Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor alpha deficient mice.

abstract：BACKGROUND:Adequate maternal nutrition during gestation is requisite for fetal nutrition and development. While a large group of epidemiological studies indicate poor fetal nutrition increases heart disease risk and mortality in later life, little work has focused on the effects of impaired maternal nutrition on fetal ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gilbert JS,Lang AL,Nijland MJ

更新日期：2005-07-14 00:00:00

abstract：BACKGROUND:In several species, considerably higher levels of estradiol-17 (E2) are synthesized in the CL. E2 has been suggested to participate in the regulation of luteal steroidogenesis and luteal cell morphology. In pregnant rats, several experiments have been carried out to examine the effects of inhibition of lutea...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Tripathy S,Asaithambi K,Jayaram P,Medhamurthy R

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Wolfram Syndrome (WS) is an autosomal recessive disorder characterised by non-autoimmune diabetes mellitus, optic atrophy, cranial diabetes insipidus and sensorineural deafness. Some reports have described hypogonadism in male WS patients. The aim of our study was to find out whether Wfs1 deficient (Wfs1KO) ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Noormets K,Kõks S,Kavak A,Arend A,Aunapuu M,Keldrimaa A,Vasar E,Tillmann V

更新日期：2009-08-10 00:00:00

abstract：BACKGROUND:TGF-beta is a multifunctional growth factor involved in regulating a variety of cellular activities. Unlike mammals, the function of TGF-beta in the reproduction of lower vertebrates, such as fish, is not clear. Recently, we showed that TGF-beta1 inhibits gonadotropin- and 17alpha, 20beta-dihydroxyprogestero...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Kohli G,Clelland E,Peng C

更新日期：2005-09-30 00:00:00

abstract：BACKGROUND:The G protein-coupled estrogen receptor (GPER) is thought to be involved in non-genomic estrogen responses as well as processes such as cell proliferation and migration. In this study, we analyzed GPER expression patterns from endometriosis samples and normal endometrial tissue samples and compared these exp...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Samartzis N,Samartzis EP,Noske A,Fedier A,Dedes KJ,Caduff R,Fink D,Imesch P

更新日期：2012-04-20 00:00:00

abstract：:Trophoblast cells are unique because they are one of the few mammalian cell types that do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to IFN-gamma. The absence of MHC class II antigen expression on trophoblast cells has been postulated to be one of the ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Murphy SP,Choi JC,Holtz R

更新日期：2004-07-05 00:00:00

abstract：BACKGROUND:Recent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation. METHODS:To investigate serum IL-18 concentrations in PCOS patients and focus on its relationship between obesity and insulin re...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Yang Y,Qiao J,Li R,Li MZ

更新日期：2011-01-18 00:00:00

abstract：BACKGROUND:The syncytialization of cytotrophoblast cells to syncytiotrophoblast is central to human placental transport and hormone production. Many techniques for in vitro study of this process have been proposed and new investigators to the field may find the literature in the field daunting. Here, we present a strai...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Li L,Schust DJ

更新日期：2015-07-09 00:00:00

abstract：BACKGROUND:Morphometric and morphokinetic evaluation of in vitro cultured human embryos allows evaluation without time restriction and reduces intra- and inter-observer variability. Even though these technologies have been reported to improve the quality of cleavage stage embryo evaluation during fresh culture, possibl...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Fernandez Gallardo E,Spiessens C,D'Hooghe T,Debrock S

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:To assess the amount of variability in ovarian follicular growth rate and maximum follicular diameter related to different centers, women and cycles of the same women in a multicenter observational study of follicular growth. METHODS:Secondary analysis of a prospective cohort study from eight centers in Eur...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Mikolajczyk RT,Stanford JB,Ecochard R

更新日期：2008-12-10 00:00:00

abstract：BACKGROUND:Patients hoping to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hyperplasia (AEH) . Such treatment generally involves frequent intrauterine operations, including dilati...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Inoue O,Hamatani T,Susumu N,Yamagami W,Ogawa S,Takemoto T,Hirasawa A,Banno K,Kuji N,Tanaka M,Aoki D

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:There is limited literature investigating the effects of body mass index (BMI) and androgen level on in vitro fertilization (IVF) outcomes with a gonadotropin-releasing hormone (GnRH)-antagonist protocol in polycystic ovary syndrome (PCOS). Androgen-related variation in the effect of body mass index (BMI) on...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Yang W,Yang R,Lin M,Yang Y,Song X,Zhang J,Yang S,Song Y,Li J,Pang T,Deng F,Zhang H,Wang Y,Li R,Jiao J

更新日期：2018-11-19 00:00:00

abstract：:The endometrium undergoes cyclic remodelling throughout the menstrual cycle in preparation for embryo implantation which occurs in a short window during the mid-secretory phase. It is during this short 'receptive window' that the endometrial luminal epithelium acquires adhesive capacity permitting blastocysts firm adh...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Santos LL,Ling CK,Dimitriadis E

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:A decrease in HOXA11 expression in eutopic mid-secretory endometrium has been found in women with endometriosis-associated infertility. METHODS:Using Real-time quantitative PCR (RQ-PCR) and western blotting analysis we studied the HOXA11 transcript and protein levels in mid-luteal eutopic endometrium from e...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Szczepańska M,Wirstlein P,Skrzypczak J,Jagodziński PP

更新日期：2012-01-10 00:00:00

abstract：:Although Calbindin-D9k (CaBP-9k), a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this gene and its protein are not clearly understood. Uterine CaBP-9k may be involved in controlling myometrial activity rela...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Choi KC,Leung PC,Jeung EB

更新日期：2005-11-16 00:00:00

abstract：:Cloning by nuclear transfer using mammalian somatic cells has enormous potential application. However, somatic cloning has been inefficient in all species in which live clones have been produced. High abortion and fetal mortality rates are commonly observed. These developmental defects have been attributed to incomple...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Tian XC,Kubota C,Enright B,Yang X

更新日期：2003-11-13 00:00:00

abstract：:The present study evaluates the participation of the vagus nerve in pre-pubertal rats with unilateral ovariectomy on puberty onset, and on progesterone, testosterone and estradiol serum levels, and the compensatory responses of the ovary. Unilateral vagotomy did not modify the onset of puberty in unilaterally ovariect...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Morales L,Ricardo B,Bolaños A,Chavira R,Domínguez R

更新日期：2007-06-13 00:00:00

abstract：BACKGROUND:Pregnancy-associated plasma protein-A2 (PAPP-A2) is consistently upregulated in the placentae of pregnancies complicated by preeclampsia and fetal growth restriction. The causes and significance of this upregulation remain unknown, but it has been hypothesized that it is a compensatory response to improve pl...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Christians JK,Lennie KI,Huicochea Munoz MF,Binning N

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:To evaluate the relationship between endometrial thickness on day of human chorionic gonadotrophin administration (hCG) and pregnancy outcome in a large number of consecutive in vitro fertilization and embryo transfer (IVF-ET) cycles. METHODS:A retrospective cohort study including all patients who had IVF-E...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Al-Ghamdi A,Coskun S,Al-Hassan S,Al-Rejjal R,Awartani K

更新日期：2008-09-02 00:00:00

abstract：BACKGROUND:To evaluate the association between leukocytes (polymorphonuclear granulocytes -PMNL) and semen parameters at different leukocyte concentrations. METHODS:This was a retrospective clinical study at a university hospital andrology clinic. Semen samples from infertile men were analyzed for sperm morphology and...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lackner JE,Agarwal A,Mahfouz R,du Plessis SS,Schatzl G

更新日期：2010-02-05 00:00:00

abstract：BACKGROUND:Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadotropin in mammals. However, it...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Han X,He Y,Zeng G,Wang Y,Sun W,Liu J,Sun Y,Yu J

更新日期：2017-05-02 00:00:00

abstract：:A majority of common metabolic diseases can result in excessive lipolysis, leading to elevated levels of non-esterified fatty acids (NEFAs) in the body fluids. In females, increased NEFA levels in the follicular fluid markedly alter the functions of intrafollicular cells such as granulosa cells (GCs) and oocytes. Ther...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Baddela VS,Sharma A,Vanselow J

更新日期：2020-06-06 00:00:00

abstract：BACKGROUND:We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa. METHODS:Freshly ejaculated semen was collected from forty-eight normozoospermic human donors. We analyzed the expression of substance P, neurokinin A, neur...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Pinto FM,Ravina CG,Subiran N,Cejudo-Román A,Fernández-Sánchez M,Irazusta J,Garrido N,Candenas L

更新日期：2010-08-26 00:00:00

abstract：:Human spermatozoa generate low levels of reactive oxygen species in order to stimulate key events, such as tyrosine phosphorylation, associated with sperm capacitation. However, if the generation of these potentially pernicious oxygen metabolites becomes elevated for any reason, spermatozoa possess a limited capacity ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Baker MA,Aitken RJ

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:Endocannabinoids (ECs) are important contributors to implantation and decidualization and are suppressed in early pregnancy. Elevated levels of anandamide (AEA), the endogenous ligand for the CB1 and CB2 receptors (R), interfere with receptivity of the blastocyst. Ang-(1-7) is down-regulated in the implantat...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Brosnihan KB,Pulgar VM,Gallagher PE,Neves LA,Yamaleyeva LM

更新日期：2015-01-17 00:00:00

abstract：BACKGROUND:In-situ hybridisation studies demonstrate that Notch receptors and ligands are expressed in granulosa cells (GCs) and in the theca layer vasculature of growing follicles. Notch signaling involves cell-to-cell interaction mediated by transmembrane receptors and ligands. This signaling pathway may represent a ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Jovanovic VP,Sauer CM,Shawber CJ,Gomez R,Wang X,Sauer MV,Kitajewski J,Zimmermann RC

更新日期：2013-05-15 00:00:00

abstract：BACKGROUND:Human uterine leiomyoma (fibroids; LYO) are the most common benign neoplasms in reproductive-aged women. Dysregulated extracellular matrix and irregular LYO reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression are thought to be mediated by aberrant microRNA (miR) expression. The relat...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Guan Y,Guo L,Zukerberg L,Rueda BR,Styer AK

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Secreted protein of Ly-6 domain 1 (SOLD1), a secretory-type member of the Ly-6 superfamily, is expressed in both fetal and maternal tissues throughout gestation. SOLD1 mRNA is expressed in the endometrium and in trophoblast mononucleate and binucleate cells, suggesting it plays an important role not only in ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Awad M,Koshi K,Kizaki K,Takahashi T,Hashizume K

更新日期：2014-06-21 00:00:00

abstract：BACKGROUND:We demonstrated that E2 conjugated to BSA (E2BSA) induces a rapid membrane-initiated inhibition of LH secretion followed hours later by a slight increase in LH secretion. Whether these actions of E2BSA are restricted to the pituitary gland and whether the membrane-initiated pathway of E2BSA contributes to th...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Arreguin-Arevalo JA,Ashley RL,Wagenmaker ER,Oakley AE,Karsch FJ,Nett TM

更新日期：2010-05-10 00:00:00

abstract：BACKGROUND:The physiological state of the dominant follicle is important as it may be linked to the competence of the oocyte within. The objective of this study was to analyze, by transcriptomic analysis, the changes occurring in granulosa cells from dominant follicles at different phases of follicular growth. METHODS...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Girard A,Dufort I,Douville G,Sirard MA

更新日期：2015-03-08 00:00:00