[Human serum alcaline phosphatase and ageing].

Abstract:

BACKGROUND:In experimental ageing models an inverse relationship between age and alkaline phosphatase activity has been observed. OBJECTIVE:To characterize serum levels of alkaline phosphatase activity in humans according to age and gender. METHODS:Serum alkaline phosphatase was determined in a random sample of 203 community dwellers aged 40 or more years. RESULTS:In men (n=87) total serum alkaline phosphatase markedly increased from the 5th to the 6th decade and then stabilized. For women (n=116) there was a slight increase in total serum alkaline phosphatase from the 5th to the 6th decade, followed by a bend upward after 69 years of age. There was a significant positive correlation between total serum alkaline phosphatase and age for the whole population. CONCLUSIONS:Serum alkaline phosphatase activity appears as a biomarker of age in humans, similarly to what has been described for experimental animal models.

journal_name

Acta Med Port

journal_title

Acta medica portuguesa

authors

Negrão MR,Martins MJ,Ramos E,Barros H,Hipólito-Reis C,Azevedo I

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

395-400

issue

6

eissn

0870-399X

issn

1646-0758

journal_volume

16

pub_type

杂志文章
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  • [Periodic fever with aphthous stomatitis, pharyngitis and adenitis: report of 21 cases].

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