Abstract:
: Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impacts on the health of elderly people. The "free-radical theory of aging" was proposed to explain aging as a consequence of the accumulation of reactive oxygen species (ROS). However, recent findings contradict this theory, and it now seems that mechanisms mediating longevity act through induction of oxidative stress. In fact, calorie restriction - a powerful way of delaying aging - increases ROS accumulation due to stimulation of the basal metabolic rate; moreover, reports show that antioxidant therapy is detrimental to healthy aging. We also now know that genetic manipulation of the insulin-like-growth-factor-1/insulin signal (IIS) has a profound impact on the rate of aging and that the IIS is modulated by calorie restriction and physical exercise. The IIS regulates activation of nitric oxide synthase (eNOS), the activity of which is essential to improving lifespan through calorie restriction, as demonstrated by experiments on eNOS knockout mice. Indeed, eNOS has a key role in maintaining vascular integrity during aging by activating vasorelaxation and allowing migration and angiogenesis. In this review, we will overview current literature on these topics and we will try to convince the reader of the importance of vascular integrity and nitric oxide production in determining healthy aging.
journal_name
Immun Ageingjournal_title
Immunity & ageing : I & Aauthors
Puca AA,Carrizzo A,Ferrario A,Villa F,Vecchione Cdoi
10.1186/1742-4933-9-26subject
Has Abstractpub_date
2012-11-15 00:00:00pages
26issue
1issn
1742-4933pii
1742-4933-9-26journal_volume
9pub_type
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-017-0100-9
更新日期:2017-07-27 00:00:00
abstract:BACKGROUND:The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a good candidate, since vitamin A concentrations classically decrease during aging whereas it may poss...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-10
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pub_type: 杂志文章
doi:10.1186/1742-4933-11-10
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-018-0126-7
更新日期:2018-09-08 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12979-018-0122-y.]. ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12979-018-0123-x
更新日期:2018-08-21 00:00:00
abstract:BACKGROUND:Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Ma...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-016-0074-z
更新日期:2016-05-31 00:00:00
abstract:BACKGROUND:Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiologic mechanisms remain elusive and clinical studies on the relationship between inflammatory markers a...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-020-00211-y
更新日期:2020-12-21 00:00:00
abstract::In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's D...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0147-x
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Sarcopenia is an important cause of morbidity and mortality in older adults, with immunosenescence and inflammation being possible underlying mechanisms. We investigated the relationship between latent cytomegalovirus (CMV) infection, Interleukin 6 (IL-6) levels, muscle size and strength in a group of health...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-33
更新日期:2013-08-13 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-8
更新日期:2013-02-25 00:00:00
abstract:BACKGROUND:The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome by cellular stress leads to activation of the inflammasome, and NLRP3 gene polymorphisms have been associated with autoinflammatory diseases. Inflammasomes have also been implicated in the initiation or progression of metabolic disor...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0047-7
更新日期:2015-10-31 00:00:00
abstract:: The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of "successful and u...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-8
更新日期:2012-04-23 00:00:00
abstract:Background:Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clinical subtypes of late AMD. Results:We sampled fresh venous blood from patients with geographic atrop...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0160-0
更新日期:2019-08-15 00:00:00
abstract:BACKGROUND:Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence th...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0031-2
更新日期:2015-05-20 00:00:00
abstract:Background:Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune res...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0146-y
更新日期:2019-02-23 00:00:00
abstract:BACKGROUND:Neurodegenerative disorders such Alzheimer's disease (AD) are often characterized by senile plaques and neurofibrillary tangle. In addition, reactive astrogliosis, microglia activation and a chronic inflammation are found in AD brain. Activated microglia has been reported to express a large number of beta ch...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-6
更新日期:2013-02-21 00:00:00
abstract::Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon contributes to the well-known age-associated increase in the occurrence of many cancers in the elderly. However, ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-5-11
更新日期:2008-09-24 00:00:00
abstract:BACKGROUND:There is strong evidence that an individual's genetic background is an important predisposing factor to longevity. In the present study we analysed the frequency of HLA class I, class II, as well as the TNF-alpha -308 polymorphism that may be related to an increased life span in Mexican Mestizo healthy elder...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-13
更新日期:2005-11-03 00:00:00
abstract::Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natura...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-17
更新日期:2005-11-29 00:00:00
abstract::The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. These two experimental models will be comp...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-4-7
更新日期:2007-09-29 00:00:00
abstract:BACKGROUND:Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians. RESULTS:We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLRY and YSPTLFY...
journal_title:Immunity & ageing : I & A
pub_type:
doi:10.1186/s12979-016-0064-1
更新日期:2016-03-22 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 社论
doi:10.1186/s12979-020-00180-2
更新日期:2020-04-11 00:00:00
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journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-36
更新日期:2013-08-19 00:00:00
abstract:BACKGROUND:Ageing brings about the gradual deterioration of the immune system, also known as immunosenescence. The role of non-coding circular RNA in immunosenescence is under studied. Using circular RNA microarray data, we assembled Comparison groups (C1, C2, C3 and C4) that allowed us to compare the circular RNA expr...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0042-z
更新日期:2015-10-08 00:00:00
abstract::Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". T...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-23
更新日期:2012-10-31 00:00:00
abstract::Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decrease of serum total and specific IgE. Atopic disorders are complex diseases that involve interactions among sever...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-9
更新日期:2005-05-31 00:00:00
abstract:BACKGROUND:The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin olive oil, common to all Mediterranean countries. Olive oil is the main source of fat and can modu...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-016-0067-y
更新日期:2016-04-05 00:00:00
abstract::Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/s12979-015-0046-8
更新日期:2015-11-04 00:00:00
abstract:: Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 com...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-6
更新日期:2010-05-27 00:00:00
abstract::The age-related dysregulation and decline of the immune system-collectively termed "immunosenescence"-has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinate...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/s12979-019-0164-9
更新日期:2019-09-13 00:00:00