Potential targets of transforming growth factor-beta1 during inhibition of oocyte maturation in zebrafish.

abstract：BACKGROUND:Patients hoping to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hyperplasia (AEH) . Such treatment generally involves frequent intrauterine operations, including dilati...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Inoue O,Hamatani T,Susumu N,Yamagami W,Ogawa S,Takemoto T,Hirasawa A,Banno K,Kuji N,Tanaka M,Aoki D

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:Women with Polycystic Ovary Syndrome (PCOS) present a heterogeneous reproductive and metabolic profile with an increased lifetime risk of Type 2 Diabetes (T2D). Early biomarkers of these metabolic disturbances in PCOS women have not been identified. The abundance of circulating insulin gene promotor cell-fre...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Udesen PB,Sørensen AE,Joglekar MV,Hardikar AA,Wissing MLM,Englund AM,Dalgaard LT

更新日期：2019-04-05 00:00:00

abstract：BACKGROUND:Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadotropin in mammals. However, it...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Han X,He Y,Zeng G,Wang Y,Sun W,Liu J,Sun Y,Yu J

更新日期：2017-05-02 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 9-18% of women in reproductive age that causes hyperandrogenism and infertility due to dysfunctional follicular maturation and anovulation. The etiology of PCOS is still poorly known, and information from experimental animal models may help imp...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Paixão L,Ramos RB,Lavarda A,Morsh DM,Spritzer PM

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Di(2-ethylhexyl) phthalate (DEHP) exposure reduces embryo implantations, increases embryonic loss, and decreases fetal body weights. However, whether it is associated with the alteration of luteal function remains unknown. Thus, our aim in this study was to explore the effect and mechanism of DEHP on luteal ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Guo M,Lai L,Zong T,Lin Y,Yang B,Zhang L,Li M,Kuang H

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) has been recognized as a metabolic disorder, manifested by abdominal obesity, insulin resistance, dyslipidemia and hypertension. Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor family, is a pleiotropic protein known for its antiangiogenic, ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lecke SB,Morsch D,Spritzer PM

更新日期：2013-08-14 00:00:00

abstract：BACKGROUND:New anticancer treatments have increased survival rates for cancer patients, but often at the cost of sterility. Several strategies are currently available for preserving fertility. However, the chances of achieving a pregnancy with one technique are still limited. A combination of methods is therefore recom...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Dittrich R,Lotz L,Mueller A,Hoffmann I,Wachter DL,Amann KU,Beckmann MW,Hildebrandt T

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:Leukocytes represent the predominant source of reactive oxygen species both in seminal plasma and in sperm suspensions and have been demonstrated to negatively influence sperm function and fertilization rate in assisted reproduction procedures. Peroxidase test is the standard method recommended by WHO to det...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Ricci G,Perticarari S,Boscolo R,Simeone R,Martinelli M,Fischer-Tamaro L,Guaschino S,Presani G

更新日期：2009-11-19 00:00:00

abstract：BACKGROUND:Secreted protein of Ly-6 domain 1 (SOLD1), a secretory-type member of the Ly-6 superfamily, is expressed in both fetal and maternal tissues throughout gestation. SOLD1 mRNA is expressed in the endometrium and in trophoblast mononucleate and binucleate cells, suggesting it plays an important role not only in ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Awad M,Koshi K,Kizaki K,Takahashi T,Hashizume K

更新日期：2014-06-21 00:00:00

abstract：:Macaques are menstruating nonhuman primates that provide important animal models for studies of hormonal regulation in the uterus. In women and macaques the decline of progesterone (P) at the end of the cycle triggers endometrial expression of a variety of matrix metalloproteinase (MMP) enzymes that participate in tis...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Slayden OD,Brenner RM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) international body mass index (BMI) cut-off points defining pre-pregnancy BMI categories in the Institute of Medicine (IOM) guidelines are not directly applicable to Asians. We aimed to define the optimal gestational weight gain (GWG) for the Korean population based on Asi...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Choi SK,Lee G,Kim YH,Park IY,Ko HS,Shin JC

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential ri...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Huang J,Ni R,Chen X,Huang L,Mo Y,Yang D

更新日期：2010-11-17 00:00:00

abstract：BACKGROUND:Testicular microliths are calcifications found within the seminiferous tubules. In humans, testicular microlithiasis (TM) has an unknown etiology but may be significantly associated with testicular germ cell tumors. Factors inducing microlith development may also, therefore, act as susceptibility factors for...

journal_title：Reproductive biology and endocrinology : RB&E

authors： O'Shaughnessy PJ,Monteiro A,Verhoeven G,De Gendt K,Abel MH

更新日期：2009-08-27 00:00:00

abstract：BACKGROUND:To evaluate the association between leukocytes (polymorphonuclear granulocytes -PMNL) and semen parameters at different leukocyte concentrations. METHODS:This was a retrospective clinical study at a university hospital andrology clinic. Semen samples from infertile men were analyzed for sperm morphology and...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lackner JE,Agarwal A,Mahfouz R,du Plessis SS,Schatzl G

更新日期：2010-02-05 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the relationship between a purported luteinizing hormone/chorionic gonadotropin (LHCGR) high function polymorphism (rs4539842/insLQ) and outcome to controlled ovarian hyperstimulation (COH). METHODS:This was a prospective study of 172 patients undergoing COH at the Fer...

journal_title：Reproductive biology and endocrinology : RB&E

authors： O'Brien TJ,Kalmin MM,Harralson AF,Clark AM,Gindoff I,Simmens SJ,Frankfurter D,Gindoff P

更新日期：2013-07-25 00:00:00

abstract：:The prolonged lockdown of health services providing high-complexity fertility treatments -as currently recommended by many reproductive medicine entities- is detrimental for society as a whole, and infertility patients in particular. Globally, approximately 0.3% of all infants born every year are conceived using assis...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Alviggi C,Esteves SC,Orvieto R,Conforti A,La Marca A,Fischer R,Andersen CY,Bühler K,Sunkara SK,Polyzos NP,Strina I,Carbone L,Bento FC,Galliano D,Yarali H,Vuong LN,Grynberg M,Drakopoulos P,Xavier P,Llacer J,Neuspil

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:The fibrinolytic system and its inhibitors play a number of roles, apart from their function in blood haemostasis and thrombosis, namely in ovarian folliculogenesis and in ovulation. Plasminogen is converted to active plasmin at the time of follicular rupture through a decrease in plasminogen activator inhib...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Burchall GF,Pouniotis DS,Teede HJ,Ranasinha S,Walters KA,Piva TJ

更新日期：2019-03-16 00:00:00

abstract：:Preimplantation embryo development involves four stages: fertilization, cell cleavage, morula and blastocyst formation. During these stages, maternal and zygotic epigenetic factors play crucial roles. The gene expression profile is changed dramatically, chromatin is modified and core histone elements undergo significa...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Shi L,Wu J

更新日期：2009-06-05 00:00:00

abstract：BACKGROUND:L-carnitine (LC), and its acetylated form, acetyl L-carnitine (ALC), have immense functional capabilities to regulate the oxidative and metabolic status of the female reproductive system. The vulnerability of this system to free radicals demand for advanced strategies to combat them. For this purpose, the 'q...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Agarwal A,Sengupta P,Durairajanayagam D

更新日期：2018-01-26 00:00:00

abstract：BACKGROUND:Spermatic cord torsion can lead to testis ischemia (I) and subsequent ischemia-reperfusion (I/R) causing germ cell-specific apoptosis. Previously, we demonstrated that the hypoxia-inducible factor-1 (HIF-1) transcription factor, a key regulator of physiological responses to hypoxia, is abundant in Leydig cel...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Palladino MA,Shah A,Tyson R,Horvath J,Dugan C,Karpodinis M

更新日期：2012-12-05 00:00:00

abstract：BACKGROUND:The synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex with the redox partner NADPH-cytochrome P450 oxidoreductase (CPR) fo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Dos Santos AC,Conley AJ,de Oliveira MF,Oliveira GB,Viana DC,Assis Neto AC

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase 2 (MMP-2) has been reported to be an important regulator of cell migration and invasion through degradation of the extracellular matrix (ECM) in many diseases, such as cancer and endometriosis. Here, we found calcium-activated neutral protease 7 (CAPN 7) expression was markedly upreg...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Liu H,Jiang Y,Jin X,Zhu L,Shen X,Zhang Q,Wang B,Wang J,Hu Y,Yan G,Sun H

更新日期：2013-07-15 00:00:00

abstract：:Fertilin alpha (ADAM-1) and beta (ADAM-2) are integral membrane proteins of the ADAM family that form a fertilin complex involved in key steps of the sperm-oocyte membrane interaction. In the present work, we analyzed the presence of ADAM-1 and ADAM-2 mRNAs, the spermatozoa proteins' processing and their sub-cellular ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Fàbrega A,Guyonnet B,Dacheux JL,Gatti JL,Puigmulé M,Bonet S,Pinart E

更新日期：2011-06-30 00:00:00

abstract：BACKGROUND:Oocyte donation is a medical technique used principally for woman with ovarian failure. Optimizing donor recruitment is essential to obtain the best results with this technique. Understanding how donor parameters influence outcome for the recipients is fundamental. The aim of this study was to determine whet...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Delesalle AS,Robin G,Thomas-Desrousseaux P,Dewailly D,Catteau-Jonard S

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:High levels of dopamine (DA) were described in human ovary and recently evidence for DA receptors in granulosa and luteal cells has been provided, as well. However, neither the full repertoire of ovarian receptors for DA, nor their specific role, is established. Human granulosa cells (GCs) derived from women...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Rey-Ares V,Lazarov N,Berg D,Berg U,Kunz L,Mayerhofer A

更新日期：2007-10-25 00:00:00

abstract：OBJECTIVE:To assess the effectiveness and safety of omega-3 fatty acid for patients with PCOS. METHODS:In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of omega-3 fatty acid versus placebo or western medicine in women with PCOS. The study's registration number is CRD420...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Yang K,Zeng L,Bao T,Ge J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:To examine the effects of IVF, ICSI and FET, as well as in vitro culture, on the safety of offspring, this study was conducted from the perspective of genetic imprinting to investigate whether assisted reproductive technology would influence the parental and maternal imprinting genes. METHODS:Eighteen foetu...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Ji M,Wang X,Wu W,Guan Y,Liu J,Wang J,Liu W,Shen C

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:A decrease in HOXA11 expression in eutopic mid-secretory endometrium has been found in women with endometriosis-associated infertility. METHODS:Using Real-time quantitative PCR (RQ-PCR) and western blotting analysis we studied the HOXA11 transcript and protein levels in mid-luteal eutopic endometrium from e...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Szczepańska M,Wirstlein P,Skrzypczak J,Jagodziński PP

更新日期：2012-01-10 00:00:00

abstract：BACKGROUND:High altitude is associated with both low pulse oxygen saturation at birth and more pre-term deliveries. The present study was performed to determine pulse oxygen saturation in newborns at term in Cerro de Pasco (4340 m) and Lima (150 m) to test the hypothesis that low pulse oxygen saturation at birth at hig...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gonzales GF,Salirrosas A

更新日期：2005-09-12 00:00:00

abstract：BACKGROUND:The E2F family of transcription factors is required for the activation or repression of differentially expressed gene programs during the cell cycle in normal and abnormal development of tissues. We previously determined that members of the retinoblastoma protein family that interacts with the E2F family are...

journal_title：Reproductive biology and endocrinology : RB&E

authors： El-Darwish KS,Parvinen M,Toppari J

更新日期：2006-12-05 00:00:00