Abstract:
INTRODUCTION:The relationship between lymphomas and autoimmune diseases has been reported as bi-directional, however there is a few data in pediatric population. The aim of this work is to evaluate the prevalence of autoimmune diseases in children and adolescents with Hodgkin's lymphoma followed in a Pediatric Oncology Unit. MATERIAL AND METHODS:By reviewing Hodgkin's lymphomas data from the past 16 years (collected prospectively), an apparently large incidence of autoimmune diseases, mostly in female patients, was noted. We decided to do this retrospective study with an update on follow-up. Data analyzed: age, gender, autoimmune disease, temporal relation with lymphoma, lymphoma's stage, histologic subtype and treatment. RESULTS:Fifty-two cases were included, 7 (13.5%) of which, all female, had an autoimmune disease diagnosed previously, simultaneously or after lymphoma. Autoimmune diseases were: juvenile idiopathic arthritis, inflammatory bowel disease, Behçet's disease, autoimmune hepatitis, systemic erythematosus lupus, Hashimoto's thyroiditis and idiopathic thrombocytopenic purpura. The diagnosis was made after lymphoma in 4 patients, before in 2 and simultaneously in 1 patient. All cases, except the one with simultaneous diagnosis, are out of treatment and without oncologic disease relapse. No deaths were registered. DISCUSSION:There was an important prevalence of autoimmune diseases in girls with Hodgkin's lymphoma. We present data and discuss the possible causes based on a literature review. CONCLUSIONS:This relationship should be invoked, requiring more studies, especially in pediatric age. :Introdução: A relação entre linfomas e doenças autoimunes é descrita na literatura como bidirecional, existindo poucos dados em idade pediátrica. Este trabalho tem como objetivo avaliar a prevalência de doenças autoimunes em crianças e adolescentes com linfoma de Hodgkin seguidos num Serviço de Oncologia Pediátrica. Material e Métodos: Ao rever a casuística do Serviço de linfomas de Hodgkin nos últimos 16 anos (dados colhidos prospetivamente), constatou-se uma incidência aparentemente elevada de doenças autoimunes nas raparigas pelo que se realizou um estudo retrospetivo, com atualização do seguimento fora de tratamento, relativamente à existência de doenças autoimunes. Avaliaram-se: idade, sexo, tipo de doença autoimune, relação temporal com o linfoma, estádio e grupo histológico do linfoma e terapêutica efetuada. Resultados: Incluíram-se 52 casos de linfoma de Hodgkin, dos quais sete (13,5%), todos do sexo feminino, tiveram uma doença autoimune diagnosticada previamente, em simult'neo ou posteriormente ao linfoma. As doenças autoimunes encontradas foram: artrite idiopática juvenil, doença inflamatória intestinal, doença de Behçet, hepatite autoimune, lúpus eritematoso sistémico, tiroidite de Hashimoto e púrpura trombocitopénica idiopática. Em quatro doentes o diagnóstico foi posterior ao linfoma, em dois, prévio, e num simult'neo. Todos os casos, exceto o diagnóstico simult'neo, estão fora de tratamento e sem recidiva da doença oncológica. Não se verificaram óbitos. Discussão: Verificou-se uma importante prevalência de doenças autoimunes nas raparigas com linfoma de Hodgkin. Apresentamos os dados e discutimos possíveis causas desta relação com base numa revisão bibliográfica. Conclusões: Esta associação deve ser evocada, sendo necessário mais estudos, sobretudo em idade pediátrica.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Jerónimo M,Silva S,Benedito M,Brito MJdoi
10.20344/amp.6207subject
Has Abstractpub_date
2015-11-01 00:00:00pages
749-53issue
6eissn
0870-399Xissn
1646-0758journal_volume
28pub_type
杂志文章abstract::The Panels of São Vicente de Fora, a polyptych dated from 1470 to 1480, are a work composed of 6 panels, authored by Nuno Gonçalves, a painter of King Afonso V. This work reveals one of the most remarkable collective portraits of European painting, making this polyptych an inexhaustible source of readings and interpre...
journal_title:Acta medica portuguesa
pub_type: 历史文章,杂志文章
doi:
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:Functional foods are those that promote health and well-being and/or decrease the risk of certain chronic diseases. It is known that young people' knowledge about functional foods is low. The aim of this study is to assess the psychometric proprieties of the "Attitudes towards Functional Foods Scale" in a ...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:10.20344/amp.9284
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:10.20344/amp.5777
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:10.20344/amp.6329
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abstract::The Portuguese population is affected by the highest mortality rates in all the countries of the European Union. The highest mortality rates occur in some districts on the north coast where, in 1995, the rates standardised by age were above 200/100,000/annum, with the lowest figures in some districts in the interior a...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract:INTRODUCTION:In the context of a pronounced population ageing and rising mortality due to chronic illnesses, this national epidemiological study compares the places where people die with population preferences. MATERIAL AND METHODS:Data on numbers of deaths in 2010 by gender, age group, region of residence NUTS II and...
journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
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abstract::In Portugal, piroxicam is one of the most prescribed non-steroidal anti-inflammatory agents (NSAIDs) and is frequently associated to photosensitivity skin reactions, well known by all dermatologists. The authors review the physiopathology and clinical patterns of this adverse drug reaction. Importance is given to the ...
journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
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doi:10.20344/amp.6517
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doi:
更新日期:2012-07-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:
更新日期:2014-09-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
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journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
更新日期:1998-12-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,评审
doi:
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journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
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doi:
更新日期:2001-07-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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更新日期:2011-03-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
更新日期:2011-11-01 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章
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更新日期:2017-09-29 00:00:00
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journal_title:Acta medica portuguesa
pub_type: 杂志文章,评审
doi:
更新日期:2002-05-01 00:00:00