Can an effective SARS-CoV-2 vaccine be developed for the older population?

abstract：BACKGROUND:Since the COVID-19 outbreak an unprecedented challenge for healthcare systems around the world has been placed. In Cuba, the first case of COVID-19 was reported on March 11. Elderly with multiple comorbidities have been the most risky population. Although most patients present a mild to moderate disease, som...

journal_title：Immunity & ageing : I & A

authors： Saavedra D,Añé-Kourí AL,Sánchez N,Filgueira LM,Betancourt J,Herrera C,Manso L,Chávez E,Caballero A,Hidalgo C,Lorenzo G,Cepeda M,Valenzuela C,Ramos M,León K,Mazorra Z,Crombet T

更新日期：2020-11-14 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12979-018-0122-y.]. ...

journal_title：Immunity & ageing : I & A

authors： Lanzer KG,Cookenham T,Reiley WW,Blackman MA

更新日期：2018-08-21 00:00:00

abstract：BACKGROUND:Sarcopenia is an important cause of morbidity and mortality in older adults, with immunosenescence and inflammation being possible underlying mechanisms. We investigated the relationship between latent cytomegalovirus (CMV) infection, Interleukin 6 (IL-6) levels, muscle size and strength in a group of health...

journal_title：Immunity & ageing : I & A

authors： Kilgour AH,Firth C,Harrison R,Moss P,Bastin ME,Wardlaw JM,Deary IJ,Starr JM

更新日期：2013-08-13 00:00:00

abstract：: The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of "successful and u...

journal_title：Immunity & ageing : I & A

authors： Balistreri CR,Candore G,Accardi G,Bova M,Buffa S,Bulati M,Forte GI,Listì F,Martorana A,Palmeri M,Pellicanò M,Vaccarino L,Scola L,Lio D,Colonna-Romano G

更新日期：2012-04-23 00:00:00

abstract：:Streptococcus pneumoniae is a serious worldwide pathogen and the focus of numerous vaccine development projects. Currently the most widely accepted surrogate marker for evaluating the efficacy of a given vaccine is to utilize ELISA. Measurement of antibody concentration by ELISA without reduction in cross-reactive ant...

journal_title：Immunity & ageing : I & A

authors： Kolibab K,Smithson SL,Shriner AK,Khuder S,Romero-Steiner S,Carlone GM,Westerink MA

更新日期：2005-06-27 00:00:00

abstract：BACKGROUND:The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome by cellular stress leads to activation of the inflammasome, and NLRP3 gene polymorphisms have been associated with autoinflammatory diseases. Inflammasomes have also been implicated in the initiation or progression of metabolic disor...

journal_title：Immunity & ageing : I & A

authors： Kunnas T,Määttä K,Nikkari ST

更新日期：2015-10-31 00:00:00

abstract：:Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decrease of serum total and specific IgE. Atopic disorders are complex diseases that involve interactions among sever...

journal_title：Immunity & ageing : I & A

authors： Mediaty A,Neuber K

更新日期：2005-05-31 00:00:00

abstract：BACKGROUND:Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bone marrow (BM) microenvironment. Multiparameter flow cytometry (MFC) allows the simultaneous study of...

journal_title：Immunity & ageing : I & A

authors： Pojero F,Casuccio A,Di Bassiano F,Gervasi F,Colonna Romano G,Caruso C

更新日期：2015-06-04 00:00:00

abstract：: Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impacts on the health of elderly people. The "free-radical theory of aging" was proposed to explain aging as a con...

journal_title：Immunity & ageing : I & A

authors： Puca AA,Carrizzo A,Ferrario A,Villa F,Vecchione C

更新日期：2012-11-15 00:00:00

abstract：:The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. These two experimental models will be comp...

journal_title：Immunity & ageing : I & A

authors： Mocchegiani E,Giacconi R,Muti E,Cipriano C,Costarelli L,Tesei S,Gasparini N,Malavolta M

更新日期：2007-09-29 00:00:00

abstract：Background:Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clinical subtypes of late AMD. Results:We sampled fresh venous blood from patients with geographic atrop...

journal_title：Immunity & ageing : I & A

authors： Subhi Y,Nielsen MK,Molbech CR,Liisborg C,Søndergaard HB,Sellebjerg F,Sørensen TL

更新日期：2019-08-15 00:00:00

abstract：:ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with d...

journal_title：Immunity & ageing : I & A

authors： Rizzo C,Caruso C,Vasto S

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians. RESULTS:We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLRY and YSPTLFY...

journal_title：Immunity & ageing : I & A

authors： Han J,Park SH,Kim DJ,Kim H,Choi YH,Lee JH,Park SC,Chung J

更新日期：2016-03-22 00:00:00

abstract：:It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and insulin signaling, mediated by acute exercise, could be associated with modulation of protein-tyro...

journal_title：Immunity & ageing : I & A

authors： de Moura LP,Souza Pauli LS,Cintra DE,de Souza CT,da Silva ASR,Marinho R,de Melo MAR,Ropelle ER,Pauli JR

更新日期：2013-02-25 00:00:00

abstract：Background:Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. M...

journal_title：Immunity & ageing : I & A

authors： Tang Y,Liang P,Chen J,Fu S,Liu B,Feng M,Lin B,Lee B,Xu A,Lan HY

更新日期：2018-09-08 00:00:00

abstract：:Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or neurodegenerative diseases among the elderly. CDD are of complex diagnosis, difficult to treat and absorbing an ...

journal_title：Immunity & ageing : I & A

authors： Licastro F,Caruso C

更新日期：2010-12-16 00:00:00

abstract：BACKGROUND:Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhesion, and resolution of inflammation in patients with neovascular age-related macular degeneration (...

journal_title：Immunity & ageing : I & A

authors： Krogh Nielsen M,Hector SM,Allen K,Subhi Y,Sørensen TL

更新日期：2017-07-27 00:00:00

abstract：Background:Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune res...

journal_title：Immunity & ageing : I & A

authors： Malovini A,Accardi G,Aiello A,Bellazzi R,Candore G,Caruso C,Ligotti ME,Maciag A,Villa F,Puca AA

更新日期：2019-02-23 00:00:00

abstract：BACKGROUND:The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin olive oil, common to all Mediterranean countries. Olive oil is the main source of fat and can modu...

journal_title：Immunity & ageing : I & A

authors： Accardi G,Aiello A,Gargano V,Gambino CM,Caracappa S,Marineo S,Vesco G,Carru C,Zinellu A,Zarcone M,Caruso C,Candore G

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:Ageing brings about the gradual deterioration of the immune system, also known as immunosenescence. The role of non-coding circular RNA in immunosenescence is under studied. Using circular RNA microarray data, we assembled Comparison groups (C1, C2, C3 and C4) that allowed us to compare the circular RNA expr...

journal_title：Immunity & ageing : I & A

authors： Wang YH,Yu XH,Luo SS,Han H

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patients' responsiveness to anti-VEGF therapy. RESULTS:Ninety-six nAMD patients (including 61 with choro...

journal_title：Immunity & ageing : I & A

authors： Lechner J,Chen M,Hogg RE,Toth L,Silvestri G,Chakravarthy U,Xu H

更新日期：2016-02-16 00:00:00

abstract：:Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natura...

journal_title：Immunity & ageing : I & A

authors： Srinivasan V,Maestroni GJ,Cardinali DP,Esquifino AI,Perumal SR,Miller SC

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a good candidate, since vitamin A concentrations classically decrease during aging whereas it may poss...

journal_title：Immunity & ageing : I & A

authors： Minet-Quinard R,Farges MC,Thivat E,Deleine C,Mayot G,Brtko J,Ribalta J,Winklhofer-Roob B,Rock E,Vasson MP

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. However, although CMV infection occurs during childhood, relatively little is know about the typical quantity and quality of T cell responses in pediatric ...

journal_title：Immunity & ageing : I & A

authors： Komatsu H,Inui A,Sogo T,Fujisawa T,Nagasaka H,Nonoyama S,Sierro S,Northfield J,Lucas M,Vargas A,Klenerman P

更新日期：2006-12-08 00:00:00

abstract：:Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, ...

journal_title：Immunity & ageing : I & A

authors： Dattilo S,Mancuso C,Koverech G,Di Mauro P,Ontario ML,Petralia CC,Petralia A,Maiolino L,Serra A,Calabrese EJ,Calabrese V

更新日期：2015-11-04 00:00:00

abstract：BACKGROUND:CD90 (Thy-1) is a small glycoprotein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells, and is often used as a marker in adoptive transfer experiments to distinguish donor and recipient T cells with different CD90 subtypes. We have performed adoptive transfer experiments...

journal_title：Immunity & ageing : I & A

authors： Jiang J,Fisher E,Murasko DM

更新日期：2013-08-19 00:00:00

abstract：BACKGROUND:The age-related weakening of the immune system makes elderly subjects less responsive to influenza vaccination. In the last years, two "enhanced vaccines" were licensed for individuals aged ≥65 years, one being a subunit vaccine (Fluad®) containing the MF59 adjuvant administered intramuscularly (IM-MF59) and...

journal_title：Immunity & ageing : I & A

authors： Camilloni B,Basileo M,Di Martino A,Donatelli I,Iorio AM

更新日期：2014-05-16 00:00:00

abstract：BACKGROUND:Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence th...

journal_title：Immunity & ageing : I & A

authors： Schneider S,Koch W,Hoppmann P,Ubrich R,Kemmner S,Steinlechner E,Heemann U,Laugwitz KL,Kastrati A,Baumann M

更新日期：2015-05-20 00:00:00

abstract：UNLABELLED: BACKGROUND:Respiratory Syncytial Virus (RSV) causes significant disease in the elderly, in part, because immunosenescence impairs protective immune responses to infection in this population. Despite previous and current efforts, there is no RSV vaccine currently licensed in infants or elderly adults. Adjuv...

journal_title：Immunity & ageing : I & A

authors： Cherukuri A,Stokes KL,Patton K,Kuo H,Sakamoto K,Lambert S,Stillman E,Moore ML,Lee S

更新日期：2012-10-02 00:00:00

abstract：:Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon contributes to the well-known age-associated increase in the occurrence of many cancers in the elderly. However, ...

journal_title：Immunity & ageing : I & A

authors： Derhovanessian E,Solana R,Larbi A,Pawelec G

更新日期：2008-09-24 00:00:00