Evaluating infusate parameters for direct drug delivery to the brainstem: a comparative study of convection-enhanced delivery versus osmotic pump delivery.

abstract：OBJECT:Convection-enhanced delivery (CED) is an increasingly used novel local/regional delivery method targeted directly to tissue. It relies on a continuous pressure gradient for distribution of therapeutic agents into the interstitial space, with administration of the infusate over a few days. Cintredekin besudotox (...

journal_title：Neurosurgical focus

authors： Kunwar S,Chang SM,Prados MD,Berger MS,Sampson JH,Croteau D,Sherman JW,Grahn AY,Shu VS,Dul JL,Husain SR,Joshi BH,Pedain C,Puri RK

更新日期：2006-04-15 00:00:00

abstract：:The benefits of anterior interbody arthrodesis in deformity surgery are well known and include load sharing and increased fusion rates. A minimally invasive lateral transpsoas approach to the anterior lumbar spine is a promising alternative to traditional interbody techniques for the treatment of adult degenerative sc...

journal_title：Neurosurgical focus

authors： Amin BY,Mummaneni PV,Ibrahim T,Zouzias A,Uribe J

更新日期：2013-07-01 00:00:00

abstract：OBJECT:The percentage of patients responding to conservative treatment for cervical radiculopathy secondary to nerve root compression is not well quantified. To clarify this question, the authors retrospectively reviewed the records obtained over a 4-year period in patients with cervical radiculopathy to determine thei...

journal_title：Neurosurgical focus

authors： Olivero WC,Dulebohn SC

更新日期：2002-02-15 00:00:00

abstract：:OBJECTIVE The objective of this study was to identify clinically relevant predictors of progression-free survival and functional outcomes in patients who underwent surgery for intramedullary spinal cord tumors (ISCTs). METHODS An institutional spinal tumor registry and billing records were reviewed to identify adult p...

journal_title：Neurosurgical focus

authors： Samuel N,Tetreault L,Santaguida C,Nater A,Moayeri N,Massicotte EM,Fehlings MG

更新日期：2016-08-01 00:00:00

abstract：OBJECT:The authors present a series of 4 patients with rare facial nerve tumors. The relevant literature is reviewed and is discussed regarding diagnostic features, the role of operative management, and surgical approach. METHODS:A retrospective chart review was conducted for patients with tumors of the facial nerve t...

journal_title：Neurosurgical focus

authors： Ross L,Drazin D,Eboli P,Lekovic GP

更新日期：2013-03-01 00:00:00

abstract：OBJECT:Although a rarely reported occurrence, late failure of endoscopic third ventriculostomy (ETV) may occur in children as a result of a variety of factors. Delay in recognition of symptoms can lead to harmful deterioration in the patient's condition. The authors undertook this study to assess the capacity of cine p...

journal_title：Neurosurgical focus

authors： Faggin R,Calderone M,Denaro L,Meneghini L,d'Avella D

更新日期：2011-04-01 00:00:00

abstract：:The development of less invasive methods to evacuate intracerebral hematomas (ICHs) has improved outcome in patients with traumatic brain injury. Eighteen patients with ICHs underwent surgery via one of two methods: stereotactic endoscopic removal (SER) or stereotactic catheter drainage (SCD). The outcome results were...

journal_title：Neurosurgical focus

authors： Kim MH,Song JH,Kim SH,Park DB,Shin KM

更新日期：1996-10-15 00:00:00

abstract：:Deep brain stimulation (DBS) has been reported to have beneficial effects in severe, treatment-refractory cases of obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). In this report, the authors present the first case in which DBS was used to treat the neuropsychiatric symptoms of Kleefstra syndrome, a rar...

journal_title：Neurosurgical focus

authors： Segar DJ,Chodakiewitz YG,Torabi R,Cosgrove GR

更新日期：2015-06-01 00:00:00

abstract：:OBJECTIVE The aim of this study was to identify and discuss operative nuances utilizing image guidance in the surgical management of aggressive sacral tumors. METHODS The authors report on their single-institution, multi-surgeon, retrospective case series involving patients with pathology-proven aggressive sacral tumo...

journal_title：Neurosurgical focus

authors： Drazin D,Bhamb N,Al-Khouja LT,Kappel AD,Kim TT,Johnson JP,Brien E

更新日期：2017-01-01 00:00:00

abstract：:For a physician has the worth of many other warriors, both for the excision of arrows and for the administration of soothing drugs. Homer, Iliad XI.514-515 Ever since armed conflict has been used as a means to settle disputes among men, there have been those who have been tasked to mend the wounds that ravage a soldie...

journal_title：Neurosurgical focus

authors： Klimo P Jr,Ragel BT

更新日期：2010-05-01 00:00:00

abstract：OBJECT:The management of pediatric intraventricular tumors is highly dependent on identification of the tumor type. Choroid plexus papillomas, a common intraventricular tumor in children, can be difficult to distinguish radiographically from choroid plexus carcinomas and other common pediatric central nervous system (C...

journal_title：Neurosurgical focus

authors： Krieger MD,Panigrahy A,McComb JG,Nelson MD,Liu X,Gonzalez-Gomez I,Gilles F,Bluml S

更新日期：2005-06-15 00:00:00

abstract：:Brain-machine interface (BMI) is the latest solution to a lack of control for paralyzed or prosthetic limbs. In this paper the authors focus on the design of anatomical robotic hands that use BMI as a critical intervention in restorative neurosurgery and they justify the requirement for lower-level neuromusculoskeleta...

journal_title：Neurosurgical focus

authors： Matsuoka Y,Afshar P,Oh M

更新日期：2006-05-15 00:00:00

abstract：:OBJECT Cushing's disease (CD) is a potentially lethal neuroendocrinopathy that often requires specialized multidisciplinary treatment to achieve optimized outcomes. The authors analyzed data pertaining to patient, hospital, and admission characteristics as they relate to outcomes following transsphenoidal surgery (TSS...

journal_title：Neurosurgical focus

authors： Wilson D,Jin DL,Wen T,Carmichael JD,Cen S,Mack WJ,Zada G

更新日期：2015-02-01 00:00:00

abstract：:In addition to standard management for the treatment of the acute phase of spinal cord injury (SCI), implementation of novel neuroprotective interventions offers the potential for significant reductions in morbidity and long-term health costs. A better understanding of the systemic changes after SCI could provide insi...

journal_title：Neurosurgical focus

authors： Wallace DJ,Sayre NL,Patterson TT,Nicholson SE,Hilton D,Grandhi R

更新日期：2019-03-01 00:00:00

abstract：:The Pipeline embolization device (PED) has become a very important tool in the treatment of nonruptured cerebral aneurysms. However, a patient's difficult anatomy or vascular stenosis may affect the device delivery. The purpose of this article was to describe an alternate technique for PED deployment when ipsilateral ...

journal_title：Neurosurgical focus

authors： Valle-Giler EP,Atallah E,Tjoumakaris S,Rosenwasser RH,Jabbour P

更新日期：2017-06-01 00:00:00

abstract：OBJECT:The middle third of the clivus and the region around the petrous internal carotid artery (ICA) is a difficult area of the skull base in terms of access. This is a deep area rich with critical neurovascular structures, which is often host to typical skull base diseases. Expanded endoscopic endonasal approaches of...

journal_title：Neurosurgical focus

authors： Kassam AB,Gardner P,Snyderman C,Mintz A,Carrau R

更新日期：2005-07-15 00:00:00

abstract：:Drug addiction represents a significant public health concern that has high rates of relapse despite optimal medical therapy and rehabilitation support. New therapies are needed, and deep brain stimulation (DBS) may be an effective treatment. The past 15 years have seen numerous animal DBS studies for addiction to var...

journal_title：Neurosurgical focus

authors： Wang TR,Moosa S,Dallapiazza RF,Elias WJ,Lynch WJ

更新日期：2018-08-01 00:00:00

abstract：:Vein of Galen malformations are rare congenital intracranial vascular malformations. Based on reports in the literature, spontaneous thrombosis or regression of these lesions is rare. Patients have variable outcomes from an asymptomatic course to death. The reasons behind spontaneous thrombosis are not entirely unders...

journal_title：Neurosurgical focus

authors： Moftakhar P,Danielpour M,Maya M,Alexander MJ

更新日期：2009-11-01 00:00:00

abstract：:Intraoperative optical imaging (IOI) is a marker-free, contactless, and noninvasive imaging technique that is able to visualize metabolic changes of the brain surface following neuronal activation. Although it has been used in the past mainly for the identification of functional brain areas under general anesthesia, t...

journal_title：Neurosurgical focus

authors： Oelschlägel M,Meyer T,Morgenstern U,Wahl H,Gerber J,Reiß G,Koch E,Steiner G,Kirsch M,Schackert G,Sobottka SB

更新日期：2020-02-01 00:00:00

abstract：:The most commonly accepted indications for cervical disc arthroplasty (CDA) are 1- and 2-level cervical disc herniation or spondylosis causing radiculopathy or myelopathy that is refractory to medical management. Unlike anterior cervical discectomy and fusion (ACDF), which eliminates motion, CDA aims to restore the ph...

journal_title：Neurosurgical focus

authors： Tu TH,Chang CC,Wu JC,Fay LY,Huang WC,Cheng H

更新日期：2017-01-01 00:00:00

abstract：OBJECT:Ossification of the posterior longitudinal ligament (OPLL) is a disorder afflicting as many as 2% of East Asians. However, reports of OPLL in non-Asians have been sporadic in the medical literature. This study describes clinical and radiographic findings with OPLL in non-Asians at a tertiary care center treating...

journal_title：Neurosurgical focus

authors： Wang MY,Thambuswamy M

更新日期：2011-03-01 00:00:00

abstract：:Incidental findings pose considerable management dilemmas for the treating physician and psychological burden for the respective patient. With an aging population, more patients will be diagnosed with asymptomatic internal carotid artery stenosis. Patients will have to be counseled with regard to treatment options acc...

journal_title：Neurosurgical focus

authors： Taussky P,Hanel RA,Meyer FB

更新日期：2011-12-01 00:00:00

abstract：OBJECT:The DIAM is a polyester-encased silicone interspinous dynamic stabilization device that can unload the anterior column and reestablish the functional integrity of the posterior column. METHODS:The DIAM was implanted in 104 patients between May 1, 2001 and October 30, 2001. A retrospective evaluation was perform...

journal_title：Neurosurgical focus

authors： Taylor J,Pupin P,Delajoux S,Palmer S

更新日期：2007-01-15 00:00:00

abstract：OBJECT:In this report the authors review the role of bioinformatics in the design of a research project in which the molecular genetics of malignant glioma were studied. A project to characterize Pokemon expression in malignant glioma was developed, refined, and implemented using bioinformatics methods. METHODS:Using ...

journal_title：Neurosurgical focus

authors： Rovin RA,Winn R

更新日期：2005-10-15 00:00:00

abstract：:In the treatment of acoustic neuroma, operative results have improved greatly during recent years, with high rates of functional cranial nerve preservation. Because of this, it has become more important to consider issues of patient satisfaction and quality of life (QOL) following treatment for these lesions. The auth...

journal_title：Neurosurgical focus

authors： Schwartz MS,Riddle SA,Delashaw JB Jr,Horgan MA,Kellogg JX,McMenomey SO

更新日期：1998-09-15 00:00:00

abstract：OBJECT:Currently, reliable low-cost and noninvasive techniques to assess cerebral perfusion in the operating room are not available. The authors report on their first clinical experience with laser speckle contrast analysis (LASCA) as a complementary imaging tool for the noninvasive and dynamic assessment of cerebral b...

journal_title：Neurosurgical focus

authors： Hecht N,Woitzik J,Dreier JP,Vajkoczy P

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Tractography is a useful technique that is standardly applied to visualize subcortical pathways. However, brain shift hampers tractography use during the course of surgery. While intraoperative MRI (ioMRI) has been shown to be beneficial for use in oncology, intraoperative tractography can rarely be performed...

journal_title：Neurosurgical focus

authors： Ille S,Schroeder A,Wagner A,Negwer C,Kreiser K,Meyer B,Krieg SM

更新日期：2021-01-01 00:00:00

abstract：Objective:The aim of this study was to investigate the diagnostic potential of the inflammatory markers interleukin-6 (IL-6), total leukocyte count (TLC), and protein in the CSF and IL-6, C-reactive protein, and white blood cell count in the serum for the early diagnosis of ventriculitis in patients with traumatic brai...

journal_title：Neurosurgical focus

authors： Lenski M,Biczok A,Neufischer K,Tonn JC,Briegel J,Thon N

更新日期：2019-11-01 00:00:00

abstract：:Frontal sinus fractures are heterogeneous, and management of these fractures is often modified based on injury pattern and institutional experience. The optimal initial treatment of frontal sinus fractures is controversial. Treatment strategies are aimed at correcting cosmetic deformity, as well as at preventing delay...

journal_title：Neurosurgical focus

authors： Castro B,Walcott BP,Redjal N,Coumans JV,Nahed BV

更新日期：2012-06-01 00:00:00

abstract：:OBJECT Although the length of hospital stay is often used as a measure of quality of care, data evaluating the predictors of extended hospital stay after craniotomy for tumor are limited. The goals of this study were to use multivariate regression to examine which preoperative characteristics and postoperative complic...

journal_title：Neurosurgical focus

authors： Dasenbrock HH,Liu KX,Devine CA,Chavakula V,Smith TR,Gormley WB,Dunn IF

更新日期：2015-12-01 00:00:00