Abstract:
INTRODUCTION:There is a growing number of randomised controlled trials (RCTs) that focus on functional changes in the brain detected by functional MRI (fMRI) and gut microbiota composition changes after using probiotics.However, the effect of probiotics on functional changes in the brain through gut microbiota remains controversial in existing RCTs. Furthermore, to our knowledge, there is no systematic review to evaluate the effect of probiotics on functional changes in the brain through gut microbiota. Therefore, we aim to summarise literatures evaluating the potential association between probiotics, gut microbiota and functional changes in the brain to elucidate whether probiotics influence gut microbiota and affect functional changes in the brain through gut microbiota. METHODS AND ANALYSIS:China National Knowledge Infrastructure, Wanfang Data, VIP Databases (the Chongqing VIP Chinese Science and Technology Periodical Database), SinoMed, PubMed, Web of Science, MEDLINE (The National Library of Medicine), EMBASE (Excerpt Medica Database), Scopus, the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov will be searched until July 2019. The Grey Literature in Europe (OpenSIGLE) database and Google search engine will also be used. The reference lists of each included study will be reviewed to determine whether there are any further relevant studies. RCTs using probiotics compared with a placebo/control will be included. We will use risk of bias assessment and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to assess the quality of evidence. The results of the systematic review will be synthesised narratively in the domains of the three primary outcome measures: (1) Increased/decreased activity in brain regions or altered functional connectivity (FC) of brain detected by fMRI and their association with changes in behaviour, gastrointestinal/emotional symptoms after using probiotics. (2) Changes in composition and diversity of the gut microbiota and their association with changes in behaviour, gastrointestinal/emotional symptoms after using probiotics. (3) Increased/decreased activity in brain regions or altered FC of brain detected by fMRI and the changes in composition or diversity of the gut microbiota after administration of probiotics. ETHICS AND DISSEMINATION:The results will be disseminated through a peer-reviewed publication. As no private and confidential patient data will be included in the reporting, there are no ethical considerations associated with this protocol. PROSPERO REGISTRATION NUMBER:CRD42019145114.
journal_name
BMJ Openjournal_title
BMJ openauthors
Liu L,Ni X,Tian T,Li X,Li F,Sun M,Chen J,Zhou S,Zhao Ldoi
10.1136/bmjopen-2020-037582subject
Has Abstractpub_date
2020-08-11 00:00:00pages
e037582issue
8issn
2044-6055pii
bmjopen-2020-037582journal_volume
10pub_type
杂志文章相关文献
BMJ Open文献大全abstract:INTRODUCTION:Ambient air pollution is a global environmental problem, which causes adverse health effects and premature deaths worldwide. Although regular exercise and physical activity have evident health benefits, the influence of long-term air pollution exposure during regular outdoor running has not been definitive...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040529
更新日期:2020-12-10 00:00:00
abstract:OBJECTIVE:To determine research priorities for the management of broken bones of the upper limb in people over 50, which represent the shared priorities of patients, their families, carers and healthcare professionals. DESIGN/SETTING:A national (UK) research priority setting partnership. PARTICIPANTS:People aged 50 a...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030028
更新日期:2019-12-15 00:00:00
abstract:OBJECTIVE:To compare the prevalence of work-related potential traumatic events (PTEs), support protocols and mental health symptoms across Dutch gynaecologists, orthopaedic surgeons and paediatricians. DESIGN:Cross-sectional study, supplementary analysis of combined data. SETTING:Nationwide survey between 2014 and 20...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033816
更新日期:2020-09-02 00:00:00
abstract:OBJECTIVE:To determine the extent of agreement and patterns of disagreement between wound swab and tissue samples in patients with an infected diabetic foot ulcer (DFU). DESIGN:Multicentre, prospective, cross-sectional study. SETTING:Primary and secondary care foot ulcer/diabetic outpatient clinics and hospital wards...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-019437
更新日期:2018-01-31 00:00:00
abstract:INTRODUCTION:Drug-related problems (DRPs) are a major cause of unplanned hospital admissions among elderly people, and transitions of care have been emphasised as a key area for improving patient safety. We have designed a complex clinical pharmacist intervention that targets people ≥75 years of age undergoing transiti...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036650
更新日期:2020-04-27 00:00:00
abstract:OBJECTIVE:To identify what women report influences their preferred mode of birth after caesarean section. DESIGN:Systematic review of qualitative literature using meta-ethnography. DATA SOURCES:Medline, EMBASE, ASSIA, CINAHL and PsycINFO (1996 until April 2013; updated September 2015). Hand-searched journals, referen...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2015-008881
更新日期:2016-01-08 00:00:00
abstract:INTRODUCTION:Tobacco causes kidney damage that can progress to chronic kidney disease. However, the diagnostic parameters used in clinics are not effective in identifying smokers at risk. Our first objective is to more effectively detect subclinical renal damage in smokers. In addition, we hypothesise that tobacco cons...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032918
更新日期:2020-03-08 00:00:00
abstract:INTRODUCTION:Perioperative chemotherapy is the gold standard treatment of the resectable gastro-oesophageal adenocarcinoma. However, 70% of patients cannot receive the complete sequence because of a postoperative complication or a decrease in functional and nutritional reserves. Recently, a new concept appeared in dige...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2016-012876
更新日期:2016-12-07 00:00:00
abstract:OBJECTIVE:Obtaining informed consent is a cornerstone requirement of conducting ethical research. Traditional paper-based consent is often excessively lengthy and may fail to achieve the desired participant understanding of study requirements. Multimedia tools including video and audio may be a useful alternative. This...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-036977
更新日期:2020-07-26 00:00:00
abstract:OBJECTIVES:Childhood asthma is a complex condition where many environmental factors are implicated in causation. The aim of this study was to complete a systematic review of the literature describing associations between environmental exposures and the development of asthma in young children. SETTING:A systematic revi...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2014-006554
更新日期:2014-11-24 00:00:00
abstract:INTRODUCTION:Anticoagulant therapy in patients with cancer with venous thromboembolism (VTE) increases the risk of both VTE recurrence and haemorrhagic complication. Direct oral anticoagulants (DOACs) have been shown to be effective in preventing VTE recurrence, and comparable to conventional therapy in preventing VTE ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031698
更新日期:2019-11-05 00:00:00
abstract:INTRODUCTION:Policing practices are key drivers of HIV among people who inject drugs (PWID). This paper describes the protocol for the first study to prospectively examine the impact of a police education programme (PEP) to align law enforcement and HIV prevention. PEPs incorporating HIV prevention (including harm redu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-008958
更新日期:2015-08-10 00:00:00
abstract:INTRODUCTION:Systemic hypertension (HTN) is a common risk factor for cardiovascular disease. In Mexico, HTN prevalence has increased over time and is currently 31%. Nonetheless, information about the country's HTN incidence and its associated risk factors is scarce. Understanding this condition is a priority for identi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016773
更新日期:2017-07-31 00:00:00
abstract:OBJECTIVE:To assess serum B12, folate and the associated homocysteine (Hcy) levels among women of childbearing age in the UK and examine their association with dietary intake in relation to the UK Recommended Nutrient Intakes (RNIs) for B12 and folate. DESIGN:Cross-sectional study. SETTING:Data from two publicly avai...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011247
更新日期:2016-08-12 00:00:00
abstract:OBJECTIVE:Osteosarcopenic obesity (OSO) may be associated with an increased prevalence of hypertension. The aim of this study was to examine the difference in the prevalence of OSO and hypertension among four minority populations in China and explore the relationship between OSO and hypertension by sex. DESIGN:This st...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026818
更新日期:2019-07-18 00:00:00
abstract:OBJECTIVE:To examine current trends in the characteristics of patients visiting California emergency departments (EDs) in order to better direct the allocation of acute care resources. DESIGN:A retrospective study. SETTING:We analysed ED utilisation trends between 2005 and 2015 in California using non-public patient ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-021392
更新日期:2018-07-23 00:00:00
abstract:INTRODUCTION:Pain is an expected and appropriate experience following traumatic musculoskeletal injury. By contrast, chronic pain and disability are unhelpful yet common sequelae of trauma-related injuries. Presently, the mechanisms that underlie the transition from acute to chronic disabling post-traumatic pain are no...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017876
更新日期:2018-04-28 00:00:00
abstract:INTRODUCTION:To realise universal health coverage in an ageing society, adequate provision of appropriately trained human resources is essential. The nurse practitioner (NP) is an autonomous and independent, advanced practice nurse capable of providing treatment and care that can be substituted for some aspects of a me...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2014-006670
更新日期:2015-06-23 00:00:00
abstract:OBJECTIVE:Exposure to electric shock has been associated with an increased risk of developing delayed cardiac arrhythmias and cardiac diseases. We examined whether electric shock patients have an increased risk of developing cardiac disease, cardiac arrhythmias or death compared with the general Danish population. DES...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015967
更新日期:2017-08-28 00:00:00
abstract:OBJECTIVES:A central tenet of organised cancer screening is that all persons in a target population are invited. The aims of this study were to identify participant and physician factors associated with response to mailed physician-linked invitations (study 1) and to evaluate their effectiveness in an organised colorec...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-004494
更新日期:2014-03-12 00:00:00
abstract:BACKGROUND:Large gaps exist in the implementation of guideline recommendations for cardiovascular disease (CVD) risk management. Electronic decision support (EDS) systems are promising interventions to close these gaps but few have undergone clinical trial evaluation in Australia. We have developed HealthTracker, a mul...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002177
更新日期:2012-11-19 00:00:00
abstract:OBJECTIVES:The optimal method of identifying people with chronic obstructive pulmonary disease (COPD) from electronic primary care records is not known. We assessed the accuracy of different approaches using the Clinical Practice Research Datalink, a UK electronic health record database. SETTING:951 participants regis...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005540
更新日期:2014-07-23 00:00:00
abstract:OBJECTIVES:Pharmacoepidemiological studies are an important hypothesis-testing tool in the evaluation of postmarketing drug safety. Despite the potential to produce robust value-added data, interpretation of findings can be hindered due to well-recognised methodological limitations of these studies. Therefore, assessme...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001362
更新日期:2012-09-25 00:00:00
abstract:INTRODUCTION:Dementia and Imagination is a multidisciplinary research collaboration bringing together arts and science to address current evidence limitations around the benefits of visual art activities in dementia care. The research questions ask: Can art improve quality of life and well-being? If it does make a diff...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011634
更新日期:2016-11-02 00:00:00
abstract:OBJECTIVE:This study examined the risk factors associated with failure of enhanced recovery protocol after major hepatobiliary and pancreatic (HBP) surgery. SETTING AND PARTICIPANTS:A retrospective cohort of 194 adult patients undergoing major HBP surgery at a university hospital in Hong Kong was followed up for 30 da...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005330
更新日期:2014-07-10 00:00:00
abstract:OBJECTIVE:To investigate timely access to palliative medicines/drugs (PMs) from community pharmacies to inform palliative care service delivery. DESIGN:Mixed methods in two sequential phases: (1) prospective audit of prescriptions and concurrent survey of patients/representatives collecting PMs from pharmacy and (2) i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029016
更新日期:2019-11-24 00:00:00
abstract:INTRODUCTION:Current perspectives present feedback as a dynamic, dialogic process. It is widely accepted that feedback can have an impact on workplace performance, however, how dialogic feedback is enacted with the learner in authentic healthcare settings is less apparent. This paper seeks to describe the design and de...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034945
更新日期:2020-06-08 00:00:00
abstract:OBJECTIVES:This study examined National Health Insurance claims data to investigate the epidemiology of shoulder disorders in Korea. Detailed information on medical services and related costs was assessed by major shoulder disorder category. DESIGN AND SETTING:The 2014 National Patient Sample dataset provided by the H...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015848
更新日期:2017-07-12 00:00:00
abstract:OBJECTIVE:To analyse the spatial-temporal clustering of the HIV/AIDS epidemic in Chongqing and to explore its association with the economic indices of AIDS prevention and treatment. METHODS:Data on the HIV/AIDS epidemic and economic indices of AIDS prevention and treatment were obtained from the annual reports of the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006669
更新日期:2015-03-27 00:00:00
abstract:OBJECTIVES:This study examines the impact of the type of method used on the estimation of the burden of diseases. DESIGN:Comparison of methods of estimating disease burden. SETTING:Four metrics of burden of disease estimation, namely, years of potential life lost (YPLL), non-age weighted years of life lost (YLL) with...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027825
更新日期:2019-08-18 00:00:00