Abstract：
:The aim of the study was to assess, in patients with non insulin dependent diabetes mellitus (NIDDM), either with previous failure to sulphonylureas or insulin treated since the disease started, if the combination of gliclazide to insulin therapy might induce a reduction of daily insulin requirement. 30 caucasian type II patients used to self-monitoring (11 female, 19 male, mean age 55.78 +/- 8.07) with residual pancreatic function (glucagon induced C-peptide release = 1.01 +/- 0.70 microgram/ml) entered the study. 8 were excluded for non compliance or for high antiinsulin antibodies levels and 4 are still under study. Each patients was given, for 3 months, 240 mg of gliclazide in addition to usual daily dose of insulin. Data presented as mean +/- s.e.m. were analysed with analysis of variance (p less than 0.05). Mean initial values of main parameters were as follows: glycaemia 192.7 +/- 33.1 mg/100 ml, insulinaemia 9.5 +/- 4.5 microUI/ml, daily insulin requirements 33.11 +/- 10.47 U/d, HbA1 C 7.5 +/- 1.7%. Total cholesterol 240.1 +/- 52.2 mg/10 ml, triglycerides 120.6 +/- 60.3 mg/100 ml. After 3 months treatment significant reduction in mean daily insulin requirements (20.78 +/- 16.15 U/d) was observed. In 13 patients (72.2%) while keeping good metabolic control (HbA1 C 7.46 +/- 1.63), insulin therapy was reduced (9 patients) or even stopped (4 patients). In the other 5, insulin was maintained or slightly increased. The increase in glucagon induced C-peptide release (1.41 +/- 0.99 micrograms/ml) did not reach significance, while glycaemia and insulinaemia were not changed (196.0 +/- 34.1 mg/100 ml, 11.02 +/- 5.05 microUI/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Ruas MM,Carvalheiro M,Geraldes E,Carrilho F,Bastos M,Fagulha A,Paiva I,Rodrigues F,Gomes Lsubject
Has Abstractpub_date
1991-03-01 00:00:00pages
76-8issue
2eissn
0870-399Xissn
1646-0758journal_volume
4pub_type
杂志文章abstract：INTRODUCTION:Children who visit emergency departments and leave without being seen represent a multifactorial problem. We aimed to compare the sociodemographic characteristics of children who left and of those who did not leave, as well as to evaluate parental reasoning, subsequent use of medical care and patient outco...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.9962
更新日期：2018-02-28 00:00:00
abstract：:Because the metabolic syndrome (MS) poses a growing public health problem, it is crucial to identify related modifiable risk factors. The MS is a multifaceted syndrome, however, physical activity (PA) is thought to be one of the protective factors in MS occurrence. The purpose of this study is to analyse recent litera...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：:In this article we reviewed some examples of our experience in clinical applications of functional MRI (fMRI) in the motor and verbal fluency tasks evaluation. Seventeen patients with supratentorial cerebral pathology (5 arteriovenous malformations--AVMs, 2 meningiomas, 1 tuberculoma, 1 cortical tuberoma, 1 DNET, 2 ce...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:Mitochondrial Encephalomyopathies are primary disorders of energy metabolism recently described. They are the result of mitochondrial abnormalities with a wide spectrum of syndromes implying a multisystemic but predominantly muscular and cerebral involvement. Biochemical, histological, imagiologic and clinical feature...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1994-06-01 00:00:00
abstract：:In about 28% of patients, dyslipidemia has a secondary cause. Many times, the treatment of these causes can lead to the total correction of dyslipidemia. We describe the case of a 50-year-old female patient with class II obesity and primary biliary cirrhosis, evaluated for mixed dyslipidemia with poor control (statins...
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更新日期：2020-03-02 00:00:00
abstract：:Lithopedions are extremely rare conditions. Less than 300 cases were described worldwide. We report a case occurring in a woman of 77 years of age, admitted with dehydration, urinary tract infection and infected limb pressure ulcers. She had been recently admitted in a Surgery ward for incarcerated umbilical hernia. A...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：:Twelve cases of extreme umbilical blood flow impairement (8 cases with loss of end-diastolic blood flow and 4 cases with reversed flow) found among 658 pregnancies studied by continuous Doppler between April 1st 1989 and March 31st 1990, are reported. The findings were associated to intra-uterine growth retardation (9...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:Hidrosadenitis supurativa is a chronic inflammatory disease with great physical and psychological impact. Although conservative treatments may be effective in mild forms of the disease, extensive surgical resection and reconstruction are necessary in more severe forms of the disease. The purpose of this paper is to de...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.8656
更新日期：2018-01-31 00:00:00
abstract：INTRODUCTION:The relationship between lymphomas and autoimmune diseases has been reported as bi-directional, however there is a few data in pediatric population. The aim of this work is to evaluate the prevalence of autoimmune diseases in children and adolescents with Hodgkin's lymphoma followed in a Pediatric Oncology...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.6207
更新日期：2015-11-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2007-03-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2008-05-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1998-05-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
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journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
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更新日期：1995-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-07-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
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更新日期：2019-11-04 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
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更新日期：1998-02-01 00:00:00
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journal_title：Acta medica portuguesa
pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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journal_title：Acta medica portuguesa
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doi：
更新日期：2004-03-01 00:00:00
