Comorbidity index in central cancer registries: the value of hospital discharge data.

Abstract:

Background:The presence of comorbid medical conditions can significantly affect a cancer patient's treatment options, quality of life, and survival. However, these important data are often lacking from population-based cancer registries. Leveraging routine linkage to hospital discharge data, a comorbidity score was calculated for patients in the California Cancer Registry (CCR) database. Methods:California cancer cases diagnosed between 1991 and 2013 were linked to statewide hospital discharge data. A Deyo and Romano adapted Charlson Comorbidity Index was calculated for each case, and the association of comorbidity score with overall survival was assessed with Kaplan-Meier curves and Cox proportional hazards models. Using a subset of Medicare-enrolled CCR cases, the index was validated against a comorbidity score derived using Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data. Results:A comorbidity score was calculated for 71% of CCR cases. The majority (60.2%) had no relevant comorbidities. Increasing comorbidity score was associated with poorer overall survival. In a multivariable model, high comorbidity conferred twice the risk of death compared to no comorbidity (hazard ratio 2.33, 95% CI: 2.32-2.34). In the subset of patients with a SEER-Medicare-derived score, the sensitivity of the hospital discharge-based index for detecting any comorbidity was 76.5. The association between overall mortality and comorbidity score was stronger for the hospital discharge-based score than for the SEER-Medicare-derived index, and the predictive ability of the hospital discharge-based score, as measured by Harrell's C index, was also slightly better for the hospital discharge-based score (C index 0.62 versus 0.59, P<0.001). Conclusions:Despite some limitations, using hospital discharge data to construct a comorbidity index for cancer registries is a feasible and valid method to enhance registry data, which can provide important clinically relevant information for population-based cancer outcomes research.

journal_name

Clin Epidemiol

journal_title

Clinical epidemiology

authors

Lichtensztajn DY,Giddings BM,Morris CR,Parikh-Patel A,Kizer KW

doi

10.2147/CLEP.S146395

subject

Has Abstract

pub_date

2017-11-20 00:00:00

pages

601-609

issn

1179-1349

pii

clep-9-601

journal_volume

9

pub_type

杂志文章
  • The impact of moderate wine consumption on the risk of developing prostate cancer.

    abstract:Objective:To investigate the impact of moderate wine consumption on the risk of prostate cancer (PCa). We focused on the differential effect of moderate consumption of red versus white wine. Design:This study was a meta-analysis that includes data from case-control and cohort studies. Materials and methods:A systemat...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章,评审

    doi:10.2147/CLEP.S163668

    authors: Vartolomei MD,Kimura S,Ferro M,Foerster B,Abufaraj M,Briganti A,Karakiewicz PI,Shariat SF

    更新日期:2018-04-17 00:00:00

  • Potential misinterpretations caused by collapsing upper categories of comorbidity indices: An illustration from a cohort of older breast cancer survivors.

    abstract:BACKGROUND:Comorbidity indices summarize complex medical histories into concise ordinal scales, facilitating stratification and regression in epidemiologic analyses. Low subject prevalence in the highest strata of a comorbidity index often prompts combination of upper categories into a single stratum ('collapsing'). O...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/clep.s5757

    authors: Ahern TP,Bosco JL,Silliman RA,Yood MU,Field TS,Wei F,Lash TL

    更新日期:2009-08-09 00:00:00

  • Validity of First-Time Diagnoses of Inherited Ichthyosis in the Danish National Patient Registry and the Danish Pathology Registry.

    abstract:Purpose:Inherited ichthyosis is a monogenetic disease characterized by hyperkeratosis and scaling of the skin, with large interindividual variation in severity. It can affect quality of life for patients and their families. Population-based data on inherited ichthyosis are lacking, which hampers studies into its epidem...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S232956

    authors: Kristensen MH,Schmidt SAJ,Kibsgaard L,Hove H,Sommerlund M,Koppelhus U

    更新日期:2020-06-19 00:00:00

  • Maternal and infant characteristics: differences and similarities between the Nordic countries and the US.

    abstract:BACKGROUND:Data from the Nordic health care registers have been of great value in perinatal epidemiological research. It has been assumed that findings from the Nordic population (Denmark, Finland, Iceland, Norway, and Sweden) are applicable to other populations as well, including the population of the US. OBJECTIVE:T...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S106126

    authors: Löfling L,Bröms G,Bahmanyar S,Kieler H

    更新日期:2016-08-03 00:00:00

  • Association between Global Assessment of Functioning scores and indicators of functioning, severity, and prognosis in first-time schizophrenia.

    abstract:BACKGROUND:Assessment of psychosocial functioning in people with schizophrenia is important. The Global Assessment of Functioning (GAF-F) scale represents a widely applied, easy, and quick tool, but its validity and reliability have been debated. The aim was to investigate whether GAF-F scores are associated with other...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S109036

    authors: Köhler O,Horsdal HT,Baandrup L,Mors O,Gasse C

    更新日期:2016-09-02 00:00:00

  • The Validity of Intracerebral Hemorrhage Diagnoses in the Danish Patient Registry and the Danish Stroke Registry.

    abstract:Purpose:To establish the validity of intracerebral hemorrhage (ICH) diagnoses in the Danish Stroke Registry (DSR) and the Danish National Patient Registry (DNPR). Patients and Methods:Based on discharge summaries and brain imaging reports, we estimated the positive predictive value (PPV) of a first-ever diagnosis code...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S267583

    authors: Hald SM,Kring Sloth C,Agger M,Schelde-Olesen MT,Højholt M,Hasle M,Bogetofte H,Olesrud I,Binzer S,Madsen C,Krone W,García Rodríguez LA,Al-Shahi Salman R,Hallas J,Gaist D

    更新日期:2020-12-01 00:00:00

  • The Danish National Prescription Registry in studies of a biological pharmaceutical: palivizumab - validation against two external data sources.

    abstract:BACKGROUND:National prescription databases are important tools in pharmacoepidemiological studies investigating potential long-term adverse events after drug use. Palivizumab is a biological pharmaceutical used as passive prophylaxis against severe infection with respiratory syncytial virus in high-risk children. OBJE...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S73355

    authors: Haerskjold A,Henriksen L,Way S,Malham M,Hallas J,Pedersen L,Stensballe LG

    更新日期:2015-05-08 00:00:00

  • Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on "real-world" data: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.

    abstract:Purpose:This paper aims to compare the clinical effectiveness of oral anti-osteoporosis drugs based on the observed risk of fracture while on treatment in primary care actual practice. Materials and methods:We investigated two primary care records databases covering UK National Health Service (Clinical Practice Resear...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S164112

    authors: Khalid S,Calderon-Larrañaga S,Hawley S,Ali MS,Judge A,Arden N,van Staa T,Cooper C,Javaid MK,Prieto-Alhambra D

    更新日期:2018-10-09 00:00:00

  • Rural and urban disparities in the care of Canadian patients with inflammatory bowel disease: a population-based study.

    abstract:Background and aims:Canada's large geographic area and low population density pose challenges in access to specialized health care for remote and rural residents. We compared health services use, surgical rate, and specialist gastroenterologist care in rural and urban inflammatory bowel disease (IBD) patients in Canada...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S178056

    authors: Benchimol EI,Kuenzig ME,Bernstein CN,Nguyen GC,Guttmann A,Jones JL,Potter BK,Targownik LE,Catley CA,Nugent ZJ,Tanyingoh D,Mojaverian N,Underwood FE,Siddiq S,Otley AR,Bitton A,Carroll MW,deBruyn JC,Dummer TJ,El-Matar

    更新日期:2018-11-08 00:00:00

  • The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors.

    abstract::The management of brain-dead organ donors is complex. The use of inotropic agents and replacement of depleted hormones (hormonal replacement therapy) is crucial for successful multiple organ procurement, yet the optimal hormonal replacement has not been identified, and the statistical adjustment to determine the best ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S71403

    authors: Mi Z,Novitzky D,Collins JF,Cooper DK

    更新日期:2014-12-22 00:00:00

  • Fetal Programming of Semen Quality (FEPOS) Cohort - A DNBC Male-Offspring Cohort.

    abstract:Background:Prenatal exposures may contribute to male infertility in adult life, but large-scale epidemiological evidence is still lacking. The Fetal Programming of Semen quality (FEPOS) cohort was founded to provide means to examine if fetal exposures can interfere with fetal reproductive development and ultimately lea...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S242631

    authors: Keglberg Hærvig K,Bonde JP,Ramlau-Hansen CH,Toft G,Hougaard KS,Specht IO,Giwercman A,Nybo Andersen AM,Olsen J,Lindh C,Bjerre Høyer B,Tøttenborg SS

    更新日期:2020-07-17 00:00:00

  • Survival of invasive bladder cancer patients, 1998-2009; a central and northern Denmark population-based cohort study.

    abstract:OBJECTIVE:Invasive bladder cancer (IBC) is a common urological malignancy accounting for 4%-5% of all cancers in Denmark. Our aim was to examine possible changes in short- and long-term survival of patients with IBC during 1998-2009. STUDY DESIGN AND SETTING:Data on all patients (N = 4032) with an incident diagnosis o...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S20615

    authors: Lund L,Erichsen R,Nørgaard M,Larsen EH,Borre M,Jacobsen J

    更新日期:2011-01-01 00:00:00

  • Chronic diseases in the children of women with maternal thyroid dysfunction: a nationwide cohort study.

    abstract:Objective:Maternal thyroid disease (TD) during pregnancy is associated with adverse birth outcomes, but little is known on its long-term outcomes. We aimed to examine if children born to mothers with TD have increased disease risk during childhood and adolescence. Patients and methods:A register-based cohort study was...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S167128

    authors: Jølving LR,Nielsen J,Kesmodel US,Nielsen RG,Nørgård BM,Beck-Nielsen SS

    更新日期:2018-09-28 00:00:00

  • Physical Activity as an Effect Modifier of the Association Between Obesity and Venous Thromboembolism: A Danish Population-Based Cohort Study.

    abstract:Purpose:Obesity is an established risk factor for venous thromboembolism (VTE), while studies on physical inactivity and VTE risk show conflicting results. We examined whether physical activity modified the association between obesity and VTE. Patients and Methods:We conducted a population-based cohort study by combin...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S275079

    authors: Solli H,Olsen M,Larsen FB,Pedersen L,Schmidt M

    更新日期:2020-12-08 00:00:00

  • Emergent trends in the reported incidence of prostate cancer in Nigeria.

    abstract:BACKGROUND:To date there has not been any nationwide age-standardized incidence data reported for prostate cancer in Nigeria. We examined and integrated diverse trends in the age-specific incidence of prostate cancer into a comprehensive trend for Nigeria, and examined how best the existing data could generate a countr...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S23536

    authors: Ifere GO,Abebe F,Ananaba GA

    更新日期:2012-01-01 00:00:00

  • The database of the Danish Renal Cancer Group.

    abstract:AIM OF THE DATABASE:The main purpose of the database of the Danish Renal Cancer Group (DaRenCaData) is to improve the quality of renal cancer treatment in Denmark and secondarily to conduct observational research. STUDY POPULATION:DaRenCaData includes all Danish patients with a first-time diagnosis of renal cancer in ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章,评审

    doi:10.2147/CLEP.S106042

    authors: Petersen AC,Søgaard M,Mehnert F,Larsen EH,Donskov F,Azawi NH,Kromann-Andersen B

    更新日期:2016-10-25 00:00:00

  • Existing data sources for clinical epidemiology: The Danish National Database of Reimbursed Prescriptions.

    abstract::The Danish health care system provides partial reimbursement of most prescription medications in Denmark. The dispensation of prescription medications is registered in administrative databases. Each time a prescription is redeemed at a pharmacy, an electronic record is generated with information related to the user, p...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S37587

    authors: Johannesdottir SA,Horváth-Puhó E,Ehrenstein V,Schmidt M,Pedersen L,Sørensen HT

    更新日期:2012-01-01 00:00:00

  • The trends and projections in the incidence and mortality of liver cancer in urban Shanghai: a population-based study from 1973 to 2020.

    abstract:Background:In 2012, liver cancer ranked as the fifth and eighth most common cancer in men and women, respectively, in urban Shanghai. This study aims to present the trend and projection of age-specific incidence and mortality of liver cancer in Shanghai. Methods:We extracted data of liver cancer incident cases and dea...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S153951

    authors: Bai L,Liu Z,Fang Q,Yan Q,Shi O,Bao P,Mu L,Chen X,Zhang T

    更新日期:2018-03-09 00:00:00

  • A nationwide population-based cross-sectional survey of health-related quality of life in patients with myeloproliferative neoplasms in Denmark (MPNhealthSurvey): survey design and characteristics of respondents and nonrespondents.

    abstract:OBJECTIVE:The Department of Hematology, Zealand University Hospital, Denmark, and the National Institute of Public Health, University of Southern Denmark, created the first nationwide, population-based, and the most comprehensive cross-sectional health-related quality of life (HRQoL) survey of patients with myeloprolif...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S117587

    authors: Brochmann N,Flachs EM,Christensen AI,Andersen CL,Juel K,Hasselbalch HC,Zwisler AD

    更新日期:2017-03-02 00:00:00

  • Under-recording of hospital bleeding events in UK primary care: a linked Clinical Practice Research Datalink and Hospital Episode Statistics study.

    abstract:Background:Primary care databases represent a rich source of data for health care research; however, the quality of recording of secondary care events in these databases is uncertain. This study sought to investigate the completeness of recording of hospital admissions for bleeds in primary care records and explore the...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S170304

    authors: McDonald L,Sammon CJ,Samnaliev M,Ramagopalan S

    更新日期:2018-09-04 00:00:00

  • Reliability of recurrent pregnancy loss diagnosis coding in the Swedish National Patient Register: a validation study.

    abstract::Background: The Swedish National Patient Registry (NPR) is a nationwide registry that is used extensively for epidemiological research. Using the NPR, we recently found a recurrent pregnancy loss (RPL) incidence of 650/100,000 (0.65%) pregnant women in Sweden. It is of great importance that the quality of the coding i...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S199206

    authors: Rasmark Roepke E,Christiansen OB,Hansson SR

    更新日期:2019-05-08 00:00:00

  • The RECORD reporting guidelines: meeting the methodological and ethical demands of transparency in research using routinely-collected health data.

    abstract::Routinely-collected health data (RCD) are now used for a wide range of studies, including observational studies, comparative effectiveness research, diagnostics, studies of adverse effects, and predictive analytics. At the same time, limitations inherent in using data collected without specific a priori research quest...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S110528

    authors: Nicholls SG,Langan SM,Sørensen HT,Petersen I,Benchimol EI

    更新日期:2016-10-19 00:00:00

  • Labor augmentation during birth and later cognitive ability in young adulthood.

    abstract:Purpose:Synthetic oxytocin for labor augmentation during birth has been linked to negative neurodevelopment effects in children. We examined whether maternal labor augmentation was associated with lower cognitive ability in young adulthoods. Patients and methods:We identified 330,107 individuals (96.6% were men), with...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S181012

    authors: Stokholm L,Talge NM,Christensen GT,Juhl M,Mortensen LH,Strandberg-Larsen K

    更新日期:2018-11-26 00:00:00

  • HPV self-sampling in cervical cancer screening: the effect of different invitation strategies in various socioeconomic groups - a randomized controlled trial.

    abstract:Background:Participation in cervical cancer screening varies by socioeconomic status. The aims were to assess if offering human papilloma virus (HPV) self-sampling kits has an effect on screening participation among various socioeconomic groups and to determine if two invitation strategies for offering self-sampling in...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S164826

    authors: Tranberg M,Bech BH,Blaakær J,Jensen JS,Svanholm H,Andersen B

    更新日期:2018-08-23 00:00:00

  • Validity of the recorded codes of gonadotropin-releasing hormone agonist treatment and orchiectomies in the Danish National Patient Registry.

    abstract:PURPOSE:Large-scale observational studies based on existing medical databases may have an important role in studies of long-term effects of different treatments in prostate cancer patients if the coding of the treatment is valid. We therefore estimated the positive predictive value (PPV) and negative predictive value (...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S32313

    authors: Jespersen CG,Borre M,Nørgaard M

    更新日期:2012-01-01 00:00:00

  • Automated data-adaptive analytics for electronic healthcare data to study causal treatment effects.

    abstract:Background:Decision makers in health care increasingly rely on nonrandomized database analyses to assess the effectiveness, safety, and value of medical products. Health care data scientists use data-adaptive approaches that automatically optimize confounding control to study causal treatment effects. This article summ...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章,评审

    doi:10.2147/CLEP.S166545

    authors: Schneeweiss S

    更新日期:2018-07-06 00:00:00

  • SpineData - a Danish clinical registry of people with chronic back pain.

    abstract:BACKGROUND:Large-scale clinical registries are increasingly recognized as important resources for quality assurance and research to inform clinical decision-making and health policy. We established a clinical registry (SpineData) in a conservative care setting where more than 10,000 new cases of spinal pain are assesse...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S83830

    authors: Kent P,Kongsted A,Jensen TS,Albert HB,Schiøttz-Christensen B,Manniche C

    更新日期:2015-08-13 00:00:00

  • Risk of Anemia in Patients with Newly Identified Chronic Kidney Disease - A Population-Based Cohort Study.

    abstract:Purpose:Anemia is prevalent in patients with chronic kidney disease (CKD), but the longitudinal risk of anemia in patients with newly identified CKD is unknown. We therefore examined the risks of experiencing anemia in persons with newly identified CKD. Patients and Methods:This cohort study included adult patients wi...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S259648

    authors: Vestergaard SV,Heide-Jørgensen U,van Haalen H,James G,Hedman K,Birn H,Thomsen RW,Christiansen CF

    更新日期:2020-09-11 00:00:00

  • Lifestyle factors among proton pump inhibitor users and nonusers: a cross-sectional study in a population-based setting.

    abstract:PURPOSE:Lifestyle factors may influence observed associations between proton pump inhibitor (PPI) usage and health outcomes. The aim of the study reported here was to examine characteristics and differences in lifestyle among PPI users and nonusers. METHODS:This cross-sectional study utilized data from a 2006 populati...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S49354

    authors: Hvid-Jensen F,Nielsen RB,Pedersen L,Funch-Jensen P,Drewes AM,Larsen FB,Thomsen RW

    更新日期:2013-12-04 00:00:00

  • Age-specific cancer survival in Estonia: recent trends and data quality.

    abstract:BACKGROUND:A number of population-based studies have demonstrated lower cancer survival in elderly patients than among middle-aged or younger patients. Also, data quality in cancer registries has been shown to be associated with age. The objective of this study was to examine the recent age-specific cancer survival tre...

    journal_title:Clinical epidemiology

    pub_type: 杂志文章

    doi:10.2147/CLEP.S87699

    authors: Innos K,Lang K,Pärna K,Aareleid T

    更新日期:2015-07-29 00:00:00