Taste receptors, innate immunity and longevity: the case of TAS2R16 gene.


Background:Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune response plays a key role in the attainment of longevity, it is not surprising that the rs978739 polymorphism of the bitter taste receptor TAS2R16 gene has been shown to be associated with longevity in a population of 941 individuals ranging in age from 20 to 106 years from Calabria (Italy). There are many possible candidate genes for human longevity, however of the many genes tested, only APOE and FOXO3 survived to association in replication studies. So, it is necessary to validate in other studies genes proposed to be associated with longevity. Thus, we analysed the association of the quoted polymorphism in a population of long lived individuals (LLIs) and controls from another Italian population from Cilento. Methods:The analysis has been performed on data previously obtained with genome-wide association study on a population of LLIs (age range 90-109 years) and young controls (age range 18-45 years) from Cilento (Italy). Results:Statistical power calculations showed that the analysed cohort represented by 410 LLIs and 553 young controls was sufficiently powered to replicate the association between rs978739 and the longevity phenotype according to the effect size and frequencies described in the previous paper, under a dominant and additive genetic model. However, no evidence of association between rs978739 and the longevity phenotype was observed according to the additive or dominant model. Conclusion:There are several reasons for the failure of the confirmation of a previous study. However, the differences between the two studies in terms of environment of the population adopted and of the criteria of inclusion have made difficult the replication of the findings.


Immun Ageing


Malovini A,Accardi G,Aiello A,Bellazzi R,Candore G,Caruso C,Ligotti ME,Maciag A,Villa F,Puca AA




Has Abstract


2019-02-23 00:00:00










  • Correction to: Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection.

    abstract::[This corrects the article DOI: 10.1186/s12979-018-0122-y.]. ...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章,已发布勘误


    authors: Lanzer KG,Cookenham T,Reiley WW,Blackman MA

    更新日期:2018-08-21 00:00:00

  • CMV and Immunosenescence: from basics to clinics.

    abstract::Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". T...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Solana R,Tarazona R,Aiello AE,Akbar AN,Appay V,Beswick M,Bosch JA,Campos C,Cantisán S,Cicin-Sain L,Derhovanessian E,Ferrando-Martínez S,Frasca D,Fulöp T,Govind S,Grubeck-Loebenstein B,Hill A,Hurme M,Kern F,Larbi A,

    更新日期:2012-10-31 00:00:00

  • Can an effective SARS-CoV-2 vaccine be developed for the older population?

    abstract::The emergence of SARS-CoV-2 and its inordinately rapid spread is posing severe challenges to the wellbeing of millions of people worldwide, health care systems and the global economy. While many younger people experience no or mild symptoms on infection, older adults are highly susceptible to life-threatening respirat...

    journal_title:Immunity & ageing : I & A

    pub_type: 社论


    authors: Pawelec G,Weng NP

    更新日期:2020-04-11 00:00:00

  • Neutrophils are immune cells preferentially targeted by retinoic acid in elderly subjects.

    abstract:BACKGROUND:The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a good candidate, since vitamin A concentrations classically decrease during aging whereas it may poss...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Minet-Quinard R,Farges MC,Thivat E,Deleine C,Mayot G,Brtko J,Ribalta J,Winklhofer-Roob B,Rock E,Vasson MP

    更新日期:2010-08-20 00:00:00

  • Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians.

    abstract:BACKGROUND:Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians. RESULTS:We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLRY and YSPTLFY...

    journal_title:Immunity & ageing : I & A



    authors: Han J,Park SH,Kim DJ,Kim H,Choi YH,Lee JH,Park SC,Chung J

    更新日期:2016-03-22 00:00:00

  • Association of Toll-like receptor 4 polymorphism with age-dependent systolic blood pressure increase in patients with coronary artery disease.

    abstract:BACKGROUND:Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence th...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Schneider S,Koch W,Hoppmann P,Ubrich R,Kemmner S,Steinlechner E,Heemann U,Laugwitz KL,Kastrati A,Baumann M

    更新日期:2015-05-20 00:00:00

  • Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I. Antibody concentrations, avidity and functional activity.

    abstract::Streptococcus pneumoniae is a serious worldwide pathogen and the focus of numerous vaccine development projects. Currently the most widely accepted surrogate marker for evaluating the efficacy of a given vaccine is to utilize ELISA. Measurement of antibody concentration by ELISA without reduction in cross-reactive ant...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Kolibab K,Smithson SL,Shriner AK,Khuder S,Romero-Steiner S,Carlone GM,Westerink MA

    更新日期:2005-06-27 00:00:00

  • Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing.

    abstract:BACKGROUND:Ageing brings about the gradual deterioration of the immune system, also known as immunosenescence. The role of non-coding circular RNA in immunosenescence is under studied. Using circular RNA microarray data, we assembled Comparison groups (C1, C2, C3 and C4) that allowed us to compare the circular RNA expr...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Wang YH,Yu XH,Luo SS,Han H

    更新日期:2015-10-08 00:00:00

  • The prognostic value of biomarkers in stroke.

    abstract:BACKGROUND:Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Ma...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Iemolo F,Sanzaro E,Duro G,Giordano A,Paciaroni M

    更新日期:2016-05-31 00:00:00

  • Human leukocyte antigen class I, class II, and tumor necrosis factor-alpha polymorphisms in a healthy elder Mexican Mestizo population.

    abstract:BACKGROUND:There is strong evidence that an individual's genetic background is an important predisposing factor to longevity. In the present study we analysed the frequency of HLA class I, class II, as well as the TNF-alpha -308 polymorphism that may be related to an increased life span in Mexican Mestizo healthy elder...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Soto-Vega E,Richaud-Patin Y,Llorente L

    更新日期:2005-11-03 00:00:00

  • Predictive diagnostics and personalized medicine for the prevention of chronic degenerative diseases.

    abstract::Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or neurodegenerative diseases among the elderly. CDD are of complex diagnosis, difficult to treat and absorbing an ...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Licastro F,Caruso C

    更新日期:2010-12-16 00:00:00

  • The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population.

    abstract:Background:Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. M...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Tang Y,Liang P,Chen J,Fu S,Liu B,Feng M,Lin B,Lee B,Xu A,Lan HY

    更新日期:2018-09-08 00:00:00

  • Lag-time in Alzheimer's disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform.

    abstract::In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's D...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Massaccesi L,Galliera E,Galimberti D,Fenoglio C,Arcaro M,Goi G,Barassi A,Corsi Romanelli MM

    更新日期:2019-04-01 00:00:00

  • Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD.

    abstract:BACKGROUND:The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patients' responsiveness to anti-VEGF therapy. RESULTS:Ninety-six nAMD patients (including 61 with choro...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Lechner J,Chen M,Hogg RE,Toth L,Silvestri G,Chakravarthy U,Xu H

    更新日期:2016-02-16 00:00:00

  • BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factors.

    abstract:: Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 com...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Rea IM

    更新日期:2010-05-27 00:00:00

  • Acute exercise decreases PTP-1B protein level and improves insulin signaling in the liver of old rats.

    abstract::It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and insulin signaling, mediated by acute exercise, could be associated with modulation of protein-tyro...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: de Moura LP,Souza Pauli LS,Cintra DE,de Souza CT,da Silva ASR,Marinho R,de Melo MAR,Ropelle ER,Pauli JR

    更新日期:2013-02-25 00:00:00

  • An adjuvanted respiratory syncytial virus fusion protein induces protection in aged BALB/c mice.

    abstract:UNLABELLED: BACKGROUND:Respiratory Syncytial Virus (RSV) causes significant disease in the elderly, in part, because immunosenescence impairs protective immune responses to infection in this population. Despite previous and current efforts, there is no RSV vaccine currently licensed in infants or elderly adults. Adjuv...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Cherukuri A,Stokes KL,Patton K,Kuo H,Sakamoto K,Lambert S,Stillman E,Moore ML,Lee S

    更新日期:2012-10-02 00:00:00

  • Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses.

    abstract:BACKGROUND:Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. However, although CMV infection occurs during childhood, relatively little is know about the typical quantity and quality of T cell responses in pediatric ...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Komatsu H,Inui A,Sogo T,Fujisawa T,Nagasaka H,Nonoyama S,Sierro S,Northfield J,Lucas M,Vargas A,Klenerman P

    更新日期:2006-12-08 00:00:00

  • T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II.

    abstract:BACKGROUND:Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiologic mechanisms remain elusive and clinical studies on the relationship between inflammatory markers a...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Sbierski-Kind J,Goldeck D,Buchmann N,Spranger J,Volk HD,Steinhagen-Thiessen E,Pawelec G,Demuth I,Spira D

    更新日期:2020-12-21 00:00:00

  • The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration.

    abstract:Background:Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clinical subtypes of late AMD. Results:We sampled fresh venous blood from patients with geographic atrop...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Subhi Y,Nielsen MK,Molbech CR,Liisborg C,Søndergaard HB,Sellebjerg F,Sørensen TL

    更新日期:2019-08-15 00:00:00

  • An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients.

    abstract:BACKGROUND:Since the COVID-19 outbreak an unprecedented challenge for healthcare systems around the world has been placed. In Cuba, the first case of COVID-19 was reported on March 11. Elderly with multiple comorbidities have been the most risky population. Although most patients present a mild to moderate disease, som...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Saavedra D,Añé-Kourí AL,Sánchez N,Filgueira LM,Betancourt J,Herrera C,Manso L,Chávez E,Caballero A,Hidalgo C,Lorenzo G,Cepeda M,Valenzuela C,Ramos M,León K,Mazorra Z,Crombet T

    更新日期:2020-11-14 00:00:00

  • Endothelial nitric oxide synthase, vascular integrity and human exceptional longevity.

    abstract:: Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impacts on the health of elderly people. The "free-radical theory of aging" was proposed to explain aging as a con...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Puca AA,Carrizzo A,Ferrario A,Villa F,Vecchione C

    更新日期:2012-11-15 00:00:00

  • Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells.

    abstract:BACKGROUND:CD90 (Thy-1) is a small glycoprotein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells, and is often used as a marker in adoptive transfer experiments to distinguish donor and recipient T cells with different CD90 subtypes. We have performed adoptive transfer experiments...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Jiang J,Fisher E,Murasko DM

    更新日期:2013-08-19 00:00:00

  • Melatonin, immune function and aging.

    abstract::Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natura...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Srinivasan V,Maestroni GJ,Cardinali DP,Esquifino AI,Perumal SR,Miller SC

    更新日期:2005-11-29 00:00:00

  • Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans.

    abstract::The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. These two experimental models will be comp...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Mocchegiani E,Giacconi R,Muti E,Cipriano C,Costarelli L,Tesei S,Gasparini N,Malavolta M

    更新日期:2007-09-29 00:00:00

  • Possible role of ABO system in age-related diseases and longevity: a narrative review.

    abstract::ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with d...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章,评审


    authors: Rizzo C,Caruso C,Vasto S

    更新日期:2014-11-01 00:00:00

  • Immunity, ageing and cancer.

    abstract::Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon contributes to the well-known age-associated increase in the occurrence of many cancers in the elderly. However, ...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Derhovanessian E,Solana R,Larbi A,Pawelec G

    更新日期:2008-09-24 00:00:00

  • Antibody responses to intradermal or intramuscular MF59-adjuvanted influenza vaccines as evaluated in elderly institutionalized volunteers during a season of partial mismatching between vaccine and circulating A(H3N2) strains.

    abstract:BACKGROUND:The age-related weakening of the immune system makes elderly subjects less responsive to influenza vaccination. In the last years, two "enhanced vaccines" were licensed for individuals aged ≥65 years, one being a subunit vaccine (Fluad®) containing the MF59 adjuvant administered intramuscularly (IM-MF59) and...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Camilloni B,Basileo M,Di Martino A,Donatelli I,Iorio AM

    更新日期:2014-05-16 00:00:00

  • Nutraceutical effects of table green olives: a pilot study with Nocellara del Belice olives.

    abstract:BACKGROUND:The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin olive oil, common to all Mediterranean countries. Olive oil is the main source of fat and can modu...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Accardi G,Aiello A,Gargano V,Gambino CM,Caracappa S,Marineo S,Vesco G,Carru C,Zinellu A,Zarcone M,Caruso C,Candore G

    更新日期:2016-04-05 00:00:00

  • Correlation between CD117+ myeloma plasma cells and hematopoietic progenitor cells in different categories of patients.

    abstract:BACKGROUND:Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bone marrow (BM) microenvironment. Multiparameter flow cytometry (MFC) allows the simultaneous study of...

    journal_title:Immunity & ageing : I & A

    pub_type: 杂志文章


    authors: Pojero F,Casuccio A,Di Bassiano F,Gervasi F,Colonna Romano G,Caruso C

    更新日期:2015-06-04 00:00:00