Evaluating the cognitive consequences of mild traumatic brain injury and concussion by using electrophysiology.

Abstract:

OBJECT:Mild traumatic brain injury (MTBI), often referred to as concussion when it occurs in sports, produces persistent cognitive problems in at least 15% of patients. Unfortunately, conventional neuropsychological tests usually yield results within normal limits in this population. The main objective of this event-related potential (ERP) study was to understand brain functioning during the performance of a working memory (WM) task in patients who have sustained an MTBI, mostly due to motor vehicle accident or sports concussion. This study also aimed for a better understanding of the association between brain functioning as measured with ERP, behavioral performance on the WM task, postconcussion symptoms, type of injury (that is, sports concussion vs other types), and time since the injury. METHODS:Forty-four patients with MTBI (7.6 ± 8.4 months postinjury) were tested on a visual WM task with simultaneous recording of ERP, and were compared with 40 control volunteers who were their equivalent for age and sex. Amplitude and latency of frontal (N200 and N350) and parietal (P200 and P300) ERP waves were measured and were compared between groups. Correlation analyses were also performed between ERP characteristics, clinical variables, and behavioral performance. RESULTS:A significant group difference was found for behavioral performance on the WM task, in which the MTBI group had a lower percentage of correct answers than the control group (p < 0.05). The patients with MTBI also had smaller amplitudes of both frontal N350 and parietal P300 ERP components when compared with control volunteers (p < 0.05). No changes were found for latency of ERP components. Smaller ERP amplitudes were associated with slower reaction times and worse accuracy on the WM task among patients with MTBI (p < 0.05). Types of injury (that is, sports concussion vs other mechanisms) were not associated with different ERP characteristics. CONCLUSIONS:Abnormal ERP results are observed in patients after MTBI or sports concussion, even for those in the nonacute stage after their injury. Current standard clinical evaluations most often fail to detect cerebral dysfunction after MTBI, even when patients or athletes report symptoms. Clinicians should be aware that patients with MTBI, including sports concussion, probably have underlying mild but persistent cerebral dysfunctions that require further investigation.

journal_name

Neurosurg Focus

journal_title

Neurosurgical focus

authors

Gosselin N,Bottari C,Chen JK,Huntgeburth SC,De Beaumont L,Petrides M,Cheung B,Ptito A

doi

10.3171/2012.10.FOCUS12253

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

E7: 1-7

issue

6

issn

1092-0684

journal_volume

33

pub_type

杂志文章
  • Brief history of endoscopic transsphenoidal surgery--from Philipp Bozzini to the First World Congress of Endoscopic Skull Base Surgery.

    abstract::Since its inception, one of the major issues in transsphenoidal surgery has been the adequate visualization of anatomical structures. As transsphenoidal surgery evolved, technical advancements improved the surgical view of the operative field and the orientation. The operating microscope replaced Cushing's headlight a...

    journal_title:Neurosurgical focus

    pub_type: 历史文章,杂志文章,评审

    doi:10.3171/foc.2005.19.6.4

    authors: Doglietto F,Prevedello DM,Jane JA Jr,Han J,Laws ER Jr

    更新日期:2005-12-15 00:00:00

  • Herpes simplex reactivation following neurosurgery: case report and review of the literature.

    abstract::Herpes simplex encephalitis is a common viral encephalitis associated with significant morbidity and mortality if not diagnosed and treated early. Neurosurgery may be an impetus for viral reactivation, either from direct nerve manipulation or high-dose steroids often administered during cases. The authors present the ...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/2019.5.FOCUS19281

    authors: McLaughlin DC,Achey RL,Geertman R,Grossman J

    更新日期:2019-08-01 00:00:00

  • Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies.

    abstract:OBJECT:Convection-enhanced delivery (CED) is an increasingly used novel local/regional delivery method targeted directly to tissue. It relies on a continuous pressure gradient for distribution of therapeutic agents into the interstitial space, with administration of the infusate over a few days. Cintredekin besudotox (...

    journal_title:Neurosurgical focus

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kunwar S,Chang SM,Prados MD,Berger MS,Sampson JH,Croteau D,Sherman JW,Grahn AY,Shu VS,Dul JL,Husain SR,Joshi BH,Pedain C,Puri RK

    更新日期:2006-04-15 00:00:00

  • Contralateral C-7 transfer: is direct repair really superior to grafting?

    abstract::It is not uncommon for a severe traumatic brachial plexus injury to involve all 5 roots, resulting in a flail upper limb. In such cases, surgical reconstruction is often palliative, providing only rudimentary function. Nerve transfers are the mainstay of reconstructive strategies due to the predominance of root avulsi...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2017.4.FOCUS1794

    authors: Bhatia A,Doshi P,Koul A,Shah V,Brown JM,Salama M

    更新日期:2017-07-01 00:00:00

  • Frailty predicts worse outcomes after intracranial meningioma surgery irrespective of existing prognostic factors.

    abstract:OBJECTIVE:Frailty has been recognized as a predictor of adverse surgical outcomes across multiple surgical disciplines, but until now the relationship between frailty and intracranial meningioma surgery has not been studied. The goal of the present study was to determine the relationship between increasing frailty (det...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2020.7.FOCUS20324

    authors: Theriault BC,Pazniokas J,Adkoli AS,Cho EK,Rao N,Schmidt M,Cole C,Gandhi C,Couldwell WT,Al-Mufti F,Bowers CA

    更新日期:2020-10-01 00:00:00

  • Conduits for cerebrovascular bypass and lessons learned from the cardiovascular experience.

    abstract::Direct cerebral revascularization is an important procedure in the treatment of certain complex aneurysms and skull base tumors when acute sacrifice of the internal carotid artery is required. It likely remains an appropriate treatment in a small subgroup of patients with cerebral ischemia refractory to maximal medica...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:

    authors: Liu JK,Kan P,Karwande SV,Couldwell WT

    更新日期:2003-03-15 00:00:00

  • German military neurosurgery at home and abroad.

    abstract::For many years, the experience of neurosurgeons from the German Armed Forces was limited to the peacetime care of patients in Germany. In 1995, German military neurosurgeons were deployed abroad for the first time. Since the beginning of the International Security Assistance Force mission, there has been a rapidly inc...

    journal_title:Neurosurgical focus

    pub_type: 历史文章,杂志文章

    doi:10.3171/2010.2.FOCUS1010

    authors: Mauer UM,Schulz C,Rothe R,Kunz U

    更新日期:2010-05-01 00:00:00

  • Technical considerations in transforaminal endoscopic spine surgery at the thoracolumbar junction: report of 3 cases.

    abstract::OBJECTIVE In this study the authors describe the technical considerations and feasibility of transforaminal discectomy and foraminoplasty for the treatment of lumbar radiculopathy in patients who have herniated discs at the thoracolumbar junction. METHODS After institutional review board approval, charts from 3 consec...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2015.10.FOCUS15372

    authors: Telfeian AE,Jasper GP,Oyelese AA,Gokaslan ZL

    更新日期:2016-02-01 00:00:00

  • Use of polylactide resorbable film as a barrier to postoperative peridural adhesion in an ovine dorsal laminectomy model.

    abstract:OBJECT:The purpose of this study was to evaluate the performance of a resorbable polylactide film in the sheep posterior spine in the presence of a combined laminectomy and durotomy defect. METHODS:A resorbable polylactide film was used to cover the combined defects in the eight sheep used in this study. Two surgical ...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.2004.16.3.3

    authors: Klopp LS,Welch WC,Tai JW,Toth JM,Cornwall GB,Turner AS

    更新日期:2004-03-15 00:00:00

  • Intraoperative monitoring of cerebral blood flow by laser speckle contrast analysis.

    abstract:OBJECT:Currently, reliable low-cost and noninvasive techniques to assess cerebral perfusion in the operating room are not available. The authors report on their first clinical experience with laser speckle contrast analysis (LASCA) as a complementary imaging tool for the noninvasive and dynamic assessment of cerebral b...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2009.8.FOCUS09148

    authors: Hecht N,Woitzik J,Dreier JP,Vajkoczy P

    更新日期:2009-10-01 00:00:00

  • Facial paralysis caused by malignant skull base neoplasms.

    abstract:OBJECT:Bell palsy remains the most common cause of facial paralysis. Unfortunately, this term is often erroneously applied to all cases of facial paralysis. METHODS:The authors performed a retrospective review of data obtained in 11 patients who were treated at a university-based referral practice between July 1988 an...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.2002.12.5.3

    authors: Marzo SJ,Leonetti JP,Petruzzelli G

    更新日期:2002-05-15 00:00:00

  • Neurosurgery at the epicenter of the COVID-19 pandemic in Indonesia: experience from a Surabaya academic tertiary hospital.

    abstract:OBJECTIVE:Global outbreak of the novel coronavirus disease 2019 (COVID-19) has forced healthcare systems worldwide to reshape their facilities and protocols. Although not considered the frontline specialty in managing COVID-19 patients, neurosurgical service and training were also significantly affected. This article f...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2020.9.FOCUS20559

    authors: Suryaningtyas W,Wahyuhadi J,Turchan A,Subagio EA,Parenrengi MA,Apriawan T,Al Fauzi A,Bajamal AH

    更新日期:2020-12-01 00:00:00

  • Lumbosacral ependymomas: a review of the management of intradural and extradural tumors.

    abstract:OBJECT:The goal of this study was to review the management of intra- and extradural ependymomas. Spinal ependymomas most commonly occur as intramedullary tumors throughout the spinal axis. In the lumbosacral region, ependymomas are most commonly associated with the conus medullaris and cauda equina, but can also occur ...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/foc.2003.15.5.13

    authors: Fassett DR,Schmidt MH

    更新日期:2003-11-15 00:00:00

  • The role of radiosurgery for hemangiopericytomas.

    abstract:OBJECT:Hemangiopericytomas represent a small subset of meningeal tumors. Despite their relatively uncommon nature, they are aggressive tumors known for recurrence. Resection is the standard treatment in most, although regrowth and metastases are common even after resection. The authors evaluate the role of stereotactic...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.2003.14.5.15

    authors: Chang SD,Sakamoto GT

    更新日期:2003-05-15 00:00:00

  • Hypothalamic hamartomas. Part 1. Clinical, neuroimaging, and neurophysiological characteristics.

    abstract::Hypothalamic hamartomas are uncommon but well-recognized developmental malformations that are classically associated with gelastic seizures and other refractory seizure types. The clinical course is often progressive and, in addition to the catastrophic epileptic syndrome, patients commonly exhibit debilitating cognit...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/2013.3.FOCUS1355

    authors: Mittal S,Mittal M,Montes JL,Farmer JP,Andermann F

    更新日期:2013-06-01 00:00:00

  • Ventral fusion versus dorsal fusion: determining the optimal treatment for cervical spondylotic myelopathy.

    abstract::Cervical spondylotic myelopathy (CSM) often can be surgically treated by either ventral or dorsal decompression and fusion. However, there is a lack of high-level evidence on the relative advantages and disadvantages for these treatments of CSM. The authors' goal was to provide a comprehensive review of the relative b...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/2013.4.FOCUS13103

    authors: Alvin MD,Lubelski D,Benzel EC,Mroz TE

    更新日期:2013-07-01 00:00:00

  • Clinical utility of arterial spin labeling imaging in disorders of the nervous system.

    abstract::Neuroimaging is an indispensable tool in the workup and management of patients with neurological disorders. Arterial spin labeling (ASL) is an imaging modality that permits the examination of blood flow and perfusion without the need for contrast injection. Noninvasive in nature, ASL provides a feasible alternative to...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/2019.9.FOCUS19567

    authors: Soldozy S,Galindo J,Snyder H,Ali Y,Norat P,Yağmurlu K,Sokolowski JD,Sharifi K,Tvrdik P,Park MS,Kalani MYS

    更新日期:2019-12-01 00:00:00

  • High flow EC-IC bypass for a giant left MCA aneurysm.

    abstract::Giant cerebral aneurysms may be treated through a variety of options, including aneurysm trapping with concurrent bypass. This video describes the case of a large, recurrent, left middle cerebral artery aneurysm that was treated using a high flow, radial artery bypass graft, from the external carotid artery to the lef...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2015.V1.FOCUS14548

    authors: Arias EJ,Zipfel GJ

    更新日期:2015-01-01 00:00:00

  • Ultrastructure protection and attenuation of lipid peroxidation after blockade of presynaptic release of glutamate by lamotrigine in experimental spinal cord injury.

    abstract:OBJECT:Lamotrigine is an antiepileptic drug that inhibits presynaptic voltage-gated sodium channels and reduces the presynaptic release of glutamate in pathological states. Neuroprotective effects of this drug have already been demonstrated in cerebral ischemia models. The aim of the present study was to determine the ...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/FOC.2008.25.11.E6

    authors: Tufan K,Oztanir N,Ofluoglu E,Ozogul C,Uzum N,Dursun A,Pasaoglu H,Pasaoglu A

    更新日期:2008-01-01 00:00:00

  • Integration of functional neuronavigation and intraoperative MRI in surgery for drug-resistant extratemporal epilepsy close to eloquent brain areas.

    abstract:OBJECT:The authors performed a retrospective study to assess the impact of functional neuronavigation and intraoperative MRI (iMRI) on surgery of extratemporal epileptogenic lesions on postsurgical morbidity and seizure control. METHODS:Twenty-five patients (14 females and 11 males) underwent extratemporal resections ...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2013.2.FOCUS12397

    authors: Sommer B,Grummich P,Coras R,Kasper BS,Blumcke I,Hamer HM,Stefan H,Buchfelder M,Roessler K

    更新日期:2013-04-01 00:00:00

  • Spinal cord injury and the human microbiome: beyond the brain-gut axis.

    abstract::In addition to standard management for the treatment of the acute phase of spinal cord injury (SCI), implementation of novel neuroprotective interventions offers the potential for significant reductions in morbidity and long-term health costs. A better understanding of the systemic changes after SCI could provide insi...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/2018.12.FOCUS18206

    authors: Wallace DJ,Sayre NL,Patterson TT,Nicholson SE,Hilton D,Grandhi R

    更新日期:2019-03-01 00:00:00

  • Machine learning-based preoperative predictive analytics for lumbar spinal stenosis.

    abstract::OBJECTIVEPatient-reported outcome measures (PROMs) following decompression surgery for lumbar spinal stenosis (LSS) demonstrate considerable heterogeneity. Individualized prediction tools can provide valuable insights for shared decision-making. The authors aim to evaluate the feasibility of predicting short- and long...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2019.2.FOCUS18723

    authors: Siccoli A,de Wispelaere MP,Schröder ML,Staartjes VE

    更新日期:2019-05-01 00:00:00

  • Improved restoration of thoracic kyphosis using a rod construct with differentiated rigidity in the surgical treatment of adolescent idiopathic scoliosis.

    abstract::OBJECTIVE The objective of this study was to compare postoperative sagittal alignment among 3 rod constructs with different rigidity profiles. METHODS This was a dual-center retrospective cohort study involving 2 consecutive cohorts in which patients were surgically treated for adolescent idiopathic scoliosis. Lenke T...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,多中心研究

    doi:10.3171/2017.7.FOCUS17351

    authors: Ohrt-Nissen S,Dragsted C,Dahl B,Ferguson JAI,Gehrchen M

    更新日期:2017-10-01 00:00:00

  • Sanger Brown and Edward Schäfer before Heinrich Klüver and Paul Bucy: their observations on bilateral temporal lobe ablations.

    abstract::Fifty years before a report on the complete bitemporal lobectomy syndrome in primates, known as the Klüver-Bucy syndrome, was published, 2 talented investigators working at the University College in London, England-neurologist Sanger Brown and physiologist Edward Schäfer-also made this discovery. The title of their wo...

    journal_title:Neurosurgical focus

    pub_type: 传,历史文章,杂志文章

    doi:10.3171/2017.6.FOCUS17265

    authors: Vannemreddy PSSV,Stone JL

    更新日期:2017-09-01 00:00:00

  • Craniofacial reconstruction with a fast resorbing polymer: a 6- to 12-month clinical follow-up review.

    abstract:OBJECT:Resorbable polymer implants have become a compelling option in the treatment of acquired and congenital craniofacial deformities. In particular, the resorbable polylactide and polyglycolide polymers have demonstrated excellent safety profiles in multiple in vitro, animal, and clinical studies and are currently b...

    journal_title:Neurosurgical focus

    pub_type: 临床试验,杂志文章

    doi:10.3171/foc.2004.16.3.13

    authors: Cohen SR,Holmes RE,Meltzer HS,Levy ML,Beckett MZ

    更新日期:2004-03-15 00:00:00

  • Incidental vertebral lesions.

    abstract::Incidental vertebral lesions on imaging of the spine are commonly encountered in clinical practice. Contributing factors include the aging population, the increasing prevalence of back pain, and increased usage of MR imaging. Additionally, refinements in CT and MR imaging have increased the number of demonstrable lesi...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/2011.9.FOCUS11207

    authors: Coumans JV,Walcott BP

    更新日期:2011-12-01 00:00:00

  • Role of the neurofibromatosis type 2 gene in the development of tumors of the nervous system.

    abstract::Germ line and somatic mutations in the neurofibromatosis Type 2 (NF2) tumor suppressor gene predispose individuals to tumors of the nervous system, including schwannomas and meningiomas. Since identification of the NF2 gene more than a decade ago, a large body of information has been collected on the nature and conseq...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/foc.2005.19.5.7

    authors: Ruttledge MH,Rouleau GA

    更新日期:2005-11-15 00:00:00

  • Peripheral nervous system injury after high-dose single-fraction image-guided stereotactic radiosurgery for spine tumors.

    abstract::OBJECTIVE The object of this study was to determine the percentage of high-dose (1800-2600 cGy) single-fraction stereotactic radiosurgery (SF-SRS) treatments to the spine that result in peripheral nervous system (PNS) injury. METHODS All patients treated with SF-SRS for primary or metastatic spine tumors between Janua...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2016.11.FOCUS16348

    authors: Stubblefield MD,Ibanez K,Riedel ER,Barzilai O,Laufer I,Lis E,Yamada Y,Bilsky MH

    更新日期:2017-03-01 00:00:00

  • Upward transtentorial herniation following frontoorbital advancement for syndromic craniosynostosis: case report.

    abstract::The authors describe the case of a boy with Muenke syndrome, an autosomal dominant disorder associated with craniosynostosis. The family history was significant for syndromic craniosynostosis in the patient's maternal grandmother, who died in adulthood after a craniofacial reconstruction. The patient, her grandson, un...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2015.2.FOCUS151

    authors: Mehta V,Bakhsheshian J,Dorafshar AH,Ahn ES

    更新日期:2015-05-01 00:00:00

  • Curative Onyx embolization of tentorial dural arteriovenous fistulas.

    abstract:OBJECT:The authors conducted a study to review their experience with tentorial dural arteriovenous fistulas (DAVFs) treated with transarterial endovascular embolization in which Onyx was used. METHODS:The authors reviewed prospectively collected data in 9 patients with tentorial DAVFs treated with Onyx embolization be...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2011.12.FOCUS11323

    authors: Puffer RC,Daniels DJ,Kallmes DF,Cloft HJ,Lanzino G

    更新日期:2012-05-01 00:00:00