Ventilator-associated pneumonia using a heated humidifier or a heat and moisture exchanger: a randomized controlled trial [ISRCTN88724583].

abstract：:Microcirculatory dysfunction plays a pivotal role in the development of the clinical manifestations of severe sepsis. Prior to the advent of new imaging technologies, clinicians had been limited in their ability to assess the microcirculation at the bedside. Clinical evidence of microcirculatory perfusion has historic...

journal_title：Critical care (London, England)

authors： Trzeciak S,Rivers EP

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown, however, a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study, we tr...

journal_title：Critical care (London, England)

authors： Mokart D,Kipnis E,Guerre-Berthelot P,Vey N,Capo C,Sannini A,Brun JP,Blache JL,Mege JL,Blaise D,Guery BP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Providing supplemental amino acids to ICU patients during a 3-h period results in improved whole-body net protein balance, without an increase in amino acid oxidation. The primary objective was to investigate if a 24-h intravenous amino acid infusion in critically ill patients has a sustained effect on whole...

journal_title：Critical care (London, England)

authors： Sundström Rehal M,Liebau F,Tjäder I,Norberg Å,Rooyackers O,Wernerman J

更新日期：2017-12-06 00:00:00

abstract：INTRODUCTION:The aim of this study was to assess the effect of low-dose corticosteroid therapy in reducing shock duration after severe burn. METHODS:A placebo-controlled, double-blind, randomized clinical trial (RCT) was performed on two parallel groups in the burn intensive care unit (ICU). Patients were randomized t...

journal_title：Critical care (London, England)

authors： Venet F,Plassais J,Textoris J,Cazalis MA,Pachot A,Bertin-Maghit M,Magnin C,Rimmelé T,Monneret G,Tissot S

更新日期：2015-01-26 00:00:00

abstract：BACKGROUND:Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there are a number of animal models of TBI using progesterone for head injury, the effects of progesterone on neurologic outcome of acute TBI patients remain unclear. The ai...

journal_title：Critical care (London, England)

authors： Xiao G,Wei J,Yan W,Wang W,Lu Z

更新日期：2008-01-01 00:00:00

abstract：:This commentary on a paper by Bendel and colleagues in the previous issue of Critical Care describes the difficulty in assessing the sufficiency of adrenal responses to endogenous, stress-induced adrenocorticotropic hormone (ACTH) release by the pituitary or to exogenous ACTH administration in the critically ill patie...

journal_title：Critical care (London, England)

authors： Groeneveld AB,Beishuizen A,Molenaar N

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:(1,3)-β-D-Glucan has been widely used in clinical practice for the diagnosis of invasive Candida infections. However, such serum biomarker showed potential to guide antimicrobial therapy in order to reduce the duration of empirical antifungal treatment in critically ill septic patients with suspected invasiv...

journal_title：Critical care (London, England)

authors： De Pascale G,Posteraro B,D'Arrigo S,Spinazzola G,Gaspari R,Bello G,Montini LM,Cutuli SL,Grieco DL,Di Gravio V,De Angelis G,Torelli R,De Carolis E,Tumbarello M,Sanguinetti M,Antonelli M

更新日期：2020-09-05 00:00:00

abstract：:Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes dysregulation of vasodilatory and vasoconstrictive properties of smooth vascular muscle cells. Specific bypas...

journal_title：Critical care (London, England)

authors： Busse LW,Barker N,Petersen C

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility in patients at risk o...

journal_title：Critical care (London, England)

authors： Favre E,Bernini A,Morelli P,Pasquier J,Miroz JP,Abed-Maillard S,Ben-Hamouda N,Oddo M

更新日期：2020-02-24 00:00:00

abstract：INTRODUCTION:The anaesthetic agent propofol (2,6-diisopropylphenol) has been shown to be an effective neuroprotective agent in different in vitro models of brain injury induced by oxygen and glucose deprivation. We examined its neuroprotective properties in an in vitro model of traumatic brain injury. METHODS:In this ...

journal_title：Critical care (London, England)

authors： Rossaint J,Rossaint R,Weis J,Fries M,Rex S,Coburn M

更新日期：2009-01-01 00:00:00

abstract：:Many aspects of left ventricular function are explained by considering ventricular pressure-volume characteristics. Contractility is best measured by the slope, Emax, of the end-systolic pressure-volume relationship. Ventricular systole is usefully characterized by a time-varying elastance (ΔP/ΔV). An extended area, t...

journal_title：Critical care (London, England)

authors： Walley KR

更新日期：2016-09-10 00:00:00

abstract：INTRODUCTION:Contrast-enhanced ultrasound (CEUS) is a new technique that might enable portable and non-invasive organ perfusion quantification at the bedside. However, it has not yet been tested in critically ill patients. We sought to establish CEUS's feasibility, safety, reproducibility and potential diagnostic value...

journal_title：Critical care (London, England)

authors： Schneider AG,Goodwin MD,Schelleman A,Bailey M,Johnson L,Bellomo R

更新日期：2013-07-12 00:00:00

abstract：:Three pulse contour systems for monitoring cardiac output - LiDCO Plus™, PiCCO Plus™ and FloTrac™ - were compared in postcardiac surgery patients. None of the three methods demonstrated good trending ability according to concordance analysis. Pulse contour systems remain unreliable in the haemodynamically unstable pat...

journal_title：Critical care (London, England)

authors： Critchley LA

更新日期：2011-01-19 00:00:00

abstract：BACKGROUND:Esophageal pressure (Pes) can provide information to guide mechanical ventilation in acute respiratory failure. However, both relative changes and absolute values of Pes can be affected by inappropriate filling of the esophageal balloon and by the elastance of the esophagus wall. We evaluated the feasibility...

journal_title：Critical care (London, England)

authors： Mojoli F,Iotti GA,Torriglia F,Pozzi M,Volta CA,Bianzina S,Braschi A,Brochard L

更新日期：2016-04-11 00:00:00

abstract：BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) is a rare though often fatal hyperinflammatory syndrome mimicking sepsis in the critically ill. Diagnosis relies on the HLH-2004 criteria and HScore, both of which have been developed in pediatric or adult non-critically ill patients, respectively. Therefore, we aimed...

journal_title：Critical care (London, England)

authors： Knaak C,Nyvlt P,Schuster FS,Spies C,Heeren P,Schenk T,Balzer F,La Rosée P,Janka G,Brunkhorst FM,Keh D,Lachmann G

更新日期：2020-05-24 00:00:00

abstract：INTRODUCTION:Protocols for the delivery of analgesia, sedation and delirium care of the critically ill, mechanically ventilated patient have been shown to improve outcomes but are not uniformly used. The extent to which elements of analgesia, sedation and delirium guidelines are incorporated into order sets at hospital...

journal_title：Critical care (London, England)

authors： Dale CR,Hayden SJ,Treggiari MM,Curtis JR,Seymour CW,Yanez ND 3rd,Fan VS

更新日期：2012-06-18 00:00:00

abstract：BACKGROUND:Impaired microcirculatory perfusion and tissue oxygenation during critical illness are associated with adverse outcome. The aim of this study was to detect alterations in tissue oxygenation or microvascular reactivity and their ability to predict outcome in critically ill patients using thenar near-infrared ...

journal_title：Critical care (London, England)

authors： Donati A,Damiani E,Domizi R,Scorcella C,Carsetti A,Tondi S,Monaldi V,Adrario E,Romano R,Pelaia P,Singer M

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Delayed patient admission to the intensive care unit (ICU) due to lack of bed availability is a common problem, but the effect on patient outcome is not fully known. METHODS:A retrospective study was performed using departmental computerised records to determine the effect of delayed ICU admission and tem...

journal_title：Critical care (London, England)

authors： O'Callaghan DJ,Jayia P,Vaughan-Huxley E,Gribbon M,Templeton M,Skipworth JR,Gordon AC

更新日期：2012-10-01 00:00:00

abstract：:An influenza pandemic threatens to be the most lethal public health crisis to confront the world. Physicians will have critical roles in diagnosis, containment and treatment of influenza, and their commitment to treat despite increased personal risks is essential for a successful public health response. The obligation...

journal_title：Critical care (London, England)

authors： Anantham D,McHugh W,O'Neill S,Forrow L

更新日期：2008-01-01 00:00:00

abstract：:In an effort to reduce the complications related to invasive ventilation, the use of noninvasive ventilation (NIV) has increased over the last years in patients with acute respiratory failure. However, failure rates for NIV remain high in specific patient categories. Several studies have identified factors that contri...

journal_title：Critical care (London, England)

authors： Oppersma E,Doorduin J,van der Heijden EH,van der Hoeven JG,Heunks LM

更新日期：2013-12-05 00:00:00

abstract：:Many alarms, as they now exist in most monitoring systems, are not usually perceived as helpful by the medical staff because of the high incidence of false alarms. This paper gives an overview of the problems related to their current design and the objectives of monitoring. The current approaches used to improve the s...

journal_title：Critical care (London, England)

authors： Chambrin MC

更新日期：2001-08-01 00:00:00

abstract：:The rate of oxygen consumption by certain tissues is impaired when mice or rats are injected with lipopolysaccharide. A similar change in the rate of oxygen consumption is observed when Caco-2 human enterocyte-like cells are incubated in vitro with cytomix, a cocktail of cytokines containing tumor necrosis factor, IL-...

journal_title：Critical care (London, England)

authors： Fink MP

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing intensive with conventional glycaemic control in TBI requiring admission to an intensive care unit (ICU). METHODS:We systematically se...

journal_title：Critical care (London, England)

authors： Hermanides J,Plummer MP,Finnis M,Deane AM,Coles JP,Menon DK

更新日期：2018-01-19 00:00:00

abstract：INTRODUCTION:Expanding the criteria for deceased organ donors increases the risk of delayed graft function (DGF) and complicates kidney transplant outcome. We studied whether donor neutrophil gelatinase-associated lipocalin (NGAL), a novel biomarker for acute kidney injury, could predict DGF after transplantation. MET...

journal_title：Critical care (London, England)

authors： Hollmen ME,Kyllönen LE,Inkinen KA,Lalla ML,Merenmies J,Salmela KT

更新日期：2011-01-01 00:00:00

abstract：:Type 2 diabetes has reached epidemic proportions in many parts of the world. The disease is projected to continue to increase and double within the foreseeable future. Dysglycaemia develops in the form of hyperglycaemia, hypoglycaemia and marked glucose variability in critically ill adults whether they are known to ha...

journal_title：Critical care (London, England)

authors： Smith FG,Sheehy AM,Vincent JL,Coursin DB

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Patients in intensive care units (ICUs) often receive sedation for prolonged periods. In order to better understand the impact of sub-optimal sedation practice on outcomes, we performed a systematic review, including observational studies and controlled trials which were conducted in sedated patients in th...

journal_title：Critical care (London, England)

authors： Jackson DL,Proudfoot CW,Cann KF,Walsh T

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hypothesis that a biomarker panel would be useful for biologic confirmation of the clinical diagn...

journal_title：Critical care (London, England)

authors： Ware LB,Koyama T,Zhao Z,Janz DR,Wickersham N,Bernard GR,May AK,Calfee CS,Matthay MA

更新日期：2013-10-24 00:00:00

abstract：BACKGROUND:Several biological markers of lung injury are predictors of morbidity and mortality in patients with acute lung injury (ALI). The low tidal volume lung-protective ventilation strategy is associated with a significant decrease in plasma biomarker levels compared to the high tidal volume ventilation strategy. ...

journal_title：Critical care (London, England)

authors： Cepkova M,Brady S,Sapru A,Matthay MA,Church G

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:We compared the effects of mechanical ventilation with a lower tidal volume (V(T)) strategy versus those of greater V(T) in patients with or without acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) on the use of opioids and sedatives. METHODS:This is a secondary analysis of a previously ...

journal_title：Critical care (London, England)

authors： Wolthuis EK,Veelo DP,Choi G,Determann RM,Korevaar JC,Spronk PE,Kuiper MA,Schultz MJ

更新日期：2007-01-01 00:00:00

abstract：:The previous review in this series introduced the notion of data description and outlined some of the more common summary measures used to describe a dataset. However, a dataset is typically only of interest for the information it provides regarding the population from which it was drawn. The present review focuses on...

journal_title：Critical care (London, England)

authors： Whitley E,Ball J

更新日期：2002-04-01 00:00:00