Abstract：
INTRODUCTION:Progressive multifocal leucoencefalopathy (PML) is a subacute demielinating disease of the Central Nervous System caused by the neurotropic virus John Cunningham (JC), common in immunodeficient patients, namely in HIV infection. PML encephalic lesions have a progressive nature that needs characterization and progressive study, especially for evaluating the therapeutic response. MATERIAL AND METHODS:The authors reviewed diffusion-weight MR imaging of PML lesions in four patients, characterizing the different lesional areas in DWI and ADC maps, and correlating these data with previous published studies, namely regarding histological correlation and lesion time course. RESULTS:The four cases studied showed heterogeneity in DWI and ADC maps, with restriction in water diffusion in the periphery of each lesion. DISCUSSION/CONCLUSION:Diffusion-weighted MR images allows characterization of PML lesions, highlighting their heterogeneity and asynchrony. These data allow important knowledge on lesions temporal evolution and treatment response.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Barata Tavares J,Geraldo AF,Neto L,Reimão S,Campos JGsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
34-7eissn
0870-399Xissn
1646-0758journal_volume
25 Suppl 1pub_type
杂志文章,评审abstract：:Central diabetes insipidus, is a syndrome characterized by the excretion of abnormally elevated volumes of diluted urine, due to the diminution of reabsorption of water in the collecting ducts, induced by the diminution of production of antidiuretic hormone. The involvement of the central nervous system in the leukaem...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
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journal_title：Acta medica portuguesa
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doi：
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.11987
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
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doi：
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
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doi：
更新日期：2002-09-01 00:00:00
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更新日期：2013-07-01 00:00:00
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pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
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doi：
更新日期：2008-03-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章
doi：
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journal_title：Acta medica portuguesa
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doi：
更新日期：2012-11-01 00:00:00
