Association of Toll-like receptor 4 polymorphism with age-dependent systolic blood pressure increase in patients with coronary artery disease.

Abstract:

BACKGROUND:Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence that Toll-like receptor 4 (TLR4) modulate inflammation and contribute to age-dependent SBP increase. However, there are no data about TLR4 and age-dependent blood pressure increase in human. METHODS AND RESULTS:We therefor investigate a human cohort of 2679 patients with CAD aged between 50-80 years. Genotypes were determined for the TLR4 single nucleotide polymorphism rs4986790 (TLR4 896A/G). Patients were stratified according to tertiles of age and the upper tertile was compared to lower tertiles. In this cohort we show that older patients with the TLR4 896 G allele had significantly lower SBP (TLR4 G allele carriers: 148.2 ± 30.4 mmHg versus A/A allele carrier: 154.9 ± 27.2 mmHg; P < 0.05) and lower pulse pressure (TLR4 G allele carriers: 69.1 ± 29.7 mmHg versus A/A allele carrier: 75.5 ± 26.4 mmHg; P < 0.05) as compared to TLR4 896A/A allele carrier. CONCLUSION:We demonstrate an association between the TLR4 SNP rs4986790 genotype and age-dependant blood pressure increase in patients with coronary artery disease.

journal_name

Immun Ageing

authors

Schneider S,Koch W,Hoppmann P,Ubrich R,Kemmner S,Steinlechner E,Heemann U,Laugwitz KL,Kastrati A,Baumann M

doi

10.1186/s12979-015-0031-2

subject

Has Abstract

pub_date

2015-05-20 00:00:00

pages

4

issn

1742-4933

pii

31

journal_volume

12

pub_type

杂志文章
  • Acute exercise decreases PTP-1B protein level and improves insulin signaling in the liver of old rats.

    abstract::It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and insulin signaling, mediated by acute exercise, could be associated with modulation of protein-tyro...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-10-8

    authors: de Moura LP,Souza Pauli LS,Cintra DE,de Souza CT,da Silva ASR,Marinho R,de Melo MAR,Ropelle ER,Pauli JR

    更新日期:2013-02-25 00:00:00

  • Monocyte chemoattractant protein-1 promoter polymorphism and plasma levels in alzheimer's disease.

    abstract:BACKGROUND:Neurodegenerative disorders such Alzheimer's disease (AD) are often characterized by senile plaques and neurofibrillary tangle. In addition, reactive astrogliosis, microglia activation and a chronic inflammation are found in AD brain. Activated microglia has been reported to express a large number of beta ch...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-10-6

    authors: Porcellini E,Ianni M,Carbone I,Franceschi M,Licastro F

    更新日期:2013-02-21 00:00:00

  • Total and specific serum IgE decreases with age in patients with allergic rhinitis, asthma and insect allergy but not in patients with atopic dermatitis.

    abstract::Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decrease of serum total and specific IgE. Atopic disorders are complex diseases that involve interactions among sever...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-2-9

    authors: Mediaty A,Neuber K

    更新日期:2005-05-31 00:00:00

  • The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration.

    abstract:Background:Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clinical subtypes of late AMD. Results:We sampled fresh venous blood from patients with geographic atrop...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/s12979-019-0160-0

    authors: Subhi Y,Nielsen MK,Molbech CR,Liisborg C,Søndergaard HB,Sellebjerg F,Sørensen TL

    更新日期:2019-08-15 00:00:00

  • Possible role of ABO system in age-related diseases and longevity: a narrative review.

    abstract::ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with d...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章,评审

    doi:10.1186/1742-4933-11-16

    authors: Rizzo C,Caruso C,Vasto S

    更新日期:2014-11-01 00:00:00

  • Altered activation state of circulating neutrophils in patients with neovascular age-related macular degeneration.

    abstract:BACKGROUND:Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhesion, and resolution of inflammation in patients with neovascular age-related macular degeneration (...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/s12979-017-0100-9

    authors: Krogh Nielsen M,Hector SM,Allen K,Subhi Y,Sørensen TL

    更新日期:2017-07-27 00:00:00

  • Melatonin, immune function and aging.

    abstract::Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natura...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-2-17

    authors: Srinivasan V,Maestroni GJ,Cardinali DP,Esquifino AI,Perumal SR,Miller SC

    更新日期:2005-11-29 00:00:00

  • Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses.

    abstract:BACKGROUND:Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. However, although CMV infection occurs during childhood, relatively little is know about the typical quantity and quality of T cell responses in pediatric ...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-3-11

    authors: Komatsu H,Inui A,Sogo T,Fujisawa T,Nagasaka H,Nonoyama S,Sierro S,Northfield J,Lucas M,Vargas A,Klenerman P

    更新日期:2006-12-08 00:00:00

  • Nutraceutical effects of table green olives: a pilot study with Nocellara del Belice olives.

    abstract:BACKGROUND:The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin olive oil, common to all Mediterranean countries. Olive oil is the main source of fat and can modu...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/s12979-016-0067-y

    authors: Accardi G,Aiello A,Gargano V,Gambino CM,Caracappa S,Marineo S,Vesco G,Carru C,Zinellu A,Zarcone M,Caruso C,Candore G

    更新日期:2016-04-05 00:00:00

  • Human leukocyte antigen class I, class II, and tumor necrosis factor-alpha polymorphisms in a healthy elder Mexican Mestizo population.

    abstract:BACKGROUND:There is strong evidence that an individual's genetic background is an important predisposing factor to longevity. In the present study we analysed the frequency of HLA class I, class II, as well as the TNF-alpha -308 polymorphism that may be related to an increased life span in Mexican Mestizo healthy elder...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-2-13

    authors: Soto-Vega E,Richaud-Patin Y,Llorente L

    更新日期:2005-11-03 00:00:00

  • Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians.

    abstract:BACKGROUND:Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians. RESULTS:We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLRY and YSPTLFY...

    journal_title:Immunity & ageing : I & A

    pub_type:

    doi:10.1186/s12979-016-0064-1

    authors: Han J,Park SH,Kim DJ,Kim H,Choi YH,Lee JH,Park SC,Chung J

    更新日期:2016-03-22 00:00:00

  • Immunity, ageing and cancer.

    abstract::Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon contributes to the well-known age-associated increase in the occurrence of many cancers in the elderly. However, ...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-5-11

    authors: Derhovanessian E,Solana R,Larbi A,Pawelec G

    更新日期:2008-09-24 00:00:00

  • The prognostic value of biomarkers in stroke.

    abstract:BACKGROUND:Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Ma...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/s12979-016-0074-z

    authors: Iemolo F,Sanzaro E,Duro G,Giordano A,Paciaroni M

    更新日期:2016-05-31 00:00:00

  • Genetics of longevity. data from the studies on Sicilian centenarians.

    abstract:: The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of "successful and u...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-9-8

    authors: Balistreri CR,Candore G,Accardi G,Bova M,Buffa S,Bulati M,Forte GI,Listì F,Martorana A,Palmeri M,Pellicanò M,Vaccarino L,Scola L,Lio D,Colonna-Romano G

    更新日期:2012-04-23 00:00:00

  • Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans.

    abstract::The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. These two experimental models will be comp...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-4-7

    authors: Mocchegiani E,Giacconi R,Muti E,Cipriano C,Costarelli L,Tesei S,Gasparini N,Malavolta M

    更新日期:2007-09-29 00:00:00

  • Endothelial nitric oxide synthase, vascular integrity and human exceptional longevity.

    abstract:: Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impacts on the health of elderly people. The "free-radical theory of aging" was proposed to explain aging as a con...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-9-26

    authors: Puca AA,Carrizzo A,Ferrario A,Villa F,Vecchione C

    更新日期:2012-11-15 00:00:00

  • Neutrophils are immune cells preferentially targeted by retinoic acid in elderly subjects.

    abstract:BACKGROUND:The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a good candidate, since vitamin A concentrations classically decrease during aging whereas it may poss...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-7-10

    authors: Minet-Quinard R,Farges MC,Thivat E,Deleine C,Mayot G,Brtko J,Ribalta J,Winklhofer-Roob B,Rock E,Vasson MP

    更新日期:2010-08-20 00:00:00

  • BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factors.

    abstract:: Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 com...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-7-6

    authors: Rea IM

    更新日期:2010-05-27 00:00:00

  • Taste receptors, innate immunity and longevity: the case of TAS2R16 gene.

    abstract:Background:Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune res...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/s12979-019-0146-y

    authors: Malovini A,Accardi G,Aiello A,Bellazzi R,Candore G,Caruso C,Ligotti ME,Maciag A,Villa F,Puca AA

    更新日期:2019-02-23 00:00:00

  • Lag-time in Alzheimer's disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform.

    abstract::In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's D...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/s12979-019-0147-x

    authors: Massaccesi L,Galliera E,Galimberti D,Fenoglio C,Arcaro M,Goi G,Barassi A,Corsi Romanelli MM

    更新日期:2019-04-01 00:00:00

  • Can an effective SARS-CoV-2 vaccine be developed for the older population?

    abstract::The emergence of SARS-CoV-2 and its inordinately rapid spread is posing severe challenges to the wellbeing of millions of people worldwide, health care systems and the global economy. While many younger people experience no or mild symptoms on infection, older adults are highly susceptible to life-threatening respirat...

    journal_title:Immunity & ageing : I & A

    pub_type: 社论

    doi:10.1186/s12979-020-00180-2

    authors: Pawelec G,Weng NP

    更新日期:2020-04-11 00:00:00

  • Correction to: Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection.

    abstract::[This corrects the article DOI: 10.1186/s12979-018-0122-y.]. ...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s12979-018-0123-x

    authors: Lanzer KG,Cookenham T,Reiley WW,Blackman MA

    更新日期:2018-08-21 00:00:00

  • Antibody responses to intradermal or intramuscular MF59-adjuvanted influenza vaccines as evaluated in elderly institutionalized volunteers during a season of partial mismatching between vaccine and circulating A(H3N2) strains.

    abstract:BACKGROUND:The age-related weakening of the immune system makes elderly subjects less responsive to influenza vaccination. In the last years, two "enhanced vaccines" were licensed for individuals aged ≥65 years, one being a subunit vaccine (Fluad®) containing the MF59 adjuvant administered intramuscularly (IM-MF59) and...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-11-10

    authors: Camilloni B,Basileo M,Di Martino A,Donatelli I,Iorio AM

    更新日期:2014-05-16 00:00:00

  • CMV and Immunosenescence: from basics to clinics.

    abstract::Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". T...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-9-23

    authors: Solana R,Tarazona R,Aiello AE,Akbar AN,Appay V,Beswick M,Bosch JA,Campos C,Cantisán S,Cicin-Sain L,Derhovanessian E,Ferrando-Martínez S,Frasca D,Fulöp T,Govind S,Grubeck-Loebenstein B,Hill A,Hurme M,Kern F,Larbi A,

    更新日期:2012-10-31 00:00:00

  • Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD.

    abstract:BACKGROUND:The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patients' responsiveness to anti-VEGF therapy. RESULTS:Ninety-six nAMD patients (including 61 with choro...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/s12979-016-0060-5

    authors: Lechner J,Chen M,Hogg RE,Toth L,Silvestri G,Chakravarthy U,Xu H

    更新日期:2016-02-16 00:00:00

  • Correlation between CD117+ myeloma plasma cells and hematopoietic progenitor cells in different categories of patients.

    abstract:BACKGROUND:Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bone marrow (BM) microenvironment. Multiparameter flow cytometry (MFC) allows the simultaneous study of...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/s12979-015-0032-1

    authors: Pojero F,Casuccio A,Di Bassiano F,Gervasi F,Colonna Romano G,Caruso C

    更新日期:2015-06-04 00:00:00

  • The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population.

    abstract:Background:Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. M...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/s12979-018-0126-7

    authors: Tang Y,Liang P,Chen J,Fu S,Liu B,Feng M,Lin B,Lee B,Xu A,Lan HY

    更新日期:2018-09-08 00:00:00

  • Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I. Antibody concentrations, avidity and functional activity.

    abstract::Streptococcus pneumoniae is a serious worldwide pathogen and the focus of numerous vaccine development projects. Currently the most widely accepted surrogate marker for evaluating the efficacy of a given vaccine is to utilize ELISA. Measurement of antibody concentration by ELISA without reduction in cross-reactive ant...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-2-10

    authors: Kolibab K,Smithson SL,Shriner AK,Khuder S,Romero-Steiner S,Carlone GM,Westerink MA

    更新日期:2005-06-27 00:00:00

  • Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases.

    abstract::Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, ...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章,评审

    doi:10.1186/s12979-015-0046-8

    authors: Dattilo S,Mancuso C,Koverech G,Di Mauro P,Ontario ML,Petralia CC,Petralia A,Maiolino L,Serra A,Calabrese EJ,Calabrese V

    更新日期:2015-11-04 00:00:00

  • Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells.

    abstract:BACKGROUND:CD90 (Thy-1) is a small glycoprotein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells, and is often used as a marker in adoptive transfer experiments to distinguish donor and recipient T cells with different CD90 subtypes. We have performed adoptive transfer experiments...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章

    doi:10.1186/1742-4933-10-36

    authors: Jiang J,Fisher E,Murasko DM

    更新日期:2013-08-19 00:00:00