Proteinuria as a predictor of complications of pre-eclampsia.

abstract：BACKGROUND:Although nut consumption has been associated with a reduced risk of cardiovascular disease and all-cause mortality, data on less common causes of death has not been systematically assessed. Previous reviews missed several studies and additional studies have since been published. We therefore conducted a syst...

journal_title：BMC medicine

authors： Aune D,Keum N,Giovannucci E,Fadnes LT,Boffetta P,Greenwood DC,Tonstad S,Vatten LJ,Riboli E,Norat T

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:Pendred syndrome, an autosomal-recessive disorder characterized by deafness and goiter, is caused by a mutation of SLC26A4, which codes for the anion exchanger pendrin. We investigated the relationship between pendrin expression and deafness using mice that have (Slc26a4+/+ or Slc26a4+/-) or lack (Slc26a4-/-...

journal_title：BMC medicine

authors： Jabba SV,Oelke A,Singh R,Maganti RJ,Fleming S,Wall SM,Everett LA,Green ED,Wangemann P

更新日期：2006-12-22 00:00:00

abstract：BACKGROUND:Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are established guidelines with regard to the identification and treatment of ADHD and ASD as independent con...

journal_title：BMC medicine

authors： Young S,Hollingdale J,Absoud M,Bolton P,Branney P,Colley W,Craze E,Dave M,Deeley Q,Farrag E,Gudjonsson G,Hill P,Liang HL,Murphy C,Mackintosh P,Murin M,O'Regan F,Ougrin D,Rios P,Stover N,Taylor E,Woodhouse E

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:We conducted this analysis to determine i) which journals publish high-quality, clinically relevant studies in internal medicine, general/family practice, general practice nursing, and mental health; and ii) the proportion of clinically relevant articles in each journal. METHODS:We performed an analytic sur...

journal_title：BMC medicine

authors： McKibbon KA,Wilczynski NL,Haynes RB

更新日期：2004-09-06 00:00:00

abstract：BACKGROUND:Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. METHODS:An open-label, non-inferiority, 1:1 randomized trial was conducted at three academic hospitals in So...

journal_title：BMC medicine

authors： Syn NL,Wong AL,Lee SC,Teoh HL,Yip JWL,Seet RC,Yeo WT,Kristanto W,Bee PC,Poon LM,Marban P,Wu TS,Winther MD,Brunham LR,Soong R,Tai BC,Goh BC

更新日期：2018-07-10 00:00:00

abstract：BACKGROUND:Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. METHODS:The community-based cohort included 7381 p...

journal_title：BMC medicine

authors： Carrière I,Norton J,Farré A,Wyart M,Tzourio C,Noize P,Pérès K,Fourrier-Réglat A,Ritchie K,Ancelin ML

更新日期：2017-04-19 00:00:00

abstract：BACKGROUND:The UK Clinical Aptitude Test (UKCAT) has been shown to have a modest but statistically significant ability to predict aspects of academic performance throughout medical school. Previously, this ability has been shown to be incremental to conventional measures of educational performance for the first year of...

journal_title：BMC medicine

authors： Tiffin PA,Mwandigha LM,Paton LW,Hesselgreaves H,McLachlan JC,Finn GM,Kasim AS

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Managing hearing communication for residents living with hearing loss and dementia in long-term care settings is challenging. This paper explores how care can be effective in optimising hearing communication for residents living with dementia. We argue that the underlying notion of permission or authorisatio...

journal_title：BMC medicine

authors： Crosbie B,Ferguson M,Wong G,Walker DM,Vanhegan S,Dening T

更新日期：2019-03-04 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease remains questioned. MAIN BODY:Accumulating evidence from clinical trial...

journal_title：BMC medicine

authors： Pouillon L,Vermeire S,Bossuyt P

更新日期：2019-05-08 00:00:00

abstract：BACKGROUND:There has been concern that the incidence of autism and other pervasive developmental disorders (PDDs) is increasing. Previous studies have been smaller, restricted to autism (excluding other pervasive developmental disorders such as Asperger's syndrome), included boys only, or have not been based on a natio...

journal_title：BMC medicine

authors： Smeeth L,Cook C,Fombonne PE,Heavey L,Rodrigues LC,Smith PG,Hall AJ

更新日期：2004-11-09 00:00:00

abstract：BACKGROUND:Armed conflicts are associated with a wide range of impacts on the mental health of children and adolescents. We evaluated the effectiveness of a school-based intervention aimed at reducing symptoms of posttraumatic stress disorder, depression, and anxiety (treatment aim); and improving a sense of hope and f...

journal_title：BMC medicine

authors： Tol WA,Komproe IH,Jordans MJ,Ndayisaba A,Ntamutumba P,Sipsma H,Smallegange ES,Macy RD,de Jong JT

更新日期：2014-04-01 00:00:00

abstract：:This is an Erratum to BMC Medicine 2015, 13:59, highlighting previously undeclared competing interests and including more information in the acknowledgements section.Please see related article: http://www.biomedcentral.com/1741-7015/13/59. The statement in the competing interests should read as follows: This study is ...

journal_title：BMC medicine

authors： Huang T,Xu M,Lee A,Cho S,Qi L

更新日期：2015-04-16 00:00:00

abstract：BACKGROUND:Wide implementation of mammography screening has resulted in increased numbers of women diagnosed with breast carcinoma in situ. We aimed to determine the risk of invasive breast cancer in relatives of patients with breast carcinoma in situ in comparison to the risk in relatives of patients with invasive bre...

journal_title：BMC medicine

authors： Mukama T,Fallah M,Brenner H,Xu X,Sundquist K,Sundquist J,Kharazmi E

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Armed conflict can indirectly affect population health through detrimental impacts on political and social institutions and destruction of infrastructure. This study aimed to quantify indirect mortality impacts of armed conflict in civilian populations globally and explore differential effects by armed confl...

journal_title：BMC medicine

authors： Jawad M,Hone T,Vamos EP,Roderick P,Sullivan R,Millett C

更新日期：2020-09-10 00:00:00

abstract：:In a climate of economic uncertainty, cost effectiveness analysis is a potentially important tool for making choices about health care interventions. Methods for such analyses are well established, but the results need to be interpreted carefully and are subject to bias. Making decisions based on results of cost-effec...

journal_title：BMC medicine

authors： Hill SR

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Fetal and neonatal mortality rates in low-income countries are at least 10-fold greater than in high-income countries. These differences have been related to poor access to and poor quality of obstetric and neonatal care. METHODS:This trial tested the hypothesis that teams of health care providers, administ...

journal_title：BMC medicine

authors： Pasha O,McClure EM,Wright LL,Saleem S,Goudar SS,Chomba E,Patel A,Esamai F,Garces A,Althabe F,Kodkany B,Mabeya H,Manasyan A,Carlo WA,Derman RJ,Hibberd PL,Liechty EK,Krebs N,Hambidge KM,Buekens P,Moore J,Jobe AH,

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is the only currently available midlife risk score for dementia. We compared CAIDE to Framingham cardiovascular Risk Score (FRS) and FINDRISC diabetes score as predictors of dementia and assessed the role of age in their associa...

journal_title：BMC medicine

authors： Fayosse A,Nguyen DP,Dugravot A,Dumurgier J,Tabak AG,Kivimäki M,Sabia S,Singh-Manoux A

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Clinicians are less likely to prescribe guideline-recommended treatments to people with multimorbidity than to people with a single condition. Doubts as to the applicability of clinical trials of drug treatments (the gold standard for evidence-based medicine) when people have co-existing diseases (comorbidit...

journal_title：BMC medicine

authors： Hanlon P,Hannigan L,Rodriguez-Perez J,Fischbacher C,Welton NJ,Dias S,Mair FS,Guthrie B,Wild S,McAllister DA

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:The aim of the current study was to assess the antidepressant efficacy and safety of Hypericum perforatum (St. John's wort) extract WS 5570 at doses of 600 mg/day in a single dose and 1200 mg/day in two doses. METHODS:The participants in this double-blind, randomized, placebo-controlled, multi-center clinic...

journal_title：BMC medicine

authors： Kasper S,Anghelescu IG,Szegedi A,Dienel A,Kieser M

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:The placebo response in patients with diabetes mellitus is very common. A systematic evaluation needs to be updated with the current evidence about the placebo response in diabetes mellitus and the associated factors in clinical trials of anti-diabetic medicine. METHODS:Literature research was conducted in ...

journal_title：BMC medicine

authors： Lin C,Cai X,Yang W,Lv F,Nie L,Ji L

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Involving adults lacking capacity (ALC) in research on end of life care (EoLC) or serious illness is important, but often omitted. We aimed to develop evidence-based guidance on how best to include individuals with impaired capacity nearing the end of life in research, by identifying the challenges and solut...

journal_title：BMC medicine

authors： Evans CJ,Yorganci E,Lewis P,Koffman J,Stone K,Tunnard I,Wee B,Bernal W,Hotopf M,Higginson IJ,MORECare_Capacity.

更新日期：2020-07-22 00:00:00

abstract：:Cocaine is a stimulant that leads to the rapid accumulation of catecholamines and serotonin in the brain due to prevention of their re-uptake into the neuron that released the neurotransmitter. Cocaine dependence is a public health concern and cause of significant morbidity and mortality worldwide. At present, there a...

journal_title：BMC medicine

authors： Shorter D,Kosten TR

更新日期：2011-11-03 00:00:00

abstract：BACKGROUND:The rapidly increasing number of activity-induced musculoskeletal injuries among adolescents and young adults is currently a true public health burden. The objective of this study was to investigate whether a neuromuscular training programme with injury prevention counselling is effective in preventing acute...

journal_title：BMC medicine

authors： Parkkari J,Taanila H,Suni J,Mattila VM,Ohrankämmen O,Vuorinen P,Kannus P,Pihlajamäki H

更新日期：2011-04-11 00:00:00

abstract：BACKGROUND:Preterm birth, small size for gestational age (SGA) and large size for gestational age (LGA) at birth are major risk factors for neonatal and long-term morbidity and mortality. It is unclear which periods of pregnancy are optimal for ultrasound screening to identify fetuses at risk of preterm birth, SGA or L...

journal_title：BMC medicine

authors： Erkamp JS,Voerman E,Steegers EAP,Mulders AGMGJ,Reiss IKM,Duijts L,Jaddoe VWV,Gaillard R

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on o...

journal_title：BMC medicine

authors： Skinner MK,Manikkam M,Tracey R,Guerrero-Bosagna C,Haque M,Nilsson EE

更新日期：2013-10-23 00:00:00

abstract：BACKGROUND:Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution of these efforts and of their impacts within and across endemic countries. METHODS:Using Demograph...

journal_title：BMC medicine

authors： Galactionova K,Smith TA,de Savigny D,Penny MA

更新日期：2017-10-18 00:00:00

abstract：BACKGROUND:Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spatial patterns of malaria transmission in elimination settings, with control programs having to accurat...

journal_title：BMC medicine

authors： Wesolowski A,Taylor AR,Chang HH,Verity R,Tessema S,Bailey JA,Alex Perkins T,Neafsey DE,Greenhouse B,Buckee CO

更新日期：2018-10-18 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial Parkinson's disease (PD). Variation around the LRRK2 locus also contributes to the risk of sporadic PD. The LRRK2 protein contains a central catalytic region, and pathogenic mutations cluster in the Ras of complex protein C termi...

journal_title：BMC medicine

authors： Rudenko IN,Chia R,Cookson MR

更新日期：2012-02-23 00:00:00

abstract：BACKGROUND:Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecessary biopsies. METHODS:Using a machine learning program, we identified a 25-Gen...

journal_title：BMC medicine

authors： Johnson H,Guo J,Zhang X,Zhang H,Simoulis A,Wu AHB,Xia T,Li F,Tan W,Johnson A,Dizeyi N,Abrahamsson PA,Kenner L,Feng X,Zou C,Xiao K,Persson JL,Chen L

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The likelihood of recurrence in patients with breast cancer who have HER2-positive tumors is relatively high, although trastuzumab is a remarkably effective drug in this setting. Signal transducer and activator of transcription 3 protein (STAT3), a transcription factor that is persistently tyrosine-705 phosp...

journal_title：BMC medicine

authors： Sonnenblick A,Brohée S,Fumagalli D,Vincent D,Venet D,Ignatiadis M,Salgado R,Van den Eynden G,Rothé F,Desmedt C,Neven P,Loibl S,Denkert C,Joensuu H,Loi S,Sirtaine N,Kellokumpu-Lehtinen PL,Piccart M,Sotiriou C

更新日期：2015-08-03 00:00:00