Novel therapies for malignant gliomas: a local affair?

abstract：:There has been increasing awareness that glioblastoma, which may seem histopathologically similar across many tumors, actually represents a group of molecularly distinct tumors. Emerging evidence suggests that cells even within the same tumor exhibit wide-ranging molecular diversity. Parallel to the discoveries of mol...

journal_title：Neurosurgical focus

authors： Aum DJ,Kim DH,Beaumont TL,Leuthardt EC,Dunn GP,Kim AH

更新日期：2014-12-01 00:00:00

abstract：:Since its inception, one of the major issues in transsphenoidal surgery has been the adequate visualization of anatomical structures. As transsphenoidal surgery evolved, technical advancements improved the surgical view of the operative field and the orientation. The operating microscope replaced Cushing's headlight a...

journal_title：Neurosurgical focus

authors： Doglietto F,Prevedello DM,Jane JA Jr,Han J,Laws ER Jr

更新日期：2005-12-15 00:00:00

abstract：:Deep brain stimulation (DBS) is the treatment of choice for otherwise healthy patients with advanced Parkinson disease who are suffering from disabling dyskinesias and motor fluctuations related to dopaminergic therapy. As DBS is an elective procedure, it is essential to minimize the risk of morbidity. Further, precis...

journal_title：Neurosurgical focus

authors： Kramer DR,Halpern CH,Buonacore DL,McGill KR,Hurtig HI,Jaggi JL,Baltuch GH

更新日期：2010-08-01 00:00:00

abstract：OBJECT:Currently, reliable low-cost and noninvasive techniques to assess cerebral perfusion in the operating room are not available. The authors report on their first clinical experience with laser speckle contrast analysis (LASCA) as a complementary imaging tool for the noninvasive and dynamic assessment of cerebral b...

journal_title：Neurosurgical focus

authors： Hecht N,Woitzik J,Dreier JP,Vajkoczy P

更新日期：2009-10-01 00:00:00

abstract：OBJECT:In this report the authors review the role of bioinformatics in the design of a research project in which the molecular genetics of malignant glioma were studied. A project to characterize Pokemon expression in malignant glioma was developed, refined, and implemented using bioinformatics methods. METHODS:Using ...

journal_title：Neurosurgical focus

authors： Rovin RA,Winn R

更新日期：2005-10-15 00:00:00

abstract：:Deep brain stimulation (DBS) has a record of safety and efficacy for an expanding range of indications. Recently,the Food and Drug Administration provided approval through a Humanitarian Device Exemption for DBS of the globus pallidus internus and subthalamic nucleus for the treatment of dystonia. There is increasing ...

journal_title：Neurosurgical focus

authors： Montgomery EB Jr

更新日期：2004-07-15 00:00:00

abstract：:In the treatment of acoustic neuroma, operative results have improved greatly during recent years, with high rates of functional cranial nerve preservation. Because of this, it has become more important to consider issues of patient satisfaction and quality of life (QOL) following treatment for these lesions. The auth...

journal_title：Neurosurgical focus

authors： Schwartz MS,Riddle SA,Delashaw JB Jr,Horgan MA,Kellogg JX,McMenomey SO

更新日期：1998-09-15 00:00:00

abstract：:The authors present three cases of iatrogenic paracervical abscesses caused by infiltration therapy of pain medications used in conservative treatment in patients with chronic cervicobrachialgia. All three patients had received this therapy several times before presenting with clinical signs of a local infection. The ...

journal_title：Neurosurgical focus

authors： Schütze M,Piek J

更新日期：2004-12-15 00:00:00

abstract：:Brain arteriovenous malformations (BAVMs) are an important cause of intracerebral hemorrhage (ICH) in young adults. Biological predictors of future ICH risk are lacking, and controversy exists over previous studies of natural history risk among predominantly ruptured BAVM cohorts. Recent studies have suggested that th...

journal_title：Neurosurgical focus

authors： Achrol AS,Guzman R,Varga M,Adler JR,Steinberg GK,Chang SD

更新日期：2009-05-01 00:00:00

abstract：:The prepsoas retroperitoneal approach is a minimally invasive technique used for anterior lumbar interbody fusion. The approach may have a more favorable risk profile than the transpsoas approach, decreasing the risks that come with dissecting through the psoas muscle. However, the oblique angle of the spine in the pr...

journal_title：Neurosurgical focus

authors： DiGiorgio AM,Edwards CS,Virk MS,Mummaneni PV,Chou D

更新日期：2017-08-01 00:00:00

abstract：:OBJECTIVE The treatment of cervical spinal metastases represents a controversial issue regarding the type, extent, and invasiveness of interventions. In the lumbar and thoracic spine, kypho- and vertebroplasties have been established as minimally invasive procedures for patients with metastases to the vertebral bodies...

journal_title：Neurosurgical focus

authors： Stangenberg M,Viezens L,Eicker SO,Mohme M,Mende KC,Dreimann M

更新日期：2017-08-01 00:00:00

abstract：:Cerebral venous sinus thrombosis is sometimes fatal. The standard treatment for sinus thrombosis is anticoagulation, but endovascular intervention must be considered when medical treatment fails. Mechanical thrombectomy is usually required when a large clot burden exits. Unfortunately, in sinus thrombosis attributable...

journal_title：Neurosurgical focus

authors： Matsuda Y,Okada H,Chung J,Webster Crowley R,Lopes DK

更新日期：2017-04-01 00:00:00

abstract：OBJECT:Anterior cervical discectomy (ACD) is an effective and safe treatment for nerve root or spinal cord compression caused by disc herniation or spondylosis. Cervical interbody fusion allows preservation of the physiological lordosis and stability of the cervical spine. Based on data reported in the literature, fusi...

journal_title：Neurosurgical focus

authors： Assietti R,Beretta F,Arienta C

更新日期：2002-01-15 00:00:00

abstract：:Epidermoid tumors comprise about 1% of all intracranial tumors. They are congenital lesions that arise from paramedian cisterns within the posterior fossa. These tumors present as heterogeneous hyperintense lesions on FLAIR and homogenous hyperintense lesions on DWI. Surgical resection remains the most accepted form o...

journal_title：Neurosurgical focus

authors： Cohen-Gadol AA

更新日期：2014-01-01 00:00:00

abstract：:Tumor-associated epilepsy is an important contributor to morbidity in patients with brain tumors. Proposed pathophysiological mechanisms to explain these effects range from neuronal and glial dysfunction to deranged vascular homeostasis, to ionic and pH changes. Perilesional tissue alterations play a vital role in the...

journal_title：Neurosurgical focus

authors： Rajneesh KF,Binder DK

更新日期：2009-08-01 00:00:00

abstract：:Surgery of the mind has a rather checkered past. Though its history begins with the prehistoric trephination of skulls to allow "evil spirits" to escape, the early- to mid-20th century saw a surge in the popularity of psychosurgery. The 2 prevailing operations were topectomy and leukotomy for the treatment of certain ...

journal_title：Neurosurgical focus

authors： Holland R,Kopel D,Carmel PW,Prestigiacomo CJ

更新日期：2017-09-01 00:00:00

abstract：:Recent technical advances have revolutionized the fields of surgical endoscopy, laparoscopy, thoracoscopy, and microsurgical spinal endoscopy. The authors discuss the rich history and recent evolution of these techniques. Thoracoscopy had been widely used for the treatment of pleural conditions associated with tubercu...

journal_title：Neurosurgical focus

authors： Das K,Rothberg M

更新日期：2000-10-15 00:00:00

abstract：:OBJECTIVE The authors describe their results using an endoscope as an adjunct to microsurgical resection of inferior vestibular schwannomas (VSs) with extension into the fundus of the internal auditory canal below the transverse crest. METHODS All patients who had undergone middle fossa craniotomy for VSs performed by...

journal_title：Neurosurgical focus

authors： Master AN,Roberts DS,Wilkinson EP,Slattery WH,Lekovic GP

更新日期：2018-03-01 00:00:00

abstract：:Primary leiomyosarcoma of the central nervous system is rare and has been described both de novo and following temporally remote radiotherapy for a different unrelated malignancy. The authors report the case of a 42-year-old man in whom 60Co radiation treatment had been performed for an unknown primary mass in the bra...

journal_title：Neurosurgical focus

authors： Yeh DJ,Hessler RB,Lee MR

更新日期：2002-06-15 00:00:00

abstract：:Aquaporin-4 (AQP4) channels play an important role in brain water homeostasis. Water transport across plasma membranes has a critical role in brain water exchange of the normal and the diseased brain. AQP4 channels are implicated in the pathophysiology of hydrocephalus, a disease of water imbalance that leads to CSF a...

journal_title：Neurosurgical focus

authors： Desai B,Hsu Y,Schneller B,Hobbs JG,Mehta AI,Linninger A

更新日期：2016-09-01 00:00:00

abstract：:Arteriovenous malformation (AVM) presenting with epilepsy significantly impacts patient quality of life, and it should be considered very much a seizure disorder. Although hemorrhage prevention is the primary treatment aim of AVM surgery, seizure control should also be at the forefront of therapeutic management. Sever...

journal_title：Neurosurgical focus

authors： Soldozy S,Norat P,Yağmurlu K,Sokolowski JD,Sharifi KA,Tvrdik P,Park MS,Kalani MYS

更新日期：2020-04-01 00:00:00

abstract：OBJECT:Positional plagiocephaly (PP) has been on the rise in recent years. In this review, the authors' aim was to assess the effectiveness of current recommendations to parents on this exceedingly common problem through a comprehensive literature search. Additionally, the current treatment options and the most recent ...

journal_title：Neurosurgical focus

authors： Shweikeh F,Nuño M,Danielpour M,Krieger MD,Drazin D

更新日期：2013-10-01 00:00:00

abstract：:The widespread use of fusion procedures in the management of spinal disorders has led investigators to explore the use of growth and differentiation factors in such procedures. As an adjuvant to allograft bone or as a replacement for harvested autograft, bone morphogenetic proteins (BMPs) appear to improve fusion rate...

journal_title：Neurosurgical focus

authors： Subach BR,Haid RW,Rodts GE,Kaiser MG

更新日期：2001-04-15 00:00:00

abstract：OBJECT:The DIAM is a polyester-encased silicone interspinous dynamic stabilization device that can unload the anterior column and reestablish the functional integrity of the posterior column. METHODS:The DIAM was implanted in 104 patients between May 1, 2001 and October 30, 2001. A retrospective evaluation was perform...

journal_title：Neurosurgical focus

authors： Taylor J,Pupin P,Delajoux S,Palmer S

更新日期：2007-01-15 00:00:00

abstract：:Arteriovenous fistulae of the internal maxillary artery are exceedingly rare, with less than 30 cases reported in the literature. Most of these lesions are congenital, iatrogenic, or posttraumatic. The most common presentation of internal maxillary artery fistulae is pulsatile tinnitus and headache. Because these lesi...

journal_title：Neurosurgical focus

authors： Brinjikji W,Cloft HJ,Lanzino G,Rangel-Castilla L,Morris PP

更新日期：2019-01-01 00:00:00

abstract：:Interventional neuroradiology is a less invasive modality than open neurosurgery for the treatment of a wide range of neurovascular disorders. Refinements in technique and improvements in the design of microcatheters, guide wires, and embolic materials have yielded superior clinical outcomes and provided an impetus to...

journal_title：Neurosurgical focus

authors： Ng PP,Higashida RT,Cullen S,Malek R,Halbach VV,Dowd CF

更新日期：2003-10-15 00:00:00

abstract：:The authors detail the life and career of Dr. J. Lawrence Pool, as well as his significant contributions to the field of cerebrovascular neurosurgery. The discipline of cerebrovascular neurosurgery is a young and dynamic field, which underwent rapid and substantial growth during the middle of the twentieth century. As...

journal_title：Neurosurgical focus

authors： Zacharia BE,Mocco J,Komotar RJ,Solomon RA,Quest DO

更新日期：2006-06-15 00:00:00

abstract：:In this article the authors attempt to raise awareness of the pitfalls and controversial issues in nerve tumor surgery. In a case-guided format, examples of ambiguous findings, inappropriate tumor removal, repeated surgery, and nerve repairs are provided. The authors also discuss the need to establish a correct diagno...

journal_title：Neurosurgical focus

authors： Kretschmer T,Antoniadis G,Heinen C,Börm W,Scheller C,Richter HP,Koenig RW

更新日期：2007-06-15 00:00:00

abstract：:Intravenous and intraarterial recombinant tissue plasminogen activator remains underutilized in the treatment of acute ischemic stroke, largely due to strict adherence to the concept of the therapeutic time window for administration. Recent efforts to expand the number of patients eligible for thrombolysis have been m...

journal_title：Neurosurgical focus

authors： Amenta PS,Ali MS,Dumont AS,Gonzalez LF,Tjoumakaris SI,Hasan D,Rosenwasser RH,Jabbour P

更新日期：2011-06-01 00:00:00

abstract：OBJECT:Convection-enhanced delivery (CED) is an increasingly used novel local/regional delivery method targeted directly to tissue. It relies on a continuous pressure gradient for distribution of therapeutic agents into the interstitial space, with administration of the infusate over a few days. Cintredekin besudotox (...

journal_title：Neurosurgical focus

authors： Kunwar S,Chang SM,Prados MD,Berger MS,Sampson JH,Croteau D,Sherman JW,Grahn AY,Shu VS,Dul JL,Husain SR,Joshi BH,Pedain C,Puri RK

更新日期：2006-04-15 00:00:00