Abstract:
Purpose:Anemia is prevalent in patients with chronic kidney disease (CKD), but the longitudinal risk of anemia in patients with newly identified CKD is unknown. We therefore examined the risks of experiencing anemia in persons with newly identified CKD. Patients and Methods:This cohort study included adult patients with newly identified CKD stages 3-5 defined by an estimated glomerular filtration rate (eGFR) level <60 mL/min/1.73m2 (at least two measurements ≥90 days apart) ascertained from a population-based registry with complete laboratory test results in Northern Denmark (population ~2.2 million) during 2009-2016. We calculated 1) cumulative incidence (risk) of anemia [hemoglobin <12/<13 g/dl in women/men] by CKD stage, and 2) adjusted hazard ratios (HRs) of anemia using Cox regression analyses. Results:We identified 55,940 distinct individuals with newly identified CKD stages 3-5 and no prevalent anemia [n=41,958 patients in stage 3a, n=17,875 in stage 3b, n=5182 in stage 4, and n=931 in stage 5]. After one year, 42.3% (95%-confidence interval [CI]: 41.9-42.7) of patients with CKD stages 3-5 had newly measured anemia, increasing to 67.7% (95%-CI: 67.2-68.2) after five years. The absolute and relative anemia risk increased markedly with higher CKD stages. The adjusted HR of any anemia was 5.42 (95%-CI: 5.09-5.77) in patients with CKD stage 5 compared to patients with CKD stage 3a. Conclusion:Patients with newly identified CKD stages 3-5 have a substantial risk of anemia, increasing with higher CKD stages. This study underlines that clinical awareness of anemia risk is important in patients with newly identified or progressed CKD.
journal_name
Clin Epidemioljournal_title
Clinical epidemiologyauthors
Vestergaard SV,Heide-Jørgensen U,van Haalen H,James G,Hedman K,Birn H,Thomsen RW,Christiansen CFdoi
10.2147/CLEP.S259648subject
Has Abstractpub_date
2020-09-11 00:00:00pages
953-962issn
1179-1349pii
259648journal_volume
12pub_type
杂志文章abstract:BACKGROUND:A number of studies have shown poorer survival among cancer patients with comorbidity. Several mechanisms may underlie this finding. In this review we summarize the current literature on the association between patient comorbidity and cancer prognosis. Prognostic factors examined include tumor biology, diagn...
journal_title:Clinical epidemiology
pub_type: 杂志文章,评审
doi:10.2147/CLEP.S47150
更新日期:2013-11-01 00:00:00
abstract:Background and aims:Canada's large geographic area and low population density pose challenges in access to specialized health care for remote and rural residents. We compared health services use, surgical rate, and specialist gastroenterologist care in rural and urban inflammatory bowel disease (IBD) patients in Canada...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S178056
更新日期:2018-11-08 00:00:00
abstract:Purpose:Inherited ichthyosis is a monogenetic disease characterized by hyperkeratosis and scaling of the skin, with large interindividual variation in severity. It can affect quality of life for patients and their families. Population-based data on inherited ichthyosis are lacking, which hampers studies into its epidem...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S232956
更新日期:2020-06-19 00:00:00
abstract:AIM OF THE DATABASE:The main purpose of the database of the Danish Renal Cancer Group (DaRenCaData) is to improve the quality of renal cancer treatment in Denmark and secondarily to conduct observational research. STUDY POPULATION:DaRenCaData includes all Danish patients with a first-time diagnosis of renal cancer in ...
journal_title:Clinical epidemiology
pub_type: 杂志文章,评审
doi:10.2147/CLEP.S106042
更新日期:2016-10-25 00:00:00
abstract:Background:Previous studies have shown a link between increased dietary intake of arachidonic acid (ARA) and colorectal neoplasms. It has been shown that erythrocyte phospholipid membrane concentrations of ARA are strongly determined by genetic variation. Fatty acid desaturase (FADS) controls the rate limiting step in ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S186883
更新日期:2018-12-18 00:00:00
abstract:Purpose:To identify the characteristics and initial disease severity of patients with nonalcoholic fatty liver disease (NAFLD) and assess incidence and risk factors for disease progression in a retrospective study. Methods:Patients ≥18 years of age without alcoholism or other liver diseases (eg, hepatitis B/C) were se...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S144368
更新日期:2017-12-14 00:00:00
abstract:Purpose:To develop a self-administered diagnostic screening questionnaire for lumbar spinal stenosis (LSS) consisting of items with high content validity and to investigate the diagnostic value of the questionnaire and the items. Patients and Methods:A self-reported diagnostic LSS screening questionnaire was developed...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S263646
更新日期:2020-08-19 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) remains one of the most important causes of nosocomial infections worldwide. Since the global spread of MRSA in the 1960s, MRSA strains have evolved with increased pathogenic potential. Notably, some strains are now capable of causing persistent infections not only in...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S37071
更新日期:2013-07-04 00:00:00
abstract:BACKGROUND:Physical activity (PA) and its relationship with all-cause mortality suggest a strong and consistent inverse association. This study prospectively investigated the association between PA level and mortality among participants of the Norwegian Women and Cancer (NOWAC) Study. METHODS:A total of 66,136 NOWAC p...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S22681
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Data on the safety of selective serotonin-reuptake inhibitors (SSRIs) in pregnancy are inconsistent. We examined associations between SSRI use during early pregnancy and risk of congenital malformations in infants. METHODS:Set in Northern Denmark, our population-based prevalence study included 216,042 women...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/clep.s9256
更新日期:2010-08-09 00:00:00
abstract:Background:Cost-effective primary prevention of cardiovascular disease (CVD) relies on accuracy of risk assessment. Current risk scores require clinical and laboratory measures, are expensive and are often difficult to apply in the population setting. Objective:This study sought to estimate CVD risk from individuals' ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S219708
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:The study objective was to compare the Newcastle-Ottawa Scale (NOS) and the RTI item bank (RTI-IB) and estimate interrater agreement using the RTI-IB within a systematic review on the cardiovascular safety of glucose-lowering drugs. METHODS:We tailored both tools and added four questions to the RTI-IB. Two ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S66677
更新日期:2014-10-10 00:00:00
abstract:Background:Congenital red blood cell (RBC) disorders, such as hemoglobinopathies, are frequent worldwide but with large geographical variation. Growing migration has increased the number of patients with RBC disorders in formerly low prevalence countries, eg, Denmark. However, accurate prevalences are unknown. Methods...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S250251
更新日期:2020-05-21 00:00:00
abstract:BACKGROUND:Long-term mortality and causes of death in patients with pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) are poorly documented. In this study, long-term mortality and causes of death in PTB and EPTB patients were compared with the background population and it was investigated whether mort...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S65331
更新日期:2014-11-13 00:00:00
abstract:Purpose:Sharing of detailed individual-level data continues to pose challenges in multi-center studies. This issue can be addressed in part by using analytic methods that require only summary-level information to perform the desired multivariable-adjusted analysis. We examined the feasibility and empirical validity of ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S178163
更新日期:2018-11-27 00:00:00
abstract:BACKGROUND:Validation of definitions used to identify conditions of interest is imperative to epidemiologic studies based on routinely collected data. The objective of the study was thus to estimate positive predictive values (PPVs) of International Classification of Diseases, 10th Revision (ICD-10) codes to identify c...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S139895
更新日期:2017-08-17 00:00:00
abstract:Objective:To evaluate the long-term risk of stroke and poststroke adverse outcomes in patients with heart failure (HF). Methods:We used research data from Taiwan's National Health Insurance Program from 2000 to 2005 and identified 20,072 adults aged ≥30 years who were newly diagnosed with HF. Frequency matching based ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S261179
更新日期:2020-11-05 00:00:00
abstract:Purpose:Apolipoproteins C-I, C-II, C-III and E have been associated with risk of arterial thrombotic diseases. We investigated whether these apolipoproteins have prothrombotic properties and are associated with risk of venous thromboembolism (VTE). Patients and methods:A total of 127 VTE patients and 299 controls were...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S196266
更新日期:2019-07-22 00:00:00
abstract:OBJECTIVES:Translational epidemiology studies often use archived tumor specimens to evaluate genetic hypotheses involving cancer outcomes. When the exposure of interest is a germline polymorphism, a key concern is whether the genotype assayed from tumor-derived DNA is representative of the germline. We evaluated the co...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S13811
更新日期:2010-10-22 00:00:00
abstract:BACKGROUND:The Danish National Registry of Patients (DNRP) is a potentially valuable resource for monitoring national trends in the use of chemotherapy and evaluating the benefits and harms of alternative treatments among colorectal cancer (CRC) patients in Denmark. However, the validity of chemotherapy reporting in th...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S49773
更新日期:2013-08-30 00:00:00
abstract:BACKGROUND:Although hypertrophic scar (HTS) formation following cleft lip repair is relatively common, published rates vary widely, from 1% to nearly 50%. The risk factors associated with HTS formation in cleft patients are not well characterized. The primary aim of this retrospective study of 180 cleft lip repairs is ...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S31119
更新日期:2012-01-01 00:00:00
abstract:Aim:To improve consistency between register studies in Sweden and ensure valid comparisons of possible changes in alcohol-related disorders and diseases (ARDDs) over time, we propose a definition of ARDDs. Based on this definition, we examined Sweden's incidence rates of ARDDs from 1970 to 2018 in non-primary healthcar...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S285936
更新日期:2020-12-31 00:00:00
abstract:BACKGROUND:A number of population-based studies have demonstrated lower cancer survival in elderly patients than among middle-aged or younger patients. Also, data quality in cancer registries has been shown to be associated with age. The objective of this study was to examine the recent age-specific cancer survival tre...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S87699
更新日期:2015-07-29 00:00:00
abstract:Purpose:Obesity is an established risk factor for venous thromboembolism (VTE), while studies on physical inactivity and VTE risk show conflicting results. We examined whether physical activity modified the association between obesity and VTE. Patients and Methods:We conducted a population-based cohort study by combin...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S275079
更新日期:2020-12-08 00:00:00
abstract:PURPOSE:Lifestyle factors may influence observed associations between proton pump inhibitor (PPI) usage and health outcomes. The aim of the study reported here was to examine characteristics and differences in lifestyle among PPI users and nonusers. METHODS:This cross-sectional study utilized data from a 2006 populati...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S49354
更新日期:2013-12-04 00:00:00
abstract:BACKGROUND:National prescription databases are important tools in pharmacoepidemiological studies investigating potential long-term adverse events after drug use. Palivizumab is a biological pharmaceutical used as passive prophylaxis against severe infection with respiratory syncytial virus in high-risk children. OBJE...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S73355
更新日期:2015-05-08 00:00:00
abstract:INTRODUCTION:Smoking is a main risk factor for morbidity and mortality in people living with human immunodeficiency virus (PLHIV), but its potential association with renal impairment remains to be established. METHODS:We did a nationwide population-based cohort study in Danish PLHIV to evaluate the association between...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S83530
更新日期:2015-08-28 00:00:00
abstract:BACKGROUND:Case-control studies are a common and efficient means of studying rare diseases or illnesses with long latency periods. Matching of cases and controls is frequently employed to control the effects of known potential confounding variables. The analysis of matched data requires specific statistical methods. M...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S30816
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:To date there has not been any nationwide age-standardized incidence data reported for prostate cancer in Nigeria. We examined and integrated diverse trends in the age-specific incidence of prostate cancer into a comprehensive trend for Nigeria, and examined how best the existing data could generate a countr...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S23536
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Data from the Nordic health care registers have been of great value in perinatal epidemiological research. It has been assumed that findings from the Nordic population (Denmark, Finland, Iceland, Norway, and Sweden) are applicable to other populations as well, including the population of the US. OBJECTIVE:T...
journal_title:Clinical epidemiology
pub_type: 杂志文章
doi:10.2147/CLEP.S106126
更新日期:2016-08-03 00:00:00