Effects of bone marrow mesenchymal stem cells (BM-MSCs) on rat pial microvascular remodeling after transient middle cerebral artery occlusion.

abstract：:The loss of hippocampal interneurons has been considered as one reason for the onset of temporal lobe epilepsy (TLE) by shifting the excitation-inhibition balance. Yet, there are many different interneuron types which show differential vulnerability in the context of an epileptogenic insult. We used the intrahippocamp...

journal_title：Frontiers in cellular neuroscience

authors： Marx M,Haas CA,Häussler U

更新日期：2013-10-01 00:00:00

abstract：:At the frog semicircular canals, the afferent fibers display high spontaneous activity (mEPSPs), due to transmitter release from hair cells. mEPSP and spike frequencies are modulated by stimulation that activates the hair cell receptor conductance. The relation between receptor current and transmitter release cannot b...

journal_title：Frontiers in cellular neuroscience

authors： Martini M,Canella R,Rubbini G,Fesce R,Rossi ML

更新日期：2015-06-23 00:00:00

abstract：:Gastrointestinal (GI) pain is a common clinical problem, for which effective therapy is quite limited. Sensations from the GI tract, including pain, are mediated largely by neurons in the dorsal root ganglia (DRG), and to a smaller extent by vagal afferents emerging from neurons in the nodose/jugular ganglia. Neurons ...

journal_title：Frontiers in cellular neuroscience

authors： Hanani M

更新日期：2015-10-13 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00

abstract：:Proper brain neuronal circuitry formation and synapse development is dependent on specific cues, either genetic or epigenetic, provided by the surrounding neural environment. Within these signals, thyroid hormones (T3 and T4) play crucial role in several steps of brain morphogenesis including proliferation of progenit...

journal_title：Frontiers in cellular neuroscience

authors： Dezonne RS,Stipursky J,Araujo AP,Nones J,Pavão MS,Porcionatto M,Gomes FC

更新日期：2013-08-12 00:00:00

abstract：:The remarkable ability of the nervous system to modify its structure and function is mostly experience and activity modulated. The molecular basis of neuronal plasticity has been studied in higher behavioral processes, such as learning and memory formation. However, neuronal plasticity is not restricted to higher brai...

journal_title：Frontiers in cellular neuroscience

authors： Farca-Luna AJ,Sprecher SG

更新日期：2013-07-04 00:00:00

abstract：:Secreted amyloid precursor protein-alpha (sAPPα), generated by enzymatic processing of the APP, possesses a range of neurotrophic and neuroprotective properties and plays a critical role in the molecular mechanisms of memory and learning. One of the key active regions of sAPPα is the central APP domain (E2) that conta...

journal_title：Frontiers in cellular neuroscience

authors： Morrissey JA,Bigus E,Necarsulmer JC,Srinivasan V,Peppercorn K,O'Leary DJ,Mockett BG,Tate WP,Hughes SM,Parfitt KD,Abraham WC

更新日期：2019-10-18 00:00:00

abstract：:The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus. However, the effects of ghrelin on the excitability of different PVN neuronal populations have not been ...

journal_title：Frontiers in cellular neuroscience

authors： Dos-Santos RC,Grover HM,Reis LC,Ferguson AV,Mecawi AS

更新日期：2018-08-24 00:00:00

abstract：:Intermittent fasting (IF) was suggested to be a powerful nutritional strategy to prevent the onset of age-related neurodegenerative diseases associated with compromised brain bioenergetics. Whether the application of IF in combination with a mitochondrial insult could buffer the neurodegenerative process has never bee...

journal_title：Frontiers in cellular neuroscience

authors： Tatulli G,Mitro N,Cannata SM,Audano M,Caruso D,D'Arcangelo G,Lettieri-Barbato D,Aquilano K

更新日期：2018-01-17 00:00:00

abstract：:The Hessian fly, Mayetiola destructor Say (Diptera, Cecidomyiidae), is a pest of wheat and belongs to a group of gall-inducing herbivores. This species has a unique life history and several ecological features that differentiate it from other Diptera such as Drosophila melanogaster and blood-feeding mosquitoes. These ...

journal_title：Frontiers in cellular neuroscience

authors： Andersson MN,Corcoran JA,Zhang DD,Hillbur Y,Newcomb RD,Löfstedt C

更新日期：2016-09-07 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of the motor neurons that innervate muscle, resulting in gradual paralysis and culminating in the inability to breathe or swallow. This neuronal degeneration occurs in a spatiotemporal manner from a point of onset in the central nervo...

journal_title：Frontiers in cellular neuroscience

authors： McAlary L,Chew YL,Lum JS,Geraghty NJ,Yerbury JJ,Cashman NR

更新日期：2020-11-04 00:00:00

abstract：:The brain relies on GABAergic neurons to control the ongoing activity of neuronal networks. GABAergic neurons control the firing pattern of excitatory cells, the temporal structure of membrane potential oscillations and the time window for integration of synaptic inputs. These actions require a fine control of the tim...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-05-13 00:00:00

abstract：:P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory transduction, neuro-immune communication and inflammatory response. P2X receptors constitute a gene family of calcium-permeable ATP-gated cation channels therefore the regulation of P2X signaling is critical for both membran...

journal_title：Frontiers in cellular neuroscience

authors： Bernier LP,Ase AR,Séguéla P

更新日期：2013-11-25 00:00:00

abstract：:Thrombin is a serine protease playing an essential role in the blood coagulation cascade. Recent work, however, has identified a novel role for thrombin-mediated signaling pathways in the central nervous system. Binding of thrombin to protease-activated receptors (PARs) in the brain appears to have multiple actions af...

journal_title：Frontiers in cellular neuroscience

authors： Maggio N,Blatt I,Vlachos A,Tanne D,Chapman J,Segal M

更新日期：2013-03-05 00:00:00

abstract：:Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN) generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian...

journal_title：Frontiers in cellular neuroscience

authors： Sabado V,Vienne L,Nagoshi E

更新日期：2017-10-12 00:00:00

abstract：:Despite a century of intensive investigation the effective treatment of protein aggregation diseases remains elusive. Ordinarily, molecular chaperones ensure that proteins maintain their functional conformation. The appearance of misfolded proteins that aggregate implies the collapse of the cellular chaperone quality ...

journal_title：Frontiers in cellular neuroscience

authors： Koutras C,Braun JE

更新日期：2014-07-08 00:00:00

abstract：:To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic in...

journal_title：Frontiers in cellular neuroscience

authors： Yang Z,Tan Q,Cheng D,Zhang L,Zhang J,Gu EW,Fang W,Lu X,Liu X

更新日期：2018-11-21 00:00:00

abstract：:Neurotransmitter is released from presynaptic nerve terminals at fast-transmitting synapses by the action potential-gating of voltage dependent calcium channels (CaV), primarily of the CaV2.1 and CaV2.2 types. Entering Ca2+ diffuses to a nearby calcium sensor associated with a docked synaptic vesicle (SV) and initiate...

journal_title：Frontiers in cellular neuroscience

authors： Snidal CA,Li Q,Elliott BB,Mah HK,Chen RHC,Gardezi SR,Stanley EF

更新日期：2018-05-11 00:00:00

abstract：:Hippocampal neurogenesis persists throughout adult life and plays an important role in learning and memory. Although the influence of physical exercise on neurogenesis has been intensively studied, there is controversy in regard to how the impact of exercise may vary with its regime. Less is known about how distinct e...

journal_title：Frontiers in cellular neuroscience

authors： So JH,Huang C,Ge M,Cai G,Zhang L,Lu Y,Mu Y

更新日期：2017-01-31 00:00:00

abstract：:Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q10 (CoQ10) administration are known to st...

journal_title：Frontiers in cellular neuroscience

authors： Salehpour F,Farajdokht F,Mahmoudi J,Erfani M,Farhoudi M,Karimi P,Rasta SH,Sadigh-Eteghad S,Hamblin MR,Gjedde A

更新日期：2019-03-19 00:00:00

abstract：:Alterations in NGF/TrkA signaling have been suggested to underlie the selective degeneration of the cholinergic basal forebrain neurons occurring in vivo in AD (Counts and Mufson, 2005; Mufson et al., 2008; Niewiadomska et al., 2011) and significant reduction of cognitive decline along with an improvement of cholinerg...

journal_title：Frontiers in cellular neuroscience

authors： Latina V,Caioli S,Zona C,Ciotti MT,Amadoro G,Calissano P

更新日期：2017-03-15 00:00:00

abstract：:Anoxic depolarization (AD) is a hallmark of ischemic brain damage. AD is associated with a spreading wave of neuronal depolarization and an increase in light transmittance. However, initiation and spread of AD across the layers of the somatosensory cortex, which is one of the most frequently affected brain regions in ...

journal_title：Frontiers in cellular neuroscience

authors： Juzekaeva E,Nasretdinov A,Gainutdinov A,Sintsov M,Mukhtarov M,Khazipov R

更新日期：2017-12-15 00:00:00

abstract：:Serotonin, or 5-hydroxytryptamine (5-HT), is a well-known neurotransmitter that plays vital roles in neural activities and social behaviors. Clinically, deficiency of serotonin is linked with many psychiatric disorders. Interestingly, a large proportion of serotonin is also produced outside the central nervous system ...

journal_title：Frontiers in cellular neuroscience

authors： Lv J,Liu F

更新日期：2017-03-13 00:00:00

abstract：:Anabolic-androgenic steroids (AAS) are lipophilic hormones often taken in excessive quantities by athletes and bodybuilders to enhance performance and increase muscle mass. AAS exert well known toxic effects on specific cell and tissue types and organ systems. The attention that androgen abuse has received lately shou...

journal_title：Frontiers in cellular neuroscience

authors： Basile JR,Binmadi NO,Zhou H,Yang YH,Paoli A,Proia P

更新日期：2013-05-09 00:00:00

abstract：:Epilepsy is a disorder of abnormal brain activity typified by spontaneous and recurrent seizures. MicroRNAs (miRNAs) are short non-coding RNAs, critical for the post-transcriptional regulation of gene expression. MiRNA dysregulation has previously been implicated in the induction of epilepsy. In this study, we examine...

journal_title：Frontiers in cellular neuroscience

authors： Gao X,Guo M,Meng D,Sun F,Guan L,Cui Y,Zhao Y,Wang X,Gu X,Sun J,Qi S

更新日期：2019-04-12 00:00:00

abstract：:Amyloid beta (Aβ) is a peptide cleaved from amyloid precursor protein that contributes to the formation of senile plaques in Alzheimer's disease (AD). The relationship between Aβ and astrocyte proliferation in AD remains controversial. Despite pathological findings of increased astrocytic mitosis in AD brains, in vitr...

journal_title：Frontiers in cellular neuroscience

authors： Ohki EC,Langan TJ,Rodgers KR,Chou RC

更新日期：2017-09-26 00:00:00

abstract：:Background: Recent studies have found that rifampicin has neuroprotective properties in neurodegenerative diseases. However, the exact mechanisms of action remain unclear. The nuclear factor erythroid 2-related factor 2 (Nrf2) has been considered a potential target for neuroprotection. In this study, we examined wheth...

journal_title：Frontiers in cellular neuroscience

authors： Chen B,Cao H,Chen L,Yang X,Tian X,Li R,Cheng O

更新日期：2016-11-29 00:00:00

abstract：:[This corrects the article on p. 56 in vol. 11, PMID: 28303091.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Owens R,Grabert K,Davies CL,Alfieri A,Antel JP,Healy LM,McColl BW

更新日期：2017-08-24 00:00:00

abstract：:The GABAB receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in a number of disorders including multiple sclerosis (MS), but its precise mechanism of action is unknown. Neuroinflammation drives the central pathology in MS and is mediated by both immunoreactive glial cells a...

journal_title：Frontiers in cellular neuroscience

authors： Crowley T,Fitzpatrick JM,Kuijper T,Cryan JF,O'Toole O,O'Leary OF,Downer EJ

更新日期：2015-07-28 00:00:00

abstract：:A major challenge in the development of pharmacotherapies for autism is the failure to identify pathophysiological mechanisms that could be targetable. The majority of developing strategies mainly aim at restoring the brain excitatory/inhibitory imbalance described in autism, by targeting glutamate or GABA receptors. ...

journal_title：Frontiers in cellular neuroscience

authors： DelaCuesta-Barrutia J,Peñagarikano O,Erdozain AM

更新日期：2020-10-30 00:00:00