A minimally invasive catheter-based ultrasound technology for therapeutic interventions in brain: initial preclinical studies.

Abstract:

:OBJECTIVE Minimally invasive procedures may allow surgeons to avoid conventional open surgical procedures for certain neurological disorders. This paper describes the iterative process for development of a catheter-based ultrasound thermal therapy applicator. METHODS Using an ultrasound applicator with an array of longitudinally stacked and angularly sectored tubular transducers within a catheter, the authors conducted experimental studies in porcine liver, in vivo and ex vivo, in order to characterize the device performance and lesion patterns. In addition, they applied the technique in a rodent model of Parkinson's disease to investigate the feasibility of its application in brain. RESULTS Thermal lesions with multiple shapes and sizes were readily achieved in porcine liver. The feasibility of catheter-based focused ultrasound in the treatment of brain conditions was demonstrated in a rodent model of Parkinson's disease. CONCLUSIONS The authors show proof of principle of a catheter-based ultrasound system that can create lesions with concurrent thermode-based measurements.

journal_name

Neurosurg Focus

journal_title

Neurosurgical focus

authors

Ghoshal G,Gee L,Heffter T,Williams E,Bromfield C,Rund L,Ehrhardt JM,Diederich CJ,Fischer GS,Pilitsis JG,Burdette EC

doi

10.3171/2017.11.FOCUS17631

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

E13

issue

2

issn

1092-0684

journal_volume

44

pub_type

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