Abstract:
Background:Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. Methods:Serum levels of high sensitive C-reactive protein (hs-CRP), glucose (Glu), triglyceride (TG), cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), superoxide dismutase (SOD), serum creatinine (SCr), serum uric acid (SUA) were measured in 6060healthy subjects (3672 male and 2388 female, mean age:45.9 years) who received routine physical examination at Sun Yat-sen Memorial Hospital, Guangzhou, China. Results:In total of 6060 healthy people, serum levels of hs-CRP were significantly increased with ageing (P < 0.05), particularly in those with age over 45-year-old (1.31[0.69-2.75] vs 1.05[0.53-2.16]mg/L, P < 0.001). Interestingly, levels of serum hs-CRP were significantly higher in male than female population (1.24[0.65-2.57] vs 1.07[0.53-2.29]mg/L, P < 0.001). Correlation analysis also revealed that serum levels of hs-CRP positively correlated with age and SUA, but inversely correlated with serum levels of HDL-c and SOD (all P < 0.05). Conclusions:Baseline levels of serum hs-CRP are increased with ageing and are significantly higher in male than female healthy population. In addition, elevated serum levels of hs-CRP are also associated with increased SUA but decreased HDL-c and SOD. Thus, serum levels of hs-CRP may be an indicator associated with ageing in healthy Chinese population.
journal_name
Immun Ageingjournal_title
Immunity & ageing : I & Aauthors
Tang Y,Liang P,Chen J,Fu S,Liu B,Feng M,Lin B,Lee B,Xu A,Lan HYdoi
10.1186/s12979-018-0126-7subject
Has Abstractpub_date
2018-09-08 00:00:00pages
21issn
1742-4933pii
126journal_volume
15pub_type
杂志文章abstract::It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and insulin signaling, mediated by acute exercise, could be associated with modulation of protein-tyro...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-8
更新日期:2013-02-25 00:00:00
abstract::The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. These two experimental models will be comp...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-4-7
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journal_title:Immunity & ageing : I & A
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-020-00211-y
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journal_title:Immunity & ageing : I & A
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doi:10.1186/s12979-016-0060-5
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journal_title:Immunity & ageing : I & A
pub_type:
doi:10.1186/s12979-016-0064-1
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abstract::The emergence of SARS-CoV-2 and its inordinately rapid spread is posing severe challenges to the wellbeing of millions of people worldwide, health care systems and the global economy. While many younger people experience no or mild symptoms on infection, older adults are highly susceptible to life-threatening respirat...
journal_title:Immunity & ageing : I & A
pub_type: 社论
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abstract:BACKGROUND:The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a good candidate, since vitamin A concentrations classically decrease during aging whereas it may poss...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-10
更新日期:2010-08-20 00:00:00
abstract::ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with d...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/1742-4933-11-16
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0146-y
更新日期:2019-02-23 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-016-0067-y
更新日期:2016-04-05 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-S1-S1
更新日期:2010-12-16 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-3-11
更新日期:2006-12-08 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/s12979-019-0164-9
更新日期:2019-09-13 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-9
更新日期:2005-05-31 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-36
更新日期:2013-08-19 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-23
更新日期:2012-10-31 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-5-11
更新日期:2008-09-24 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-21
更新日期:2012-10-02 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0042-z
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-11-10
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-016-0074-z
更新日期:2016-05-31 00:00:00
abstract:: Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impacts on the health of elderly people. The "free-radical theory of aging" was proposed to explain aging as a con...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-26
更新日期:2012-11-15 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12979-018-0122-y.]. ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12979-018-0123-x
更新日期:2018-08-21 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-33
更新日期:2013-08-13 00:00:00
abstract:BACKGROUND:Since the COVID-19 outbreak an unprecedented challenge for healthcare systems around the world has been placed. In Cuba, the first case of COVID-19 was reported on March 11. Elderly with multiple comorbidities have been the most risky population. Although most patients present a mild to moderate disease, som...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-020-00207-8
更新日期:2020-11-14 00:00:00
abstract:BACKGROUND:Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhesion, and resolution of inflammation in patients with neovascular age-related macular degeneration (...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-017-0100-9
更新日期:2017-07-27 00:00:00
abstract::Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natura...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-17
更新日期:2005-11-29 00:00:00
abstract::Streptococcus pneumoniae is a serious worldwide pathogen and the focus of numerous vaccine development projects. Currently the most widely accepted surrogate marker for evaluating the efficacy of a given vaccine is to utilize ELISA. Measurement of antibody concentration by ELISA without reduction in cross-reactive ant...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-10
更新日期:2005-06-27 00:00:00
abstract:Background:Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clinical subtypes of late AMD. Results:We sampled fresh venous blood from patients with geographic atrop...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0160-0
更新日期:2019-08-15 00:00:00