Abstract：
BACKGROUND:Despite the effectiveness of methylphenidate for treating ADHD, up to 30% of individuals with ADHD show poor responses to methylphenidate. Neuroimaging biomarkers to predict medication responses remain elusive. This study characterized neuroanatomical features that differentiated between clinically good and poor methylphenidate responders with ADHD. METHODS:Using a naturalistic observation design selected from a larger cohort, we included 79 drug-naive individuals (aged 6-42 years) with ADHD without major psychiatric comorbidity, who had acceptable baseline structural MRI data quality. Based on a retrospective chart review, we defined responders by individuals' responses to at least one-month treatment with methylphenidate. A nonparametric mass-univariate voxel-based morphometric analysis was used to compare regional gray matter volume differences between good and poor responders. A multivariate pattern recognition based on the support vector machine was further implemented to identify neuroanatomical indicators to predict an individual's response. RESULTS:63 and 16 individuals were classified in the good and poor responder group, respectively. Using the small-volume correction procedure based on the hypothesis-driven striatal and default-mode network masks, poor responders had smaller regional volumes of the left putamen as well as larger precuneus volumes compared to good responders at baseline. The machine learning approach identified that volumetric information among these two regions alongside the left frontoparietal regions, occipital lobes, and posterior/inferior cerebellum could predict clinical responses to methylphenidate in individuals with ADHD. CONCLUSION:Our results suggest regional striatal and precuneus gray matter volumes play a critical role in mediating treatment responses in individuals with ADHD.
journal_name
BMC Psychiatryjournal_title
BMC psychiatryauthors
Chang JC,Lin HY,Lv J,Tseng WI,Gau SSdoi
10.1186/s12888-021-03040-5subject
Has Abstractpub_date
2021-01-11 00:00:00pages
26issue
1issn
1471-244Xpii
10.1186/s12888-021-03040-5journal_volume
21pub_type
杂志文章相关文献
BMC Psychiatry文献大全abstract：BACKGROUND:The weight-gain caused by many psychotropic drugs is a major cause for poor compliance with such medications and could also increase cardio-vascular morbidity among psychiatric patients. Recent reports have shown that the anticonvulsant topiramate causes weight loss in various patient groups. The drug has al...
journal_title：BMC psychiatry
pub_type： 临床试验,杂志文章
doi：10.1186/1471-244X-5-19
更新日期：2005-04-07 00:00:00
abstract：BACKGROUND:Criticisms that generic measures of health-related quality of life (HRQoL) are not sensitive to impairment in anorexia nervosa (AN) has spurred the development of disease-specific measures. This study aimed to compare the psychometric properties of a generic to a disease-specific measure of HRQoL. METHODS:6...
journal_title：BMC psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-244X-13-284
更新日期：2013-11-07 00:00:00
abstract：BACKGROUND:Executive functioning impairment is common in substance use disorder and is a major risk factor for poor treatment outcomes, including treatment drop-out and relapse. Cognitive remediation interventions seek to improve executive functioning and offer a promising approach to increase the efficacy of alcohol a...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-019-2044-4
更新日期：2019-02-13 00:00:00
abstract：BACKGROUND:Clinician training deficits and a low and declining autopsy rate adversely impact the quality of death certificates in the United States. Self-report and records data for the general population indicate that proximate mental and physical health of minority suicides was at least as poor as that of white suici...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/1471-244X-9-10
更新日期：2009-03-18 00:00:00
abstract：BACKGROUND:With an ageing population in most Western countries, people are living longer but often with one or more chronic physical health problems. Older people in physically poor health are at greater risk of developing clinical depression. Cognitive Behavioural Therapy (CBT) and Problem Solving Therapy (PST) have b...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/1471-244X-12-207
更新日期：2012-11-22 00:00:00
abstract：BACKGROUND:Mood and anxiety disorders are leading causes of disability and mortality, due largely to their onset during adolescence and young adulthood and broader impact on functioning. Key factors that are associated with disability and these disorders in young people are social and economic participation (e.g. educa...
journal_title：BMC psychiatry
pub_type： 杂志文章,评审
doi：10.1186/s12888-016-0852-3
更新日期：2016-05-23 00:00:00
abstract：BACKGROUND:Internet-based treatments appear to be a promising way to enhance the in vivo exposure approach, specifically in terms of acceptability and access to treatment. However, the literature on specific phobias is scarce, and, as far as we know, there are no studies on Flying Phobia (FP). This study aims to invest...
journal_title：BMC psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12888-019-2060-4
更新日期：2019-03-06 00:00:00
abstract：BACKGROUND:Cognitive tests currently used in healthcare and research settings do not account for bias in performance that arises due to cultural context. At present there are no universally accepted steps or minimum criteria for culturally adapting cognitive tests. We propose a methodology for developing specific guide...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-020-02893-6
更新日期：2020-10-06 00:00:00
abstract：BACKGROUND:We compared the attention abilities of a group of first-episode schizophrenia (FES) patients and a group of healthy participants using the Attention Network Test (ANT), a standard procedure that estimates the functional state of three neural networks controlling the efficiency of three different attentional ...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/1471-244X-12-154
更新日期：2012-09-22 00:00:00
abstract：BACKGROUND:To explore the potential correlation between 10-year atherosclerotic cardiovascular disease (ASCVD) risk and depressive symptoms in a general population. METHODS:A cross-sectional study involving 11,956 permanent residents of Liaoning Province in China ≥35 years of age was conducted. Depressive symptoms wer...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-019-2114-7
更新日期：2019-04-26 00:00:00
abstract：BACKGROUND:The Temperament and Character Inventory (TCI) is a psychological test that is frequently used to assess personality traits. Many studies have shown the potential of the inventory to predict the treatment response of patients with major depressive disorder (MDD). Previously, we showed the association between ...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-016-0997-0
更新日期：2016-08-12 00:00:00
abstract：:Upon publication of the original article (1) it was highlighted by the authors that there was just one error in the manuscript in the 'Sample size' subsection of the Methods/Design. ...
journal_title：BMC psychiatry
pub_type： 杂志文章,已发布勘误
doi：10.1186/s12888-018-1694-y
更新日期：2018-05-07 00:00:00
abstract：BACKGROUND:Accurate assessment of suicidality is of major importance. We aimed to evaluate trained clinicians' ability to assess suicidality against a structured assessment made by trained raters. METHOD:Treating clinicians classified 218 adolescent psychiatric outpatients suffering from a depressive mood disorder int...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/1471-244X-8-97
更新日期：2008-12-31 00:00:00
abstract：BACKGROUND:Spirituality has received increased attention in the psychiatric literature; however, it remains underexplored on a global level. Knowledge about spirituality of persons with schizophrenia is often hampered by positive and negative symptoms, which limit their expression of spiritual needs and shift mental-he...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-016-0796-7
更新日期：2016-04-02 00:00:00
abstract：BACKGROUND:The purpose of this article was to conduct a review of the types of training offered to people with schizophrenia in order to help them develop strategies to cope with or compensate for neurocognitive or sociocognitive deficits. METHODS:We conducted a search of the literature using keywords such as "schizop...
journal_title：BMC psychiatry
pub_type： 杂志文章,评审
doi：10.1186/1471-244X-14-139
更新日期：2014-05-14 00:00:00
abstract：BACKGROUND:Accurate diagnosis of delirium is very important for prevention and treatment. Present study was designed to validate the 3-Minute Diagnostic Interview for CAM-defined Delirium Chinese version (3D-CAM-CN) in surgical ICU patients. METHODS:In this prospective diagnostic study, the 3D-CAM was translated into ...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-020-02544-w
更新日期：2020-03-24 00:00:00
abstract：BACKGROUND:Information technologies such as websites, mobile phone applications, and virtual reality programs have been shown to deliver innovative and effective treatments for mental illness. Much of the research studying electronic mental health interventions focuses on symptom reduction; however, to facilitate the i...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-015-0614-7
更新日期：2015-10-14 00:00:00
abstract：BACKGROUND:Changes in the residential and care settings of patients with severe mental illness (SMI) are a concern because of the large variety of possible negative consequences. This study describes patterns of changes in the residential and care settings of SMI patients and explores associations between these changes...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-016-1137-6
更新日期：2016-12-03 00:00:00
abstract：BACKGROUND:Major depressive disorder (MDD) is a major public health burden in conflict areas. However, it is not known for how long and by how much the observed high rates of MDD seen in conflict settings persist into the post-conflict period. METHODS:A cross sectional survey was employed seven years after the conflic...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-015-0423-z
更新日期：2015-03-14 00:00:00
abstract：BACKGROUND:A number of characteristics associated with Autism Spectrum Disorders (ASD) are over-represented among patients with Anorexia Nervosa (AN) as well as among relatives of these patients. Yet the co-occurrence of autistic traits in AN has not been fully explored and no previous study has directly compared self-...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/1471-244X-13-222
更新日期：2013-09-10 00:00:00
abstract：:The prevalence of depression appears to have increased over the past three decades. While this may be an artefact of diagnostic practices, it is likely that there are factors about modernity that are contributing to this rise. There is now compelling evidence that a range of lifestyle factors are involved in the patho...
journal_title：BMC psychiatry
pub_type： 杂志文章,评审
doi：10.1186/1471-244X-14-107
更新日期：2014-04-10 00:00:00
abstract：BACKGROUND:Asverin® (tipepidine hibenzate) has been used as an antitussive for > 50 years in Japan. Studies revealed that tipepidine modulates monoamine levels, by inhibiting G-protein-activated inwardly rectifying potassium (GIRK) channels, expecting the potential therapeutic effects of tipepidine for attention-defici...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-020-02932-2
更新日期：2020-11-10 00:00:00
abstract：BACKGROUND:Understanding the biological underpinnings of relapse in alcohol dependency is a major issue in addiction research. Based on recent evidence regarding the relevance of occipital visual evoked response potentials (ERPs) in addiction research, and its significance for relapse research, we assessed occipital ER...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-016-0782-0
更新日期：2016-03-21 00:00:00
abstract：BACKGROUND:Recent prevalence studies suggest that self-harm among adolescents in sub-Saharan Africa is as common as it is in high income countries. However, very few qualitative studies exploring first-person accounts of adolescent self-harm are available from sub-Saharan Africa. We sought to explore the experiences an...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-020-02599-9
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Schizophrenia is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, and the L-arginine:ADMA ratio are markers of endothelial dysfunction that predict mortality and adverse outcome in a range of cardiovasc...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-015-0455-4
更新日期：2015-04-03 00:00:00
abstract：BACKGROUND:Structural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done. METHODS:In global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa...
journal_title：BMC psychiatry
pub_type： 杂志文章,meta分析
doi：10.1186/1471-244X-13-110
更新日期：2013-04-09 00:00:00
abstract：BACKGROUND:Although there is some quantitative evidence to suggest the benefits of group psychoeducation for people with bipolar disorder, patients' perspectives and experiences of group psychoeducation require in-depth exploration to enable us to better understand the feasibility, acceptability and impact of these int...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-015-0556-0
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Patient suicide is a professional hazard for mental health professionals and an event likely to trigger stress reactions among them. This study aimed to identify typical profiles of professionals after a patient suicide to address the severity of stress reactions and its discriminant variables. METHODS:Ment...
journal_title：BMC psychiatry
pub_type： 杂志文章
doi：10.1186/s12888-015-0655-y
更新日期：2015-10-28 00:00:00
abstract：UNLABELLED:The WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age. BACKGROUND:Children of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depressio...
journal_title：BMC psychiatry
pub_type： 临床试验,杂志文章
doi：10.1186/s12888-015-0692-6
更新日期：2015-12-09 00:00:00
abstract：BACKGROUND:Individuals affected by severe Borderline Personality Disorder (BPD) are often heavy users of Mental Health Services (MHS). Short-term treatments currently used in BPD therapy are useful to target disruptive behaviors but they are less effective in reducing heavy MHS use. Therefore, alternative short-term tr...
journal_title：BMC psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-244X-11-181
更新日期：2011-11-21 00:00:00
