Abstract:
OBJECTIVE:To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR). PATIENTS AND METHODS:We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes. RESULTS:There was a strong positive correlation between the two methods but the Cockroft Gault formula underestimated the GFR. CONCLUSIONS:The formula gives a accurate estimates of GFR, when GFR is <100 ml/min/1,73 m2. Beside the underestimation, the formula could be used in the management of diabetic nephropathy because the repeated isotope assessments of renal function are impracticable.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Guimarães J,Bastos M,Melo M,Carvalheiro Msubject
Has Abstractpub_date
2007-03-01 00:00:00pages
145-50issue
2eissn
0870-399Xissn
1646-0758journal_volume
20pub_type
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