:Intraoperative fluorescence imaging is particularly well-suited for surgical applications due to its inherently high sensitivity, resolution, and ability to provide images in real-time. To date, the intraoperative observation of fluorescence has largely been subjective. With the need to show objective evidence in orde...

journal_title：Theranostics

authors： Tummers WS,Warram JM,van den Berg NS,Miller SE,Swijnenburg RJ,Vahrmeijer AL,Rosenthal EL

更新日期：2018-10-22 00:00:00

abstract：:Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, unders...

journal_title：Theranostics

authors： De Sarno F,Ponsiglione AM,Russo M,Grimaldi AM,Forte E,Netti PA,Torino E

更新日期：2019-02-28 00:00:00

abstract：:The α-chemokine CXCL12 (stromal derived factor-1; SDF-1) and its corresponding G(αI) protein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell niches. CXCL12 has also been identified as a strong chemoattractant for HSPCs and imp...

journal_title：Theranostics

authors： Ratajczak MZ,Serwin K,Schneider G

更新日期：2013-01-01 00:00:00

abstract：:Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent thrombus organization limits direct blood contact with fibrin, the target of blood-based fibri...

journal_title：Theranostics

authors： Stein-Merlob AF,Kessinger CW,Erdem SS,Zelada H,Hilderbrand SA,Lin CP,Tearney GJ,Jaff MR,Reed GL,Henke PK,McCarthy JR,Jaffer FA

更新日期：2015-09-13 00:00:00

abstract：:High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to co...

journal_title：Theranostics

authors： El Kaffas A,Gangeh MJ,Farhat G,Tran WT,Hashim A,Giles A,Czarnota GJ

更新日期：2018-01-01 00:00:00

abstract：:Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the im...

journal_title：Theranostics

authors： Chen Y,Zhang M,Jin H,Li D,Xu F,Wu A,Wang J,Huang Y

更新日期：2017-08-15 00:00:00

abstract：:Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for d...

journal_title：Theranostics

authors： Son DJ,Zheng J,Jung YY,Hwang CJ,Lee HP,Woo JR,Baek SY,Ham YW,Kang MW,Shong M,Kweon GR,Song MJ,Jung JK,Han SB,Kim BY,Yoon DY,Choi BY,Hong JT

更新日期：2017-10-16 00:00:00

abstract：:The mineral dust-induced gene (mdig) is overexpressed in a number of human cancers, suggesting critical roles of this gene played on the pathogenesis of cancers. Unlike several other JmjC-domain containing proteins that exhibit histone demethylase activity, it remains enigmatic whether mdig is involved in the demethyl...

journal_title：Theranostics

authors： Zhang Q,Thakur C,Fu Y,Bi Z,Wadgaonkar P,Xu L,Liu Z,Liu W,Wang J,Kidder BL,Chen F

更新日期：2020-01-01 00:00:00

abstract：:Molecular photoacoustic imaging (PA) is a promising technology to understand tumor pathology and guide precision therapeutics. Despite the capability of activatable PA probes to image tumor-specific biomarkers, limitations in their molecular structure hamper them from effective drug delivery and the drug release monit...

journal_title：Theranostics

authors： Yang Z,Song J,Tang W,Fan W,Dai Y,Shen Z,Lin L,Cheng S,Liu Y,Niu G,Rong P,Wang W,Chen X

更新日期：2019-01-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent in Asia. The survival rate of OSCC patients has not improved over the past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes. Improvement in therapeutic st...

journal_title：Theranostics

authors： Su SC,Lin CW,Liu YF,Fan WL,Chen MK,Yu CP,Yang WE,Su CW,Chuang CY,Li WH,Chung WH,Yang SF

更新日期：2017-02-26 00:00:00

abstract：:Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic administration. Here...

journal_title：Theranostics

authors： Fan B,Kang L,Chen L,Sun P,Jin M,Wang Q,Bae YH,Huang W,Gao Z

更新日期：2017-01-01 00:00:00

abstract：:Colitis-associated colon cancer (CAC) is a widely recognized cancer, while treatment with the existing chemotherapeutic drugs affords limited clinical benefits. Herein we proposed a site-specific, combination nanotherapy strategy for targeted treatment of CAC by the oral route. Methods: A reactive oxygen species (ROS)...

journal_title：Theranostics

authors： Zhang Q,Zhang F,Li S,Liu R,Jin T,Dou Y,Zhou Z,Zhang J

更新日期：2019-05-31 00:00:00

abstract：:The limited clinical efficacy of monotherapies in the clinic has urged the development of novel combination platforms. Taking advantage of light-triggered photodynamic treatment combined together with the controlled release of nanomedicine, it has been possible to treat cancer without eliciting any adverse effects. Ho...

journal_title：Theranostics

authors： Hameed S,Bhattarai P,Liang X,Zhang N,Xu Y,Chen M,Dai Z

更新日期：2018-11-03 00:00:00

abstract：:Acute liver failure is characterized by the rapid development of liver dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate the potential role of soyasaponin II in acute liver failure and establish the...

journal_title：Theranostics

authors： Wang F,Gong S,Wang T,Li L,Luo H,Wang J,Huang C,Zhou H,Chen G,Liu Z,Zhang Q,Jiang Y,Chen P

更新日期：2020-02-03 00:00:00

abstract：:Periodontitis is a widespread oral disease that results in the loss of alveolar bone. Low-intensity pulsed ultrasound (LIPUS), which is a new therapeutic option, promotes alveolar bone regeneration in periodontal bone injury models. This study investigated the protective effect of LIPUS on oxidative stress in periodon...

journal_title：Theranostics

authors： Ying S,Tan M,Feng G,Kuang Y,Chen D,Li J,Song J

更新日期：2020-08-01 00:00:00

abstract：:Rationale: The overall success rate of prostate cancer (PCa) diagnosis and therapy has been improved over the years. However, genomic and phenotypic heterogeneity remains a major challenge for effective detection and treatment of PCa. Efforts to better classify PCa into functional subtypes and elucidate the molecular ...

journal_title：Theranostics

authors： Bai Y,Yang Y,Yan Y,Zhong J,Blee AM,Pan Y,Ma T,Karnes RJ,Jimenez R,Xu W,Huang H

更新日期：2019-05-24 00:00:00

abstract：:Mitochondria in cancer cells maintain a more negative membrane potential than normal cells. Mitochondria are the primary source of cellular reactive oxygen species (ROS), which are necessary for photodynamic therapy. Thus, the strategy of targeting mitochondria can maximize the photodynamic therapeutic efficiency for ...

journal_title：Theranostics

authors： Yue C,Yang Y,Zhang C,Alfranca G,Cheng S,Ma L,Liu Y,Zhi X,Ni J,Jiang W,Song J,de la Fuente JM,Cui D

更新日期：2016-10-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field still suffers from poor data reproducibility. This is especially true in cases of infants, conside...

journal_title：Theranostics

authors： Prieto-Fernández E,Aransay AM,Royo F,González E,Lozano JJ,Santos-Zorrozua B,Macias-Camara N,González M,Garay RP,Benito J,Garcia-Orad A,Falcón-Pérez JM

更新日期：2019-06-19 00:00:00

abstract：:Marfan syndrome (MFS) is a rare genetic disease characterized by a matrix metalloproteases (MMPs) dysregulation that leads to extracellular matrix degradation. Consequently, MFS patients are prone to develop progressive thoracic aortic enlargement and detrimental aneurysm. Since MMPs are activated by the extracellular...

journal_title：Theranostics

authors： Rurali E,Perrucci GL,Gaetano R,Pini A,Moschetta D,Gentilini D,Nigro P,Pompilio G

更新日期：2019-04-12 00:00:00

abstract：:Despite significant advances in cancer diagnostics and treatment, ovarian cancers (OC) continue to kill more than 150,000 women every year worldwide. Due to the relatively asymptomatic nature and the advanced stage of the disease at the time of diagnosis, OC is the most lethal gynecologic malignancy. The current treat...

journal_title：Theranostics

authors： Di Lorenzo G,Ricci G,Severini GM,Romano F,Biffi S

更新日期：2018-07-30 00:00:00

abstract：:The recently reported results of Lu et al. (Theranostics. 2018; 8: 1312-26) - highlighting GLUT1 expression as a marker for sensitivity of gastric cancer cells to therapeutic doses of ascorbate - are discussed in the light of additional factors potentially affecting the underlying processes, such as the concomitant ex...

journal_title：Theranostics

authors： Corti A,Belcastro E,Pompella A

更新日期：2018-11-15 00:00:00

abstract：:Background: Programmed cell death protein 1 (PD1) inhibitors have revolutionized cancer therapy, yet many patients fail to respond. Thus, the identification of accurate predictive biomarkers of therapy response will improve the clinical benefit of anti-PD1 therapy. Method: We assessed the baseline serological autoanti...

journal_title：Theranostics

authors： Tan Q,Wang D,Yang J,Xing P,Yang S,Li Y,Qin Y,He X,Liu Y,Zhou S,Duan H,Liang T,Wang H,Wang Y,Jiang S,Zhao F,Zhong Q,Zhou Y,Wang S,Dai J,Yao J,Wu D,Zhang Z,Sun Y,Han X,Yu X,Shi Y

更新日期：2020-05-16 00:00:00

abstract：:Biological cancer therapies, such as oncolytic, or replication-selective viruses have advantages over traditional therapeutics as they can employ multiple different mechanisms to target and destroy cancers (including direct cell lysis, immune activation and vascular collapse). This has led to their rapid recent clinic...

journal_title：Theranostics

authors： Rojas JJ,Thorne SH

更新日期：2012-01-01 00:00:00