Tumor-associated epilepsy.

Abstract:

:Tumor-associated epilepsy is an important contributor to morbidity in patients with brain tumors. Proposed pathophysiological mechanisms to explain these effects range from neuronal and glial dysfunction to deranged vascular homeostasis, to ionic and pH changes. Perilesional tissue alterations play a vital role in the generation of tumor-associated seizures. Clinical studies have determined that tumor-associated seizures are usually focal with secondary generalization and often resistant to antiepileptic drugs. Tumor histopathological characteristics and location are independent factors that impact seizure burden. Further understanding of the mechanisms of tumor-associated epilepsy may lead to new types of treatments targeted at perilesional tissue alterations.

journal_name

Neurosurg Focus

journal_title

Neurosurgical focus

authors

Rajneesh KF,Binder DK

doi

10.3171/2009.5.FOCUS09101

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

E4

issue

2

issn

1092-0684

journal_volume

27

pub_type

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