Abstract:
:The recent concept of neural genoarchitecture (or genoarchitectonics) is examined from several angles, aiming to clarify the rationale for this new approach in causal and descriptive neuroanatomy. Gene expression patterns can be used as topographic stains revealing architectonic borders that may clarify, dispute, or complicate existing brain anatomical subdivisions based on other methods, while increasing our understanding of how they arise in ontogenesis and evolution. A section of the text deals with differential regulation of gene expression in an ontogenetic causal network, attending to the structure of the genome and the functional peculiarities of enhancer and repressor regulatory regions that modulate gene transcription. The emergence of regionally characteristic sets of active transcription factors represents a critical concept, molecular identity, which can be applied to discrete brain territories and neuronal populations. Gene regulation is tied to positional effects, that is, topologically invariant domains of gene expression and natural boundaries, which can be correlated with anatomic ones. The large-scale stability of these patterns among vertebrates underpins molecularly the structural brain Bauplan, and is the fundament of field homology. The study of genoarchitectonic boundaries is presented as a crucial objective of modern neuroanatomic research. At most brain regions, new neuronal populations are being detected thanks to their differential genoarchitectonic features.
journal_name
Front Neuroanatjournal_title
Frontiers in neuroanatomyauthors
Puelles L,Ferran JLdoi
10.3389/fnana.2012.00047subject
Has Abstractpub_date
2012-11-16 00:00:00pages
47issn
1662-5129journal_volume
6pub_type
杂志文章abstract::The mammalian oculomotor nucleus receives a strong γ-aminobutyric acid (GABA)ergic synaptic input, whereas such projections have rarely been reported in fish. In order to determine whether this synaptic organization is preserved across vertebrates, we investigated the GABAergic projections to the oculomotor nucleus in...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2011.00007
更新日期:2011-02-04 00:00:00
abstract::Calcium stores in neurons are heterogeneous in compartmentalization and molecular composition. Danio rerio (zebrafish) is an animal model with a simply folded cerebellum similar in cellular organization to that of mammals. The aim of the study was to identify new endoplasmic reticulum (ER) calcium store markers in zeb...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2020.00015
更新日期:2020-04-21 00:00:00
abstract::Expansion microscopy and light sheet imaging (ExLSM) provide a viable alternative to existing tissue clearing and large volume imaging approaches. The analysis of intact volumes of brain tissue presents a distinct challenge in neuroscience. Recent advances in tissue clearing and light sheet microscopy have re-addresse...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2019.00002
更新日期:2019-01-31 00:00:00
abstract::Gestational exposure to valproic acid (VPA) is known to cause behavioral deficits of sociability, matching similar alterations in human autism spectrum disorder (ASD). Available data are scarce on the neuromorphological changes in VPA-exposed animals. Here, we focused on alterations of the dopaminergic system, which i...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2020.00029
更新日期:2020-06-05 00:00:00
abstract::The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety disorders, depression, addiction, and dysfunctional social behaviors. Many of these behaviors and...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2016.00036
更新日期:2016-04-07 00:00:00
abstract::A subset of monoamine neurons releases glutamate as a cotransmitter due to presence of the vesicular glutamate transporters VGLUT2 or VGLUT3. In addition to mediating vesicular loading of glutamate, it has been proposed that VGLUT3 enhances serotonin (5-HT) vesicular loading by the vesicular monoamine transporter (VMA...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2016.00039
更新日期:2016-04-12 00:00:00
abstract::Blue tits (Cyanistes coeruleus) are songbirds, used as model animals in numerous studies covering a wide field of research. Nevertheless, the distribution of neuropeptides in the brain of this avian species remains largely unknown. Here we present some of the first results on distribution of Vasotocine (AVT) and Vasoa...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2015.00090
更新日期:2015-07-14 00:00:00
abstract::The auditory system contains a diverse array of interconnected anatomical structures that mediate the perception of sound. The cochlear nucleus of the hindbrain serves as the initial site of convergence for auditory stimuli, while the inferior colliculus of the midbrain serves as an integration and relay station for a...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2017.00067
更新日期:2017-08-22 00:00:00
abstract::Biological impacts of light beyond vision, i.e., non-visual functions of light, signify the need to better understand light detection (or photoreception) systems in vertebrates. Photopigments, which comprise light-absorbing chromophores bound to a variety of G-protein coupled receptor opsins, are responsible for visua...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2016.00048
更新日期:2016-04-27 00:00:00
abstract::Larger mammalian cerebral cortices tend to have increasingly folded surfaces, often considered to result from the lateral expansion of the gray matter (GM), which, in a volume constrained by the cranium, causes mechanical compression that is relieved by inward folding of the white matter (WM), or to result from differ...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2012.00003
更新日期:2012-02-02 00:00:00
abstract::The claustrum is a narrow subcortical brain structure that resides between the striatum and insular cortex. The function of the claustrum is not fully described, and while our previous work supports a role for the claustrum in top-down cognitive control of action, other evidence suggests the claustrum may be involved ...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2018.00100
更新日期:2018-11-26 00:00:00
abstract::Enough species have now been subject to systematic quantitative analysis of the relationship between the morphology and cellular composition of their brain that patterns begin to emerge and shed light on the evolutionary path that led to mammalian brain diversity. Based on an analysis of the shared and clade-specific ...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2014.00077
更新日期:2014-08-11 00:00:00
abstract::Standard stereotaxic reference systems play a key role in human brain studies. Stereotaxic coordinate systems have also been developed for experimental animals including non-human primates, dogs, and rodents. However, they are lacking for other species being relevant in experimental neuroscience including sheep. Here,...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2015.00069
更新日期:2015-06-04 00:00:00
abstract::[This corrects the article on p. 99 in vol. 9, PMID: 26300740.]. ...
journal_title:Frontiers in neuroanatomy
pub_type: 已发布勘误
doi:10.3389/fnana.2015.00146
更新日期:2015-11-17 00:00:00
abstract::Hippocampal sclerosis is the most frequent pathology encountered in resected mesial temporal structures from patients with intractable temporal lobe epilepsy (TLE). Here, we have used stereological methods to compare the overall density of synapses and neurons between non-sclerotic and sclerotic hippocampal tissue obt...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2011.00008
更新日期:2011-02-24 00:00:00
abstract::Early telencephalic development involves the migration of diverse cell types that can be identified by specific molecular markers. Most prominent among them are Cajal-Retzius (CR) cells that emanate mainly from the cortical hem and to a lesser extent from rostrolateral, septal and caudo-medial regions. One additional ...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2017.00097
更新日期:2017-11-01 00:00:00
abstract::The radial dimension expands during central nervous system development after the proliferative neuroepithelium is molecularly patterned. The process is associated with neurogenesis, radial glia scaffolding, and migration of immature neurons into the developing mantle stratum. Radial histogenetic units, defined as a de...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2020.590011
更新日期:2020-11-10 00:00:00
abstract::The white matter (WM) of the adult human neocortex contains the so-called "interstitial neurons". They are most numerous in the superficial WM underlying the cortical gyri, and decrease in density toward the deep WM. They are morphologically heterogeneous. A subgroup of interstitial neurons display pyramidal-cell like...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/neuro.05.007.2009
更新日期:2009-06-09 00:00:00
abstract::The hypothalamus has been a central topic in neuroanatomy because of its important physiological functions, but its mature organization remains elusive. Deciphering its embryonic and adult organization is crucial in an evolutionary approach of the organization of the vertebrate forebrain. Here we studied the molecular...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2015.00037
更新日期:2015-04-08 00:00:00
abstract::Diffusion tensor imaging (DTI) and tractography offer the unique possibility to visualize the developing white matter macroanatomy of the human fetal brain in vivo and in utero and are currently under investigation for their potential use in the diagnosis of developmental pathologies of the human central nervous syste...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2015.00164
更新日期:2015-12-24 00:00:00
abstract::Most studies in mammals and birds have demonstrated common patterns of hypothalamic development highlighted by the combination of developmental regulatory genes (genoarchitecture), supporting the notion of the hypothalamus as a component of the secondary prosencephalon, topologically rostral to the diencephalon. In ou...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2015.00003
更新日期:2015-02-03 00:00:00
abstract::Lateralization of motor control refers to the ability to produce pure unilateral or asymmetric movements. It is required for a variety of coordinated activities, including skilled bimanual tasks and locomotion. Here we discuss the neuroanatomical substrates and pathophysiological underpinnings of lateralized motor out...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2015.00075
更新日期:2015-06-02 00:00:00
abstract::Embryonic development in mammals has evolved a platform for genomic conflict between mothers and embryos and, by extension, between maternal and paternal genomes. The evolutionary interests of the mother and embryo may be maximized through the promotion of sex-chromosome genes and imprinted alleles, resulting in the r...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2013.00002
更新日期:2013-04-09 00:00:00
abstract::Although the olfactory sense has always been considered with less interest than the visual, auditive or somatic senses, it does plays a major role in our ordinary life, with important implication in dangerous situations or in social and emotional behaviors. Traditional Diffusion Tensor signal model and related tractog...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2017.00032
更新日期:2017-04-10 00:00:00
abstract::In mammalian cerebrum there exist two distinct types of interneurons expressing nitric oxide synthase (NOS). Type I neurons are large in size and exhibit heavy nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemical reaction, while type II cells are small with light NADPH-d reactivity. The time ...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2015.00011
更新日期:2015-02-16 00:00:00
abstract::How does the size of the glial and neuronal cells that compose brain tissue vary across brain structures and species? Our previous studies indicate that average neuronal size is highly variable, while average glial cell size is more constant. Measuring whole cell sizes in vivo, however, is a daunting task. Here we use...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2014.00127
更新日期:2014-11-12 00:00:00
abstract::In the olfactory bulb (OB) a sophisticated neuronal network mediates the primary processing of sensory information and extensive investigations over the past decades have greatly improved our understanding of the morphology and neuronal organization of the OB. However, efforts have mostly been focused on the different...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2017.00125
更新日期:2017-12-18 00:00:00
abstract::Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine (ACh), has an exon-skipping splice variant which is expressed preferentially in the peripheral nervous system (PNS) and thus termed peripheral ChAT (pChAT). A rabbit antiserum previously produced against rat pChAT (rpChAT) has been used for immuno...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2019.00037
更新日期:2019-04-16 00:00:00
abstract::Drug addiction is a severe neuropsychiatric disorder characterized by loss of control over motivated behavior. The need for effective treatments mandates a greater understanding of the causes and identification of new therapeutic targets for drug development. Drugs of abuse subjugate normal reward-related behavior to ...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2011.00060
更新日期:2011-09-20 00:00:00
abstract::Onuf's nucleus is a small group of neurons located in the ventral horns of the sacral spinal cord. The motor neurons (MNs) of Onuf's nucleus innervate striated voluntary muscles of the pelvic floor and are histologically and biochemically comparable to the other somatic spinal MNs. However, curiously, these neurons al...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2020.572013
更新日期:2020-09-04 00:00:00