Abstract:
: The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of "successful and unsuccessful ageing". They are equipped to reach the extreme limits of human life span and, most importantly, to show relatively good health, being able to perform their routine daily life and to escape fatal age-related diseases, such as cardiovascular diseases and cancer. Thus, particular attention has been centered on their genetic background and immune system. In this review, we report our data gathered for over 10 years in Sicilian centenarians. Based on results obtained, we suggest longevity as the result of an optimal performance of immune system and an over-expression of anti-inflammatory sequence variants of immune/inflammatory genes. However, as well known, genetic, epigenetic, stochastic and environmental factors seem to have a crucial role in ageing and longevity. Epigenetics is associated with ageing, as demonstrated in many studies. In particular, ageing is associated with a global loss of methylation state. Thus, the aim of future studies will be to analyze the weight of epigenetic changes in ageing and longevity.
journal_name
Immun Ageingjournal_title
Immunity & ageing : I & Aauthors
Balistreri CR,Candore G,Accardi G,Bova M,Buffa S,Bulati M,Forte GI,Listì F,Martorana A,Palmeri M,Pellicanò M,Vaccarino L,Scola L,Lio D,Colonna-Romano Gdoi
10.1186/1742-4933-9-8subject
Has Abstractpub_date
2012-04-23 00:00:00pages
8issue
1issn
1742-4933pii
1742-4933-9-8journal_volume
9pub_type
杂志文章abstract::The age-related dysregulation and decline of the immune system-collectively termed "immunosenescence"-has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinate...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/s12979-019-0164-9
更新日期:2019-09-13 00:00:00
abstract::Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". T...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-23
更新日期:2012-10-31 00:00:00
abstract:: Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impacts on the health of elderly people. The "free-radical theory of aging" was proposed to explain aging as a con...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-26
更新日期:2012-11-15 00:00:00
abstract::Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/s12979-015-0046-8
更新日期:2015-11-04 00:00:00
abstract:BACKGROUND:The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin olive oil, common to all Mediterranean countries. Olive oil is the main source of fat and can modu...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-016-0067-y
更新日期:2016-04-05 00:00:00
abstract:Background:Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. M...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-018-0126-7
更新日期:2018-09-08 00:00:00
abstract::The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. These two experimental models will be comp...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-4-7
更新日期:2007-09-29 00:00:00
abstract:BACKGROUND:Neurodegenerative disorders such Alzheimer's disease (AD) are often characterized by senile plaques and neurofibrillary tangle. In addition, reactive astrogliosis, microglia activation and a chronic inflammation are found in AD brain. Activated microglia has been reported to express a large number of beta ch...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-6
更新日期:2013-02-21 00:00:00
abstract:Background:Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clinical subtypes of late AMD. Results:We sampled fresh venous blood from patients with geographic atrop...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0160-0
更新日期:2019-08-15 00:00:00
abstract::Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natura...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-17
更新日期:2005-11-29 00:00:00
abstract:BACKGROUND:Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence th...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0031-2
更新日期:2015-05-20 00:00:00
abstract:: Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 com...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-6
更新日期:2010-05-27 00:00:00
abstract:BACKGROUND:Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bone marrow (BM) microenvironment. Multiparameter flow cytometry (MFC) allows the simultaneous study of...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0032-1
更新日期:2015-06-04 00:00:00
abstract::In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's D...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0147-x
更新日期:2019-04-01 00:00:00
abstract::The emergence of SARS-CoV-2 and its inordinately rapid spread is posing severe challenges to the wellbeing of millions of people worldwide, health care systems and the global economy. While many younger people experience no or mild symptoms on infection, older adults are highly susceptible to life-threatening respirat...
journal_title:Immunity & ageing : I & A
pub_type: 社论
doi:10.1186/s12979-020-00180-2
更新日期:2020-04-11 00:00:00
abstract::ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with d...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/1742-4933-11-16
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Ma...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-016-0074-z
更新日期:2016-05-31 00:00:00
abstract:BACKGROUND:Sarcopenia is an important cause of morbidity and mortality in older adults, with immunosenescence and inflammation being possible underlying mechanisms. We investigated the relationship between latent cytomegalovirus (CMV) infection, Interleukin 6 (IL-6) levels, muscle size and strength in a group of health...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-33
更新日期:2013-08-13 00:00:00
abstract:BACKGROUND:The age-related weakening of the immune system makes elderly subjects less responsive to influenza vaccination. In the last years, two "enhanced vaccines" were licensed for individuals aged ≥65 years, one being a subunit vaccine (Fluad®) containing the MF59 adjuvant administered intramuscularly (IM-MF59) and...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-11-10
更新日期:2014-05-16 00:00:00
abstract:Background:Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune res...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0146-y
更新日期:2019-02-23 00:00:00
abstract::Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decrease of serum total and specific IgE. Atopic disorders are complex diseases that involve interactions among sever...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-9
更新日期:2005-05-31 00:00:00
abstract:BACKGROUND:Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. However, although CMV infection occurs during childhood, relatively little is know about the typical quantity and quality of T cell responses in pediatric ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-3-11
更新日期:2006-12-08 00:00:00
abstract:BACKGROUND:Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhesion, and resolution of inflammation in patients with neovascular age-related macular degeneration (...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-017-0100-9
更新日期:2017-07-27 00:00:00
abstract:UNLABELLED: BACKGROUND:Respiratory Syncytial Virus (RSV) causes significant disease in the elderly, in part, because immunosenescence impairs protective immune responses to infection in this population. Despite previous and current efforts, there is no RSV vaccine currently licensed in infants or elderly adults. Adjuv...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-21
更新日期:2012-10-02 00:00:00
abstract:BACKGROUND:Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians. RESULTS:We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLRY and YSPTLFY...
journal_title:Immunity & ageing : I & A
pub_type:
doi:10.1186/s12979-016-0064-1
更新日期:2016-03-22 00:00:00
abstract::Streptococcus pneumoniae is a serious worldwide pathogen and the focus of numerous vaccine development projects. Currently the most widely accepted surrogate marker for evaluating the efficacy of a given vaccine is to utilize ELISA. Measurement of antibody concentration by ELISA without reduction in cross-reactive ant...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-10
更新日期:2005-06-27 00:00:00
abstract:BACKGROUND:The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a good candidate, since vitamin A concentrations classically decrease during aging whereas it may poss...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-10
更新日期:2010-08-20 00:00:00
abstract:BACKGROUND:CD90 (Thy-1) is a small glycoprotein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells, and is often used as a marker in adoptive transfer experiments to distinguish donor and recipient T cells with different CD90 subtypes. We have performed adoptive transfer experiments...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-36
更新日期:2013-08-19 00:00:00
abstract:BACKGROUND:Ageing brings about the gradual deterioration of the immune system, also known as immunosenescence. The role of non-coding circular RNA in immunosenescence is under studied. Using circular RNA microarray data, we assembled Comparison groups (C1, C2, C3 and C4) that allowed us to compare the circular RNA expr...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0042-z
更新日期:2015-10-08 00:00:00
abstract::Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or neurodegenerative diseases among the elderly. CDD are of complex diagnosis, difficult to treat and absorbing an ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-S1-S1
更新日期:2010-12-16 00:00:00