Abstract:
Purpose:Erector spinae plane block (ESPB) is a newly reported interfascial plane block in pain management, and it can block the nerves exactly in line with the area of the posterior lumbar surgery. The objective of this research was to determine the effectiveness of pre-operative ESPB in enhancing recovery of posterior lumbar surgery. Patients and Methods:A total of 60 patients undergoing open posterior lumbar decompression surgery under general anesthesia were randomized into two groups. T12 group was performed pre-operatively bilateral ESPB with ropivacaine at the T12 level, but control group did not receive the block. The primary outcome was the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score at 10 minutes after extubation. Secondary outcomes included intraoperative sufentanil consumption, postoperative morphine consumption, first time to ambulation after surgery and hospital length of stay after surgery. All participants were followed up to hospital discharge. Results:The mean (SD) MOAA/S scores at 10 minutes after extubation were 4.2 (95% CI, 4.0 to 4.4), and 3.4 (95% CI, 3.2 to 3.6) in the T12 and control groups (P <0.001), respectively. Intraoperative sufentanil consumption (P =0.007) and postoperative morphine consumption (P =0.003) were lower in the T12 group than in the control group. Although first time to ambulation after surgery was sooner in the T12 group than in the control group (P =0.003), hospital length of stay was similar (P=0.054). Conclusion:Pre-operative bilateral ESPB at T12 can enhance recovery after posterior lumbar surgery and reduce perioperative opioid consumption.
journal_name
J Pain Resjournal_title
Journal of pain researchauthors
Zhang TJ,Zhang JJ,Qu ZY,Zhang HY,Qiu Y,Hua Zdoi
10.2147/JPR.S248171subject
Has Abstractpub_date
2020-04-05 00:00:00pages
709-717issn
1178-7090pii
248171journal_volume
13pub_type
abstract:Background:It is becoming increasingly important to understand the mechanisms of spinal cord stimulation (SCS) in alleviating neuropathic pain as novel stimulation paradigms arise. Purpose:Additionally, the small anatomic scale of current SCS animal models is a barrier to more translational research. Methods:Using ch...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S139843
更新日期:2018-06-15 00:00:00
abstract:Purpose:Brachial plexopathy can sometimes cause severe chronic pain. There are many possible treatments for such neuropathic pain, including neuromodulation. However, rigorous scientific evidence on the usefulness of spinal cord stimulation (SCS) is still scarce. Here, we report the use of high-frequency (10 kHz) SCS (...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S168031
更新日期:2018-11-27 00:00:00
abstract:PURPOSE:Since receiving a warning from the US Food and Drug Administration (FDA) about injection of corticosteroids into the epidural space having serious adverse events, we have sought alternative medications for injection at this site. Hyaluronic acid (HA) has anti-adhesive, anti-inflammatory, and lubricating propert...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S122861
更新日期:2017-01-25 00:00:00
abstract::Cancer and cancer treatment-related chronic pain affect a significant number of patients. The etiology of this pain is diverse and may include nociceptive and/or neuropathic characteristics. Treatment is often multifactorial and may require advanced interventional techniques, such as spinal cord stimulation (SCS). Thi...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S263857
更新日期:2020-12-07 00:00:00
abstract:Background:G protein-gated inwardly rectifying potassium (GIRK) channels are involved in the regulation of neuronal excitability. Four GIRK subunits (GIRK1-4) are expressed in rat dorsal root ganglia (DRGs). Recently, we have characterized the expression of GIRK1 and -2, and both are downregulated in rat DRGs and spina...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S233744
更新日期:2020-02-17 00:00:00
abstract:Purpose:Despite the rise in opioid-related hospitalizations, there has been little research regarding opioid-related healthcare utilization. The objective of this study was to estimate the mean adjusted hospital costs, payments, and length of stay (LOS) for opioid-related visits for the nation and each of the nine US c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S184724
更新日期:2018-12-04 00:00:00
abstract:Purpose:The quadratus lumborum block (QLB) is a relatively new regional analgesic technique that could provide analgesia to the abdominal wall and reduce postoperative opioid consumption. We investigated the opioid-sparing effect of a unilateral lateral QLB in laparoscopic nephrectomy. Patients and Methods:A total of ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S257466
更新日期:2020-07-03 00:00:00
abstract::Pain is the most common reason people visit emergency rooms. Pain does not discriminate on the basis of gender, race or age. The state of pain management in the emergency department (ED) is disturbing. ED physicians often do not provide adequate analgesia to their patients, do not meet patients' expectations in treati...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:
更新日期:2008-12-09 00:00:00
abstract:OBJECTIVES:Effective postoperative pain management is crucial in the care of surgical patients. Opioids, which are commonly used in managing postoperative pain, have a potential for tolerance and addiction, along with sedating side effects. Gabapentin's use as a multimodal analgesic regimen to treat neuropathic pain ha...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S112626
更新日期:2016-09-12 00:00:00
abstract:OBJECTIVE:To characterize the steady-state pharmacokinetic profile of hydromorphone extended-release (ER) in patients with chronic pain taking concomitant medications. METHODS:This open-label repeat-dose study enrolled 22 patients (mean age, 51.4 years; 81.8% female). All patients were receiving at least one concomita...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S33807
更新日期:2012-01-01 00:00:00
abstract:Background:The use of complementary and alternative medicine (CAM) therapies has increased in children, especially in those with chronic health conditions. However, this increase may not translate into acceptance of CAM in the perioperative setting. We surveyed caregivers of patients undergoing surgery to determine the...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S156585
更新日期:2018-03-01 00:00:00
abstract:Background:Preoperative anxiety is associated with postoperative hyperalgesia; however, few studies have investigated the mechanism underlying this association in female surgical patients. Research has suggested that ON cells in the rostral ventromedial medulla (RVM) receive nerve impulses via cholecystokinin 2 (CCK2) ...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S187715
更新日期:2019-07-03 00:00:00
abstract:Purpose:The study aimed at the evaluation of the impact of intravenous (IV) dexamethasone on efficacy and duration of analgesia of paravertebral block (PVB) in patients undergoing modified radical mastectomy (MRM). Patients and methods:This randomized, double-blind controlled trial included 50 patients with breast can...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S181788
更新日期:2018-12-19 00:00:00
abstract::Osteoarthritis (OA) is a common degenerative disease that affects the vast majority of the elderly and may eventually embark on the road of the total knee arthroplasty (TKA), although controversy still exists in the medical community about the best therapies for osteoarthritis. Compared with physical therapy, oral ana...
journal_title:Journal of pain research
pub_type: 杂志文章,评审
doi:10.2147/JPR.S260878
更新日期:2020-08-04 00:00:00
abstract::Purpose: The study aimed to evaluate the analgesic efficiency of dexmedetomidine (DEX) when added to levobupivacaine in continuous ultrasound-guided serratus anterior plane block (SAPB) performed at the end of major thoracic surgery. Methods: This randomized, double-blind trial included 50 adults undergoing thoracic s...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S195431
更新日期:2019-04-30 00:00:00
abstract:Objective:To report a rare case of spontaneous fusion (SF) following cervical disc arthroplasty (CDA), to review the related literature, and to propose a new measure to prevent it. Methods:The course of a patient with SF is described here. The potential causes, risk factors, and preventive measure of SF after CDA publ...
journal_title:Journal of pain research
pub_type:
doi:10.2147/JPR.S242646
更新日期:2020-04-21 00:00:00
abstract:Introduction:Cannabidiol (CBD) is reported to produce pain relief, but the clinically relevant cellular and molecular mechanisms remain uncertain. The TRPV1 receptor integrates noxious stimuli and plays a key role in pain signaling. Hence, we conducted in vitro studies, to elucidate the efficacy and mechanisms of CBD f...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S258433
更新日期:2020-09-11 00:00:00
abstract:Background:Pain is a common and undertreated non-motor symptom in patients with Parkinson's disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions. Objective:We aimed to assess efficacy and tolerability of tapentadol in PD patients. Methods:We retrospectively reviewe...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S164939
更新日期:2018-09-13 00:00:00
abstract:Background:Despite the increasing prevalence of opioid use disorder (OUD) in pregnant women, there are limited studies on their anesthesia care and analgesic outcomes after cesarean delivery (CD). Methods:Patients with OUD on either buprenorphine or methadone maintenance therapy who underwent CD at our institution fro...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S284874
更新日期:2020-12-30 00:00:00
abstract:Background:To date, there has been no study on the effects of interleukin-10 (IL-10) on complex regional pain syndrome (CRPS) rodent models, despite the anti-allodynic effect of IL-10 in previous studies. Thus, the aim of this study was to investigate the effect of IL-10 in a CRPS mouse model and find whether early inh...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S166624
更新日期:2018-09-04 00:00:00
abstract:Purpose:Although the use of opioids is increasing in South Korea, there have been no studies on the serious complications caused by the opioids. The aim of this study was to investigate the rare but serious complications through medicolegal analysis. Materials and Methods:From January 1994 to December 2019, we retrosp...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S256759
更新日期:2020-06-25 00:00:00
abstract:OBJECTIVES:To determine whether X-ray, computed tomography (CT), bone scan, and clinical impression accurately reflect the level of vertebral fracture in patients about to undergo vertebroplasty. DESIGN:Retrospective observational study, utilizing patient inpatient notes, referral correspondence, and clinicians' priva...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S32151
更新日期:2013-05-10 00:00:00
abstract:Introduction:Sickle cell disease (SCD) is an inherited blood disorder characterized by abnormally shaped sickle cells. The hallmark of this disease is intermittent, painful vaso-occlusive episodes (VOE), but a subset of individuals with SCD experience chronic pain. The mechanism of transition to chronic pain is not wel...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S150066
更新日期:2018-02-23 00:00:00
abstract:Background:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis patients often present with psychiatric symptoms, cognitive dysfunction, epilepsy and memory deficits. A previous study has suggested that headache can occurr during the early stages of anti-NMDAR encephalitis. However, the exact association between hea...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S189301
更新日期:2019-01-30 00:00:00
abstract:Background:The prevalence of neuropathic pain (NeP) has been estimated within specific health conditions; however, there are no published data on its broad prevalence in the US. The current exploratory study addresses this gap using the validated PainDetect questionnaire as a screener for probable NeP in a general-popu...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S127014
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Despite growing interest in the therapeutic use of cannabis to manage chronic pain, only limited data that address these issues are available. In recent years, a number of nations have introduced specific laws to allow patients to use cannabis preparations to treat a variety of medical conditions. In 2015, t...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S132814
更新日期:2017-05-22 00:00:00
abstract:BACKGROUND:No proof of efficacy, in the form of a randomized controlled trial (RCT), exists to support pulsed radiofrequency (PRF) treatment of the dorsal root ganglion (DRG) for chronic lumbar radicular (CLR) pain. We determined the feasibility of a larger trial (primary objective), and also explored the efficacy of P...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S55749
更新日期:2014-01-10 00:00:00
abstract:Background:Suspecting carpal tunnel syndrome (CTS) in patients with hand pain is usual. Considering the variable rate of false-negative results in nerve conduction study (NCS), as a frequent reference confirmatory standard test, we aimed to evaluate the diagnostic accuracy of neuromuscular ultrasound in patients with c...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S164004
更新日期:2018-07-10 00:00:00
abstract:BACKGROUND:Waiting list management at chronic pain clinics has become a serious problem throughout Canada. We analyzed the waiting list at the Centre hospitalier de l'Université de Montréal (CHUM) Pain Centre. METHODS:The present study is an observational, prospective study. We used a specifically designed survey ques...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S46118
更新日期:2013-07-08 00:00:00
abstract:PURPOSE:The treatment of central neuropathic pain remains amongst the biggest challenges for pain specialists. The main objective of this study was to assess gabapentin (GBP), amitriptyline (AMI), and carbamazepine (CARBA) for the treatment of a rodent central neuropathic pain model. METHODS:Male Sprague Dawley rats w...
journal_title:Journal of pain research
pub_type: 杂志文章
doi:10.2147/JPR.S55201
更新日期:2013-12-17 00:00:00